Mammary gland development pathway - Puberty (Stage 2 of 4) (Homo sapiens)

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33112311331213Estrogen signaling pathwayMAMMARY GLAND DEVELOPMENTPATHWAYInvolutionPregnancy and lactationPubertyEmbryonic developmentMYCEGFPGRAREGSTAT5AFOSL1FN1ERBB2VIMTIMP1ESR1NRIP1CCND1AP1DNADNA


The primary mammary gland persists until puberty, when it grows and becomes branched. This results in the formation of secondary mammary gland.

ESR1 and NRIP1 co-regulates PGR, STAT5A and AREG, which control proliferation and differentiation during mammary gland development. NRIP1 is also required for ductal elongation, in both epithelial and in stromal compartments 1. Estrogen may also execute its growth effect through EGF. Especially, ERBB2, an EGF receptor, may activate or inhibit the growth according to the stage of development. In puberty, ERBB2 impairs the mammary epithelial cell proliferation 2.

AP1 regulates postnatal mammary gland development, mainly in puberty. Some AP1-dependent genes are shown in the figure 3. FOSL1 is a FOS family member. FOS family members dimerize with JUN family members to form AP1 complex. MYC and CCND1 are associated with cell proliferation. VIM is a component of intermediate filaments and FN1 are related to cell adhesion and migration. TIMP1 is a protease inhibitor.

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  1. Nautiyal J, Steel JH, Mane MR, Oduwole O, Poliandri A, Alexi X, Wood N, Poutanen M, Zwart W, Stingl J, Parker MG; ''The transcriptional co-factor RIP140 regulates mammary gland development by promoting the generation of key mitogenic signals.''; Development, 2013 PubMed Europe PMC
  2. Mukherjee S, Louie SG, Campbell M, Esserman L, Shyamala G; ''Ductal growth is impeded in mammary glands of C-neu transgenic mice.''; Oncogene, 2000 PubMed Europe PMC
  3. Shen Q, Zhang Y, Uray IP, Hill JL, Kim HT, Lu C, Young MR, Gunther EJ, Hilsenbeck SG, Chodosh LA, Colburn NH, Brown PH; ''The AP-1 transcription factor regulates postnatal mammary gland development.''; Dev Biol, 2006 PubMed Europe PMC


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102407view19:58, 22 December 2018EgonwReplaced a secondary ChEBI ID with primary ID.
102390view12:50, 22 December 2018DeSlConnected unconnected lines; changed vertical lines to graphical iso interaction.
102389view12:43, 22 December 2018DeSlAnnotated all nodes
87747view09:48, 25 July 2016ElisaOntology Term : 'regulatory pathway' added !
77103view22:05, 17 July 2014KhanspersOntology Term : 'milk secreting cell' added !
75428view18:27, 29 May 2014Biodados
75427view18:19, 29 May 2014Biodados
75426view18:12, 29 May 2014Biodados
75425view17:52, 29 May 2014BiodadosModified description
75424view17:39, 29 May 2014BiodadosNew pathway

External references


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NameTypeDatabase referenceComment
AREGGeneProductENSG00000109321 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
DNAMetaboliteCHEBI:16991 (ChEBI)
EGFGeneProductENSG00000138798 (Ensembl)
ERBB2GeneProductENSG00000141736 (Ensembl)
ESR1GeneProductENSG00000091831 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
FOSL1GeneProductENSG00000175592 (Ensembl)
MYCGeneProduct4609 (Entrez Gene)
NRIP1GeneProductENSG00000180530 (Ensembl)
PGRGeneProductENSG00000082175 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
TIMP1GeneProductENSG00000102265 (Ensembl)
VIMGeneProductENSG00000026025 (Ensembl)

Annotated Interactions

No annotated interactions

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