B Cell Receptor Signaling Pathway (Mus musculus)

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MitochondriaNucleusECCY->PMDeacetylationCY->PMCY->PMCY->NUCY->NUComplexMolecular associationDeubiquitinationDDPM->CYCY->PMCY->PMDExtracellularProteolytic cleavageMolecule in the pathwayAccesion Number: NetPath 12CY->PMCY->PMPlasma membraneEnzyme ComplexDGolgi apparatusDControlCY->PMDPalmitoylationARP2/3PMNU->CYCY->PMNU->CYDPhosphorylationSumoylationENDReaction through unknown mechanisms/moleculesCytoplasmCY->PMMTCY->PMTranslocationDCY->NUDPM->CYCY->NUCY->PMCY->PMCY->PMCY->NUMT->CYDDemethylationUbiquitinationDRecruitmentEndoplasmic reticulumDGlycosylationActivationCYMethylationCY->PMCY->MTDDephosphorylationNUAcetylationCY->NUCY->PMDMAInhibitionDCY->NULigandCY->NUERCY->PMDesumoylationEndosome(Protein-protein interaction)AutophosphorylationCY->PMProteins in a complex interactionGOReceptorSh2b2Rps6ka1Hdac5Inpp5dPtk2bAkt1Sos1Cmtm3Ppp3caGab1CrklCcnd2Foxo1CblbGab1Shc1Itpr2ItkBrafHdac7PrkcbPILRBCcne1Hcls1Bcl2Atf2Vav2CrkCd79bDusp4Cd79aLynGrb2Arpc5Casp7BtkRapgef1Arpc4Ctnnb1Gm10108BtkGsk3aIkbkgPik3ap1Nedd9Ptk2Gtf2iBcar1Cd79aDok3RelaPip5k1bRelCrkBank1Cd19PrkceCcnd3Bcl2l11Hcls1Pip5k1bStat3Ptpn6Ppp3r1Atp2b4Zap70Plcg1Rasa1FynArpc2Ctnnb1LynStap1Map2k2Rapgef1Hdac7Plcg2Cd22BlnkMapkapk2Hcls1Gtf2iPip5k1aInpp5dChukPrkcbBlkPip4k2bPlekha1Sh3bp2Cd72Rap2aCard11Cr2Mapk3Fcgr2bBaxGrb2CskRelCasp9Prkd1Pip5k1bMap3k7Dapp1Creb1Plekha1Cd81RPS6Nfatc3Card11Cd5HnrnpkLcp2Chst15Nfatc3Plekha2PrkcePtpn6PrkcdActr3Mapk4Vav1SykPlcg2Mapk8Elk1Pik3cgDok1ChukMapk14IkbkbSla2Stat1Nfatc1Pik3ap1Pdk2Ptpn11Mapk1Pip4k2bWasPip5k1cPrkcdRasgrp3Lat2Hdac5Pip4k2cLat2Arpc1bBaxAkt1Cdk7Map4k1TecShc1Sos2Pik3r2Gsk3bBlnkNfatc2Pdpk1Pip4k2aRPS6KB1Bcl6Itpr1Gm10108Raf1Lime1Pik3r1Rasgrp3CblCdk6Actr2IGHMSykMap2k1RhoaLynGene SymbolNfatc2NfkbiaCcna2Cdk2PtprcPlekha2Rps6ka1Dapp1HckPtpn6Ppp3cbIkbkbRb1PrkcqArpc3Pip4k2bNck1JunRelaDusp6Ptpn18Bcl10LckCdk4SykGab2


Description

The B cell receptor includes membrane μ heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation of the cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) present in Ig alpha and beta. This leads to activation of several non-receptor tyrosine kinases including those of the Src, Tec and Syk family of kinases. Downstream messengers include DAG, IP3, MAPK/ERK and JNK signaling modules. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_12

