Prostaglandin Synthesis and Regulation (Rattus norvegicus)

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PG SynthasesCell MembranePhospholipidsGq signalingpathwayprolactinreleaseCytoplasmInactive MetabolitesCortisoneCortisolCalciumCalciumPtgisPtgs2PGF2aArachidonic AcidHsd11b2Ptgs1Prostaglandin H2Ptger3EdnrbPtgdsPtger2Anxa5Anxa4Edn1Ptger4PtgirPGF2aPtgfrAnxa2Pla2g4aPTGDRScgb1a1S100a10PGE2ANXA8Anxa1Anxa3Cyp11a1Hsd11b1EdnraTXA2PrlCortisolProgesteroneS100a6PGI2Tbxas1Ptger1Anxa6Hpgd


No description


GenMAPP notes 
Adapted from Gross, G et al. 2000, Society for Gynecologic Investigation; 7:88-95
GenMAPP remarks 
See note for more details
This pathway was inferred from Homo sapiens pathway WP98(r20887) with a 80% conversion rate.

Quality Tags

Ontology Terms



No bibliography


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109407view18:00, 16 March 2020L DupuisConverted interactions to graphical lines
106976view13:43, 17 September 2019MaintBotHMDB identifier normalization
71789view20:33, 17 October 2013MaintBotAutomated update of data sources
69399view18:59, 8 July 2013MaintBotUpdated to 2013 gpml schema
67607view11:32, 26 June 2013DdiglesOntology Term : 'prostaglandin metabolic pathway' added !
41716view02:38, 2 March 2011MaintBotRemoved redundant pathway information and comments
34095view19:17, 9 December 2009MaintBotAutomatic update of empty xrefs
32392view16:59, 15 August 2009MaintBotFixed text labels
32040view13:28, 14 August 2009MaintBotFixed group labels
31427view21:00, 13 August 2009MaintBotFixed text labels
30941view00:40, 30 July 2009MaintBotConverted from Homo sapiens
21317view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Prostaglandin synthesis regulation]] moved to [[Pathway:WP303]]: Moved to stable identifier
8346view13:46, 7 January 2008MaintBot[[Pathway:Rat:Prostaglandin synthesis regulation]] moved to [[Pathway:Rattus norvegicus:Prostaglandin synthesis regulation]]: Renaming species
7791view16:17, 18 December 2007MaintBotfixed category names
7394view12:42, 4 November 2007MaintBotAdded categories to GPML
6587view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Prostaglandin_synthesis_regulation]]

External references


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NameTypeDatabase referenceComment
ANXA8GeneProduct306283 (Entrez Gene)
Anxa1GeneProduct25380 (Entrez Gene)
Anxa2GeneProduct56611 (Entrez Gene)
Anxa3GeneProduct25291 (Entrez Gene)
Anxa4GeneProduct79124 (Entrez Gene)
Anxa5GeneProduct25673 (Entrez Gene)
Anxa6GeneProduct79125 (Entrez Gene)
Arachidonic AcidMetabolite
CalciumMetaboliteHMDB0000464 (HMDB)
Cyp11a1GeneProduct29680 (Entrez Gene)
Edn1GeneProduct24323 (Entrez Gene) PMID: 1474344
EdnraGeneProduct24326 (Entrez Gene)
EdnrbGeneProduct50672 (Entrez Gene)
HpgdGeneProduct79242 (Entrez Gene)
Hsd11b1GeneProduct25116 (Entrez Gene)
Hsd11b2GeneProduct25117 (Entrez Gene)
PGE2MetaboliteHMDB0003175 (HMDB)
PGF2aMetaboliteHMDB0001139 (HMDB)
PGI2MetaboliteHMDB0001335 (HMDB)
PTGDRGeneProduct498475 (Entrez Gene)
Pla2g4aGeneProduct24653 (Entrez Gene)
PrlGeneProduct24683 (Entrez Gene)
Prostaglandin H2Metabolite
PtgdsGeneProduct25526 (Entrez Gene)
Ptger1GeneProduct25637 (Entrez Gene)
Ptger2GeneProduct81752 (Entrez Gene)
Ptger3GeneProduct24929 (Entrez Gene)
Ptger4GeneProduct84023 (Entrez Gene)
PtgfrGeneProduct25652 (Entrez Gene)
PtgirGeneProduct292661 (Entrez Gene)
PtgisGeneProduct25527 (Entrez Gene)
Ptgs1GeneProduct24693 (Entrez Gene)
Ptgs2GeneProduct29527 (Entrez Gene)
S100a10GeneProduct81778 (Entrez Gene) PMID: 12962548 relationship with Annexin 2
S100a6GeneProduct85247 (Entrez Gene)
Scgb1a1GeneProduct25575 (Entrez Gene) PMID: 7615804, PMID: 3292559
TXA2MetaboliteHMDB0001452 (HMDB)
Tbxas1GeneProduct24886 (Entrez Gene)

Annotated Interactions

No annotated interactions
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