Signaling by SCF-KIT (Homo sapiens)

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3, 6, 8, 13, 38...15, 17, 37, 4929, 32, 629, 2145, 665, 193224, 25, 34, 60171, 4, 7, 16, 25...4, 25211131, 67692114, 22, 27, 35, 46336618, 22, 35, 43, 443251, 54, 59, 6622, 23, 4122, 27, 28, 36, 47...22, 26, 3512, 559, 10, 2113, 57, 6833, 5622, 48, 63, 68212, 3013, 20, 42, 6133Src family tyrosinekinases (SFKs)[cytosol]Src family tyrosinekinases (SFKs)[cytosol]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]p21 RAS [plasmamembrane]sSCF dimer[extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]sSCF dimer[extracellularregion]p-KIT (S741,746):PKCalpha [plasmamembrane]Adapterproteins:p-KITcomplex [plasmamembrane]p-STATs [cytosol]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]p-STAT dimer[cytosol]sSCF dimer[extracellularregion]p-JAK2:SFKs:p-KITcomplex:p-STATdimers [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]sSCF dimer[extracellularregion]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplex [plasmamembrane]sSCF dimer[extracellularregion]SHP-1:p-c-Kitcomplex [plasmamembrane]p-SHP2:p-KIT complex[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]Grb2:SOS:p-c-Kit/p-APS:p-c-Kitcomplex [plasmamembrane, cytosol,extracellularregion]SOCS1:p-KIT complex[plasma membrane]LNK:p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]nucleoplasmp-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]Adapter proteins[cytosol]Src family tyrosinekinases (SFKs)[cytosol]RAC1-GTP [cytosol]p-APS dimer:p-KITcomplex [plasmamembrane]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]GRB2:SOS1 [cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]KIT:sSCF dimer[plasma membrane]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]GRB2:SOS1:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Grb2:SOS:p-c-Kit/p-APS:p-c-Kitcomplex [plasmamembrane, cytosol,extracellularregion]sSCF dimer[extracellularregion]p-APS dimer:p-KITcomplex [plasmamembrane]GRB2:SOS1 [cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-STATs [cytosol]sSCF dimer[extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]Tyrosinekinases:p-KITcomplex [plasmamembrane]p21 RAS [plasmamembrane]PTPRO:KIT [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]GRB2:SOS1 [cytosol]PI3K alpha [cytosol]SFKs:p-KIT complex[plasma membrane]GRB2:SOS1:p-KITcomplex [plasmamembrane]cytosolSOCS6:p-c-Kit:sSCFdimer:p-c-Kit[plasma membrane]SFKs:p-8Y-KIT:sSCFdimer:p-8Y-KIT[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]p-APS dimer:p-KITcomplex [plasmamembrane]sSCF dimer[extracellularregion]JAK2:SFKS:p-KITcomplex [plasmamembrane]APS dimer [cytosol]Tyrosine kinases[cytosol]Src family tyrosinekinases (SFKs)[cytosol]Src family tyrosinekinases (SFKs)[cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]APSdimer:p-c-Kit:SFKscomplex [plasmamembrane]PI3K alpha [cytosol]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]SFKs:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]SFKs:p-KIT