Signaling by SCF-KIT (Homo sapiens)

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8, 26, 51, 63, 76...43, 5727, 45, 50, 8117, 4259, 7411212, 30, 604, 15, 28, 767, 9, 47, 69, 80308, 46, 79, 801732, 34, 35, 7429, 336, 25, 37, 56, 62...4040, 647811, 14, 23, 6616, 69, 805838, 48, 808, 52, 7617, 39, 42504041, 491, 435, 13, 18, 32, 36...173062, 68-70, 803, 50cytosolnucleoplasmADPADPp-JAK2:SFKs:p-KITcomplexKITLG-1(26-190) ADPp-JAK2:SFKs:p-KITcomplex:STATsKITLG-1(26-190) TEC STATsGRB2-1:SOS1LYN SRC-1 p21 RAS:GTPKITLG-1(26-190) p-Y705-STAT3 Tyrosinekinases:p-KITcomplexSH2B3p-7Y-KIT STAT3 GRAP2 PI3K:p-KIT:sSCFdimer:p-KITADPFYN p-Y699-STAT5B GRB2-1 FER GRAP2 p-JAK2:SFKs:p-KITcomplex:p-STATsKIT p-7Y-KIT SH2B2 TEC p-7Y-KIT FYN KITLG-1(26-190) LCK GRB2-1 RAC1:GTPLCK HRAS SRC-1 GRB10 VAV1LCK PIP3 activates AKTsignalingp-STAT dimersGTPp-Y699-STAT5B GRB2-1 PTPRUp-Y142,Y160,Y174-VAV1 SRC-1 PIK3R2 MMP9 YES1 SOCS6:p-c-Kit:sSCFdimer:p-c-KitSOCS6 GRB2-1 YES1 GAB2 Adapter proteinsp-Y701-STAT1-1 KITLG-1(26-190) FYN p-Y701-STAT1-1 p-Y694-STAT5A GAB2:GRB2:p-SHP2:p-KIT complexp-7Y-KIT p-Y-GAB2 LYN ATPKITLG-1(26-190) STAT5A SOS1 p-JAK2:SFKs:p-KITcomplex:p-STATdimersFER P13K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexYES1 p-7Y-KIT PIK3R3 PIK3R1 PRKCA CHEK1 SOS1 CBL ADPp-Y1007-JAK2 KITLG-1(26-190)KITLG-1(26-190) FYN APS dimerGTP p-7Y-KIT:sSCFdimer:p-7Y-KITGRB10 CHEK1 GRB2-1 SRC-1 p-7Y-KIT p-7Y-KIT KITLG-1(26-190) PIK3R3 HRAS STAT5B SH2B3 LYN PTPRU SRC-1 LCK ATPLYN p21 RAS:GDPKITLG-1GDP KITLG-1(26-190) FYN p-7Y-KIT GRB2:SOS1:p-KITcomplexATPp-7Y-KIT LYN p-Y694-STAT5A GRB2-1 Endopeptidases forSCF processingKITLG-1(26-190) KITLG-1(26-190) KIT:sSCF dimerKITLG-1(26-190) KITLG-1(26-190) p-Y629-SH2B2 GRB7 FYN FYN p-7Y-KIT p-Y546,Y584-PTPN11 p-Y705-STAT3 KITLG-1(26-190) FYN p-APS dimer:p-KITcomplexSrc family