Host Interactions with Influenza Factors (Homo sapiens)

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113921, 4, 7, 865PB1-F2 ANT 3 Complex NS1 Homodimer NS1 Homodimer NS1 Homodimer cytosolNS1 Homodimer NS1 HomodimerPKR Complex NS1Viral dsRNA Complex NS1 Homodimer NS1 Homodimer CPSFNS1 Complex NS1PAB II Complex mitochondrial intermembrane spacemitochondrial inner membraneGolgi lumennucleoplasmTGFB1EIF2AK2 NANS1PAB II ComplexSLC25A6Viral dsRNA SLC25A6 NS1 NS1 CPSF4NS1 HomodimerNS1 NS1 NS1 NS1 EIF2AK2PB1-F2TGFB1CCDS7620PABPN1 PB1-F2 ANT 3 ComplexNS1 HomodimerCPSF4 NS1Viral dsRNA ComplexCPSFNS1 ComplexNS1 HomodimerPKR ComplexPABPN11010


Description

Infection of a human host cell with influenza virus triggers an array of host processes that interfere with viral replication, notably the production of type I interferon. The viral NS1 protein plays a central role in these virus-host interactions. Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=168253

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Ontology Terms

 

Bibliography

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  1. O'Neill RE, Jaskunas R, Blobel G, Palese P, Moroianu J.; ''Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import.''; PubMed Europe PMC Scholia
  2. Fortes P, Beloso A, Ortín J.; ''Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport.''; PubMed Europe PMC Scholia
  3. Suntharalingam M, Wente SR.; ''Peering through the pore: nuclear pore complex structure, assembly, and function.''; PubMed Europe PMC Scholia
  4. Cronshaw JM, Krutchinsky AN, Zhang W, Chait BT, Matunis MJ.; ''Proteomic analysis of the mammalian nuclear pore complex.''; PubMed Europe PMC Scholia
  5. Noah DL, Twu KY, Krug RM.; ''Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS.''; PubMed Europe PMC Scholia
  6. Li N, Ren A, Wang X, Fan X, Zhao Y, Gao GF, Cleary P, Wang B.; ''Influenza viral neuraminidase primes bacterial coinfection through TGF-β-mediated expression of host cell receptors.''; PubMed Europe PMC Scholia
  7. Son KN, Liang Z, Lipton HL.; ''Double-Stranded RNA Is Detected by Immunofluorescence Analysis in RNA and DNA Virus Infections, Including Those by Negative-Stranded RNA Viruses.''; PubMed Europe PMC Scholia
  8. Melén K, Kinnunen L, Fagerlund R, Ikonen N, Twu KY, Krug RM, Julkunen I.; ''Nuclear and nucleolar targeting of influenza A virus NS1 protein: striking differences between different virus subtypes.''; PubMed Europe PMC Scholia
  9. Ori A, Banterle N, Iskar M, Iskar M, Andrés-Pons A, Escher C, Khanh Bui H, Sparks L, Solis-Mezarino V, Rinner O, Bork P, Lemke EA, Beck M.; ''Cell type-specific nuclear pores: a case in point for context-dependent stoichiometry of molecular machines.''; PubMed Europe PMC Scholia
  10. Chen Z, Li Y, Krug RM.; ''Influenza A virus NS1 protein targets poly(A)-binding protein II of the cellular 3'-end processing machinery.''; PubMed Europe PMC Scholia
  11. Morris SJ, Price GE, Barnett JM, Hiscox SA, Smith H, Sweet C.; ''Role of neuraminidase in influenza virus-induced apoptosis.''; PubMed Europe PMC Scholia
  12. Rabut G, Doye V, Ellenberg J.; ''Mapping the dynamic organization of the nuclear pore complex inside single living cells.''; PubMed Europe PMC Scholia
  13. Cros JF, García-Sastre A, Palese P.; ''An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein.''; PubMed Europe PMC Scholia
  14. De Marcos Lousa C, Trézéguet V, Dianoux AC, Brandolin G, Lauquin GJ.; ''The human mitochondrial ADP/ATP carriers: kinetic properties and biogenesis of wild-type and mutant proteins in the yeast S. cerevisiae.''; PubMed Europe PMC Scholia
  15. Donelan NR, Basler CF, García-Sastre A.; ''A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice.''; PubMed Europe PMC Scholia
  16. Bergmann M, Garcia-Sastre A, Carnero E, Pehamberger H, Wolff K, Palese P, Muster T.; ''Influenza virus NS1 protein counteracts PKR-mediated inhibition of replication.''; PubMed Europe PMC Scholia
  17. Chanturiya AN, Basañez G, Schubert U, Henklein P, Yewdell JW, Zimmerberg J.; ''PB1-F2, an influenza A virus-encoded proapoptotic mitochondrial protein, creates variably sized pores in planar lipid membranes.''; PubMed Europe PMC Scholia
  18. Nemeroff ME, Barabino SM, Li Y, Keller W, Krug RM.; ''Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs.''; PubMed Europe PMC Scholia
