Hematopoietic Stem Cell Differentiation (Homo sapiens)

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3Positive EffectorLegendLMO2GATA1RUN1T1PBX1HLFPRDM5ZFP37SCFTPOIL3EPOErythrocyteHematopoietic Stem Cell (HSC)MyeloblastMegakaryocyteCommon MyeloidProgenitorIL6IL1ACSF2IL1BSCFIL3CSF2CSF2CXCR4MXI12RIOK3ALK4MIR15A2MIR223MIR17MIR24AMIR155MIR181AMIR128AMIR10AMIR130AiHSC ReprogrammingFactorsErythrocyte-MegakaryocytePrecursorMIR16-11MIR4511MIR2211MIR2221MIR150TPO1TPOErythrocyte ProgenitorPlateletsGATA1GATA1GATA1ABOCD41CD42CD34CD235aSP1RUNX1NOTCH1MIR223MIR155MIR223MIR155Negative Effector


Description

Growth factors and miRNA regulating differentiation of hematopoietic stem cells (HSC) to various blood-related cell types. Note that myeloblasts branch off separately from erythrocytes and megakaryocytes. Adapted from an open access image attributed to ZooFari and Mikael Häggström (http://en.wikipedia.org/wiki/User:Mikael_H%C3%A4ggstr%C3%B6m/Gallery#Medical_collaborations) and augmented from literature and NHLBI Progenitor Cell Biology Consortium (PCBC) collaborators.

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Ontology Terms

 

Bibliography

  1. Zhang L, Sankaran VG, Lodish HF; ''MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment.''; Leukemia, 2012 PubMed Europe PMC Scholia
  2. Riddell J, Gazit R, Garrison BS, Guo G, Saadatpour A, Mandal PK, Ebina W, Volchkov P, Yuan GC, Orkin SH, Rossi DJ; ''Reprogramming committed murine blood cells to induced hematopoietic stem cells with defined factors.''; Cell, 2014 PubMed Europe PMC Scholia
  3. Slavov SN, Gimenes Teixeira HL, Rego EM; ''The role of micro-ribonucleic acids in normal hematopoiesis and leukemic T-lymphogenesis.''; Braz J Med Biol Res, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
103039view11:57, 2 February 2019MaintBotReplaced an outdated Ensembl identifiers with the new one.
102164view22:12, 4 December 2018Khanspersupdated xrefs for miRNAs
97552view14:50, 24 May 2018Mkutmonfix some of the uniprot identifiers
89818view11:53, 6 October 2016MkutmonModified description
84764view18:34, 16 March 2016KhanspersReverted to version '04:17, 18 November 2015' by Khanspers
84763view18:14, 16 March 2016WRothReverted to version '20:29, 28 September 2014' by WRoth
84762view18:14, 16 March 2016WRothReverted to version '22:37, 29 September 2014' by WRoth
84761view18:14, 16 March 2016WRothReverted to version '20:25, 28 September 2014' by WRoth
84760view18:14, 16 March 2016WRothReverted to version '20:28, 28 September 2014' by WRoth
84759view18:14, 16 March 2016WRothReverted to version '22:53, 29 September 2014' by WRoth
84758view18:14, 16 March 2016WRothReverted to version '20:39, 29 September 2014' by WRoth
84757view18:14, 16 March 2016WRothReverted to version '20:30, 28 September 2014' by WRoth
84756view18:14, 16 March 2016WRothReverted to version '18:11, 29 September 2014' by WRoth
84755view18:13, 16 March 2016WRothReverted to version '20:32, 28 September 2014' by WRoth
84754view18:13, 16 March 2016WRothReverted to version '22:51, 29 September 2014' by WRoth
84753view18:13, 16 March 2016WRothReverted to version '22:54, 29 September 2014' by WRoth
84752view18:13, 16 March 2016WRothReverted to version '23:17, 29 September 2014' by WRoth
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84749view18:13, 16 March 2016WRothReverted to version '23:32, 29 September 2014' by WRoth
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84747view18:13, 16 March 2016WRothReverted to version '23:27, 29 September 2014' by WRoth
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84743view18:12, 16 March 2016WRothReverted to version '00:26, 30 September 2014' by WRoth
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84741view18:12, 16 March 2016WRothReverted to version '01:41, 30 September 2014' by WRoth
84740view18:12, 16 March 2016WRothReverted to version '00:50, 30 September 2014' by WRoth
84739view18:12, 16 March 2016WRothReverted to version '00:41, 30 September 2014' by WRoth
84738view18:12, 16 March 2016WRothReverted to version '18:09, 30 September 2014' by WRoth
84737view18:12, 16 March 2016WRothReverted to version '02:09, 30 September 2014' by WRoth
84736view18:12, 16 March 2016WRothReverted to version '17:58, 30 September 2014' by WRoth
84735view18:12, 16 March 2016WRothReverted to version '18:47, 30 September 2014' by WRoth
84734view18:12, 16 March 2016WRothReverted to version '19:13, 30 September 2014' by WRoth
84733view18:12, 16 March 2016WRothReverted to version '18:11, 30 September 2014' by WRoth
84732view18:12, 16 March 2016WRothReverted to version '18:53, 30 September 2014' by WRoth
84731view18:12, 16 March 2016WRothReverted to version '20:06, 30 September 2014' by WRoth
84730view18:11, 16 March 2016WRothReverted to version '19:45, 30 September 2014' by WRoth
84729view18:11, 16 March 2016WRothReverted to version '18:39, 8 October 2014' by WRoth
84728view18:11, 16 March 2016WRothReverted to version '18:12, 14 October 2014' by WRoth
84727view18:11, 16 March 2016WRothReverted to version '22:43, 30 September 2014' by WRoth
84726view18:11, 16 March 2016WRothReverted to version '22:56, 30 September 2014' by WRoth
84725view18:11, 16 March 2016WRothReverted to version '19:21, 8 October 2014' by WRoth
84724view18:11, 16 March 2016WRothReverted to version '12:31, 17 November 2015' by WRoth
84723view18:11, 16 March 2016WRothReverted to version '14:50, 7 January 2015' by WRoth
83039view04:17, 18 November 2015MkutmonModified description
83013view12:31, 17 November 2015FehrhartUpdated miRNA IDs
78586view14:50, 7 January 2015MaintBotadded missing graphIds
77707view18:12, 14 October 2014KhanspersAdded interactions for negative effectors, changed node types, removed legend