tyrosinekinases (SFKs)KITLG-1(26-190) JAK2 SRC-1 p-KIT (S741,746):PKCalphaPIK3R1 LCK NRAS LCK YES1 p-7Y-KIT FYN FYN PI(3,4,5)P3GRAP FYN PIK3R1 STAT5B p-Y629-SH2B2 p-Y546,Y584-PTPN11 p-Y1007-JAK2 STAT5A KITp-Y694-STAT5A LYN PI(3,4,5)P3 KITLG-1(192-273)GAB2KITLG-1(26-190) PIK3R2 APSdimer:p-c-Kit:SFKscomplexKITLG-1(26-190) GRB7 p-7Y-KIT GRB2-1 GRB2-1 KITLG-1(26-190) LCK LCK LNK:p-7Y-KIT:sSCFdimer:p-7Y-KITSOS1 GRB2:p-SHP2:p-KITcomplexFYN p-7Y-KIT p-Y1007-JAK2 LYN KITLG-1(26-190) p-Y546,Y584-PTPN11 YES1 p-7Y-KIT SRC-1 GDP SRC-1 p-7Y-KIT LYN LYN sSCF dimerLYN LCK RAF/MAP kinasecascadeLYN YES1 p-Y546,Y584-PTPN11 p-Y705-STAT3 KRAS p-7Y-KIT p-Y-GAB2 GDPATPYES1 CMA1 p-7Y-KIT STAT1 p-7Y-KIT SFKs:p-8Y-KIT:sSCFdimer:p-8Y-KITJAK2SOCS1 LCK RAC1:GDPSOCS1:p-KIT complexNRAS KIT:sSCF dimer:KITKIT YES1 p-Y629-SH2B2 SRC-1 p-Y1007-JAK2 FES LCK KITLG-1(26-190) YES1 GDPKITLG-1(26-190) KITLG-1(26-190) p-7Y-KIT PI(4,5)P2FYN YES1 PIK3CA SRC-1 SRC-1 YES1 GTP p-7Y-KIT SOS1 LCK KITLG-1(26-190) ADPp-Y699-STAT5B STAT1 CBL:Grb2/p-APS:p-c-Kit complexFYN GRAP PIK3R3 YES1 FYN p-8Y-KIT YES1 SOCS1p-SHP2:p-KIT complexYES1 LCK KITLG-1(26-190) FYN RAC1 SRC-1 SRC-1 RAC1 STAT3 LYN p-7Y-KIT LCK KITLG-1(26-190) YES1 FYN SRC-1 GRB2-1PTPN11p-7Y-KIT LYN p-Y701-STAT1-1 LCK p-Y546,Y584-PTPN11 PTPN6 LCK KITLG-1(26-190) KRAS GTPFYN SOCS6p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexLCK ATPKITLG-1(26-190) KIT KITLG-1(26-190) ADPYES1 PTPN11 p-7Y-KIT KITLG-1(26-190) LYN ATPSRC-1 PRKCASRC-1 LYN SRC-1 SFKs:p-KIT complexLYN SRC-1 YES1 FES PIK3CA Adapterproteins:p-KITcomplexATPp-7Y-KIT PTPN6CBLADPLYN LCK YES1 SH2B2 p-VAV1:PIP3PIK3CA PTPRO:KITp-S741,S746-KIT PIK3R2 JAK2:SFKS:p-KITcomplexGrb2:SOS:p-c-Kit/p-APS:p-c-Kit complexTyrosine kinasesSHP-1:p-c-Kitcomplexp-7Y-KIT PI3K alphaLYN SHP2:SFKs:p-KIT:sSCFdimer:p-KIT10, 12, 19, 20, 22...


