Metabolism of non-coding RNA (Homo sapiens)

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13, 21, 225, 7, 9, 15, 19...63, 183, 2312nucleoplasmcytosolDDX20 SNRPD1SNUPN2xMe-SNRPD33-methylguanosine cap U4 snRNA SMN1 DDX20 NUP210 GEMIN5 SNRPE U2 snRNA GEMIN6 SMN1 GEMIN7 NUP43 NUP188 SNRPF U2 snRNA GEMIN8 GEMIN4 SNRPE GEMIN2 Spliceosomalm3GcappedsnRNA:SMN:SM:Snurportin complexSNRPD2 AAAS SEC13 7-methylguanosine cap SNRPD2Nuclear Pore Complex(NPC)NUP93 2xMe-SNRPD3 7-methylguanosine cap NUP160 U1 snRNA SNRPF NUP98-5 SEH1L-2 SMN:SM proteincomplexU6 snRNA SNRPFSNRPE NUP98-4 3-methylguanosine cap GEMIN7 NUP54 POM121C NUP88 PHAX SNRPE RAE1 GEMIN2 NUP205 SNRPD2 NUP50 2xMe-SNRPB GEMIN5 TGS1SMN1 2xMe-SNRPD1 NCBP1 2xMe-SNRPD3 U2 snRNA U2 snRNA SMN1 U6 snRNA GEMIN5 SNRPG U2 snRNA TPR DDX20 NUP58-1 2xMe-SNRPB GEMIN8 U1 snRNA 2xMe-SNRPB m7G cappedSpliceosomal snRNANUP62 CLNS1A U5 snRNA MethylosomePOM121 SNRPD2 SNRPG Spliceosomal m3Gcapped snRNAs withSMN:SM proteincomplex boundSNRPG SMN complexU1 snRNA PRMT5 GEMIN8 GEMIN7 GEMIN7 SMN1 SNRPGGEMIN2 SNRPBSNRPF U5 snRNA GEMIN4 Spliceosomal m7Gcapped snRNAs withSMN:SM proteincomplex boundU1 snRNA U4 snRNA NUP155 GEMIN4 U5 snRNA U6 snRNA GEMIN2 SEH1L-1 2xMe-SNRPD1 SNRPEWDR77 NUP58-2 NCBP1 DDX20 Cap Binding Complex(CBC)GEMIN5 2xMe-SNRPD3 NCBP2 SMN complexGEMIN6 U5 snRNA GEMIN2 GEMIN4 AdoMetU6 snRNA m7G cappedsnRNA:CBC:PHAXcomplex2xMe-SNRPD1 U4 snRNA U4 snRNA 3-methylguanosine cap GEMIN8 Me2-R108,R112-SNRPB NUPL2 NUP37 U5 snRNA SNRPE 7-methylguanosine cap DDX20 GEMIN7 SNRPG SNRPF SMN1 Spliceosomal m3Gcapped snRNA loadedwith the SM complex2xMe-SNRPD3 NUP153 GEMIN7 NUP85 2xMe-SNRPD3 RANBP2 DDX20 SNRPG GEMIN4 NUP214 U6 snRNA GEMIN6 NUP35 U1 snRNA GEMIN5 2xMe-SNRPB SNRPD2 GEMIN8 2xMe-SNRPD1 NUP98-3 GEMIN6 GEMIN8 NCBP2 SNUPN NUP107 SNRPD2 2xMe-SNRPD1 GEMIN4 GEMIN6 3-methylguanosine cap PHAXSNRPF U4 snRNA NDC1 GEMIN2 GEMIN5 NUP133 GEMIN6 4, 16254, 162, 8, 10, 11, 14...1


Description

The term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence that the majority of mammalian and other complex organism's genomes is transcribed into non-coding RNAs, many of which are alternatively spliced and/or processed into smaller products. Around 98% of all transcriptional output in humans is non-coding RNA. RNA-mediated gene regulation is widespread in higher eukaryotes and complex genetic phenomena like RNA interference are mediated by such RNAs. These non-coding RNAs are a growing list and include rRNAs, tRNAs, snRNAs, snoRNAs siRNAs, 7SL RNA, 7SK RNA, the RNA component of RNase P RNA, the RNA component of RNase MRP, and the RNA component of telomerase. View original pathway at Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 194441
Reactome-version 
Reactome version: 74