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABOGeneProductENSG00000175164 (Ensembl)
ALK4GeneProductENSG00000135503 (Ensembl)
CD235aGeneProductENSG00000170180 (Ensembl)
CD34GeneProduct
CD41GeneProductENSG00000005961 (Ensembl)
CD42GeneProductENSG00000169704 (Ensembl)
CSF2GeneProductENSG00000164400 (Ensembl)
CXCR4GeneProductENSG00000121966 (Ensembl)
EPOGeneProductENSG00000130427 (Ensembl)
GATA1GeneProductENSG00000102145 (Ensembl)
HLFGeneProductHLF (Uniprot-TrEMBL)
IL1AGeneProductENSG00000115008 (Ensembl)
IL1BGeneProductENSG00000125538 (Ensembl)
IL3GeneProductENSG00000164399 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
LMO2GeneProductLMO2 (Uniprot-TrEMBL)
MIR10AGeneProductENSG00000207777 (Ensembl)
MIR128AGeneProductENSG00000207654 (Ensembl)
MIR130AGeneProductENSG00000208009 (Ensembl)
MIR150GeneProductENSG00000207782 (Ensembl)
MIR155GeneProductENSG00000207795 (Ensembl)
MIR15AGeneProductENSG00000207718 (Ensembl)
MIR16-1GeneProductENSG00000208006 (Ensembl)
MIR17GeneProductENSG00000207745 (Ensembl)
MIR181AGeneProductENSG00000207759 (Ensembl)
MIR221GeneProductENSG00000207870 (Ensembl)
MIR222GeneProductENSG00000207870 (Ensembl)
MIR223GeneProductENSG00000207939 (Ensembl)
MIR24AGeneProductENSG00000207617 (Ensembl)
MIR451GeneProductENSG00000207794 (Ensembl)
MXI1GeneProductENSG00000119950 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
PBX1GeneProductPBX1 (Uniprot-TrEMBL)
PRDM5GeneProductPRDM5 (Uniprot-TrEMBL)
RIOK3GeneProductENSG00000101782 (Ensembl)
RUN1T1GeneProductRUN1T1 (Uniprot-TrEMBL)
RUNX1GeneProductENSG00000159216 (Ensembl)
SCFGeneProductENSG00000049130 (Ensembl)
SP1GeneProductENSG00000185591 (Ensembl)
TPOGeneProductENSG00000115705 (Ensembl)
ZFP37GeneProductZFP37 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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