Focal adhesion (Homo sapiens)

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Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. Source: KEGG

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  2. Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase: in command and control of cell motility.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
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116784view09:54, 14 May 2021EweitzModified title
106731view13:21, 17 September 2019MaintBotHMDB identifier normalization
106421view22:01, 28 August 2019KhanspersModified description
105598view04:49, 10 August 2019KhanspersModified description
105008view04:59, 28 June 2019KhanspersModified description
97459view19:25, 21 May 2018Khansperswork in progress
95135view01:02, 17 November 2017AriuttaConnected ILK to group
94849view21:23, 9 October 2017Khanspersconnected interactions, added nucleus
94846view17:59, 6 October 2017Khanspersoverhaul
94845view17:42, 6 October 2017Khanspersoverhaul in progress
92678view11:09, 28 June 2017MirellaKalafatiMetabolite was marked as gene, plant identifier instead of human
80308view20:15, 3 June 2015DtruongModified title
80207view20:58, 22 May 2015KhanspersReverted to version '20:41, 28 April 2015' by Khanspers
80193view22:52, 19 May 2015Khanspersupdated mir29c target interactions
80191view22:28, 19 May 2015KhanspersAdded mir29c interaction
80037view00:21, 2 May 2015KhanspersAdded MIR34C
79971view20:41, 28 April 2015Zariannotated Ha-Ras , Catnb and Diap1 genes
79698view12:28, 5 April 2015EgonwReplaced two non-numeric Entrez identifiers with numeric ones.
78800view18:41, 30 January 2015EgonwFixed an Entrez identifier: BIRC4 = 331.
71714view20:06, 17 October 2013MaintBotremoved data source from nodes without identifier
69965view21:06, 11 July 2013MaintBotupdating to 2013 schema
45270view18:49, 7 October 2011AlexanderPico
45269view18:49, 7 October 2011AlexanderPicoOntology Term : 'cell adhesion signaling pathway' added !
41071view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
35287view22:50, 11 February 2010KhanspersAdded lit refs
35280view22:39, 11 February 2010KhanspersLit refs
35272view20:40, 11 February 2010KhanspersModified description
32638view14:51, 21 August 2009MaintBotautoconversion of Entrez symbols to IDs
32393view16:59, 15 August 2009MaintBotFixed text labels
32041view13:29, 14 August 2009MaintBotFixed group labels
21323view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Focal adhesion KEGG]] moved to [[Pathway:WP306]]: Moved to stable identifier
13963view11:11, 20 May 2008Thomasadded connectors / groups
13899view14:12, 19 May 2008ThomasWIP on connectors
13897view13:53, 19 May 2008ThomasWIP on connectors
13895view13:37, 19 May 2008ThomasPeriodical save, work in progress
13012view11:05, 17 May 2008MaintBotSticky edges patch by Sjoerd
8058view13:46, 7 January 2008MaintBot[[Pathway:Human:Focal adhesion KEGG]] moved to [[Pathway:Homo sapiens:Focal adhesion KEGG]]: Renaming species
7651view16:07, 18 December 2007MaintBotfixed category names
7222view12:41, 4 November 2007MaintBotAdded categories to GPML
6319view22:17, 22 May 2007169.230.77.174gpml file for [[Human:Focal_adhesion_KEGG]]

