Aryl Hydrocarbon Receptor Pathway (Homo sapiens)

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7, 36, 37, 48Drug and steroid metabolismTranscriptionfactorsInflammationCo-activatorsCell proliferation and differentiationOtherPhase 2 metabolismTranscriptionHSP90AA1EGFR pathwayEP300LigandSRCAIPAHREGFRHSP90AA1TNFARNTCDC37AHRARNTAIPSRCSRCCDC37AHRARNTAHRLigandLigandLigandXREGenesTATA boxPTGES3PTGES3NCOA1UGT1A3SLC7A5820UGT1A4MYOF8IFNG2041SERPINB24TGFB1CAP24UGT1A926POLK8UGT1A748IL12A41CES326IL17BIL1B204JUNB4IL12B41MGST130UGT1A6AHRR8, 33, 50CDKN1B4CYP1B14UGT1A14, 20, 26, 33, 508, 33, 50ALDH3A120GSTA2JUND33, 5032NQO133, 50IGFBP121NFE2L2BAX504JUN17CYP1A2IL24, 20, 26, 33, 5012HES1CYP1A124, 20, 26, 33, 50


Description

The aryl hydrocarbon receptor (AhR) is a transcription factor (part of the group of nuclear receptors) that responds to the presence of aromatic hydrocarbons. It regulates genes involved xenobiotic metabolism (including for example cytochrome P540 enzymes).

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
106304view17:45, 20 August 2019KhanspersModified description
105535view06:04, 9 August 2019KhanspersModified description
95229view18:54, 26 November 2017DeSlModified description
95226view18:52, 26 November 2017DeSlOntology Term : 'aryl hydrocarbon receptor signaling pathway' added !
95142view02:47, 17 November 2017AlexanderPicoadded graphical lines
95141view02:45, 17 November 2017AlexanderPicoremoved bad interactions
95140view02:41, 17 November 2017AlexanderPicoupdated node label
95139view02:38, 17 November 2017MaintBotremoved odd charactes from node lable
88902view08:20, 17 August 2016MirellaKalafatiOntology Term : 'regulatory pathway' added !
79696view11:00, 5 April 2015EgonwFixed the references section.
79690view20:11, 4 April 2015AlexanderPicoModified title
79597view05:34, 27 March 2015EgonwUpdated the Ensembl data source.
79544view15:12, 24 March 2015RiannefijtenModified description
79543view15:10, 24 March 2015Riannefijtenfixed unconnected line
79516view07:53, 24 March 2015Riannefijtenadded reference
79486view13:14, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for 'aryl hydrocarbon receptor agonist'.
79481view13:00, 23 March 2015RiannefijtenUpdated connections and the annotations
78579view14:50, 7 January 2015MaintBotadded missing graphIds
78253view22:04, 17 December 2014KhanspersModified title
78212view14:51, 14 December 2014EgonwChanged GPML schema.
78211view14:46, 14 December 2014MaintBotModified title
78086view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AHRGeneProductENSG00000106546 (Ensembl)
AHRRGeneProductENSG00000063438 (Ensembl)
AIPGeneProductENSG00000110711 (Ensembl)
ALDH3A1GeneProductENSG00000108602 (Ensembl)
ARNTGeneProduct405 (Entrez Gene)
BAX GeneProductENSG00000087088 (Ensembl)
CAP2GeneProductENSG00000112186 (Ensembl)
CDC37GeneProductENSG00000105401 (Ensembl)
CDKN1BGeneProductENSG00000111276 (Ensembl)
CES3GeneProductENSG00000172828 (Ensembl)
CYP1A1GeneProductENSG00000140465 (Ensembl)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP1B1GeneProductENSG00000138061 (Ensembl)
EGFR pathwayPathwayWP1910 (WikiPathways)
EGFRGeneProductENSG00000146648 (Ensembl)
EP300GeneProductENSG00000100393 (Ensembl)
GSTA2GeneProductENSG00000244067 (Ensembl)
HES1GeneProductENSG00000114315 (Ensembl)
HSP90AA1 GeneProductENSG00000080824 (Ensembl)
HSP90AA1GeneProductENSG00000080824 (Ensembl)
IFNGGeneProductENSG00000111537 (Ensembl)
IGFBP1 GeneProductENSG00000146678 (Ensembl)
IL12AGeneProductENSG00000168811 (Ensembl)
IL12BGeneProductENSG00000113302 (Ensembl)
IL17BGeneProductENSG00000127743 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL2 GeneProductENSG00000109471 (Ensembl)
JUNBGeneProductENSG00000171223 (Ensembl)
JUNDGeneProductENSG00000130522 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LigandMetaboliteCHEBI:72768 (ChEBI) Omeprazole, TCDD, PCB
MGST1GeneProductENSG00000008394 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
NCOA1GeneProductENSG00000084676 (Ensembl)
NFE2L2GeneProductENSG00000116044 (Ensembl)
NQO1GeneProductENSG00000181019 (Ensembl)
POLKGeneProductENSG00000122008 (Ensembl)
PTGES3GeneProductENSG00000110958 (Ensembl)
SERPINB2GeneProductENSG00000197632 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
SRC GeneProductENSG00000197122 (Ensembl)
SRC GeneProductENSG00000197122 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TNF GeneProductENSG00000232810 (Ensembl)
UGT1A1GeneProductENSG00000241635 (Ensembl)
UGT1A3GeneProductENSG00000243135 (Ensembl)
UGT1A4GeneProductENSG00000244474 (Ensembl)
UGT1A6GeneProductENSG00000167165 (Ensembl)
UGT1A7GeneProductENSG00000244122 (Ensembl)
UGT1A9GeneProductENSG00000241119 (Ensembl)

Annotated Interactions

No annotated interactions

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