Proprotein convertase subtilisin/kexin type 9 (PCSK9) mediated LDL receptor degradation (Homo sapiens)

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1EndocytosisHepatocyteLDL particlesGolgi apparatusLDLRPCSK9PCSK9LDLRLDLRLDL-receptor synthesisLDLRPCSK9LDLRLysosomaldegradationPCSK9LDLRPCSK9LDLRPCSK9SecretionLDL-receptor recyclingLDLREndosomeLDLRLDLR


No description

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Ontology Terms



  1. Brautbar A, Ballantyne CM; ''Pharmacological strategies for lowering LDL cholesterol: statins and beyond.''; Nat Rev Cardiol, 2011 PubMed Europe PMC Scholia


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89409view20:16, 10 September 2016AlexanderPicoModified title
89108view15:11, 22 August 2016EveloModified description
89107view15:10, 22 August 2016EveloModified title
89106view15:10, 22 August 2016EveloModified title
89105view15:09, 22 August 2016EveloModified description
88292view15:00, 1 August 2016FehrhartOntology Term : 'lipoprotein metabolic pathway' added !
83009view09:34, 17 November 2015FehrhartUpdated ensembl ID for LDLR
78515view10:29, 7 January 2015MaintBotadded missing graphIds
77448view13:36, 9 September 2014SusanConnect line
77430view11:51, 8 September 2014SusanModified description
77429view11:50, 8 September 2014SusanNew pathway

External references


NameTypeDatabase referenceComment
LDLRGeneProductENSG00000270150 (Ensembl)
PCSK9GeneProductENSG00000169174 (Ensembl)

Annotated Interactions

No annotated interactions

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