External references


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NameTypeDatabase referenceComment
ACTBGeneProduct60 (Entrez Gene)
ACTG1GeneProduct71 (Entrez Gene)
ACTN1GeneProduct87 (Entrez Gene)
ACTN4GeneProductENSG00000130402 (Ensembl)
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ARHGAP35GeneProductENSG00000160007 (Ensembl)
ARHGAP5GeneProduct394 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BIRC2GeneProduct329 (Entrez Gene)
BIRC3GeneProduct330 (Entrez Gene)
BLKGeneProduct640 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
BUB1B-PAK6GeneProductENSG00000259288 (Ensembl)
CAPN2GeneProductENSG00000162909 (Ensembl)
CAV1GeneProduct857 (Entrez Gene) CAV1; caveolin 1 caveolae protein 22kD
CAV2GeneProduct858 (Entrez Gene) CAV2; caveolin 2
CAV3GeneProduct859 (Entrez Gene) CAV3; caveolin 3
CCND1GeneProduct595 (Entrez Gene)
CCND2GeneProduct894 (Entrez Gene)
CCND3GeneProduct896 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CHADGeneProduct1101 (Entrez Gene)
COL1A1GeneProduct1277 (Entrez Gene)
COL1A2GeneProduct1278 (Entrez Gene)
COL2A1GeneProduct1280 (Entrez Gene)
COL4A1GeneProduct1282 (Entrez Gene)
COL4A2GeneProduct1284 (Entrez Gene)
COL4A4GeneProduct1286 (Entrez Gene)
COL4A6GeneProduct1288 (Entrez Gene)
COL5A2GeneProduct1290 (Entrez Gene)
COL5A3GeneProduct50509 (Entrez Gene)
COL6A2GeneProduct1292 (Entrez Gene)
COMPGeneProduct1311 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProductENSG00000099942 (Ensembl)
CatnbGeneProduct1499 (Entrez Gene)
Cell CyclePathway
Cell MotilityPathway
DIAPH1GeneProductENSG00000131504 (Ensembl)
DOCK1GeneProduct1793 (Entrez Gene) DOCK1; dedicator of cyto-kinesis
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
FGRGeneProduct2268 (Entrez Gene)
FIGFGeneProduct2277 (Entrez Gene)
FLNAGeneProduct2316 (Entrez Gene)
FLNBGeneProductENSG00000136068 (Ensembl)
FLNCGeneProductENSG00000128591 (Ensembl)
FLT1GeneProduct2321 (Entrez Gene)
FN1GeneProduct2335 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene) FYN; FYN oncogene related to SRC FGR YES [EC:]
GRB2GeneProduct2885 (Entrez Gene) GRB2; growth factor receptor-bound protein 2
GSK3BGeneProduct2932 (Entrez Gene)
HCKGeneProduct3055 (Entrez Gene)
HGFGeneProduct3082 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IBSPGeneProduct3381 (Entrez Gene)
IGF1GeneProduct3479 (Entrez Gene)
IGF1RGeneProduct3480 (Entrez Gene)
ILKGeneProduct3611 (Entrez Gene) ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10GeneProduct8515 (Entrez Gene)
ITGA11GeneProduct22801 (Entrez Gene)
ITGA1GeneProductENSG00000213949 (Ensembl)
ITGA2GeneProduct3673 (Entrez Gene)
ITGA2BGeneProduct3674 (Entrez Gene)
ITGA3GeneProduct3675 (Entrez Gene)
ITGA4GeneProduct3676 (Entrez Gene)
ITGA5GeneProduct3678 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
ITGA7GeneProduct3679 (Entrez Gene)
ITGA8GeneProduct8516 (Entrez Gene)
ITGA9GeneProduct3680 (Entrez Gene)
ITGAVGeneProduct3685 (Entrez Gene)
ITGB1GeneProduct3688 (Entrez Gene)
ITGB3GeneProduct3690 (Entrez Gene)
ITGB4GeneProduct3691 (Entrez Gene)
ITGB5GeneProduct3693 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
ITGB7GeneProduct3695 (Entrez Gene)
ITGB8GeneProduct3696 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
KDRGeneProduct3791 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
LAMA4GeneProduct3910 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
LAMC1GeneProduct3915 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
LAMC3GeneProduct10319 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene) MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAPK10GeneProductENSG00000109339 (Ensembl)
MAPK1GeneProduct5594 (Entrez Gene) MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK3GeneProductENSG00000102882 (Ensembl) MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
METGeneProduct4233 (Entrez Gene)
MYL10GeneProductENSG00000106436 (Ensembl)
MYL12AGeneProductENSG00000101608 (Ensembl)
MYL12BGeneProductENSG00000118680 (Ensembl)
MYL2GeneProductENSG00000111245 (Ensembl)
MYL5GeneProductENSG00000215375 (Ensembl)
MYL7GeneProductENSG00000106631 (Ensembl)
