Kit receptor signaling pathway (Homo sapiens)

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ReceptorGOEndoplasmic reticulumDemethylationNucleusInhibitionProteolytic cleavageUbiquitinationAutophosphorlationEnzyme complexPMGlycosylationENDephosphorylationMolecule in the pathwayECCY->PMMolecular associationGene SymbolAccession Number: NetPath 6; cellmap:6DesumoylationTranslocationERSumoylationLigandAcetylationMTReaction through unknown mechanisms/moleculesDControlPalmitoylationPlasma MembraneCY(Protein-protein interaction)Golgi apparatusNUCytoplasmDDeacetylationDeubiquitinationProteins in a complex interactionMitochondrionp85 complexEndosomePhosphorylationMethylationExtracellularRecruitmentActivationKITLGSOCS5VAV1STAT3BTKDOK1GRAPGRB2MITFGRB7PTPRUCISHSRCSOCS1FESRASA1CBLBKITEPORKITLGPLCE1SOCS6MPDZEP300JAK2RPS6KA1PIK3R2BADAKT1CRKHCKPRKCB1CRKLGRB10SOS1CBLCLTCFYNPTPN11INPP5DMATKSTAP1LYNSH3KBP1SPRED2SPRED1PIK3CGCSF2RBMAPK1STAT5AFGRPTPN6RAF1DOK1SOCS4PIK3R1PRKCAHRASTRAILR1ABL1SHC1TECSTAT1APSSTAT5BMAP2K1YES1VAV2KITPLCG1


Description

Kit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets among others. Binding of Kit receptor to stem cell factor leads to an intracellular cascade of events that includes activation of PI 3-kinase, Src family kinases and PLC gamma. Activating mutations in the Kit receptor are associated with several human malignancies include leukemias, gastrointestinal stromal tumors and mastocytomas. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_6

Comments

GenMAPP notes 
NetPath 6; cellmap:6 - Kit Receptor Signaling Pathway. The Kit Receptor signaling pathway was kindly reviewed by Imke Ehlers in Peter Besmer’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
108331view21:17, 6 December 2019L DupuisConverted interactions to graphical lines in legend
78799view18:30, 30 January 2015EgonwCopied Entrez IDs for STAT5B and STAT5A from nodes elsewhere in the pathway.
78539view10:30, 7 January 2015MaintBotadded missing graphIds
72102view21:45, 24 October 2013Mkutmonadded datasource for "GAB2", "FYN", "CRKL" and "GRB2"
68995view17:44, 8 July 2013MaintBotUpdated to 2013 gpml schema
67427view11:00, 26 June 2013DdiglesOntology Term : 'Stem Cell Factor signaling pathway' added !
47975view14:28, 23 April 2012NetPathModified description
44883view10:10, 6 October 2011MartijnVanIerselOntology Term : 'cytokine mediated signaling pathway' added !
44603view21:15, 21 September 2011KhanspersUpdating content to NetSlim
44112view20:36, 24 August 2011KhanspersReverted to version '23:42, 1 March 2011' by Khanspers
44033view23:13, 22 August 2011KhanspersModified description
44032view23:12, 22 August 2011KhanspersUpdating pathway from NetSlim
41172view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
35649view21:40, 12 February 2010KhanspersModified description
21319view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Kit-Receptor NetPath 6]] moved to [[Pathway:WP304]]: Moved to stable identifier
13001view11:01, 17 May 2008MaintBotSticky edges patch by Sjoerd
8230view13:46, 7 January 2008MaintBot[[Pathway:Human:Kit-Receptor NetPath 6]] moved to [[Pathway:Homo sapiens:Kit-Receptor NetPath 6]]: Renaming species
7735view16:14, 18 December 2007MaintBotfixed category names
7271view12:41, 4 November 2007MaintBotAdded categories to GPML
6347view22:18, 22 May 2007A.Pandeygpml file for [[Human:Kit-Receptor_NetPath_6]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
APSGeneProduct10603 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BTKGeneProduct695 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CBLBGeneProduct868 (Entrez Gene)
CISHGeneProduct1154 (Entrez Gene)
CLTCGeneProduct1213 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CSF2RBGeneProduct1439 (Entrez Gene)
DOK1GeneProduct1796 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
EPORGeneProduct2057 (Entrez Gene)
FESGeneProduct2242 (Entrez Gene)
FGRGeneProduct2268 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GRAPGeneProduct10750 (Entrez Gene)
GRB10GeneProduct2887 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GRB7GeneProduct2886 (Entrez Gene)
HCKGeneProduct3055 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
KITGeneProduct3815 (Entrez Gene)
KITLGGeneProduct4254 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MATKGeneProduct4145 (Entrez Gene)
MITFGeneProduct4286 (Entrez Gene)
MPDZGeneProduct8777 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCE1GeneProduct51196 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
PTPRUGeneProduct10076 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RPS6KA1GeneProduct6195 (Entrez Gene)
SH3KBP1GeneProduct30011 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS4GeneProduct122809 (Entrez Gene)
SOCS5GeneProduct9655 (Entrez Gene)
SOCS6GeneProduct9306 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SPRED1GeneProduct161742 (Entrez Gene)
SPRED2GeneProduct200734 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAP1GeneProduct26228 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
TECGeneProduct7006 (Entrez Gene)
TRAILR1GeneProduct8797 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VAV2GeneProduct7410 (Entrez Gene)
YES1GeneProduct7525 (Entrez Gene)

Annotated Interactions

No annotated interactions
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