Eicosanoid Synthesis (Rattus norvegicus)

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1Prostaglandin E215-Hydroperoxy Eicosatetraenoic Acid12-Hydroperoxy Eicosatetraenoic AcidCell MembraneThromboxane A36-Keto-Prostaglandin F2-alphaPla2g6Ltc4sPGD2 11-ketoreducLeukotriene D4PGE2 9-ketoreducGGT1Leukotriene A4Peroxidase?Leukotriene B4Prostaglandin F2aAlox5apProstaglandin H2Thromboxane B215-HETEArachidonic acidAlox15bPtgisAlox12Alox15Pla2g6Leukotriene C4Pnpla8Ptges2Pla2g2aProstaglandin D2Tbxas15-HPETELeukotriene E4Ptgs1Prostaglandin I2Ptgs2Alox5apPtgesLta4hPtgds5-HETEThromboxane A2Alox5Alox15Peroxidase?Peroxidase?Alox512-HETEDpep1


In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia


This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 70% conversion rate.

Quality Tags

Ontology Terms



  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC


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106975view13:43, 17 September 2019MaintBotHMDB identifier normalization
89523view11:02, 16 September 2016Mkutmonontology tag fix
89481view13:39, 15 September 2016Mkutmonremove space from ontology term id
77414view08:20, 7 September 2014EgonwConfirmed two more Labels as metabolites.
77388view09:45, 5 September 2014EgonwConverted two labels into metabolite DataNodes but without an identifier.
71781view20:31, 17 October 2013MaintBotAutomated update of data sources
71298view16:57, 17 October 2013MaintBotAutomated update of data sources
69362view18:54, 8 July 2013MaintBotUpdated to 2013 gpml schema
67185view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62846view05:04, 3 May 2013MaintBotUpdated UniProt data source
41676view02:35, 2 March 2011MaintBotRemoved redundant pathway information and comments
35472view12:09, 12 February 2010ThomasModified description
35470view12:09, 12 February 2010Thomasadded literature
34066view19:08, 9 December 2009MaintBotAutomatic update of empty xrefs
32031view13:26, 14 August 2009MaintBotFixed group labels
30921view00:34, 30 July 2009MaintBotConverted from Homo sapiens
21297view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Eicosanoid Synthesis]] moved to [[Pathway:WP293]]: Moved to stable identifier
8006view13:46, 7 January 2008MaintBot[[Pathway:Rat:Eicosanoid Synthesis]] moved to [[Pathway:Rattus norvegicus:Eicosanoid Synthesis]]: Renaming species
7626view16:05, 18 December 2007MaintBotfixed category names
7339view12:42, 4 November 2007MaintBotAdded categories to GPML
19421view22:20, 22 May 2007M.Ramirezgpml file for [[Rat:Eicosanoid_Synthesis]]
6533view22:20, 22 May 2007A.Kwagpml file for [[Rat:Eicosanoid_Synthesis]]

External references


View all...
NameTypeDatabase referenceComment
5-HPETEMetaboliteHMDB01193 (HMDB)
Alox12GeneProduct287454 (Entrez Gene)
Alox15GeneProduct81639 (Entrez Gene)
Alox15bGeneProduct266604 (Entrez Gene)
Alox5GeneProduct25290 (Entrez Gene)
Alox5apGeneProduct29624 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
Dpep1GeneProduct94199 (Entrez Gene)
GGT1GeneProduct116568 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
Lta4hGeneProduct299732 (Entrez Gene)
Ltc4sGeneProduct114097 (Entrez Gene)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
Pla2g2aGeneProduct29692 (Entrez Gene)
Pla2g6GeneProduct360426 (Entrez Gene)
Pnpla8GeneProduct314075 (Entrez Gene)
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
PtgdsGeneProduct25526 (Entrez Gene)
Ptges2GeneProduct311865 (Entrez Gene)
PtgesGeneProduct59103 (Entrez Gene)
PtgisGeneProduct25527 (Entrez Gene)
Ptgs1GeneProduct24693 (Entrez Gene)
Ptgs2GeneProduct29527 (Entrez Gene)
Tbxas1GeneProduct24886 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)

Annotated Interactions

No annotated interactions
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