Isoprenoid Precursor Biosynthesis in Pf acipoplasts (Plasmodium falciparum)

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Description

No description

Quality Tags

Ontology Terms

 

Bibliography

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  1. Borrmann S, Lundgren I, Oyakhirome S, Impouma B, Matsiegui PB, Adegnika AA, Issifou S, Kun JF, Hutchinson D, Wiesner J, Jomaa H, Kremsner PG; ''Fosmidomycin plus clindamycin for treatment of pediatric patients aged 1 to 14 years with Plasmodium falciparum malaria.''; Antimicrob Agents Chemother, 2006 PubMed
  2. Wiemer AJ, Hsiao CH, Wiemer DF; ''Isoprenoid metabolism as a therapeutic target in gram-negative pathogens.''; Curr Top Med Chem, 2010 PubMed
  3. Hunter WN; ''Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites.''; Curr Top Med Chem, 2011 PubMed
  4. Hunter WN; ''The non-mevalonate pathway of isoprenoid precursor biosynthesis.''; J Biol Chem, 2007 PubMed
  5. Borrmann S, Adegnika AA, Matsiegui PB, Issifou S, Schindler A, Mawili-Mboumba DP, Baranek T, Wiesner J, Jomaa H, Kremsner PG; ''Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children.''; J Infect Dis, 2004 PubMed
  6. Ruangweerayut R, Looareesuwan S, Hutchinson D, Chauemung A, Banmairuroi V, Na-Bangchang K; ''Assessment of the pharmacokinetics and dynamics of two combination regimens of fosmidomycin-clindamycin in patients with acute uncomplicated falciparum malaria.''; Malar J, 2008 PubMed
  7. Yeh E, DeRisi JL; ''Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.''; PLoS Biol, 2011 PubMed
  8. Yao ZK, Krai PM, Merino EF, Simpson ME, Slebodnick C, Cassera MB, Carlier PR; ''Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies.''; Bioorg Med Chem Lett, 2015 PubMed
  9. Wu W, Herrera Z, Ebert D, Baska K, Cho SH, DeRisi JL, Yeh E; ''A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis.''; Antimicrob Agents Chemother, 2015 PubMed


History

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CompareRevisionActionTimeUserComment
84376view05:52, 18 February 2016EgonwOntology Term : 'PW:0000650' removed !
84375view05:51, 18 February 2016EgonwOntology Term : 'signaling pathway pertinent to development' added !
81807view15:56, 30 August 2015EgonwOK, finally got around to encoding the last bit from the paper.
81124view08:41, 25 July 2015EgonwOntology Term : 'Plasmodium infection pathway' added !
81096view08:06, 22 July 2015EgonwOntology Term : 'Plasmodium falciparum malaria' added !
81095view08:05, 22 July 2015EgonwOntology Term : 'DOID:14067' removed !
81094view08:00, 22 July 2015EgonwOntology Term : 'Plasmodium falciparum malaria' added !
81093view07:58, 22 July 2015EgonwOntology Term : 'Plasmodium falciparum malaria' added !
81092view07:53, 22 July 2015EgonwOntology Term : 'Plasmodium falciparum malaria' added !
81077view04:52, 21 July 2015EgonwAdded a disease ontology tag.
80388view18:55, 12 June 2015AlexanderPicoConnected edge and tweaked label fonts
80139view12:46, 14 May 2015EgonwIndicated the human cell embedding.
80138view12:44, 14 May 2015EgonwSet the species to Plasmodium falciparum.
80061view05:53, 4 May 2015EgonwModified description
80058view09:55, 3 May 2015EgonwModified title
80055view08:55, 3 May 2015EgonwAdded MMV008138.
80054view08:19, 3 May 2015EgonwAdded an inhibitor which has been tested for use against malaria (see 3 new references).
80053view08:11, 3 May 2015EgonwAdded (some of) the human-parasite interaction.
80052view07:45, 3 May 2015EgonwModified description
80051view07:44, 3 May 2015EgonwMore content copied in. Now a proper Human cell, with an P. falciparum acipoplast embedded in it.
80050view16:26, 2 May 2015EgonwAdded ChEBI and Entrez Gene identifiers.
80049view11:28, 2 May 2015EgonwAdded a 4th paper.
80048view11:11, 2 May 2015EgonwModified description
80047view11:10, 2 May 2015EgonwAdded two more publications.
80046view11:01, 2 May 2015EgonwNew pathway

External references

Datanodes

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NameTypeDatabase referenceComment
CDP-MEMetaboliteCHEBI:16578 (ChEBI) 4-Diphosphocytidyl-2-C-methylerythritol
CDP-MEPMetabolite443200 (PubChem-compound) 4-Diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate
D-Glyceraldehyde 3-phosphateMetaboliteHMDB01112 (HMDB)
DOXPMetaboliteCHEBI:57792 (ChEBI) 1-deoxy-D-xylulose 5-phosphate
DXSGeneProduct813741 (Entrez Gene)
Glycerone-PMetaboliteCHEBI:16108 (ChEBI)
GlycolysisPathwayWP534 (WikiPathways)
IspCGeneProduct812223 (Entrez Gene)
IspDGeneProductPFA0340w (Ensembl) PF3D7_0106900; PFA0340w; .7.7.60
IspEGeneProduct
MEPMetaboliteCHEBI:58262 (ChEBI) 2C-methyl-D-erythritol 4-phosphate
MMV008138Metabolite987146 (PubChem-compound)
PEP/Pi translocatorGeneProduct813115 (Entrez Gene)
Phosphoenolpyruvic acidMetaboliteHMDB00263 (HMDB)
Triose-P/Pi translocatorGeneProduct812861 (Entrez Gene)
fosmidomycinMetabolite555 (Chemspider)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

No annotated interactions

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