Quality Tags

Ontology Terms

 

Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
113299view11:36, 2 November 2020ReactomeTeamReactome version 74
112511view15:47, 9 October 2020ReactomeTeamReactome version 73
101423view11:30, 1 November 2018ReactomeTeamreactome version 66
100961view21:07, 31 October 2018ReactomeTeamreactome version 65
100498view19:41, 31 October 2018ReactomeTeamreactome version 64
100044view16:25, 31 October 2018ReactomeTeamreactome version 63
99596view14:58, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99214view12:43, 31 October 2018ReactomeTeamreactome version 62
94040view13:53, 16 August 2017ReactomeTeamreactome version 61
93664view11:30, 9 August 2017ReactomeTeamreactome version 61
86970view13:51, 15 July 2016MkutmonOntology Term : 'non-coding RNA pathway' added !
86786view09:26, 11 July 2016ReactomeTeamreactome version 56
83121view10:02, 18 November 2015ReactomeTeamVersion54
81460view12:59, 21 August 2015ReactomeTeamVersion53
76932view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76637view12:01, 16 July 2014ReactomeTeamFixed remaining interactions
75967view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75670view10:58, 10 June 2014ReactomeTeamReactome 48 Update
75025view13:53, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74669view08:44, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2xMe-SNRPB ProteinP14678 (Uniprot-TrEMBL)
2xMe-SNRPD1 ProteinP62314 (Uniprot-TrEMBL)
2xMe-SNRPD3 ProteinP62318 (Uniprot-TrEMBL)
2xMe-SNRPD3ProteinP62318 (Uniprot-TrEMBL)
3-methylguanosine cap MetaboliteCHEBI:1604 (ChEBI)
7-methylguanosine cap MetaboliteCHEBI:17825 (ChEBI)
7-methylguanosine cap MetaboliteCHEBI:2274 (ChEBI)
AAAS ProteinQ9NRG9 (Uniprot-TrEMBL)
AdoMetMetaboliteCHEBI:15414 (ChEBI)
CLNS1A ProteinP54105 (Uniprot-TrEMBL)
Cap Binding Complex (CBC)ComplexR-HSA-162460 (Reactome)
DDX20 ProteinQ9UHI6 (Uniprot-TrEMBL)
GEMIN2 ProteinO14893 (Uniprot-TrEMBL)
GEMIN4 ProteinP57678 (Uniprot-TrEMBL)
GEMIN5 ProteinQ8TEQ6 (Uniprot-TrEMBL)
GEMIN6 ProteinQ8WXD5 (Uniprot-TrEMBL)
GEMIN7 ProteinQ9H840 (Uniprot-TrEMBL)
GEMIN8 ProteinQ9NWZ8 (Uniprot-TrEMBL)
Me2-R108,R112-SNRPB ProteinP14678 (Uniprot-TrEMBL)