Comments

GenMAPP notes 
NetPath 12 - B Cell Receptor Signaling pathway. NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks 
http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP23(r20725) with a 97% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
111054view15:02, 3 July 2020L DupuisConverted interactions to graphical lines in legend
89906view13:24, 6 October 2016MkutmonModified description
89904view13:21, 6 October 2016MkutmonModified description
83938view22:41, 4 January 2016MaintBotminor
67072view10:02, 26 June 2013Christine ChichesterOntology Term : 'B cell receptor signaling pathway' added !
41374view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
35701view23:12, 12 February 2010AlexanderPico
34419view23:15, 9 December 2009MaintBotAutomatic update of empty xrefs
31418view20:57, 13 August 2009MaintBotFixed text labels
30863view00:11, 30 July 2009MaintBotConverted from Homo sapiens
21255view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:B Cell Receptor NetPath 12]] moved to [[Pathway:WP274]]: Moved to stable identifier
7916view13:46, 7 January 2008MaintBot[[Pathway:Mouse:B Cell Receptor NetPath 12]] moved to [[Pathway:Mus musculus:B Cell Receptor NetPath 12]]: Renaming species
7583view16:01, 18 December 2007MaintBotfixed category names
7202view12:33, 4 November 2007MaintBotAdded categories to GPML
6416view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:B_Cell_Receptor_NetPath_12]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Actr2GeneProduct66713 (Entrez Gene)
Actr3GeneProduct74117 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Arpc1bGeneProduct11867 (Entrez Gene)
Arpc2GeneProduct76709 (Entrez Gene)
Arpc3GeneProduct56378 (Entrez Gene)
Arpc4GeneProduct68089 (Entrez Gene)
Arpc5GeneProduct67771 (Entrez Gene)
Atf2GeneProduct11909 (Entrez Gene)
Atp2b4GeneProduct381290 (Entrez Gene)
Bank1GeneProduct242248 (Entrez Gene)
BaxGeneProduct12028 (Entrez Gene)
Bcar1GeneProduct12927 (Entrez Gene)
Bcl10GeneProduct12042 (Entrez Gene)
Bcl2GeneProduct12043 (Entrez Gene)
Bcl2l11GeneProduct12125 (Entrez Gene)
Bcl6GeneProduct12053 (Entrez Gene)
BlkGeneProduct12143 (Entrez Gene)
BlnkGeneProduct17060 (Entrez Gene)
BrafGeneProduct109880 (Entrez Gene)
BtkGeneProduct12229 (Entrez Gene)
Card11GeneProduct108723 (Entrez Gene)
Casp7GeneProduct12369 (Entrez Gene)
Casp9GeneProduct12371 (Entrez Gene)
CblGeneProduct12402 (Entrez Gene)
CblbGeneProduct208650 (Entrez Gene)
Ccna2GeneProduct12428 (Entrez Gene)
Ccnd2GeneProduct12444 (Entrez Gene)
Ccnd3GeneProduct12445 (Entrez Gene)
Ccne1GeneProduct12447 (Entrez Gene)
Cd19GeneProduct12478 (Entrez Gene)
Cd22GeneProduct12483 (Entrez Gene)
Cd5GeneProduct12507 (Entrez Gene)
Cd72GeneProduct12517 (Entrez Gene)
Cd79aGeneProduct12518 (Entrez Gene)
Cd79bGeneProduct15985 (Entrez Gene)
Cd81GeneProduct12520 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdk4GeneProduct12567 (Entrez Gene)
Cdk6GeneProduct12571 (Entrez Gene)
Cdk7GeneProduct12572 (Entrez Gene)
Chst15GeneProduct77590 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
Cmtm3GeneProduct68119 (Entrez Gene)
Cr2GeneProduct12902 (Entrez Gene)
Creb1GeneProduct12912 (Entrez Gene)
CrkGeneProduct12928 (Entrez Gene)
CrklGeneProduct12929 (Entrez Gene)
CskGeneProduct12988 (Entrez Gene)
Ctnnb1GeneProduct12387 (Entrez Gene)
Dapp1GeneProduct26377 (Entrez Gene)
Dok1GeneProduct13448 (Entrez Gene)
Dok3GeneProduct27261 (Entrez Gene)
Dusp4GeneProduct319520 (Entrez Gene)
Dusp6GeneProduct67603 (Entrez Gene)
Elk1GeneProduct13712 (Entrez Gene)
Fcgr2bGeneProduct14130 (Entrez Gene)
Foxo1GeneProduct56458 (Entrez Gene)
FynGeneProduct14360 (Entrez Gene)
Gab1GeneProduct14388 (Entrez Gene)
