mRNA processing (Mus musculus)

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3YYYY3RNA-binding region RNP-1 (RNA recognition motif)right click on blue text for detailed informationPutative Alternative SplicingNote: New participating members shown at each stepRegulation of3RNA helicase3P-Internal methylation of mRNACleavage of mRNA at the 3’-endU4/U6hnRNP regulatorssplicing factor SF3BASR-phosphatasesexon 1pre-mRNAPoly(A)pb IIAlternative Splicingexon 2exon 1Accessory Proteins5655YYYYAG(2a)CstF3CFIYYYYexon 1AGPoly(A) pol5Cleavage at the 3’-Splice-Site and Exon LigationSR protein phosphatasesmRNA 3’-end processingFormation of pre-mRNPsAFormation of the active Spliceosomal C complexexon 2U2 snRNPPiCF II(3)exon 2Lariat Formation and 5’-Splice Site CleavageU2 snRNPFormation of the Spliceosomal E complexmRNA splicing (major pathway)Rngtt (capping enzyme)CF ImRNA cappingSR protein kinasesRNA helicase AsnRNP Sm core complexsplicesome associated helicasesSerine/Argenine Rich Proteins(SR)mRNA splice site selection5snRNP Sm core complexU2AFAGAG(2c)exon 25AAUAAAPU4 snRNPU6 snRNPRegulatorsAdditional SR proteinsPolr2aCPSF3Cap BindingKinases Phosphorylating RS domains?SF3b14bYYYYiPoPoly(A) polymerase alpha(2b)heterogeneous nuclear ribonucleoproteinsintronmRNA Cappingdegraded5YYYYCF IIhnRNPsU6SR-proteins5 G capAGSpt5Formation of the Spliceosomal A complexAdditional FactorsU5ATPRNAi pathwayInternal methylation of mRNAAFormation of the Spliceosomal B complexCstF3Formation of pre-mRNPsU2AFAU1 snRNPU2 snRNPsU4SR-kinasesAInterPro Domain Containing:Poly(A)-binding protein IIUGsplicing factor SF3AGUexon 1SR-proteinsexon 1Formation of the Spliceosomal A complexU5U1CA(2)3SR-proteins3exon 2U23SR-binding sites5SR-binding sitesexon 1Processing of Intron-Containing Pre-mRNAAdditional FactorsUGFormation of the Spliceosomal B complexGene Ontology: RNA BindingAdditional FactorsU4:U5:U6 tri-snRNP complexAGU1 snRNPexon 2AYYYYPrimary RNA transcriptMisc.mRNA polyadenylationFormation of the Spliceosomal E complexSR-repressor proteinsGMPRnmt (methyltransferase)55U5 snRNP3snRNP Sm core complex(1)535AAAAAAAMethylation of mRNA5Formation of the Spliceosomal C complexCPSFD19Bwg1357eSrp14Myef2AI462171Rbmxrt4632417O19RikSfrs16RalyHrmt1l1Tdrd7Htatsf1Ddx48Rbm10Igf2bp3AI255840Bicc1Oas1aRae1Cugbp2Rad21Tardbp1600023H17RikRbm16Prpf8BollClk1D15Ertd119eD9Mgi242600011C06RikU2af1-rs2Ddx5Rnu22700077B20RikRnu1a21500011J06RikMrpl11Pcbp2U2af22010003O18RikHnrpfCd2bp2D230005D02RikCdc40Fxr2hAI255750Mki67ipQkZfp3462700028P07RikAW1078840710005M24RikAdar1810036A22RikRnaseh2aAU045931Xrn2G3bp2-pendingExosc8Wdr55Rps28D1Pas1-rs12610101N10RikSfrs7SyncripSlc6a8Ncbp15330419I02RikRnpc18030431D03Rik6720478K01RikLsm2Rbms2Secisbp2Cugbp1D1Pas1CsadRod1Tial1Srpk2Cpeb1Auh2810036M01RikCova1Rbms1Hnrpa3Snrpd1Rps27Rbm14Dnd1AI256354Poldip3D8Ertd233eRbm18Pabpn1Ppargc1bSmn1Sfrs10Matr3-ps15730557H03RikRnu11Eif4e5031411E02RikCpeb4Rps20D830027H13RikDazlAdam5Rpl32Lrrn6aAA589495Hnrpa1Srpk1D330023I21Rik2310046H11Rik1200009B18RikIlkapPhf5a1110037F02RikMatr3AI255230C430048L16RikBat1aTia1Pcbp4Snrp1cHnrpll2810028N01RikSfrs11AI255207Oas1bSRrp40Hnrpr2410003C20RikSfrs4B230333C21RikDdx20AU023006Ewsr1Ddx39Tnrc4AI255847Prpf4Lsm7Sfrs3MGI:23873670610009D07RikDdx56Fmr1Rbm131700009P03RikHnrpcSmc1l1Ddx4Sfrs1Rbm172610023M21RikCstf2t4930506D01Rik2700088M22RikNsap1l-pendingRbm11C80672Snrpa1AI642080Mbnl1Rbms3MGI:2661424Rbed11110017C15RikRbm4Acin14921506I22RikPcolceAI503051Prpf18Sf4Cpsf2Lsm2AI843301SlbpRps9Dazap1SonAW5530501190005F20RikRbm7AI447568U4 snRNASf3a23110061K15RikSf3b2Rpl19Rps11FusFblPapolb3830425H19RikAI5046301810036E18RikEif4e3TsnSfpqRnu1a1Mettl3Rps4xHnrpabPRP17_MOUSE2810055E05RikAI256346Park7Zmat2HnrpkCstf3Eral1Exosc7MGI:1336880Zbp1Adat1Rbmx2Polr2gDhx8Taf15Cirbp4930565A21RikAI844780Prpf4b2210008M09RikDdx212610102M01RikCstf1Adarb2AW260507Ilf3Clk2Supt5hAI2552129530027K23RikElavl4Ddx19bCyp4f18Ppargc1aRnu1b6Hrmt1l2Sf3a12400002F11RikNufip11700025B16RikSbno1Uhmk1Srp68Cpeb35730557B15RikEif4e24930422M05RikAco1Rbm3Npm12610020N02RikCnot4Ppil41500012C14RikOas2Rbm12Rbm17Dhx9Tarbp2Rbm28Cpsf4Grsf14932422E22RikDicer1Rnu1a14922503N01RikHnrph1Rps29Rbm221110034O07RikClk4Pabpc1Ddx3xBB131279Rpl22RnaselAL022933NclAI462438Pabpc2SpenImp4Brunol6AI043106Rnu12Afg3l2Txnl4AI467299Lsm11Rnmtl1Rps232810442I21RikDdx243100004P22RikRbm5Sart3PrkrHnrpmSsbCstf2tEif4g2Pskh1Rnu1082600016C11RikSfrs12Dhx38Sfrs12Oas1gSrp9BC013481AI314192RdbpRpl116330548G22RikSfrs2Clk3HnrpdlAW049977Hnrpa2b1Cpsf3Mrpl23Dhx16Rbm21Matr3-ps2Nhp2l1HdpTrim21Elavl3Sfrs5Rbm9Eif3s9Lsm4LSMD1_MOUSESnrpaRefbp2Nxf7V1rc17Nhp2l1Wbscr1Oasl2PapolgAA522010Tmed10Prpf18Thoc4Sca1Rpl12D11Ertd730eD12Mgi43Sfrs8Pcbp3Hnrpa0Hnrph2HnrplSnrpd2Cdk9AI255215U2af1B230118G17Rik2610027L16RikSf3a3Sf3b3Exosc9Afg3l1G430095G15RikRbpms24930534J06RikScye1Mrps28Rpl7Nhp2l1PpieHnrpdRbpms2410112D09RikGgcx3200001K10RikRpp14D3Jfr1Rbmy1a1Ddx64930429A22RikEif3s4Dhx15Rngtt1700003D06RikMGI:1926224Slc25a41810035L17RikPpp1r14bBrca14930517K11RikExosc4Rpl26Rnu6Synj2Htf9c4930554P13RikTiaf1Dnajc8NonoRps14Ttc14Rpl394932422M17RikRps6Ciz1Hnrpa3Rps24Nhp2l1Eif4a22810441O16RikCol4a3Nsep1Cpsf5Rnpepl1AA407033PapolaAI1942702610024A01Rik1300006N24RikPpp1r8Snrpb2Pspc1Rbm6Elavl20610009J05Rik2610317D23RikSnrpd3C85084RbmxrtTlr5Ssa2Fxr1h2810411C16RikRnu1b12610015J01Rik9430070C08RikRbmxFnbp3Fusip1Pcbp1Ptbp2Tnrc6cCstf2D12Mgi40Rad52bElavl1Exosc5Prpf4Ddx19aBrunol4Dkc1MGI:1351465Wdr9Traf6Srp54Igf2bp1SnrpePum12610209F03RikSfrs9Rnpc2Rnu1b1Wbp4Snrp700610009C03RikPrpf81700047G05RikPrpf3Rnu1b2Rnaset2Msi1hA130095G20RikPum2Stau12010300K22RikHnrpuC330027G06RikZfp622Rbm8aSf3b19130414A06RikPtbp1Sfrs101700012H05Rik1190002L16RikMsi2hRps72010319N22Rik3000004N20RikPolr2aBclaf12410013L13RikSfrs14Lsm8Bard1Ncbp2SnrpfPabpc5SnrpbSnrpgC79783SpopCpsf11110033J19RikRps13Lsm15730555F13RikRbm31y2410104I19RikLgtnAI2552199630048M01Rik0610033I05RikNxf15730453I16Rik2610031L17Rik2600016F06RikRnpepU2af1-rs1Zfp3854932702K14RikOas3Rnu2Srrm1Safb2Sf3b4AI255183Rpl37C230097K14RikDdx1D5Ertd700eDdx41Rpl8Rbm19RnmtRnu1b2ZfmlRpl381700095D18RikSfrs114930562C03RikSnrpnTertNol8Akap1Sf3b5TenrRnps1H2-BfDdx25U5 snRNARbm15bSrp19Eif4g3Pabpc4Rpl9B930007L02RikAbcb4Ppm1gSfrs6