Description

Stem cell factor (SCF) is a growth factor with membrane bound and soluble forms. It is expressed by fibroblasts and endothelial cells throughout the body, promoting proliferation, migration, survival and differentiation of hematopoetic progenitors, melanocytes and germ cells.(Linnekin 1999, Ronnstrand 2004, Lennartsson and Ronnstrand 2006). The receptor for SCF is KIT, a tyrosine kinase receptor (RTK) closely related to the receptors for platelet derived growth factor receptor, colony stimulating factor 1 (Linnekin 1999) and Flt3 (Rosnet et al. 1991). Four isoforms of c-Kit have been identified in humans. Alternative splicing results in isoforms of KIT differing in the presence or absence of four residues (GNNK) in the extracellular region. This occurs due to the use of an alternate 5' splice donor site. These GNNK+ and GNNK- variants are co-expressed in most tissues; the GNNK- form predominates and was more strongly tyrosine-phosphorylated and more rapidly internalized (Ronnstrand 2004). There are also splice variants that arise from alternative usage of splice acceptor site resulting in the presence or absence of a serine residue (Crosier et al., 1993). Finally, there is an alternative shorter transcript of KIT expressed in postmeiotic germ cells in the testis which encodes a truncated KIT consisting only of the second part of the kinase domain and thus lackig the extracellular and transmembrane domains as well as the first part of the kinase domain (Rossi et al. 1991). Binding of SCF homodimers to KIT results in KIT homodimerization followed by activation of its intrinsic tyrosine kinase activity. KIT stimulation activates a wide array of signalling pathways including MAPK, PI3K and JAK/STAT (Reber et al. 2006, Ronnstrand 2004). Defects of KIT in humans are associated with different genetic diseases and also in several types of cancers like mast cell leukaemia, germ cell tumours, certain subtypes of malignant melanoma and gastrointestinal tumours. View original pathway at:Reactome.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
101337view11:22, 1 November 2018ReactomeTeamreactome version 66
100875view20:56, 31 October 2018ReactomeTeamreactome version 65
100416view19:30, 31 October 2018ReactomeTeamreactome version 64
99966view16:14, 31 October 2018ReactomeTeamreactome version 63
99520view14:49, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99162view12:41, 31 October 2018ReactomeTeamreactome version 62
93973view13:49, 16 August 2017ReactomeTeamreactome version 61
93574view11:27, 9 August 2017ReactomeTeamreactome version 61
87186view08:05, 19 July 2016EgonwOntology Term : 'signaling pathway' added !
86676view09:23, 11 July 2016ReactomeTeamreactome version 56
83115view10:00, 18 November 2015ReactomeTeamVersion54
81455view12:59, 21 August 2015ReactomeTeamVersion53
76929view08:20, 17 July 2014ReactomeTeamFixed remaining interactions
76634view12:00, 16 July 2014ReactomeTeamFixed remaining interactions
75964view10:02, 11 June 2014ReactomeTeamRe-fixing comment source
75667view10:57, 10 June 2014ReactomeTeamReactome 48 Update
75022view13:53, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74666view08:43, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
APS

dimer:p-c-Kit:SFKs

complex
ComplexR-HSA-205257 (Reactome)
APS dimerComplexR-HSA-1433305 (Reactome)
ATPMetaboliteCHEBI:15422 (ChEBI)
Adapter