complex[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]p-APS dimer[cytosol]sSCF dimer[extracellularregion]p-SHP2:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]CBL:Grb2/p-APS:p-c-Kitcomplex [plasmamembrane]Src family tyrosinekinases (SFKs)[cytosol]SFKs:p-KIT complex[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-SHP2:p-KIT complex[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]sSCF dimer[extracellularregion]SFKs:p-KIT complex[plasma membrane]KIT:sSCF dimer:KIT[plasma membrane]p-JAK2:SFKs:p-KITcomplex [plasmamembrane]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]Src family tyrosinekinases (SFKs)[cytosol]p-SHP2:p-KIT complex[plasma membrane]p-JAK2:SFKs:p-KITcomplex:STATs[plasma membrane]p-JAK2:SFKs:p-KITcomplex:p-STATs[plasma membrane]sSCF dimer[extracellularregion]P13K:p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplex [plasmamembrane]Src family tyrosinekinases (SFKs)[cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]APS dimer [cytosol]Src family tyrosinekinases (SFKs)[cytosol]SFKs:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]p-STATs[nucleoplasm]p-STAT dimers[nucleoplasm]p-APS dimer[cytosol]PI3K alpha [cytosol]p-SHP2:p-KIT complex[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p21 RAS:GDP [plasmamembrane]sSCF dimer[extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]GAB2:GRB2:p-SHP2:p-KITcomplex [plasmamembrane]sSCF dimer[extracellularregion]SHP2:SFKs:p-KIT:sSCFdimer:p-KIT [plasmamembrane]sSCF dimer[extracellularregion]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]GRB2:SOS1 [cytosol]sSCF dimer[extracellularregion]SFKs:p-KIT complex[plasma membrane]p-8Y-KIT:sSCFdimer:p-8Y-KIT[plasma membrane]GRB2:SOS1:p-KITcomplex [plasmamembrane]SFKs:p-KIT complex[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]p21 RAS:GTP [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]RAC1-GDP [cytosol]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]SFKs:p-KIT complex[plasma membrane]p-VAV1:PIP3 [plasmamembrane]SFKs:p-KIT complex[plasma membrane]p-APS dimer[cytosol]STATs [cytosol]sSCF dimer[extracellularregion]PI3K:p-KIT:sSCFdimer:p-KIT [plasmamembrane]SRC-1 [cytosol]ADPp-7Y-KIT [plasmamembrane]p-Y629-SH2B2[cytosol]LCK [cytosol]CBL [cytosol]PTPN6SRC-1 [cytosol]YES1(2-543)[cytosol]SRC-1 [cytosol]FYN(2-537) [cytosol]p-Y-GAB2 [cytosol]SRC-1 [cytosol]KITLG-1(26-190)[extracellularregion]PTPN6 [cytosol]p-7Y-KIT [plasmamembrane]CBL:Grb2/p-APS:p-c-KitcomplexAPS dimerp-Y546,Y584-PTPN11[cytosol]KITLG-1(26-190)[extracellularregion]p-Y705-STAT3[nucleoplasm]LCK [cytosol]ATPKITLG-1(26-190)[extracellularregion]KITLG-1(26-190)[extracellularregion]LYN(2-512) [cytosol]LYN(2-512) [cytosol]GTPSRC-1 [cytosol]KITLG-1(26-190)[extracellularregion]p-Y694-STAT5A[cytosol]SOCS1SOCS6Tyrosine kinasesKITLG-1(26-190)[extracellularregion]p-KIT (S741,746):PKCalphaGRB2:p-SHP2:p-KITcomplexFYN(2-537) [cytosol]ADPLCK [cytosol]APSdimer:p-c-Kit:SFKscomplexKITYES1(2-543)[cytosol]Tyrosinekinases:p-KITcomplexp-STAT