Signaling by SCF-KIT (Homo sapiens)

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8, 16, 50, 58, 63...20, 622, 6, 13, 18, 21...51, 52677, 11, 33, 504542, 459, 42, 454, 5, 35, 4112, 18, 28, 751, 22, 33, 69, 76...33, 60, 6610, 25, 33, 59, 65326434, 6422, 30, 33, 59, 70533, 1444, 50, 634743, 52394724, 39, 404523, 47418, 6133, 59, 7927, 38, 49, 633931, 56, 57, 64cytosolnucleoplasmPI(4,5)P2KITLG-1(26-190) p-7Y-KIT SOS1 GRB2-1 STAT5B SH2B3 CHEK1 p-7Y-KIT GTP SFKs:p-8Y-KIT:sSCFdimer:p-8Y-KITLYN NRAS LCK p-Y699-STAT5B TEC PIK3R2 GRB2-1 STAT5A KITLG-1(26-190) p-Y142,Y160,Y174-VAV1 PI(3,4,5)P3 p-Y701-STAT1-1 p-STAT dimersKITLG-1(26-190) Tyrosinekinases:p-KITcomplexGRB7 NRAS KITGRB2-1 SH2B2 CHEK1 SRC-1 p-7Y-KIT SOS1 YES1 KITLG-1(26-190) GTPYES1 GDP LYN GRAP2 PI(3,4,5)P3YES1 p-Y705-STAT3 p-7Y-KIT p-7Y-KIT p-Y1007-JAK2 RAC1 LCK p-VAV1:PIP3LYN PIK3CA KITLG-1Endopeptidases forSCF processingFYN KITLG-1(26-190) SOCS6SOS1 FYN ADPp-7Y-KIT p-Y699-STAT5B LCK GRB2-1p-Y694-STAT5A p-JAK2:SFKs:p-KITcomplex:p-STATdimersATPSHP-1:p-c-Kitcomplexp-Y546,Y584-PTPN11 KITLG-1(26-190) KITLG-1(26-190) LCK STATsGrb2:SOS:p-c-Kit/p-APS:p-c-Kit complexp-7Y-KIT RAF/MAP kinasecascadeTyrosine kinasesADPFYN SRC-1 PIK3R1 PI3K alphap-KIT (S741,746):PKCalphaGRB2-1 GRB2:SOS1:p-KITcomplexCBLp-7Y-KIT STAT3 SOCS1 p-Y701-STAT1-1 p-7Y-KIT GDPKITLG-1(26-190) GRAP2 FES KITLG-1(26-190) LYN ATPGRB2-1 SOS1 PIK3R1 KIT STAT1 SH2B3JAK2 PTPRULYN YES1 KIT SH2B2 PTPRU RAC1:GDPLCK p-JAK2:SFKs:p-KITcomplexSRC-1 GRB2-1 p-Y546,Y584-PTPN11 SRC-1 SFKs:p-KIT complexKITLG-1(26-190) KITLG-1(26-190) KITLG-1(26-190)PTPN6 LCK KITLG-1(26-190) LCK GRB7 SRC-1 GRAP p-7Y-KIT GRB2-1 TEC p-7Y-KIT p-Y699-STAT5B LCK GAB2:GRB2:p-SHP2:p-KIT complexATPp-S741,S746-KIT PI3K:p-KIT:sSCFdimer:p-KITJAK2LYN KITLG-1(26-190) KITLG-1(26-190) YES1 HRAS YES1 FYN LNK:p-7Y-KIT:sSCFdimer:p-7Y-KITADPPRKCA p-7Y-KIT Adapter proteinsAPSdimer:p-c-Kit:SFKscomplexp-Y-GAB2 STAT1 p-7Y-KIT p-7Y-KIT KITLG-1(26-190) p-Y1007-JAK2 sSCF dimerp-JAK2:SFKs:p-KITcomplex:p-STATsGAB2 VAV1PIK3R2 LCK PIK3CA APS dimerFES GRAP SRC-1 p-Y629-SH2B2 CBL:Grb2/p-APS:p-c-Kit complexKIT:sSCF dimerYES1 YES1 PIK3R3 GRB2-1:SOS1p-Y546,Y584-PTPN11 STAT5B SRC-1 KITLG-1(26-190) p-SHP2:p-KIT complexKIT:sSCF dimer:KITp-7Y-KIT FYN GRB10 LYN KRAS LYN ADPP13K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexSrc family tyrosinekinases (SFKs)CMA1 p-APS dimer:p-KITcomplexYES1 p-Y701-STAT1-1 p-Y705-STAT3 FYN p-7Y-KIT p-Y694-STAT5A p21 RAS:GDPSRC-1 p-Y546,Y584-PTPN11 KITLG-1(26-190) p-7Y-KIT FYN KITLG-1(192-273)SRC-1 p-JAK2:SFKs:p-KITcomplex:STATsSRC-1 ATPp-7Y-KIT SOCS1YES1 ATPKITLG-1(26-190) HRAS KIT PTPRO:KITFYN SRC-1 LYN GTP FER YES1 SRC-1 FYN GDP LCK MMP9 SRC-1 PIK3R2 SHP2:SFKs:p-KIT:sSCFdimer:p-KITFYN p-8Y-KIT LYN LYN FYN KRAS SRC-1 CBL YES1 SOCS6 KITLG-1(26-190) p-Y1007-JAK2 KITLG-1(26-190) p-Y629-SH2B2 ATPAdapterproteins:p-KITcomplexPIK3R1 FYN ADPLCK FYN p-7Y-KIT KITLG-1(26-190) FYN YES1 LCK JAK2:SFKS:p-KITcomplexRAC1:GTPLYN LYN ADPSTAT5A p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexSRC-1 YES1 LCK FYN GAB2LYN p-Y-GAB2 GTPSRC-1 GRB2:p-SHP2:p-KITcomplexp-Y694-STAT5A YES1 p-7Y-KIT PTPN6YES1 LCK PIP3 activates AKTsignalingp21 RAS:GTPRAC1 LCK p-7Y-KIT PIK3R3 YES1 p-7Y-KIT LCK KITLG-1(26-190) p-7Y-KIT:sSCFdimer:p-7Y-KITKITLG-1(26-190) FYN PTPN11SOCS1:p-KIT complexLCK KITLG-1(26-190) PIK3R3 LYN p-7Y-KIT LYN PTPN11 LYN SRC-1 p-Y1007-JAK2 LYN FYN FER GRB2-1 GRB10 p-7Y-KIT SRC-1 KITLG-1(26-190) LCK ADPp-Y705-STAT3 YES1 FYN KITLG-1(26-190) ATPp-7Y-KIT p-Y629-SH2B2 ADPPIK3CA KITLG-1(26-190) KITLG-1(26-190) p-Y546,Y584-PTPN11 PRKCASOCS6:p-c-Kit:sSCFdimer:p-c-KitKITLG-1(26-190) STAT3 GDP15, 17, 19, 29, 36...