Description

Adapted from Reactome, see: REACT 1675.1

This process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' polyadenylation, and RNA splicing, which occur in the cell nucleus before the RNA is translated.

5' Capping: Capping of the pre-mRNA involves the addition of 7-methylguanosine (m7G) to the 5' end. The cap protects the 5' end of the primary RNA transcript from attack by ribonucleases that have specificity to the 3'5' phosphodiester bonds.

3' Processing: The pre-mRNA processing at the 3' end of the RNA molecule involves cleavage of its 3' end and then the addition of about 200 adenine residues to form a poly(A) tail. As the poly(A) tails is synthesised, it binds multiple copies of poly(A) binding protein, which protects the 3'end from ribonuclease digestion.

Splicing: RNA splicing is the process by which introns, regions of RNA that do not code for protein, are removed from the pre-mRNA and the remaining exons connected to re-form a single continuous molecule.

Description adapted from Wikipedia: http://en.wikipedia.org/wiki/Post-transcriptional_modification

Comments

GenMAPP notes 
Gene lists from obtained from InterPro 9-23-2003: Mm RNA-binding region RNP-1 (RNA recognition motif)
GenMAPP remarks 
Adapted from http://www.reactome.org

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
78419view10:26, 7 January 2015MaintBotadded missing graphIds
71745view20:19, 17 October 2013MaintBotUpdated data sources
69784view13:04, 11 July 2013Cizarfixed lines to graphical lines
67497view11:09, 26 June 2013DdiglesOntology Term : 'spliceosome pathway' added !
62837view04:56, 3 May 2013MaintBotupdated uniprot data source
41325view00:24, 2 March 2011MaintBotRemoved redundant pathway information and comments
35230view18:54, 11 February 2010Khanspersupdated some xrefs
35229view18:42, 11 February 2010KhanspersModified description
28147view11:08, 28 January 2009ThomasModified description
26227view23:03, 24 November 2008AlexanderPicominor tweak
26225view23:01, 24 November 2008AlexanderPico
21333view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:mRNA processing binding Reactome]] moved to [[Pathway:WP310]]: Moved to stable identifier
8272view13:46, 7 January 2008MaintBot[[Pathway:Mouse:mRNA processing binding Reactome]] moved to [[Pathway:Mus musculus:mRNA processing binding Reactome]]: Renaming species
7756view16:15, 18 December 2007MaintBotfixed category names
7321view12:42, 4 November 2007MaintBotAdded categories to GPML
6511view22:19, 22 May 2007Nsalomonisgpml file for [[Mouse:mRNA_processing_binding_Reactome]]

