Differentiation Pathway (Homo sapiens)

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(Modified description)
Current revision (22:12, 9 November 2019) (view source)
(Modified description)
 
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<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Differentiation Pathway" Version="20121222" Organism="Homo sapiens">
<Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Differentiation Pathway" Version="20121222" Organism="Homo sapiens">
   <Comment Source="WikiPathways-category">Physiological Process</Comment>
   <Comment Source="WikiPathways-category">Physiological Process</Comment>
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   <Comment Source="WikiPathways-description">This pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. This overview differentiates between the three primary germ cell layers (ectoderm-outer layer, endoder-inner layer,mesoderm-middle layer), which are formed in the earliest state of embryonic development and give rise to different tissue types. The initial version of this pathway is a direct adaptation of the SnapShot "Directed Differentiation of Pluripotent Stem Cells" pathway authored by Luis A. Williams, Brandi N. Davis-Dusenbery, and Kevin C. Eggan, HHMI, Harvard University, Cell 149, May 25, 2012 Elsevier Inc. DOI 10.1016/j.cell.2012.05.015. http://download.cell.com/pdf/PIIS0092867412005946.pdf. This adaptation was generated by Meenakshi Venkatasubramanian and Krithika Ramasamy Subramanian at Cincinnati Children's Hospital in the laboratory of Nathan Salomonis.
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   <Comment Source="WikiPathways-description">This pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. This overview differentiates between the three primary germ cell layers (ectoderm-outer layer, endoderm-inner layer, mesoderm-middle layer), which are formed in the earliest state of embryonic development and give rise to different tissue types. The initial version of this pathway is a direct adaptation of the SnapShot "Directed Differentiation of Pluripotent Stem Cells" pathway authored by Luis A. Williams, Brandi N. Davis-Dusenbery, and Kevin C. Eggan, HHMI, Harvard University, Cell 149, May 25, 2012 Elsevier Inc. DOI 10.1016/j.cell.2012.05.015. http://download.cell.com/pdf/PIIS0092867412005946.pdf. This adaptation was generated by Meenakshi Venkatasubramanian and Krithika Ramasamy Subramanian at Cincinnati Children's Hospital in the laboratory of Nathan Salomonis.
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2848 CPTAC Assay Portal]</Comment>
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2848 CPTAC Assay Portal]</Comment>

Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

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CompareRevisionActionTimeUserComment
107905view22:12, 9 November 2019DdiglesModified description
107833view16:29, 6 November 2019DeSlModified description
107832view16:25, 6 November 2019DeSlModified description
107829view11:16, 6 November 2019DeSlChnaged 13-cis-retinol (Vit A) to all-trans-retinol (Vit. A) for linkouts.
107828view11:11, 6 November 2019DeSlUpdated Vit. A ID again
107827view10:42, 6 November 2019DeSlUpdated Vitamin A ID
106388view21:25, 28 August 2019KhanspersModified description
106210view12:10, 16 August 2019MaintBotHMDB identifier normalization
105570view06:26, 9 August 2019KhanspersModified description
102217view20:41, 11 December 2018Khanspersfixed interactions, adjusted layout and node sizing, grouped objects, added interactions and anchors
102214view00:31, 11 December 2018Khansperscreating groups and connecting interactions
89940view13:53, 6 October 2016EgonwModified description
87893view12:50, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
80009view13:05, 30 April 2015Zaricorrected Ensembl Id for NTF4
78558view10:31, 7 January 2015MaintBotadded missing graphIds
77643view13:55, 1 October 2014EgonwFixed three PubChem CIDs which incorrectly included the "CID" string.
77642view13:53, 1 October 2014EgonwReplace the CAS numbers (we don't generally have mappings) with the PubChem CIDs provided in the comment.
77579view21:46, 29 September 2014AlexanderPicoFixed "Ensembl Human" to "Ensembl"
77578view21:41, 29 September 2014AlexanderPicoAdded Hematopoietic factors from Chou (2012) PNAS
77570view18:21, 28 September 2014AlexanderPicoFixed SCFD1 to KITLG (SCF)
77488view17:30, 16 September 2014KhanspersOntology Term : 'stem cell' added !
77473view00:32, 14 September 2014NsalomonisModified description
77472view00:22, 14 September 2014NsalomonisNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/4/49/WP2848_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/4/49/WP2848_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 107905)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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