proteins:p-KIT

complex
ComplexR-HSA-1433538 (Reactome)
Adapter proteinsComplexR-HSA-1433422 (Reactome)
CBL ProteinP22681 (Uniprot-TrEMBL)
CBL:Grb2/p-APS:p-c-Kit complexComplexR-HSA-205200 (Reactome)
CBLProteinP22681 (Uniprot-TrEMBL)
CHEK1 ProteinO14757 (Uniprot-TrEMBL)
CMA1 ProteinP23946 (Uniprot-TrEMBL)
Endopeptidases for SCF processingComplexR-HSA-1433401 (Reactome)
FER ProteinP16591 (Uniprot-TrEMBL)
FES ProteinP07332 (Uniprot-TrEMBL)
FYN ProteinP06241 (Uniprot-TrEMBL)
GAB2 ProteinQ9UQC2 (Uniprot-TrEMBL)
GAB2:GRB2:p-SHP2:p-KIT complexComplexR-HSA-1433545 (Reactome)
GAB2ProteinQ9UQC2 (Uniprot-TrEMBL)
GDP MetaboliteCHEBI:17552 (ChEBI)
GDPMetaboliteCHEBI:17552 (ChEBI)
GRAP ProteinQ13588 (Uniprot-TrEMBL)
GRAP2 ProteinO75791 (Uniprot-TrEMBL)
GRB10 ProteinQ13322 (Uniprot-TrEMBL)
GRB2-1 ProteinP62993-1 (Uniprot-TrEMBL)
GRB2-1:SOS1ComplexR-HSA-109797 (Reactome)
GRB2-1ProteinP62993-1 (Uniprot-TrEMBL)
GRB2:SOS1:p-KIT complexComplexR-HSA-205202 (Reactome)
GRB2:p-SHP2:p-KIT complexComplexR-HSA-1433549 (Reactome)
GRB7 ProteinQ14451 (Uniprot-TrEMBL)
GTP MetaboliteCHEBI:15996 (ChEBI)
GTPMetaboliteCHEBI:15996 (ChEBI)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complexComplexR-HSA-1433400 (Reactome)
HRAS ProteinP01112 (Uniprot-TrEMBL)
JAK2 ProteinO60674 (Uniprot-TrEMBL)
JAK2:SFKS:p-KIT complexComplexR-HSA-1433493 (Reactome)
JAK2ProteinO60674 (Uniprot-TrEMBL)
KIT ProteinP10721 (Uniprot-TrEMBL)
KIT:sSCF dimer:KITComplexR-HSA-205208 (Reactome)
KIT:sSCF dimerComplexR-HSA-205166 (Reactome)
KITLG-1(192-273)ProteinP21583-1 (Uniprot-TrEMBL)
KITLG-1(26-190) ProteinP21583-1 (Uniprot-TrEMBL)
KITLG-1(26-190)ProteinP21583-1 (Uniprot-TrEMBL)
KITLG-1ProteinP21583-1 (Uniprot-TrEMBL)
KITProteinP10721 (Uniprot-TrEMBL)
KRAS ProteinP01116 (Uniprot-TrEMBL)
LCK ProteinP06239 (Uniprot-TrEMBL)
LNK:p-7Y-KIT:sSCF dimer:p-7Y-KITComplexR-HSA-1562562 (Reactome)
LYN ProteinP07948 (Uniprot-TrEMBL)
MMP9 ProteinP14780 (Uniprot-TrEMBL)
NRAS ProteinP01111 (Uniprot-TrEMBL)
P13K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexComplexR-HSA-1562561 (Reactome)
PI(3,4,5)P3 MetaboliteCHEBI:16618 (ChEBI)
PI(3,4,5)P3MetaboliteCHEBI:16618 (ChEBI)
PI(4,5)P2MetaboliteCHEBI:18348 (ChEBI)
PI3K alphaComplexR-HSA-198379 (Reactome)
PI3K:p-KIT:sSCF dimer:p-KITComplexR-HSA-205177 (Reactome)
PIK3CA ProteinP42336 (Uniprot-TrEMBL)
PIK3R1 ProteinP27986 (Uniprot-TrEMBL)
PIK3R2 ProteinO00459 (Uniprot-TrEMBL)
PIK3R3 ProteinQ92569 (Uniprot-TrEMBL)
PIP3 activates AKT signalingPathwayR-HSA-1257604 (Reactome) Signaling by AKT is one of the key outcomes of receptor tyrosine kinase (RTK) activation. AKT is activated by the cellular second messenger PIP3, a phospholipid that is generated by PI3K. In ustimulated cells, PI3K class IA enzymes reside in the cytosol as inactive heterodimers composed of p85 regulatory subunit and p110 catalytic subunit. In this complex, p85 stabilizes p110 while inhibiting its catalytic activity. Upon binding of extracellular ligands to RTKs, receptors dimerize and undergo autophosphorylation. The regulatory subunit of PI3K, p85, is recruited to phosphorylated cytosolic RTK domains either directly or indirectly, through adaptor proteins, leading to a conformational change in the PI3K IA heterodimer that relieves inhibition of the p110 catalytic subunit. Activated PI3K IA phosphorylates PIP2, converting it to PIP3; this reaction is negatively regulated by PTEN phosphatase. PIP3 recruits AKT to the plasma membrane, allowing TORC2 to phosphorylate a conserved serine residue of AKT. Phosphorylation of this serine induces a conformation change in AKT, exposing a conserved threonine residue that is then phosphorylated by PDPK1 (PDK1). Phosphorylation of both the threonine and the serine residue is required to fully activate AKT. The active AKT then dissociates from PIP3 and phosphorylates a number of cytosolic and nuclear proteins that play important roles in cell survival and metabolism. For a recent review of AKT signaling, please refer to Manning and Cantley, 2007.