External references

DataNodes

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NameTypeDatabase referenceComment
0610009C03RikGeneProduct66585 (Entrez Gene)
0610009D07RikGeneProduct66055 (Entrez Gene) Derived from InterPro
0610009J05RikGeneProductMGI:1921339 (MGI) Derived from InterPro
0610033I05RikGeneProduct71684 (Entrez Gene) Derived from InterPro
0710005M24RikGeneProduct76897 (Entrez Gene) Derived from InterPro
1110017C15RikGeneProduct66164 (Entrez Gene)
1110033J19RikGeneProduct66184 (Entrez Gene)
1110034O07RikGeneProduct68744 (Entrez Gene) Derived from InterPro
1110037F02RikGeneProduct66185 (Entrez Gene) Derived from InterPro
1190002L16RikGeneProduct102462 (Entrez Gene)
1190005F20RikGeneProduct98685 (Entrez Gene)
1200009B18RikGeneProduct67456 (Entrez Gene) Derived from InterPro
1300006N24RikGeneProduct71766 (Entrez Gene) Derived from InterPro
1500011J06RikGeneProduct208606 (Entrez Gene)
1500012C14RikGeneProductMGI:1914382 (MGI) Derived from InterPro
1600023H17RikGeneProductMGI:1922893 (MGI) Derived from InterPro
1700003D06RikGeneProductMGI:1919466 (MGI) Derived from InterPro
1700009P03RikGeneProduct74213 (Entrez Gene) Derived from InterPro
1700012H05RikGeneProduct76572 (Entrez Gene) Derived from InterPro
1700025B16RikGeneProduct69408 (Entrez Gene) Derived from InterPro
1700047G05RikGeneProductMGI:1914568 (MGI) Derived from InterPro
1700095D18RikGeneProductMGI:1920805 (MGI) Derived from InterPro
1810035L17RikGeneProduct380773 (Entrez Gene) Derived from InterPro
1810036A22RikGeneProductMGI:1916407 (MGI) Derived from InterPro
1810036E18RikGeneProductMGI:1925734 (MGI) Derived from InterPro
2010003O18RikGeneProduct384281 (Entrez Gene)
2010300K22RikGeneProductMGI:1913726 (MGI) Derived from InterPro
2010319N22RikGeneProductMGI:1917273 (MGI) Derived from InterPro
2210008M09RikGeneProduct207920 (Entrez Gene) Derived from InterPro
2310046H11RikGeneProductMGI:1922955 (MGI) Derived from InterPro
2400002F11RikGeneProduct66405 (Entrez Gene)
2410003C20RikGeneProduct66983 (Entrez Gene)
2410013L13RikGeneProductMGI:2149671 (MGI) Derived from InterPro
2410104I19RikGeneProduct67959 (Entrez Gene) Derived from InterPro
2410112D09RikGeneProductMGI:1920919 (MGI) Derived from InterPro
2600011C06RikGeneProduct67039 (Entrez Gene) Derived from InterPro
2600016C11RikGeneProductMGI:1919317 (MGI) Derived from InterPro
2600016F06RikGeneProductMGI:1913821 (MGI) Derived from InterPro
2610015J01RikGeneProductMGI:1917471 (MGI) Derived from InterPro
2610020N02RikGeneProduct353258 (Entrez Gene) Derived from InterPro
2610023M21RikGeneProductMGI:1924186 (MGI) Derived from InterPro
2610024A01RikGeneProduct72160 (Entrez Gene) Derived from InterPro
2610027L16RikGeneProduct67842 (Entrez Gene)
2610031L17RikGeneProduct68879 (Entrez Gene)
2610101N10RikGeneProduct67958 (Entrez Gene) Derived from InterPro
2610102M01RikGeneProductMGI:1919730 (MGI) Derived from InterPro
2610209F03RikGeneProductMGI:2149675 (MGI) Derived from InterPro
2610317D23RikGeneProduct54614 (Entrez Gene)
2700028P07RikGeneProductMGI:1924055 (MGI) Derived from InterPro
2700077B20RikGeneProductMGI:1923845 (MGI) Derived from InterPro
2700088M22RikGeneProduct67197 (Entrez Gene) Derived from InterPro
2810028N01RikGeneProduct72662 (Entrez Gene)
2810036M01RikGeneProductMGI:1919914 (MGI) Derived from InterPro
2810055E05RikGeneProduct230780 (Entrez Gene)
2810411C16RikGeneProductMGI:1916505 (MGI) Derived from InterPro
2810441O16RikGeneProduct67225 (Entrez Gene) Derived from InterPro
2810442I21RikGeneProduct72735 (Entrez Gene) Derived from InterPro
3000004N20RikGeneProduct72397 (Entrez Gene) Derived from InterPro
3100004P22RikGeneProduct68035 (Entrez Gene) Derived from InterPro
3110061K15RikGeneProductMGI:1920450 (MGI) Derived from InterPro
3200001K10RikGeneProduct381626 (Entrez Gene) Derived from InterPro
3830425H19RikGeneProductMGI:1923985 (MGI) Derived from InterPro
4632417O19RikGeneProductMGI:1925510 (MGI) Derived from InterPro
4921506I22RikGeneProduct66704 (Entrez Gene) Derived from InterPro
4922503N01RikGeneProduct230603 (Entrez Gene) Derived from InterPro
4930422M05RikGeneProductMGI:2442597 (MGI) Derived from InterPro
4930429A22RikGeneProduct208718 (Entrez Gene)
4930506D01RikGeneProductMGI:1922339 (MGI) Derived from InterPro
4930517K11RikGeneProduct68172 (Entrez Gene)
4930534J06RikGeneProductMGI:2442955 (MGI)
4930554P13RikGeneProductMGI:1922548 (MGI) Derived from InterPro
4930562C03RikGeneProduct67667 (Entrez Gene) Derived from InterPro
4930565A21RikGeneProduct319586 (Entrez Gene) Derived from InterPro
4932422E22RikGeneProduct319695 (Entrez Gene) Derived from InterPro
4932422M17RikGeneProduct74366 (Entrez Gene) Derived from InterPro
4932702K14RikGeneProduct67543 (Entrez Gene) Derived from InterPro
