TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer (Homo sapiens)

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Tyrosine phosphorylation pathwayLow-invasive Ovarian CancerComplex INADH-UbiquinoneCancer stageLegendComplex IISuccinate-UbiquinoneJAK1STAT3PyruvateERK2D-GlutamineGlucoseLactateEGFRERK1TCA CycleTyr-PGlucoseSTAT3Ser-PGlucoseEGFRJAK1STAT3Tyr-PHigh-invasive Ovarian CancerSerine phosphorylation pathwayMetabolix flux


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  1. Yang L, Moss T, Mangala LS, Marini J, Zhao H, Wahlig S, Armaiz-Pena G, Jiang D, Achreja A, Win J, Roopaimoole R, Rodriguez-Aguayo C, Mercado-Uribe I, Lopez-Berestein G, Liu J, Tsukamoto T, Sood AK, Ram PT, Nagrath D; ''Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer.''; Mol Syst Biol, 2014 PubMed Europe PMC Scholia


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112051view17:09, 17 September 2020KhanspersOntology Term : 'ovarian cancer' added !
112050view17:06, 17 September 2020Khanspersupdated phospho sites and added references
108102view10:15, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106479view19:43, 3 September 2019KhanspersModified description
106190view12:08, 16 August 2019MaintBotHMDB identifier normalization
105431view04:31, 8 August 2019KhanspersModified description
105408view15:55, 7 August 2019DeSlSmall layout changes to make textLabels more readable.
105391view17:51, 6 August 2019KhanspersModified description
105390view17:51, 6 August 2019KhanspersModified description
105389view17:50, 6 August 2019KhanspersModified description
105388view17:50, 6 August 2019KhanspersModified description
105387view17:49, 6 August 2019KhanspersModified description
90260view23:06, 27 October 2016AlexanderPicoChanged Stat3 to default node color
89885view13:01, 6 October 2016MkutmonModified description
78079view23:52, 30 November 2014Khanspersfixed unconnected interactions
77985view18:05, 4 November 2014KhanspersAdded lit ref and fixed arrow
77984view18:04, 4 November 2014KhanspersOntology Term : 'reproductive system disease' added !
77983view18:03, 4 November 2014KhanspersModified description
77956view19:38, 30 October 2014KhanspersOntology Term : 'altered citric acid cycle pathway' added !
77955view19:34, 30 October 2014KhanspersOntology Term : 'cancer' added !
77954view19:34, 30 October 2014KhanspersModified description
77917view20:00, 29 October 2014KhanspersModified title
77916view19:59, 29 October 2014KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
D-GlutamineMetaboliteHMDB03423 (HMDB)
EGFRGeneProduct1956 (Entrez Gene)
ERK1GeneProduct5595 (Entrez Gene)
ERK2GeneProduct5594 (Entrez Gene)
GlucoseMetaboliteHMDB00122 (HMDB)
JAK1GeneProduct3716 (Entrez Gene)
LactateMetaboliteHMDB00190 (HMDB)
PyruvateMetaboliteHMDB00243 (HMDB)
STAT3GeneProduct6774 (Entrez Gene)
TCA CyclePathwayWP78 (WikiPathways)

Annotated Interactions

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