PRKCA ProteinP17252 (Uniprot-TrEMBL)
PRKCAProteinP17252 (Uniprot-TrEMBL)
PTPN11 ProteinQ06124 (Uniprot-TrEMBL)
PTPN11ProteinQ06124 (Uniprot-TrEMBL)
PTPN6 ProteinP29350 (Uniprot-TrEMBL)
PTPN6ProteinP29350 (Uniprot-TrEMBL)
PTPRO:KITComplexR-HSA-1433419 (Reactome)
PTPRU ProteinQ92729 (Uniprot-TrEMBL)
PTPRUProteinQ92729 (Uniprot-TrEMBL)
RAC1 ProteinP63000 (Uniprot-TrEMBL)
RAC1:GDPComplexR-HSA-445010 (Reactome)
RAC1:GTPComplexR-HSA-442641 (Reactome)
RAF/MAP kinase cascadePathwayR-HSA-5673001 (Reactome) The RAS-RAF-MEK-ERK pathway regulates processes such as proliferation, differentiation, survival, senescence and cell motility in response to growth factors, hormones and cytokines, among others. Binding of these stimuli to receptors in the plasma membrane promotes the GEF-mediated activation of RAS at the plasma membrane and initiates the three-tiered kinase cascade of the conventional MAPK cascades. GTP-bound RAS recruits RAF (the MAPK kinase kinase), and promotes its dimerization and activation (reviewed in Cseh et al, 2014; Roskoski, 2010; McKay and Morrison, 2007; Wellbrock et al, 2004). Activated RAF phosphorylates the MAPK kinase proteins MEK1 and MEK2 (also known as MAP2K1 and MAP2K2), which in turn phophorylate the proline-directed kinases ERK1 and 2 (also known as MAPK3 and MAPK1) (reviewed in Roskoski, 2012a, b; Kryiakis and Avruch, 2012). Activated ERK proteins may undergo dimerization and have identified targets in both the nucleus and the cytosol; consistent with this, a proportion of activated ERK protein relocalizes to the nucleus in response to stimuli (reviewed in Roskoski 2012b; Turjanski et al, 2007; Plotnikov et al, 2010; Cargnello et al, 2011). Although initially seen as a linear cascade originating at the plasma membrane and culminating in the nucleus, the RAS/RAF MAPK cascade is now also known to be activated from various intracellular location. Temporal and spatial specificity of the cascade is achieved in part through the interaction of pathway components with numerous scaffolding proteins (reviewed in McKay and Morrison, 2007; Brown and Sacks, 2009).
The importance of the RAS/RAF MAPK cascade is highlighted by the fact that components of this pathway are mutated with high frequency in a large number of human cancers. Activating mutations in RAS are found in approximately one third of human cancers, while ~8% of tumors express an activated form of BRAF (Roberts and Der, 2007; Davies et al, 2002; Cantwell-Dorris et al, 2011).
SFKs:p-8Y-KIT:sSCF dimer:p-8Y-KITComplexR-HSA-1472120 (Reactome)
SFKs:p-KIT complexComplexR-HSA-205271 (Reactome)
SH2B2 ProteinO14492 (Uniprot-TrEMBL)
SH2B3 ProteinQ9UQQ2 (Uniprot-TrEMBL)
SH2B3ProteinQ9UQQ2 (Uniprot-TrEMBL)
SHP-1:p-c-Kit complexComplexR-HSA-205181 (Reactome)
SHP2:SFKs:p-KIT:sSCF dimer:p-KITComplexR-HSA-205267 (Reactome)
SOCS1 ProteinO15524 (Uniprot-TrEMBL)
SOCS1:p-KIT complexComplexR-HSA-1433442 (Reactome)
SOCS1ProteinO15524 (Uniprot-TrEMBL)
SOCS6 ProteinO14544 (Uniprot-TrEMBL)
SOCS6:p-c-Kit:sSCF dimer:p-c-KitComplexR-HSA-1470001 (Reactome)
SOCS6ProteinO14544 (Uniprot-TrEMBL)
SOS1 ProteinQ07889 (Uniprot-TrEMBL)
SRC-1 ProteinP12931-1 (Uniprot-TrEMBL)
STAT1 ProteinP42224 (Uniprot-TrEMBL)
STAT3 ProteinP40763 (Uniprot-TrEMBL)
STAT5A ProteinP42229 (Uniprot-TrEMBL)
STAT5B ProteinP51692 (Uniprot-TrEMBL)
STATsComplexR-HSA-1433551 (Reactome)
Src family tyrosine kinases (SFKs)ComplexR-HSA-211064 (Reactome)
TEC ProteinP42680 (Uniprot-TrEMBL)
Tyrosine