5031411E02RikGeneProductMGI:2445088 (MGI) Derived from InterPro
5330419I02RikGeneProductMGI:2442152 (MGI) Derived from InterPro
5730453I16RikGeneProduct269061 (Entrez Gene) Derived from InterPro
5730555F13RikGeneProduct66660 (Entrez Gene) Derived from InterPro
5730557B15RikGeneProduct67434 (Entrez Gene) Derived from InterPro
5730557H03RikGeneProductMGI:1917910 (MGI) Derived from InterPro
6330548G22RikGeneProduct76167 (Entrez Gene) Derived from InterPro
6720478K01RikGeneProductMGI:1925151 (MGI) Derived from InterPro
8030431D03RikGeneProductMGI:1924422 (MGI) Derived from InterPro
9130414A06RikGeneProductMGI:1918855 (MGI) Derived from InterPro
9430070C08RikGeneProductMGI:1924605 (MGI) Derived from InterPro
9530027K23RikGeneProduct77411 (Entrez Gene) Derived from InterPro
9630048M01RikGeneProduct320158 (Entrez Gene)
A130095G20RikGeneProductMGI:2144767 (MGI) Derived from InterPro
AA407033GeneProductMGI:2141802 (MGI) Derived from InterPro
AA522010GeneProductMGI:2141367 (MGI) Derived from InterPro
AA589495GeneProductMGI:2143495 (MGI) Derived from InterPro
AI043106GeneProduct103625 (Entrez Gene) Derived from InterPro
AI194270GeneProduct98871 (Entrez Gene) Derived from InterPro
AI255183GeneProductMGI:1353607 (MGI) Derived from InterPro
AI255207GeneProduct102459 (Entrez Gene) Derived from InterPro
AI255212GeneProduct101508 (Entrez Gene) Derived from InterPro
AI255215GeneProductMGI:2138868 (MGI) Derived from InterPro
AI255219GeneProductMGI:2143545 (MGI) Derived from InterPro
AI255230GeneProduct98285 (Entrez Gene) Derived from InterPro
AI255750GeneProductMGI:2146392 (MGI) Derived from InterPro
AI255840GeneProductMGI:2146810 (MGI) Derived from InterPro
AI255847GeneProductMGI:2138184 (MGI) Derived from InterPro
AI256346GeneProduct105123 (Entrez Gene) Derived from InterPro
AI256354GeneProduct103653 (Entrez Gene) Derived from InterPro
AI314192GeneProductMGI:2147861 (MGI) Derived from InterPro
AI447568GeneProductMGI:2139707 (MGI) Derived from InterPro
AI462171GeneProduct103232 (Entrez Gene) Derived from InterPro
AI462438GeneProduct98985 (Entrez Gene)
AI467299GeneProduct106604 (Entrez Gene) Derived from InterPro
AI503051GeneProductMGI:2141434 (MGI) Derived from InterPro
AI504630GeneProductMGI:2147572 (MGI) Derived from InterPro
AI642080GeneProduct103805 (Entrez Gene) Derived from InterPro
AI843301GeneProductMGI:2146493 (MGI) Derived from InterPro
AI844780GeneProductMGI:2141491 (MGI) Derived from InterPro
AL022933GeneProductMGI:2141534 (MGI) Derived from InterPro
AU023006GeneProduct102683 (Entrez Gene) Derived from InterPro
AU045931GeneProductMGI:2141597 (MGI) Derived from InterPro
AW049977GeneProductMGI:2142752 (MGI) Derived from InterPro
AW107884GeneProductMGI:2140554 (MGI) Derived from InterPro
AW260507GeneProductMGI:2147361 (MGI) Derived from InterPro
AW553050GeneProductMGI:2142260 (MGI) Derived from InterPro
Abcb4GeneProduct18670 (Entrez Gene) Derived from InterPro
Acin1GeneProduct56215 (Entrez Gene) Derived from InterPro
Aco1GeneProduct11428 (Entrez Gene)
Adam5GeneProduct11499 (Entrez Gene) Derived from InterPro
AdarGeneProduct56417 (Entrez Gene)
Adarb2GeneProduct94191 (Entrez Gene)
Adat1GeneProduct30947 (Entrez Gene)
Afg3l1GeneProduct114896 (Entrez Gene) Derived from InterPro
Afg3l2GeneProduct69597 (Entrez Gene) Derived from InterPro
Akap1GeneProduct11640 (Entrez Gene)
AuhGeneProduct11992 (Entrez Gene)
B230118G17RikGeneProductMGI:1915415 (MGI) Derived from InterPro
B230333C21RikGeneProduct338351 (Entrez Gene) Derived from InterPro
B930007L02RikGeneProduct321006 (Entrez Gene) Derived from InterPro
BB131279GeneProduct103061 (Entrez Gene) Derived from InterPro
BC013481GeneProduct245945 (Entrez Gene) Derived from InterPro
Bard1GeneProduct12021 (Entrez Gene)
Bat1aGeneProduct53817 (Entrez Gene)
Bclaf1GeneProduct72567 (Entrez Gene) Derived from InterPro
Bicc1GeneProduct83675 (Entrez Gene)
BollGeneProduct75388 (Entrez Gene) Derived from InterPro
Brca1GeneProduct12189 (Entrez Gene)
Brunol4GeneProduct108013 (Entrez Gene)
Brunol6GeneProduct76183 (Entrez Gene) Derived from InterPro
C230097K14RikGeneProductMGI:2441901 (MGI) Derived from InterPro
C330027G06RikGeneProduct68280 (Entrez Gene) Derived from InterPro
C430048L16RikGeneProduct77604 (Entrez Gene) Derived from InterPro
C79783GeneProductMGI:2142336 (MGI) Derived from InterPro
C80672GeneProductMGI:2143933 (MGI) Derived from InterPro
C85084GeneProductMGI:2140695 (MGI) Derived from InterPro
Cd2bp2GeneProduct70233 (Entrez Gene)
Cdc40GeneProduct71713 (Entrez Gene)
Cdk9GeneProduct107951 (Entrez Gene) Derived from InterPro
CirbpGeneProduct12696 (Entrez Gene) Derived from InterPro
Ciz1GeneProduct68379 (Entrez Gene)
Clk1GeneProduct12747 (Entrez Gene) PMID: 15010457: Inhibitor John C. Bell, PhD

