Signaling by ERBB4 (Homo sapiens)

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2-4, 7, 11...40, 4630, 3440, 4612207, 16, 256, 40, 46332929334233333, 171931, 4419292, 23, 24, 26, 39...1930331940, 4629291130, 343, 17193, 713, 30, 34454219453, 16, 25nucleoplasmcytosolmitochondrial matrixp-ERBB4cyt1 homodimers ITCH ESR1 EGF-like ligands ERBB4 JM-A CYT-2 isoform UBB(1-76) PI(4,5)P2NRG2 ERBB4/m80/s80:WWP1/ITCHEGF-like ligands ERBB4jmAcyt2s80 ERBB4jmAcyt1s80 GDPUBB(153-228) Neuregulins UBC(533-608) EGF-like ligands p-Y349,Y350-SHC1 ERBB4jmAcyt1s80 WWOXERBB4jmAcyt2s80 ATPUBC(77-152) UBB(1-76) GTPERBB4s80:p-Y694-STAT5AERBB4 CYT-1 isoforms NCOR1 p-Y349,Y350-SHC1 ERBB4jmAcyt2s80 UBC(153-228) WWP1 ERBB4 JM-A CYT-2 isoform Neuregulins TAB2:NCOR1Neuregulins ADPNRGs/EGF-likeligandsGFAP geneUbgamma-secretasecomplexEGF-like ligands ITCH WWP1 p-Y349,350-SHC1:p-ERBB4SHC1 NCOR1 ERBB4jmAcyt1s80 PIK3CAADAM17ESTG ERBB4m80 p-ERBB4cyt1homodimersNeuregulins ERBB4UBC(457-532) PSENEN EGF-like ligands ERBB4s80:TAB2:NCOR1:S100B geneERBB4jmAcyt1ECD NEDD4 SOS1 ERBB4:ERBB3heterodimerUBA52(1-76) ERBB4s80:TAB2:NCOR1UBC(533-608) ERBB4s80:ESR1:estrogenRPS27A(1-76) ERBB4s80 ESR1:estrogenERBB4 JM-A CYT-1 isoform ERBB4jmAcyt1s80 ERBB4jmAcyt2m80 PIK3CA GFAPERBB4s80p21 RAS:GTPS100BERBB4jmAcyt1s80 ERBB4 homodimersp-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform ERBB4jmAcyt2s80 UBB(153-228) UBC(1-76) ERBB4 PI(3,4,5)P3p-Y694-STAT5A GRB2-1 Ub-ERBB4:WWP1/ITCHNRG2 TAB2 UBC(533-608) UBC(609-684) ERBB4jmAcyt1s80 ESTG WWP1 ERBB4jmAcyt2s80 p-ERBB4cyt1 homodimers ERBB4jmAcyt1s80 PIK3R1:p-ERBB4cyt1p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform ERBB4 JM-A CYT-2 isoform UBC(77-152) ERBB4 p-ERBB4cyt1 homodimers ERBB4 JM-A CYT-1 isoform NRGs/EGF-likeligands:ERBB4EGF-like ligands TAB2 YAP1 ERBB4jmAcyt1s80 p-Y694-STAT5A ERBB4 JM-B CYT-1 isoform UBC(153-228) GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4ATPNCSTN UBC(1-76) ERBB4s80 UBC(305-380) ERBB4jmAcyt2s80 p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform ESTG ERBB4m80ERBB4jmAcyt1s80 p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform ERBB4 JM-A CYT-2 isoform UBC(381-456) ERBB4cyt1 homodimers ESR1 SHC1:p-ERBB4UBC(1-76) UBC(609-684) CXCL12 gene ERBB4jmAcyt2s80 ERBB4_ECDUBC(609-684) ESR1 ERBB4jmAcyt1s80 EGF-like ligands TAB2 