kinases:p-KIT

complex
ComplexR-HSA-205201 (Reactome)
Tyrosine kinasesComplexR-HSA-1433353 (Reactome)
VAV1ProteinP15498 (Uniprot-TrEMBL)
YES1 ProteinP07947 (Uniprot-TrEMBL)
p(Y)-GAB2:GRB2:p-SHP2:p-KIT complexComplexR-HSA-1562560 (Reactome)
p-7Y-KIT ProteinP10721 (Uniprot-TrEMBL)
p-7Y-KIT:sSCF dimer:p-7Y-KITComplexR-HSA-205310 (Reactome)
p-8Y-KIT ProteinP10721 (Uniprot-TrEMBL)
p-APS dimer:p-KIT complexComplexR-HSA-1433276 (Reactome)
p-JAK2:SFKs:p-KIT complex:STATsComplexR-HSA-1433527 (Reactome)
p-JAK2:SFKs:p-KIT

complex:p-STAT

dimers
ComplexR-HSA-1469999 (Reactome)
p-JAK2:SFKs:p-KIT complex:p-STATsComplexR-HSA-1470000 (Reactome)
p-JAK2:SFKs:p-KIT complexComplexR-HSA-1433552 (Reactome)
p-KIT (S741,746):PKC alphaComplexR-HSA-1433473 (Reactome)
p-S741,S746-KIT ProteinP10721 (Uniprot-TrEMBL)
p-SHP2:p-KIT complexComplexR-HSA-1433530 (Reactome)
p-STAT dimersComplexR-HSA-1566924 (Reactome)
p-VAV1:PIP3ComplexR-HSA-1433526 (Reactome)
p-Y-GAB2 ProteinQ9UQC2 (Uniprot-TrEMBL)
p-Y1007-JAK2 ProteinO60674 (Uniprot-TrEMBL)
p-Y142,Y160,Y174-VAV1 ProteinP15498 (Uniprot-TrEMBL)
p-Y546,Y584-PTPN11 ProteinQ06124 (Uniprot-TrEMBL)
p-Y629-SH2B2 ProteinO14492 (Uniprot-TrEMBL)
p-Y694-STAT5A ProteinP42229 (Uniprot-TrEMBL)
p-Y699-STAT5B ProteinP51692 (Uniprot-TrEMBL)
p-Y701-STAT1-1 ProteinP42224-1 (Uniprot-TrEMBL)
p-Y705-STAT3 ProteinP40763 (Uniprot-TrEMBL)
p21 RAS:GDPComplexR-HSA-109796 (Reactome)
p21 RAS:GTPComplexR-HSA-109783 (Reactome)
sSCF dimerComplexR-HSA-1433307 (Reactome)