Professor, Depts. of Medicine and Biochemistry, Microbiology & Immunology University of Ottawa Career Scientist, Ottawa Regional Cancer Centre Associate Scientist, The Ottawa Hospital Research Institute Telephone: 613-737-7700 ext 6893 Fax: 613-247-3524 Email: John.Bell@orcc.on.ca The control of pre-mRNA splicing by the Clk kinase family

We are studying a family of kinases which we believe provide an interface between intracellular signaling networks and the post-transcriptional mechanism of mRNA splicing. We are performing a structure:function analysis of the three Clk family members to identify domains in the three proteins which are involved in regulating splicing. Using homologous recombination we are generating null strains of mice which are lacking one, two or all three Clk genes. The Clk kinases all possess dual specificity kinase activity and yeast expression systems are being used to produce large amounts of the kinase to perform a detailed analysis of the sites of serine, threonine and tyrosine autophosphorylation within the kinase.
Clk2GeneProduct12748 (Entrez Gene)
Clk3GeneProduct102414 (Entrez Gene)
Clk4GeneProduct12750 (Entrez Gene)
Cnot4GeneProduct53621 (Entrez Gene) Derived from InterPro
Col4a3GeneProduct12828 (Entrez Gene) Derived from InterPro
Cova1GeneProduct209224 (Entrez Gene) Derived from InterPro
Cpeb1GeneProduct12877 (Entrez Gene) Derived from InterPro
Cpeb3GeneProduct208922 (Entrez Gene) Derived from InterPro
Cpeb4GeneProduct67579 (Entrez Gene) Derived from InterPro
Cpsf1GeneProduct94230 (Entrez Gene)
Cpsf2GeneProduct51786 (Entrez Gene)
Cpsf3GeneProduct54451 (Entrez Gene)
Cpsf4GeneProduct54188 (Entrez Gene)
Cpsf5GeneProduct68219 (Entrez Gene)
CsadGeneProduct246277 (Entrez Gene) Derived from InterPro
Cstf1GeneProduct67337 (Entrez Gene)
Cstf2GeneProduct108062 (Entrez Gene)
Cstf2tGeneProduct83410 (Entrez Gene) Derived from InterPro
Cstf3GeneProduct228410 (Entrez Gene)
Cugbp1GeneProduct13046 (Entrez Gene)
Cugbp2GeneProduct14007 (Entrez Gene)
Cyp4f18GeneProduct72054 (Entrez Gene) Derived from InterPro
D11Ertd730eGeneProduct193116 (Entrez Gene)
D12Mgi40GeneProduct104925 (Entrez Gene) Derived from InterPro
D12Mgi43GeneProduct104924 (Entrez Gene) Derived from InterPro
D15Ertd119eGeneProductMGI:1261777 (MGI) Derived from InterPro
D19Bwg1357eGeneProduct52874 (Entrez Gene)
D1Pas1-rs1GeneProductMGI:99524 (MGI)
D1Pas1GeneProduct110957 (Entrez Gene)
D230005D02RikGeneProduct239188 (Entrez Gene) Derived from InterPro
D330023I21RikGeneProduct237073 (Entrez Gene) Derived from InterPro
D3Jfr1GeneProduct229663 (Entrez Gene)
D5Ertd700eGeneProduct52387 (Entrez Gene) Derived from InterPro
D830027H13RikGeneProductMGI:2445140 (MGI) Derived from InterPro
D8Ertd233eGeneProduct52202 (Entrez Gene) Derived from InterPro
D9Mgi24GeneProduct102460 (Entrez Gene) Derived from InterPro
Dazap1GeneProduct70248 (Entrez Gene) Derived from InterPro
DazlGeneProduct13164 (Entrez Gene) Derived from InterPro
Ddx1GeneProduct104721 (Entrez Gene)
Ddx19aGeneProduct13680 (Entrez Gene)
Ddx19bGeneProduct234733 (Entrez Gene)
Ddx20GeneProduct53975 (Entrez Gene)
Ddx21GeneProduct56200 (Entrez Gene)
Ddx24GeneProduct27225 (Entrez Gene)
Ddx25GeneProduct30959 (Entrez Gene)
Ddx39GeneProduct68278 (Entrez Gene)
Ddx3xGeneProduct13205 (Entrez Gene)
Ddx4GeneProduct13206 (Entrez Gene)
Ddx41GeneProduct72935 (Entrez Gene)
Ddx48GeneProduct192170 (Entrez Gene)
Ddx5GeneProduct13207 (Entrez Gene)
Ddx56GeneProduct52513 (Entrez Gene)
Ddx6GeneProduct13209 (Entrez Gene)
Dhx15GeneProduct13204 (Entrez Gene)
Dhx16GeneProduct69192 (Entrez Gene)
Dhx38GeneProduct64340 (Entrez Gene)
Dhx8GeneProduct217207 (Entrez Gene)
Dhx9GeneProduct13211 (Entrez Gene)
Dicer1GeneProduct192119 (Entrez Gene)
Dkc1GeneProduct108025 (Entrez Gene)
Dnajc8GeneProduct68598 (Entrez Gene)
Dnd1GeneProduct213236 (Entrez Gene) Derived from InterPro
Eif3s4GeneProduct53356 (Entrez Gene) Derived from InterPro
Eif3s9GeneProduct27979 (Entrez Gene) Derived from InterPro
Eif4a2GeneProduct13682 (Entrez Gene)
Eif4eGeneProduct13684 (Entrez Gene)
Eif4e2GeneProduct26987 (Entrez Gene)
Eif4e3GeneProduct66892 (Entrez Gene)
Eif4g2GeneProduct13690 (Entrez Gene) Derived from InterPro
Eif4g3GeneProduct230861 (Entrez Gene)
Elavl1GeneProduct15568 (Entrez Gene) Derived from InterPro
Elavl2GeneProduct15569 (Entrez Gene) Derived from InterPro
Elavl3GeneProduct15571 (Entrez Gene) Derived from InterPro
Elavl4GeneProduct15572 (Entrez Gene) Derived from InterPro
Eral1GeneProduct57837 (Entrez Gene) Derived from InterPro
Ewsr1GeneProduct14030 (Entrez Gene) Derived from InterPro
Exosc4GeneProduct109075 (Entrez Gene)
Exosc5GeneProduct27998 (Entrez Gene)
Exosc7GeneProduct66446 (Entrez Gene)
Exosc8GeneProduct69639 (Entrez Gene)
Exosc9GeneProduct50911 (Entrez Gene)
FblGeneProduct14113 (Entrez Gene)
Fmr1GeneProduct14265 (Entrez Gene)