Gab2GeneProduct14389 (Entrez Gene)
Gene SymbolGeneProduct
Gm10108GeneProduct670717 (Entrez Gene)
Grb2GeneProduct14784 (Entrez Gene)
Gsk3aGeneProduct606496 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
Gtf2iGeneProduct14886 (Entrez Gene)
HckGeneProduct15162 (Entrez Gene)
Hcls1GeneProduct15163 (Entrez Gene)
Hdac5GeneProduct15184 (Entrez Gene)
Hdac7GeneProduct56233 (Entrez Gene)
HnrnpkGeneProduct15387 (Entrez Gene)
IGHMGeneProduct
IkbkbGeneProduct16150 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Inpp5dGeneProduct16331 (Entrez Gene)
ItkGeneProduct16428 (Entrez Gene)
Itpr1GeneProduct16438 (Entrez Gene)
Itpr2GeneProduct16439 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
Lat2GeneProduct56743 (Entrez Gene)
LckGeneProduct16818 (Entrez Gene)
Lcp2GeneProduct16822 (Entrez Gene)
Lime1GeneProduct72699 (Entrez Gene)
LynGeneProduct17096 (Entrez Gene)
Map2k1GeneProduct26395 (Entrez Gene)
Map2k2GeneProduct26396 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
Map4k1GeneProduct26411 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk14GeneProduct26416 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mapk4GeneProduct225724 (Entrez Gene)
Mapk8GeneProduct26419 (Entrez Gene)
Mapkapk2GeneProduct17164 (Entrez Gene)
Nck1GeneProduct17973 (Entrez Gene)
Nedd9GeneProduct18003 (Entrez Gene)
Nfatc1GeneProduct18018 (Entrez Gene)
Nfatc2GeneProduct18019 (Entrez Gene)
Nfatc3GeneProduct18021 (Entrez Gene)
NfkbiaGeneProduct18035 (Entrez Gene)
PILRBGeneProduct
Pdk2GeneProduct18604 (Entrez Gene)
Pdpk1GeneProduct18607 (Entrez Gene)
Pik3ap1GeneProduct83490 (Entrez Gene)
Pik3cgGeneProduct30955 (Entrez Gene)
Pik3r1GeneProduct18708 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pip4k2aGeneProduct18718 (Entrez Gene)
Pip4k2bGeneProduct108083 (Entrez Gene)
Pip4k2cGeneProduct117150 (Entrez Gene)
Pip5k1aGeneProduct18720 (Entrez Gene)
Pip5k1bGeneProduct18719 (Entrez Gene)
Pip5k1cGeneProduct18717 (Entrez Gene)
Plcg1GeneProduct18803 (Entrez Gene)
Plcg2GeneProduct234779 (Entrez Gene)
Plekha1GeneProduct101476 (Entrez Gene)
Plekha2GeneProduct83436 (Entrez Gene)
Ppp3caGeneProduct19055 (Entrez Gene)
Ppp3cbGeneProduct19056 (Entrez Gene)
Ppp3r1GeneProduct19058 (Entrez Gene)
PrkcbGeneProduct18751 (Entrez Gene)
PrkcdGeneProduct18753 (Entrez Gene)
PrkceGeneProduct18754 (Entrez Gene)
PrkcqGeneProduct18761 (Entrez Gene)
Prkd1GeneProduct18760 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
Ptk2bGeneProduct19229 (Entrez Gene)
Ptpn11GeneProduct19247 (Entrez Gene)
Ptpn18GeneProduct19253 (Entrez Gene)
Ptpn6GeneProduct15170 (Entrez Gene)
PtprcGeneProduct19264 (Entrez Gene)
RPS6GeneProduct20104 (Entrez Gene)
RPS6KB1GeneProduct72508 (Entrez Gene)
Raf1GeneProduct110157 (Entrez Gene)
Rap2aGeneProduct76108 (Entrez Gene)
Rapgef1GeneProduct107746 (Entrez Gene)
Rasa1GeneProduct218397 (Entrez Gene)
Rasgrp3GeneProduct240168 (Entrez Gene)
Rb1GeneProduct19645 (Entrez Gene)
RelGeneProduct19696 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
RhoaGeneProduct11848 (Entrez Gene)
Rps6ka1GeneProduct20111 (Entrez Gene)
Sh2b2GeneProduct23921 (Entrez Gene)
Sh3bp2GeneProduct24055 (Entrez Gene)
Shc1GeneProduct20416 (Entrez Gene)
Sla2GeneProduct77799 (Entrez Gene)
Sos1GeneProduct20662 (Entrez Gene)
Sos2GeneProduct20663 (Entrez Gene)
Stap1GeneProduct56792 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
SykGeneProduct20963 (Entrez Gene)
TecGeneProduct21682 (Entrez Gene)
Vav1GeneProduct22324 (Entrez Gene)
Vav2GeneProduct22325 (Entrez Gene)
WasGeneProduct22376 (Entrez Gene)
Zap70GeneProduct22637 (Entrez Gene)

Annotated Interactions

No annotated interactions
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