EGF-like ligands CSN2 gene ERBB4/ERBB4m80/ERBB4s80Neuregulins ERBB3-1 ADAM17 PIK3R1 p-Y694-STAT5AhomodimerEGF-like ligands NRAS ERBB4s80:TAB2:NCOR1p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform ERBB4jmAcyt2ECD EGF-like ligands ERBB4jmAcyt2s80 APH1A p-Y694-STAT5A ERBB4jmAcyt1s80 UBC(381-456) RPS27A(1-76) KRAS EGFR KRAS ERBB4jmAcyt1s80 EGFR ERBB4jmAcyt1s80 ITCH ERBB4m80 Prolactin receptorsignalingERBB4s80:ESR1:estrogen:CXCL12 geneNeuregulins UBC(457-532) ERBB4s80:p-Y694-STAT5AUBC(77-152) PGR geneNeuregulins APH1B HRAS ESR1 WWP1/ITCHERBB4jmAcyt2s80 PGRERBB4 JM-A CYT-2 isoform p21 RAS:GDPERBB4 JM-B CYT-1 isoform Neuregulins p-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform ERBB4 UBC(229-304) p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform GDP ERBB4s80:YAP1ERBB4jmAcyt2s80 GTP ERBB4 JM-B CYT-1 isoform ERBB4jmAcyt1s80 ERBB4s80:YAP1UBC(229-304) TAB2 ERBB4s80:TAB2:NCOR1:GFAP geneATPNCOR1 YAP1ERBB4jmAcyt2s80 ERBB4jmAcyt1s80 UBC(229-304) ERBB4jmAcyt1s80:NEDD4UBB(77-152) EGF-like ligands Neuregulins ERBB4:EGFRheterodimerYAP1 p-ERBB4 homodimersNeuregulins UBA52(1-76) HRAS WWOX EGF:EGFREGF SHC1NRG1/2:ERBB3EGF p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform ADPp-Y1056,Y1188,Y1242-ERBB4 JM-A CYT-1 isoform NRG1 p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform UBC(381-456) UBB(77-152) EGF-like ligands PIK3R1GRB2-1 ERBB4jmAcyt1s80dimerNCOR1 ERBB4jmAcyt2s80 ERBB4s80UBC(305-380) EGF-like ligands CXCL12 geneERBB3-1 UBC(457-532) p-Y1046,Y1178,Y1232-ERBB4 JM-B CYT-1 isoform Neuregulins SOS1 ADPNRG1 ERBB4jmAcyt1s80 ERBB4jmAcyt1m80 ERBB4m80 GRB2-1:SOS1ERBB4jmAcyt2s80 NEDD4ERBB4jmAcyt2s80 Ub-ERBB4jmAcyt1s80:NEDD4S100B geneERBB4jmAcyt1s80 EGF-like ligands ERBB4jmAcyt1s80 PIK3R1 PIP3 activates AKTsignalingUBC(153-228) p-Y694-STAT5A CSN2PGR gene RPS27A(1-76) S100B gene p-Y1172,Y1226-ERBB4 JM-A CYT-2 isoform UBB(153-228) NCOR1 UBB(1-76) ERBB4s80:p-Y694-STAT5A:CSN2 geneERBB4jmAcyt1s80 ERBB4jmAcyt2s80 ERBB4 JM-A CYT-1 isoform ERBB4s80CSN2 geneUBB(77-152) PI3K:p-ERBB4cyt1UBA52(1-76) ERBB4jmAcyt2s80 Neuregulins TAB2 p-ERBB4 JM-AhomodimersNRAS Neuregulins RAF/MAP kinasecascadeERBB4s80:ESR1:estrogen:PGR geneNeuregulins PSEN2(1-297) p-ERBB4cyt1 homodimers Zn2+ ESTG UBC(305-380) NEDD4 GFAP gene ERBB4s80:WWOXCXCL12(22-93)ERBB4s80 291, 5, 8, 9, 14...191910, 21, 37