Fnbp3GeneProduct56194 (Entrez Gene)
FusGeneProduct233908 (Entrez Gene)
Fusip1GeneProduct14105 (Entrez Gene)
Fxr1hGeneProduct14359 (Entrez Gene)
Fxr2hGeneProduct23879 (Entrez Gene)
G3bp2-pendingGeneProductMGI:1346339 (MGI) Derived from InterPro
G430095G15RikGeneProductMGI:2443869 (MGI) Derived from InterPro
GgcxGeneProduct56316 (Entrez Gene) Derived from InterPro
Grsf1GeneProduct231413 (Entrez Gene) Derived from InterPro
H2-BfGeneProduct14962 (Entrez Gene) Derived from InterPro
HdpGeneProductMGI:104612 (MGI) Derived from InterPro
Hnrpa0GeneProduct77134 (Entrez Gene) Derived from InterPro
Hnrpa1GeneProduct15382 (Entrez Gene)
Hnrpa2b1GeneProduct53379 (Entrez Gene)
Hnrpa3GeneProduct229279 (Entrez Gene) Derived from InterPro
HnrpabGeneProduct15384 (Entrez Gene)
HnrpcGeneProduct15381 (Entrez Gene)
HnrpdGeneProduct11991 (Entrez Gene)
HnrpdlGeneProduct50926 (Entrez Gene) Derived from InterPro
HnrpfGeneProduct98758 (Entrez Gene) Derived from InterPro
Hnrph1GeneProduct59013 (Entrez Gene)
Hnrph2GeneProduct56258 (Entrez Gene)
HnrpkGeneProduct15387 (Entrez Gene)
HnrplGeneProduct15388 (Entrez Gene)
HnrpllGeneProduct72692 (Entrez Gene) Derived from InterPro
HnrpmGeneProduct76936 (Entrez Gene)
HnrprGeneProduct74326 (Entrez Gene)
HnrpuGeneProduct51810 (Entrez Gene)
Hrmt1l1GeneProduct15468 (Entrez Gene)
Hrmt1l2GeneProduct15469 (Entrez Gene)
Htatsf1GeneProduct72459 (Entrez Gene) Derived from InterPro
Htf9cGeneProduct15547 (Entrez Gene) Derived from InterPro
Igf2bp1GeneProduct140486 (Entrez Gene) Derived from InterPro
Igf2bp3GeneProduct140488 (Entrez Gene) Derived from InterPro
Ilf3GeneProduct16201 (Entrez Gene)
IlkapGeneProduct67444 (Entrez Gene) Derived from InterPro
Imp4GeneProduct27993 (Entrez Gene)
LSMD1_MOUSEGeneProductQ9D2U5 (Uniprot/TrEMBL)
LgtnGeneProduct16865 (Entrez Gene)
Lrrn6aGeneProduct235402 (Entrez Gene) Derived from InterPro
Lsm11GeneProduct72290 (Entrez Gene)
Lsm1GeneProduct67207 (Entrez Gene)
Lsm2GeneProduct27756 (Entrez Gene)
Lsm4GeneProduct50783 (Entrez Gene)
Lsm7GeneProduct66094 (Entrez Gene)
Lsm8GeneProduct76522 (Entrez Gene)
MGI:1336880GeneProduct20624 (Entrez Gene)
MGI:1351465GeneProduct27041 (Entrez Gene) Derived from InterPro
MGI:1926224GeneProduct268859 (Entrez Gene) Derived from InterPro
MGI:2387367GeneProduct241490 (Entrez Gene) Derived from InterPro
MGI:2661424GeneProduct272009 (Entrez Gene) PMID: 11684676
Matr3-ps1GeneProduct17185 (Entrez Gene) Derived from InterPro
Matr3-ps2GeneProduct17186 (Entrez Gene) Derived from InterPro
Matr3GeneProduct17184 (Entrez Gene) Derived from InterPro
Mbnl1GeneProduct56758 (Entrez Gene)
Mettl3GeneProduct56335 (Entrez Gene)
Mki67ipGeneProduct67949 (Entrez Gene) Derived from InterPro
Mrpl11GeneProduct66419 (Entrez Gene)
Mrpl23GeneProduct19935 (Entrez Gene)
Mrps28GeneProduct66230 (Entrez Gene)
Msi1hGeneProduct17690 (Entrez Gene) Derived from InterPro
Msi2hGeneProduct76626 (Entrez Gene) Derived from InterPro
Myef2GeneProduct17876 (Entrez Gene) Derived from InterPro
Ncbp1GeneProduct110519 (Entrez Gene)
Ncbp2GeneProduct68092 (Entrez Gene)
NclGeneProduct17975 (Entrez Gene) Derived from InterPro
Nhp2l1GeneProduct20826 (Entrez Gene)
Nhp2l1GeneProductQ9D0T1 (SwissProt)
Nol8GeneProduct70930 (Entrez Gene) Derived from InterPro
NonoGeneProduct53610 (Entrez Gene)
Npm1GeneProduct18148 (Entrez Gene)
Nsap1l-pendingGeneProductMGI:1930916 (MGI) Derived from InterPro
Nsep1GeneProduct22608 (Entrez Gene)
Nufip1GeneProduct27275 (Entrez Gene)
Nxf1GeneProduct53319 (Entrez Gene)
Nxf7GeneProduct170722 (Entrez Gene)
Oas1aGeneProduct246730 (Entrez Gene)
Oas1bGeneProduct23961 (Entrez Gene)
Oas1gGeneProduct23960 (Entrez Gene)
Oas2GeneProduct246728 (Entrez Gene)
Oas3GeneProduct246727 (Entrez Gene)
Oasl2GeneProduct23962 (Entrez Gene)
PRP17_MOUSEGeneProductQ9DC48 (Uniprot/TrEMBL)
Pabpc1GeneProduct18458 (Entrez Gene) Derived from InterPro
Pabpc2GeneProduct18459 (Entrez Gene) Derived from InterPro
Pabpc4GeneProduct230721 (Entrez Gene) Derived from InterPro
Pabpc5GeneProduct93728 (Entrez Gene) Derived from InterPro
Pabpn1GeneProduct54196 (Entrez Gene)
PapolaGeneProduct18789 (Entrez Gene)
PapolbGeneProduct56522 (Entrez Gene)
PapolgGeneProduct216578 (Entrez Gene)
Park7GeneProduct57320 (Entrez Gene)
Pcbp1GeneProduct23983 (Entrez Gene)
Pcbp2GeneProduct18521 (Entrez Gene)
Pcbp3GeneProduct59093 (Entrez Gene)
Pcbp4GeneProduct59092 (Entrez Gene)
PcolceGeneProduct18542 (Entrez Gene) Derived from InterPro
Phf5aGeneProduct68479 (Entrez Gene)
Poldip3GeneProduct73826 (Entrez Gene) Derived from InterPro
Polr2aGeneProduct20020 (Entrez Gene)
Polr2gGeneProduct67710 (Entrez Gene)
Ppargc1aGeneProduct19017 (Entrez Gene) Derived from InterPro
Ppargc1bGeneProduct170826 (Entrez Gene) Derived from InterPro
PpieGeneProduct56031 (Entrez Gene) Derived from InterPro
Ppil4GeneProduct67418 (Entrez Gene) Derived from InterPro
