IL-3 Signaling Pathway (Homo sapiens)

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Plasma membraneCY->PMDNucleusDeacetylationMethylationDDCY->PMERDephosphorylationMolecule in the pathwayDInhibitionProteins in a complex interactionReceptorDemethylationExtracellularMADMAMolecular AssociationDControlDDMAMT->CYUbiquitinationAcetylationDesumoylationGlycosylationMAECD(Protein-protein interaction)PalmitoylationLigandRecruitmentDDMAPMGODAccession Number: NetPath 15CY->PMCY->NUEndosomeDNUDCY->NUSumoylationReaction through unknown mechanisms/moleculesDActivationDeubiquitinationTranslocationMTDENPhosphorylationCYDCytoplasmProteolytic cleavageMAAutophosphorylationEnzyme complexGolgi apparatusDMitochondrionDEndoplasmic reticulumGATA2ATF1YWHAQBMXPIK3CDSTAT1MAPK1BCL2BCL2L11PPP2CAGNB2L1CREB1FYNKCNIP3MMP9CRKCISHPIK3R1MAPKAPK2SLC2A1GRB2VCLGAB2PILRBIL3RAPXNID1RAPGEF1GSK3ACSF2RBVAV1JAK1FESYWHABRXRASTAT5BHSPB1FCER2SOCS3MAPK9BADFOXO1ASELPKRASBADPIK3CABIRC5PRKCARAP1AIL3RPS6KB2SOS1IL3DNM1TECGSK3BRAC1GATA1PTPN6RAF1CSF2RBSTAT3IL3SOCS2CHEK1LYNCDC42INPP5DPTK2JAK2AKT1PRKACASRCMAPK7SHC1NFKB1SLC2A1MAPK8PIK3R2PAK1MRASBAXATF2HCKMAPK3YWHAZIL3RASYKIL3PRKCB1MATKPTPN11CRKLMAPK14MMP2GAB1SPI1RARAMAP2K1STAT6RAC2HRASPRKCALCKBCL2L1MAPK3Gene SymbolCBLNFKB1TYK2STAT5ATNFRSF1BSHC1


Description

No description

Comments

GenMAPP notes 
NetPath:15 - IL-3 Signaling Pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
108324view21:02, 6 December 2019L DupuisConverted interactions to graphical lines in legend
78583view14:50, 7 January 2015MaintBotadded missing graphIds
72139view09:43, 25 October 2013Mkutmonadded datasources to some proteins
67374view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-3 signaling pathway' added !
63210view20:57, 8 May 2013MaintBotUpdating gpml version
61833view17:22, 19 April 2013MaintBotfixed xrefs
61676view21:17, 16 April 2013MaintBotAdded missing Data Source
48436view14:30, 24 May 2012NetPathModified description
44845view09:46, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44623view18:01, 22 September 2011KhanspersUpdating content to NetSlim
44107view20:30, 24 August 2011KhanspersReverted to version '23:43, 1 March 2011' by Khanspers
44027view22:56, 22 August 2011KhanspersAdded category
44026view22:55, 22 August 2011KhanspersModified description
44025view22:53, 22 August 2011KhanspersUpdating pathway from NetSlim
41196view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
35642view21:30, 12 February 2010KhanspersModified description
21281view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-3 NetPath 15]] moved to [[Pathway:WP286]]: Moved to stable identifier
8170view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-3 NetPath 15]] moved to [[Pathway:Homo sapiens:IL-3 NetPath 15]]: Renaming species
7705view16:11, 18 December 2007MaintBotfixed category names
7244view12:41, 4 November 2007MaintBotAdded categories to GPML
6336view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-3_NetPath_15]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
ATF1GeneProduct466 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BAXGeneProduct581 (Entrez Gene)
BCL2GeneProduct596 (Entrez Gene)
BCL2L11GeneProduct10018 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
BIRC5GeneProduct332 (Entrez Gene)
BMXGeneProduct660 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene)
CHEK1GeneProduct1111 (Entrez Gene)
CISHGeneProduct1154 (Entrez Gene)
CREB1GeneProduct1385 (Entrez Gene)
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
CSF2RBGeneProduct1439 (Entrez Gene)
DNM1GeneProduct1759 (Entrez Gene)
FCER2GeneProduct2208 (Entrez Gene)
FESGeneProduct2242 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GATA1GeneProduct2623 (Entrez Gene)
GATA2GeneProduct2624 (Entrez Gene)
GNB2L1GeneProduct10399 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3AGeneProduct2931 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
Gene SymbolGeneProduct
HCKGeneProduct3055 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
HSPB1GeneProduct3315 (Entrez Gene)
ID1GeneProduct3397 (Entrez Gene)
IL3GeneProduct3562 (Entrez Gene)
IL3RAGeneProduct3563 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
KCNIP3GeneProduct30818 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MATKGeneProduct4145 (Entrez Gene)
MMP2GeneProduct4313 (Entrez Gene)
MMP9GeneProduct4318 (Entrez Gene)
MRASGeneProduct22808 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PILRBGeneProduct29990 (Entrez Gene)
PPP2CAGeneProduct5515 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAPGEF1GeneProduct2889 (Entrez Gene)
RARAGeneProduct5914 (Entrez Gene)
RPS6KB2GeneProduct6199 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene)
SELPGeneProduct6403 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SLC2A1GeneProduct6513 (Entrez Gene)
SOCS2GeneProduct8835 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SPI1GeneProduct6688 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT5BGeneProduct6777 (Entrez Gene)
STAT6GeneProduct6778 (Entrez Gene)
SYKGeneProduct6850 (Entrez Gene)
TECGeneProduct7006 (Entrez Gene)
TNFRSF1BGeneProduct7133 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VCLGeneProduct7414 (Entrez Gene)
YWHABGeneProduct7529 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene)

Annotated Interactions

No annotated interactions
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