MethylosomeComplexR-HSA-191849 (Reactome)
NCBP1 ProteinQ09161 (Uniprot-TrEMBL)
NCBP2 ProteinP52298 (Uniprot-TrEMBL)
NDC1 ProteinQ9BTX1 (Uniprot-TrEMBL)
NUP107 ProteinP57740 (Uniprot-TrEMBL)
NUP133 ProteinQ8WUM0 (Uniprot-TrEMBL)
NUP153 ProteinP49790 (Uniprot-TrEMBL)
NUP155 ProteinO75694 (Uniprot-TrEMBL)
NUP160 ProteinQ12769 (Uniprot-TrEMBL)
NUP188 ProteinQ5SRE5 (Uniprot-TrEMBL)
NUP205 ProteinQ92621 (Uniprot-TrEMBL)
NUP210 ProteinQ8TEM1 (Uniprot-TrEMBL)
NUP214 ProteinP35658 (Uniprot-TrEMBL)
NUP35 ProteinQ8NFH5 (Uniprot-TrEMBL)
NUP37 ProteinQ8NFH4 (Uniprot-TrEMBL)
NUP43 ProteinQ8NFH3 (Uniprot-TrEMBL)
NUP50 ProteinQ9UKX7 (Uniprot-TrEMBL)
NUP54 ProteinQ7Z3B4 (Uniprot-TrEMBL)
NUP58-1 ProteinQ9BVL2-1 (Uniprot-TrEMBL)
NUP58-2 ProteinQ9BVL2-2 (Uniprot-TrEMBL)
NUP62 ProteinP37198 (Uniprot-TrEMBL)
NUP85 ProteinQ9BW27 (Uniprot-TrEMBL)
NUP88 ProteinQ99567 (Uniprot-TrEMBL)
NUP93 ProteinQ8N1F7 (Uniprot-TrEMBL)
NUP98-3 ProteinP52948-3 (Uniprot-TrEMBL)
NUP98-4 ProteinP52948-4 (Uniprot-TrEMBL)
NUP98-5 ProteinP52948-5 (Uniprot-TrEMBL)
NUPL2 ProteinO15504 (Uniprot-TrEMBL)
Nuclear Pore Complex (NPC)ComplexR-HSA-157689 (Reactome)
PHAX ProteinQ9H814 (Uniprot-TrEMBL)
PHAXProteinQ9H814 (Uniprot-TrEMBL)
POM121 ProteinQ96HA1 (Uniprot-TrEMBL)
POM121C ProteinA8CG34 (Uniprot-TrEMBL)
PRMT5 ProteinO14744 (Uniprot-TrEMBL)
RAE1 ProteinP78406 (Uniprot-TrEMBL)
RANBP2 ProteinP49792 (Uniprot-TrEMBL)
SEC13 ProteinP55735 (Uniprot-TrEMBL)
SEH1L-1 ProteinQ96EE3-1 (Uniprot-TrEMBL)
SEH1L-2 ProteinQ96EE3-2 (Uniprot-TrEMBL)
SMN complexComplexR-HSA-191762 (Reactome)
SMN complexComplexR-HSA-191881 (Reactome)
SMN1 ProteinQ16637 (Uniprot-TrEMBL)
SMN:SM protein complexComplexR-HSA-191791 (Reactome)
SNRPBProteinP14678 (Uniprot-TrEMBL)
SNRPD1ProteinP62314 (Uniprot-TrEMBL)
SNRPD2 ProteinP62316 (Uniprot-TrEMBL)
SNRPD2ProteinP62316 (Uniprot-TrEMBL)
SNRPE ProteinP62304 (Uniprot-TrEMBL)
SNRPEProteinP62304 (Uniprot-TrEMBL)
SNRPF ProteinP62306 (Uniprot-TrEMBL)
SNRPFProteinP62306 (Uniprot-TrEMBL)
SNRPG ProteinP62308 (Uniprot-TrEMBL)
SNRPGProteinP62308 (Uniprot-TrEMBL)
SNUPN ProteinO95149 (Uniprot-TrEMBL)
SNUPNProteinO95149 (Uniprot-TrEMBL)
Spliceosomal