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  20. Li Y, Chen ZY, Wang W, Baker CC, Krug RM.; ''The 3'-end-processing factor CPSF is required for the splicing of single-intron pre-mRNAs in vivo.''; PubMed Europe PMC Scholia
  21. Shimizu K, Iguchi A, Gomyou R, Ono Y.; ''Influenza virus inhibits cleavage of the HSP70 pre-mRNAs at the polyadenylation site.''; PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
101952view13:25, 20 November 2018EgonwRemoved an empty reference.
101205view11:10, 1 November 2018ReactomeTeamreactome version 66
100743view20:35, 31 October 2018ReactomeTeamreactome version 65
100287view19:11, 31 October 2018ReactomeTeamreactome version 64
99833view15:56, 31 October 2018ReactomeTeamreactome version 63
99390view14:33, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99087view12:39, 31 October 2018ReactomeTeamreactome version 62
93925view13:45, 16 August 2017ReactomeTeamreactome version 61
93509view11:25, 9 August 2017ReactomeTeamreactome version 61
87137view18:51, 18 July 2016MkutmonOntology Term : 'infectious disease pathway' added !
86605view09:22, 11 July 2016ReactomeTeamreactome version 56
83394view11:06, 18 November 2015ReactomeTeamVersion54
81586view13:07, 21 August 2015ReactomeTeamVersion53
77047view08:34, 17 July 2014ReactomeTeamFixed remaining interactions
76752view12:11, 16 July 2014ReactomeTeamFixed remaining interactions
76077view10:14, 11 June 2014ReactomeTeamRe-fixing comment source
75787view11:31, 10 June 2014ReactomeTeamReactome 48 Update
75137view14:08, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74784view08:52, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCDS7620Protein5146789 (Reactome)
CPSF NS1 ComplexComplexREACT_6585 (Reactome)
CPSF4 ProteinO95639 (Uniprot-TrEMBL)
CPSF4ProteinO95639 (Uniprot-TrEMBL)
EIF2AK2 ProteinP19525 (Uniprot-TrEMBL)
EIF2AK2ProteinP19525 (Uniprot-TrEMBL)
NAProteinP03468 (Uniprot-TrEMBL)
NS1 PAB II ComplexComplexREACT_6465 (Reactome)
NS1 Viral dsRNA ComplexComplexREACT_6623 (Reactome)
NS1 Homodimer PKR ComplexComplexREACT_6636 (Reactome)
NS1 HomodimerComplexREACT_6381 (Reactome)
NS1 HomodimerComplexREACT_6545 (Reactome)
NS1 ProteinP03496 (Uniprot-TrEMBL)
PABPN1 ProteinQ86U42 (Uniprot-TrEMBL)
PABPN1ProteinQ86U42 (Uniprot-TrEMBL)
PB1-F2 ANT 3 ComplexComplexREACT_6551 (Reactome)
PB1-F2ProteinP0C0U1 (Uniprot-TrEMBL)
SLC25A6 ProteinP12236 (Uniprot-TrEMBL)
SLC25A6ProteinP12236 (Uniprot-TrEMBL)
TGFB1ProteinP01137 (Uniprot-TrEMBL)
Viral dsRNA REACT_6589 (Reactome)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
CPSF4REACT_6168 (Reactome)
EIF2AK2REACT_6186 (Reactome)
NAmim-catalysisREACT_6229 (Reactome)
NS1 HomodimerREACT_6168 (Reactome)
NS1 HomodimerREACT_6186 (Reactome)
NS1 HomodimerREACT_6287 (Reactome)
NS1 HomodimerREACT_6339 (Reactome)
PABPN1REACT_6287 (Reactome)
PB1-F2REACT_6243 (Reactome)
REACT_6168 (Reactome) Influenza virus's non-structural protein (NS1) binds to the host cell's cleavage and host polyadenylation specificity factor (CPSF), inhibiting the ability of CPSF to bind to pre-mRNAs and thus preventing efficient 3' end processing and export of host cell mRNAs out of the nucleus.
REACT_6186 (Reactome) Influenza virus inhibits the host double-stranded-RNA-activated protein kinase (PKR) by a couple of mechanisms. One of those steps is the direct binding of PKR by the viral non-structural protein NS1.
REACT_6229 (Reactome) Influenza A virus induces apoptosis in a variety of ways including by activation of host TGF-beta by viral neuraminidase (NA).
REACT_6243 (Reactome) Influenza A virus induces apoptosis in a variety of ways including binding of viral PB1-F2 to host mitochondrial adenine nucleotide translocator 3 (ANT3).
REACT_6287 (Reactome) The influenza virus non-structural protein 1 (NS1) binds to the host cell's poly(A)-binding protein II (PABII) thus preventing PABII from properly extending the poly-A tail of pre-mRNA within the host cell nucleus. These pre-mRNAs are then prevented from exiting the nucleus.
REACT_6339 (Reactome) The ability of viral non-structural protein 1 (NS1) to sequester dsRNA is believed to be one of the primary mechanisms by which NS1 prevents activation of downstream anti-viral signaling pathways.
SLC25A6REACT_6243 (Reactome)
Viral dsRNA REACT_6339 (Reactome)
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