MYL9GeneProductENSG00000101335 (Ensembl)
MYLK2GeneProduct85366 (Entrez Gene)
MYLK3GeneProductENSG00000140795 (Ensembl)
MYLKGeneProduct4638 (Entrez Gene)
MYLK4GeneProductENSG00000145949 (Ensembl)
MYLPFGeneProductENSG00000180209 (Ensembl)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PAK3GeneProduct5063 (Entrez Gene)
PAK4GeneProduct10298 (Entrez Gene)
PAK6GeneProduct56924 (Entrez Gene)
PARVAGeneProductENSG00000197702 (Ensembl)
PARVBGeneProduct29780 (Entrez Gene)
PARVGGeneProductENSG00000138964 (Ensembl)
PDGFAGeneProduct5154 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFCGeneProduct56034 (Entrez Gene)
PDGFDGeneProduct80310 (Entrez Gene)
PDGFRAGeneProduct5156 (Entrez Gene)
PDGFRBGeneProduct5159 (Entrez Gene)
PDPK1GeneProduct5170 (Entrez Gene)
PGFGeneProduct5228 (Entrez Gene)
PI3K-Akt Signaling PathwayPathway
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP2MetaboliteCHEBI:18348 (ChEBI)
PIP3MetaboliteHMDB04249 (HMDB)
PIP5K1CGeneProduct23396 (Entrez Gene)
PPP1CAGeneProductENSG00000172531 (Ensembl)
PPP1CBGeneProductENSG00000213639 (Ensembl)
PPP1CCGeneProductENSG00000186298 (Ensembl)
PPP1R12AGeneProduct4659 (Entrez Gene)
PPP1R12BGeneProductENSG00000077157 (Ensembl)
PPP1R12CGeneProductENSG00000125503 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
PRKCBGeneProductENSG00000166501 (Ensembl) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
PRKCGGeneProductENSG00000126583 (Ensembl) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
PTENGeneProduct5728 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene) PTK2; PTK2 protein tyrosine kinase 2 [EC:
PTK6GeneProduct5753 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
Phosphatidylinositol SignalingPathway
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAC3GeneProduct5881 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene) RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1AGeneProduct5906 (Entrez Gene) RAP1A; RAP1A member of RAS oncogene family
RAP1BGeneProduct5908 (Entrez Gene) RAP1B; RAP1B member of RAS oncogene family
RAPGEF1GeneProduct2889 (Entrez Gene)
RASGRF1GeneProductENSG00000058335 (Ensembl)
RELNGeneProduct5649 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ROCK1GeneProduct6093 (Entrez Gene)
ROCK2GeneProduct9475 (Entrez Gene)
Regulation of Actin cytoskeletonPathway
SHC1GeneProduct6464 (Entrez Gene) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC2GeneProductENSG00000129946 (Ensembl) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3GeneProduct53358 (Entrez Gene) SHC3; neuronal Sh
SHC4GeneProductENSG00000185634 (Ensembl) SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SOS1GeneProduct6654 (Entrez Gene) SOS1; son of sevenless homolog 1 (Drosophila)
SPP1GeneProduct6696 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene) SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:]
SRMSGeneProduct6725 (Entrez Gene)
STYK1GeneProduct55359 (Entrez Gene)
TESK2GeneProduct10420 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene)
THBS2GeneProduct7058 (Entrez Gene)
THBS3GeneProduct7059 (Entrez Gene)
THBS4GeneProduct7060 (Entrez Gene)
TLN1GeneProduct7094 (Entrez Gene)
TLN2GeneProductENSG00000171914 (Ensembl)
TNCGeneProduct3371 (Entrez Gene)
TNK1GeneProduct8711 (Entrez Gene)
TNK2GeneProduct10188 (Entrez Gene)
TNNGeneProduct63923 (Entrez Gene)
TNRGeneProduct7143 (Entrez Gene)
TNXBGeneProduct7148 (Entrez Gene)
TXKGeneProduct7294 (Entrez Gene)
VASPGeneProduct7408 (Entrez Gene) VASP; vasodilator-stimulated phosphoprotein
VAV1GeneProduct7409 (Entrez Gene)
VAV2GeneProductENSG00000160293 (Ensembl)
VAV3GeneProductENSG00000134215 (Ensembl)
VCLGeneProduct7414 (Entrez Gene) VCL; vinculin
VEGFGeneProduct7422 (Entrez Gene)
VEGFBGeneProduct7423 (Entrez Gene)
VEGFCGeneProduct7424 (Entrez Gene)
VTNGeneProduct7448 (Entrez Gene)
VWFGeneProduct7450 (Entrez Gene)
Wnt Signaling PathwayPathway
XIAPGeneProductENSG00000101966 (Ensembl)
ZYXGeneProduct7791 (Entrez Gene) ZYX; zyxin

Annotated Interactions

No annotated interactions

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