DDX1 as a regulatory component of the Drosha microprocessor (Homo sapiens)

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1pri-miRNAOncogenic stressEpithelial-Mesenchymal Transition (EMT)and MetastasisEnhanced processing of DDX1-dependent miRNAsDNA damageATMDROSHARAD50MRE11ANBNDGCR8DDX1DDX1PDDX1pre-miRNA


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Ontology Terms



  1. Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X, Lu X; ''The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression.''; Cell Rep, 2014 PubMed Europe PMC Scholia


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106371view00:55, 23 August 2019KhanspersModified description
105565view06:20, 9 August 2019KhanspersModified description
94276view17:38, 30 August 2017Khanspersupdated for clarity and added phosphorylation
87380view11:05, 22 July 2016MaintBotadded missing graphids
87223view14:40, 19 July 2016SusanOntology Term : 'regulatory pathway' added !
84388view21:34, 18 February 2016KhanspersModified description
80337view22:31, 5 June 2015KhanspersModified description
80334view22:24, 5 June 2015KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
ATMGeneProductENSG00000149311 (Ensembl)
DDX1GeneProductENSG00000079785 (Ensembl)
DGCR8GeneProductENSG00000128191 (Ensembl)
DROSHAGeneProductENSG00000113360 (Ensembl)
MRE11AGeneProductENSG00000020922 (Ensembl)
NBNGeneProductENSG00000104320 (Ensembl)
RAD50GeneProductENSG00000113522 (Ensembl)

Annotated Interactions

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