Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation (Homo sapiens)

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1EndocytosisLDL particlesHepatocyteGolgi apparatusLDLRPCSK9PCSK9LDLRLDLRLDL-receptor synthesisLDLRPCSK9LDLRLysosomaldegradationPCSK9LDLRPCSK9LDLRPCSK9SecretionLDL-receptor recyclingLDLREndosomeLDLRLDLR


Exogenously, circulating PCSK9 protein binds to the LDLR. Once internalized into the liver cell, the PCSK9 protein directs the LDLR to the lysosome for degradation. Intrinsically, PCSK9, which is secreted from the Golgi apparatus, binds the LDLR before it reaches the cell surface, leading it to lysosomal degradation. However, the precise mechanisms by which the intrinsic degradation pathway operates are still unknown. Abbreviations: LDLR, LDL receptor; PCSK9, proprotein convertase subtilisin/kexin type 9.

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Ontology Terms



  1. Brautbar A, Ballantyne CM; ''Pharmacological strategies for lowering LDL cholesterol: statins and beyond.''; Nat Rev Cardiol, 2011 PubMed Europe PMC Scholia


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89409view20:16, 10 September 2016AlexanderPicoModified title
89108view15:11, 22 August 2016EveloModified description
89107view15:10, 22 August 2016EveloModified title
89106view15:10, 22 August 2016EveloModified title
89105view15:09, 22 August 2016EveloModified description
88292view15:00, 1 August 2016FehrhartOntology Term : 'lipoprotein metabolic pathway' added !
83009view09:34, 17 November 2015FehrhartUpdated ensembl ID for LDLR
78515view10:29, 7 January 2015MaintBotadded missing graphIds
77448view13:36, 9 September 2014SusanConnect line
77430view11:51, 8 September 2014SusanModified description
77429view11:50, 8 September 2014SusanNew pathway

External references


NameTypeDatabase referenceComment
LDLRGeneProductENSG00000130164 (Ensembl)
PCSK9GeneProductENSG00000169174 (Ensembl)

Annotated Interactions

No annotated interactions

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