Ppm1gGeneProduct14208 (Entrez Gene) PMID: 12773558
Ppp1r14bGeneProduct18938 (Entrez Gene) Derived from InterPro
Ppp1r8GeneProduct100336 (Entrez Gene)
PrkrGeneProduct19106 (Entrez Gene)
Prpf18GeneProduct67229 (Entrez Gene)
Prpf3GeneProduct70767 (Entrez Gene)
Prpf4GeneProduct70052 (Entrez Gene)
Prpf4bGeneProduct19134 (Entrez Gene)
Prpf8GeneProduct192159 (Entrez Gene)
Pskh1GeneProduct244631 (Entrez Gene) PMID: 12466556
Pspc1GeneProduct66645 (Entrez Gene) Derived from InterPro
Ptbp1GeneProduct19205 (Entrez Gene)
Ptbp2GeneProduct56195 (Entrez Gene)
Pum1GeneProduct80912 (Entrez Gene)
Pum2GeneProduct80913 (Entrez Gene)
QkGeneProduct19317 (Entrez Gene)
Rad21GeneProduct19357 (Entrez Gene)
Rad52bGeneProduct66599 (Entrez Gene) Derived from InterPro
Rae1GeneProduct66679 (Entrez Gene)
RalyGeneProduct19383 (Entrez Gene) Derived from InterPro
Rbed1GeneProduct232089 (Entrez Gene) Derived from InterPro
Rbm10GeneProduct236732 (Entrez Gene) Derived from InterPro
Rbm11GeneProduct224344 (Entrez Gene) Derived from InterPro
Rbm12GeneProduct75710 (Entrez Gene) Derived from InterPro
Rbm13GeneProduct67920 (Entrez Gene) Derived from InterPro
Rbm14GeneProduct56275 (Entrez Gene) Derived from InterPro
Rbm15bGeneProduct109095 (Entrez Gene) Derived from InterPro
Rbm16GeneProduct106583 (Entrez Gene) Derived from InterPro
Rbm17GeneProduct76938 (Entrez Gene) Derived from InterPro
Rbm18GeneProduct67889 (Entrez Gene) Derived from InterPro
Rbm19GeneProduct74111 (Entrez Gene) Derived from InterPro
Rbm21GeneProduct70044 (Entrez Gene) Derived from InterPro
Rbm22GeneProduct66810 (Entrez Gene) Derived from InterPro
Rbm28GeneProduct68272 (Entrez Gene) Derived from InterPro
Rbm3GeneProduct19652 (Entrez Gene) Derived from InterPro
Rbm31yGeneProduct74484 (Entrez Gene) Derived from InterPro
Rbm4GeneProduct19653 (Entrez Gene) Derived from InterPro
Rbm5GeneProduct83486 (Entrez Gene)
Rbm6GeneProduct19654 (Entrez Gene) Derived from InterPro
Rbm7GeneProduct67010 (Entrez Gene) Derived from InterPro
Rbm8aGeneProduct60365 (Entrez Gene) Derived from InterPro
Rbm9GeneProduct93686 (Entrez Gene) Derived from InterPro
Rbms1GeneProduct56878 (Entrez Gene) Derived from InterPro
Rbms2GeneProduct56516 (Entrez Gene) Derived from InterPro
Rbms3GeneProduct207181 (Entrez Gene) Derived from InterPro
RbmxGeneProduct19655 (Entrez Gene) Derived from InterPro
Rbmx2GeneProduct209003 (Entrez Gene) Derived from InterPro
RbmxrtGeneProduct19656 (Entrez Gene) Derived from InterPro
Rbmy1a1GeneProduct19657 (Entrez Gene) Derived from InterPro
RbpmsGeneProduct19663 (Entrez Gene) Derived from InterPro
Rbpms2GeneProduct71973 (Entrez Gene) Derived from InterPro
RdbpGeneProduct27632 (Entrez Gene) Derived from InterPro
Refbp2GeneProduct56009 (Entrez Gene) Derived from InterPro
Rnaseh2aGeneProduct69724 (Entrez Gene)
RnaselGeneProduct24014 (Entrez Gene)
Rnaset2GeneProduct68195 (Entrez Gene)
RngttGeneProduct24018 (Entrez Gene)
RnmtGeneProduct67897 (Entrez Gene)
Rnmtl1GeneProduct67390 (Entrez Gene)
Rnpc1GeneProduct56190 (Entrez Gene) Derived from InterPro
Rnpc2GeneProduct170791 (Entrez Gene)
RnpepGeneProduct215615 (Entrez Gene) Derived from InterPro
Rnpepl1GeneProduct108657 (Entrez Gene) Derived from InterPro
Rnps1GeneProduct19826 (Entrez Gene) PMID: 14729963
Rnu108GeneProduct104433 (Entrez Gene) Derived from InterPro
Rnu11GeneProduct353373 (Entrez Gene) Derived from InterPro
Rnu12GeneProduct104307 (Entrez Gene) Derived from InterPro
Rnu1a1GeneProduct19842 (Entrez Gene) Derived from InterPro
Rnu1a2GeneProduct111972 (Entrez Gene)
Rnu1b1GeneProduct19844 (Entrez Gene) Derived from InterPro
Rnu1b2GeneProduct19845 (Entrez Gene) Derived from InterPro
Rnu1b6GeneProduct19847 (Entrez Gene) Derived from InterPro
Rnu2GeneProduct19848 (Entrez Gene) Derived from InterPro
Rnu6GeneProduct19862 (Entrez Gene) GenBank sequence: M10329
Rod1GeneProduct230257 (Entrez Gene) Derived from InterPro
Rpl11GeneProduct67025 (Entrez Gene)
Rpl12GeneProduct269261 (Entrez Gene)
Rpl19GeneProduct19921 (Entrez Gene)
Rpl22GeneProduct19934 (Entrez Gene)
Rpl26GeneProduct19941 (Entrez Gene)
Rpl32GeneProduct19951 (Entrez Gene)
Rpl37GeneProduct67281 (Entrez Gene)
Rpl38GeneProduct67671 (Entrez Gene)
Rpl39GeneProduct67248 (Entrez Gene)
Rpl7GeneProduct19989 (Entrez Gene)
Rpl8GeneProduct26961 (Entrez Gene)
Rpl9GeneProduct20005 (Entrez Gene)
Rpp14GeneProduct67053 (Entrez Gene)
Rps11GeneProduct27207 (Entrez Gene)
Rps13GeneProduct68052 (Entrez Gene)
Rps14GeneProduct20044 (Entrez Gene)
Rps20GeneProduct67427 (Entrez Gene)
Rps23GeneProduct66475 (Entrez Gene)
Rps24GeneProduct20088 (Entrez Gene)
Rps27GeneProduct57294 (Entrez Gene)
Rps28GeneProduct54127 (Entrez Gene)
Rps29GeneProduct20090 (Entrez Gene)
Rps4xGeneProduct20102 (Entrez Gene)
Rps6GeneProduct20104 (Entrez Gene)
Rps7GeneProduct20115 (Entrez Gene)
Rps9GeneProduct76846 (Entrez Gene)