m3G capped

snRNA:SMN:SM:Snurportin complex
ComplexR-HSA-191778 (Reactome)
Spliceosomal m3G

capped snRNA loaded

with the SM complex
ComplexR-HSA-191870 (Reactome)
Spliceosomal m3G

capped snRNAs with SMN:SM protein

complex bound
ComplexR-HSA-191891 (Reactome)
Spliceosomal m7G

capped snRNAs with SMN:SM protein

complex bound
ComplexR-HSA-191813 (Reactome)
TGS1ProteinQ96RS0 (Uniprot-TrEMBL)
TPR ProteinP12270 (Uniprot-TrEMBL)
U1 snRNA ProteinV00590 (EMBL)
U2 snRNA ProteinX59360 (EMBL)
U4 snRNA ProteinX59361 (EMBL)
U5 snRNA ProteinX04293 (EMBL)
U6 snRNA ProteinX59362 (EMBL)
WDR77 ProteinQ9BQA1 (Uniprot-TrEMBL)
m7G capped Spliceosomal snRNAComplexR-HSA-191853 (Reactome)
m7G capped

snRNA:CBC:PHAX

complex
ComplexR-HSA-191887 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
2xMe-SNRPD3R-HSA-191790 (Reactome)
AdoMetR-HSA-191790 (Reactome)
Cap Binding Complex (CBC)ArrowR-HSA-191825 (Reactome)
Methylosomemim-catalysisR-HSA-191790 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-191825 (Reactome)
Nuclear Pore Complex (NPC)ArrowR-HSA-191830 (Reactome)
PHAXArrowR-HSA-191825 (Reactome)
R-HSA-191763 (Reactome) The nuclear import signal has two parts; Cap hypermethylation triggers nuclear import via snurportin1 binding and by receptor recognition of the Sm proteins. Snurportin1 (SPN) is an adaptor that links the assembled snRNP to the nuclear transport machinery, recruiting importin beta for nuclear import. The import receptor that recognizes the Sm proteins is not yet known.
R-HSA-191784 (Reactome) The snRNA:SMN:SM protein complex is engaged by a hypermethylase that hypermethylates the snRNA cap from m7G (7-methylguanosine) to m3G (2,2,7-trimethylguanosine).
R-HSA-191786 (Reactome) To facilitate snRNP assembly, the SMN complex must bring together the Sm proteins and an Sm-site-containing snRNA. The SMN:Sm protein complex binds to the m7G capped snRNAs in the cytoplasm.
R-HSA-191790 (Reactome) The survival of motor neurons (SMN) complex binds to Sm proteins and small nuclear RNAs (snRNAs) in the cytoplasm. Sm is part the SMN multiprotein complex that contains Gemins 2 – 7, including the DEAD-box RNA helicase Gemin3. The binding of the SMN complex to the snRNAs depends on the presence of specific, high-affinity (nanomolar) binding domains in the snRNAs. The SMN complex binds the Sm proteins through the Sm domains interaction with the Gemins, the TUDOR domain, and through unique arginine- and glycine-rich (RG) domains found in three of these, SmB, SmD1 and SmD3. The association with RG domains is strongly enhanced by the post-translational symmetric dimethylation of specific arginines in these domains, a process that is carried out by the methylosome (JBP1 or PRMT5) complex.
R-HSA-191825 (Reactome) The snRNAs, except U6 snRNA, are transcribed by RNA polymerase II, co-transcriptionally capped and exported rapidly to the cytoplasm in association with a cap-binding complex and the export factor PHAX.
R-HSA-191830 (Reactome) A properly assembled Sm core and the m3G cap structure are prerequisites for small nuclear ribonucleoprotein (snRNP) import into the nucleus. Once imported into the nucleus, the snRNPs are initially concentrated in Cajal bodies (CBs), where there is further processing of the snRNAs plus binding of additional proteins, from CRBs they transit to "speckles", from where they are engaged for pre-mRNA splicing. The SMN complexes in the nucleus are found throughout the nucleoplasm but are particularly concentrated in Gems, the "twins" of the snRNP-rich CBs.
SMN complexArrowR-HSA-191830 (Reactome)
SMN complexR-HSA-191790 (Reactome)
SMN:SM protein complexArrowR-HSA-191790 (Reactome)
SMN:SM protein complexR-HSA-191786 (Reactome)
SNRPBR-HSA-191790 (Reactome)
SNRPD1R-HSA-191790 (Reactome)
SNRPD2R-HSA-191790 (Reactome)
SNRPER-HSA-191790 (Reactome)
SNRPFR-HSA-191790 (Reactome)
SNRPGR-HSA-191790 (Reactome)
SNUPNArrowR-HSA-191830 (Reactome)
SNUPNR-HSA-191763 (Reactome)
Spliceosomal

m3G capped

snRNA:SMN:SM:Snurportin complex
ArrowR-HSA-191763 (Reactome)
Spliceosomal

m3G capped

snRNA:SMN:SM:Snurportin complex
R-HSA-191830 (Reactome)
Spliceosomal m3G

capped snRNA loaded

with the SM complex
ArrowR-HSA-191830 (Reactome)
Spliceosomal m3G

capped snRNAs with SMN:SM protein

complex bound
ArrowR-HSA-191784 (Reactome)
Spliceosomal m3G

capped snRNAs with SMN:SM protein

complex bound
R-HSA-191763 (Reactome)
Spliceosomal m7G

capped snRNAs with SMN:SM protein

complex bound
ArrowR-HSA-191786 (Reactome)
Spliceosomal m7G

capped snRNAs with SMN:SM protein

complex bound
R-HSA-191784 (Reactome)
TGS1mim-catalysisR-HSA-191784 (Reactome)
m7G capped Spliceosomal snRNAArrowR-HSA-191825 (Reactome)
m7G capped Spliceosomal snRNAR-HSA-191786 (Reactome)
m7G capped

snRNA:CBC:PHAX

complex
R-HSA-191825 (Reactome)
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