Annotated Interactions

View all...
SourceTargetTypeDatabase referenceComment
ADPArrowR-HSA-1433418 (Reactome)
ADPArrowR-HSA-1433454 (Reactome)
ADPArrowR-HSA-1433488 (Reactome)
ADPArrowR-HSA-1433506 (Reactome)
ADPArrowR-HSA-1433508 (Reactome)
ADPArrowR-HSA-1433514 (Reactome)
ADPArrowR-HSA-1433542 (Reactome)
ADPArrowR-HSA-1470009 (Reactome)
ADPArrowR-HSA-1472121 (Reactome)
ADPArrowR-HSA-205289 (Reactome)
APS

dimer:p-c-Kit:SFKs

complex
ArrowR-HSA-205319 (Reactome)
APS

dimer:p-c-Kit:SFKs

complex
R-HSA-1433506 (Reactome)
APS

dimer:p-c-Kit:SFKs

complex
mim-catalysisR-HSA-1433506 (Reactome)
APS dimerR-HSA-205319 (Reactome)
ATPR-HSA-1433418 (Reactome)
ATPR-HSA-1433454 (Reactome)
ATPR-HSA-1433488 (Reactome)
ATPR-HSA-1433506 (Reactome)
ATPR-HSA-1433508 (Reactome)
ATPR-HSA-1433514 (Reactome)
ATPR-HSA-1433542 (Reactome)
ATPR-HSA-1470009 (Reactome)
ATPR-HSA-1472121 (Reactome)
ATPR-HSA-205289 (Reactome)
Adapter

proteins:p-KIT

complex
ArrowR-HSA-1433501 (Reactome)
Adapter proteinsR-HSA-1433501 (Reactome)
CBL:Grb2/p-APS:p-c-Kit complexArrowR-HSA-205244 (Reactome)
CBLR-HSA-205244 (Reactome)
Endopeptidases for SCF processingmim-catalysisR-HSA-1433374 (Reactome)
GAB2:GRB2:p-SHP2:p-KIT complexArrowR-HSA-205234 (Reactome)
GAB2:GRB2:p-SHP2:p-KIT complexR-HSA-1433454 (Reactome)
GAB2:GRB2:p-SHP2:p-KIT complexmim-catalysisR-HSA-1433454 (Reactome)
GAB2R-HSA-205234 (Reactome)
GDPArrowR-HSA-1433415 (Reactome)
GDPArrowR-HSA-1433471 (Reactome)
GRB2-1:SOS1R-HSA-205286 (Reactome)
GRB2-1R-HSA-1433428 (Reactome)
GRB2:SOS1:p-KIT complexArrowR-HSA-205286 (Reactome)
GRB2:SOS1:p-KIT complexmim-catalysisR-HSA-1433471 (Reactome)
GRB2:p-SHP2:p-KIT complexArrowR-HSA-1433428 (Reactome)
GRB2:p-SHP2:p-KIT complexR-HSA-205234 (Reactome)
GTPR-HSA-1433415 (Reactome)
GTPR-HSA-1433471 (Reactome)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complexR-HSA-205244 (Reactome)
JAK2:SFKS:p-KIT complexArrowR-HSA-1433451 (Reactome)
JAK2:SFKS:p-KIT complexR-HSA-1433418 (Reactome)
JAK2:SFKS:p-KIT complexmim-catalysisR-HSA-1433418 (Reactome)
JAK2R-HSA-1433451 (Reactome)
KIT:sSCF dimer:KITArrowR-HSA-205231 (Reactome)
KIT:sSCF dimer:KITR-HSA-205289 (Reactome)
KIT:sSCF dimer:KITmim-catalysisR-HSA-205289 (Reactome)
KIT:sSCF dimerArrowR-HSA-205321 (Reactome)
KIT:sSCF dimerR-HSA-205231 (Reactome)
KITLG-1(192-273)ArrowR-HSA-1433374 (Reactome)
KITLG-1(26-190)ArrowR-HSA-1433374 (Reactome)
KITLG-1(26-190)R-HSA-1433395 (Reactome)
KITLG-1R-HSA-1433374 (Reactome)
KITR-HSA-1433423 (Reactome)
KITR-HSA-1433508 (Reactome)