SRrp40GeneProductFUSI MOUSE PMID: 11684676
Safb2GeneProduct224902 (Entrez Gene) Derived from InterPro
Sart3GeneProduct53890 (Entrez Gene) Derived from InterPro
Sbno1GeneProduct243272 (Entrez Gene) Derived from InterPro
Sca1GeneProduct20238 (Entrez Gene)
Scye1GeneProduct13722 (Entrez Gene)
Secisbp2GeneProduct75420 (Entrez Gene)
Sf3a1GeneProduct67465 (Entrez Gene)
Sf3a2GeneProduct20222 (Entrez Gene)
Sf3a3GeneProduct75062 (Entrez Gene)
Sf3b1GeneProduct81898 (Entrez Gene)
Sf3b2GeneProduct319322 (Entrez Gene)
Sf3b3GeneProduct101943 (Entrez Gene)
Sf3b4GeneProduct107701 (Entrez Gene)
Sf3b5GeneProduct66125 (Entrez Gene)
Sf4GeneProduct70616 (Entrez Gene) inferred from: SURP 2, G patch protein, UniProt:O60378
SfpqGeneProduct71514 (Entrez Gene)
Sfrs10GeneProduct20462 (Entrez Gene) Derived from InterPro
Sfrs1GeneProduct110809 (Entrez Gene) Antagonist splicing factor
Sfrs11GeneProduct69207 (Entrez Gene) Derived from InterPro
Sfrs12GeneProduct218543 (Entrez Gene) Derived from InterPro
Sfrs14GeneProduct234373 (Entrez Gene)
Sfrs16GeneProduct53609 (Entrez Gene)
Sfrs2GeneProduct20382 (Entrez Gene)
Sfrs3GeneProduct20383 (Entrez Gene)
Sfrs4GeneProduct57317 (Entrez Gene)
Sfrs5GeneProduct20384 (Entrez Gene)
Sfrs6GeneProduct67996 (Entrez Gene)
Sfrs7GeneProduct225027 (Entrez Gene)
Sfrs8GeneProduct231769 (Entrez Gene)
Sfrs9GeneProduct108014 (Entrez Gene) PMID: 12738786, PMID: 12024014 (associated with hnRNP A1 splicing)
SlbpGeneProduct20492 (Entrez Gene)
Slc25a4GeneProduct11739 (Entrez Gene) Derived from InterPro
Slc6a8GeneProduct102857 (Entrez Gene) Derived from InterPro
Smc1l1GeneProduct24061 (Entrez Gene)
Smn1GeneProduct20595 (Entrez Gene)
Snrp1cGeneProduct20630 (Entrez Gene)
Snrp70GeneProduct20637 (Entrez Gene)
Snrpa1GeneProduct68981 (Entrez Gene)
SnrpaGeneProduct53607 (Entrez Gene)
SnrpbGeneProduct20638 (Entrez Gene)
Snrpb2GeneProduct20639 (Entrez Gene)
Snrpd1GeneProduct20641 (Entrez Gene)
Snrpd2GeneProduct107686 (Entrez Gene)
Snrpd3GeneProduct67332 (Entrez Gene)
SnrpeGeneProduct20643 (Entrez Gene)
SnrpfGeneProduct69878 (Entrez Gene)
SnrpgGeneProduct68011 (Entrez Gene)
SnrpnGeneProduct20646 (Entrez Gene)
SonGeneProduct20658 (Entrez Gene)
SpenGeneProduct56381 (Entrez Gene) Derived from InterPro
SpopGeneProduct20747 (Entrez Gene)
Srp14GeneProduct20813 (Entrez Gene)
Srp19GeneProduct66384 (Entrez Gene)
Srp54GeneProduct24067 (Entrez Gene) PMID: 14729963
Srp68GeneProduct217337 (Entrez Gene)
Srp9GeneProduct27058 (Entrez Gene)
Srpk1GeneProduct20815 (Entrez Gene) PMID: 12773558
Srpk2GeneProduct20817 (Entrez Gene) PMID: 12773558
Srrm1GeneProduct51796 (Entrez Gene)
Ssa2GeneProduct20822 (Entrez Gene)
SsbGeneProduct20823 (Entrez Gene) Derived from InterPro
Stau1GeneProduct20853 (Entrez Gene)
Supt5hGeneProduct20924 (Entrez Gene)
SyncripGeneProduct56403 (Entrez Gene) Derived from InterPro
Synj2GeneProduct20975 (Entrez Gene) Derived from InterPro
Taf15GeneProduct70439 (Entrez Gene) Derived from InterPro
Tarbp2GeneProduct21357 (Entrez Gene)
TardbpGeneProduct230908 (Entrez Gene) Derived from InterPro
Tdrd7GeneProduct100121 (Entrez Gene) Derived from InterPro
TenrGeneProduct21744 (Entrez Gene)
TertGeneProduct21752 (Entrez Gene)
Thoc4GeneProduct21681 (Entrez Gene) Derived from InterPro
Tia1GeneProduct21841 (Entrez Gene) Derived from InterPro
Tiaf1GeneProduct21842 (Entrez Gene) Derived from InterPro
Tial1GeneProduct21843 (Entrez Gene) Derived from InterPro
Tlr5GeneProduct53791 (Entrez Gene) Derived from InterPro
Tmed10GeneProduct68581 (Entrez Gene)
Tnrc4GeneProduct78784 (Entrez Gene) Derived from InterPro
Tnrc6cGeneProduct217351 (Entrez Gene) Derived from InterPro
Traf6GeneProduct22034 (Entrez Gene) Derived from InterPro
Trim21GeneProduct20821 (Entrez Gene)
TsnGeneProduct22099 (Entrez Gene)
Ttc14GeneProduct67120 (Entrez Gene)
Txnl4GeneProduct27366 (Entrez Gene)
U2af1-rs1GeneProduct22183 (Entrez Gene) Derived from InterPro
U2af1-rs2GeneProduct22184 (Entrez Gene) Derived from InterPro
U2af1GeneProduct108121 (Entrez Gene)
U2af2GeneProduct22185 (Entrez Gene)
U4 snRNARnaM10328 (Other) GenBank sequence: M10328, M18004
U5 snRNARnaAB021173 (Other) GenBank sequence: AB021173
Uhmk1GeneProduct16589 (Entrez Gene) Derived from InterPro
V1rc17GeneProduct171190 (Entrez Gene) Derived from InterPro
Wbp4GeneProduct22380 (Entrez Gene)
Wbscr1GeneProduct22384 (Entrez Gene) Derived from InterPro
Wdr55GeneProduct67936 (Entrez Gene) Derived from InterPro
Wdr9GeneProduct93871 (Entrez Gene) Derived from InterPro
Xrn2GeneProduct24128 (Entrez Gene)
Zbp1GeneProduct58203 (Entrez Gene)
ZfmlGeneProduct18139 (Entrez Gene) Derived from InterPro
Zfp346GeneProduct26919 (Entrez Gene)
Zfp385GeneProduct29813 (Entrez Gene)
Zfp622GeneProduct52521 (Entrez Gene)
Zmat2GeneProduct66492 (Entrez Gene)

Annotated Interactions

No annotated interactions
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