dimersSRC-1 [cytosol]FYN(2-537) [cytosol]p-7Y-KIT [plasmamembrane]GAB2 [cytosol]LYN(2-512) [cytosol]ATPSHP2:SFKs:p-KIT:sSCFdimer:p-KITKITLG-1(26-190)[extracellularregion]YES1(2-543)[cytosol]p-Y1007-JAK2[cytosol]KITLG-1(26-190)[extracellularregion]p-Y694-STAT5A[nucleoplasm]KIT [plasmamembrane]RAF/MAP kinasecascadep-JAK2:SFKs:p-KITcomplexKRAS(1-186) [plasmamembrane]p-8Y-KIT [plasmamembrane]LYN(2-512) [cytosol]YES1(2-543)[cytosol]p-Y629-SH2B2[cytosol]LCK [cytosol]p-7Y-KIT [plasmamembrane]PRKCASrc family tyrosinekinases (SFKs)JAK2:SFKS:p-KITcomplexLNK:p-7Y-KIT:sSCFdimer:p-7Y-KITKITLG-1(26-190)[extracellularregion]KITLG-1(26-190)[extracellularregion]p-Y546,Y584-PTPN11[cytosol]FYN(2-537) [cytosol]GRB2-1 [cytosol]GRB2-1 [cytosol]p-7Y-KIT [plasmamembrane]NRAS [plasmamembrane]p-Y546,Y584-PTPN11[cytosol]KITLG-1(26-190)[extracellularregion]GTP [cytosol]p-VAV1:PIP3FYN(2-537) [cytosol]GRB2-1 [cytosol]SRC-1 [cytosol]p-7Y-KIT [plasmamembrane]p-JAK2:SFKs:p-KITcomplex:STATsPIK3CA [cytosol]SOS1 [cytosol]GRB2-1 [cytosol]KITLG-1(26-190)[extracellularregion]p-7Y-KIT [plasmamembrane]KITLG-1(26-190)[extracellularregion]PI(3,4,5)P3LYN(2-512) [cytosol]YES1(2-543)[cytosol]JAK2 [cytosol]KITLG-1(26-190)[extracellularregion]GRB2:SOS1p-Y701-STAT1-1[cytosol]KITLG-1(26-190)[extracellularregion]p-7Y-KIT:sSCFdimer:p-7Y-KITLCK [cytosol]SFKs:p-KIT complexKITLG-1(26-190)[extracellularregion]KITLG-1(26-190)[extracellularregion]GRB2-1 [cytosol]GRAP [cytosol]p-7Y-KIT [plasmamembrane]p-7Y-KIT [plasmamembrane]ATPSRC-1 [cytosol]YES1(2-543)[cytosol]PIK3CA [cytosol]NRAS [plasmamembrane]GDP [cytosol]p-SHP2:p-KIT complexKITLG-1(26-190)[extracellularregion]p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplexKIT [plasmamembrane]LCK [cytosol]KITLG-1(26-190)[extracellularregion]STAT1 [cytosol]SOCS1 [cytosol]p-Y699-STAT5B[nucleoplasm]PTPRO:KITFYN(2-537) [cytosol]KITLG-1(26-190)[extracellularregion]GTPATPp-APS dimer:p-KITcomplexSOS1 [cytosol]GAB2:GRB2:p-SHP2:p-KITcomplexP13K:p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplexGRAP2 [cytosol]YES1(2-543)[cytosol]p-JAK2:SFKs:p-KITcomplex:p-STATdimersGDPFYN(2-537) [cytosol]SH2B2 [cytosol]p-Y699-STAT5B[cytosol]sSCF dimerCBLPRKCA [cytosol]LYN(2-512) [cytosol]STATsGrb2:SOS:p-c-Kit/p-APS:p-c-Kitcomplexp-7Y-KIT [plasmamembrane]KITLG-1(26-190)RAC1 [cytosol]SRC-1 [cytosol]SRC-1 [cytosol]LYN(2-512) [cytosol]LCK [cytosol]KITLG-1(26-190)[extracellularregion]KIT:sSCF dimer:KITFYN(2-537) [cytosol]p-Y1007-JAK2[cytosol]p-7Y-KIT [plasmamembrane]SH2B2 [cytosol]p-7Y-KIT [plasmamembrane]SRC-1 [cytosol]LYN(2-512) [cytosol]GDPFYN(2-537) [cytosol]p-Y701-STAT1-1[cytosol]LCK [cytosol]p-Y1007-JAK2[cytosol]LYN(2-512) [cytosol]YES1(2-543)[cytosol]KITLG-1(26-190)[extracellularregion]JAK2GTP [cytosol]SOCS6 [cytosol]p-7Y-KIT [plasmamembrane]GRB2-1 [cytosol]FYN(2-537) [cytosol]ADPKITLG-1(26-190)[extracellularregion]PTPN11p-7Y-KIT [plasmamembrane]ADPp-Y1007-JAK2[cytosol]SH2B3KITLG-1p-Y701-STAT1-1[nucleoplasm]p-7Y-KIT [plasmamembrane]SRC-1 [cytosol]KITLG-1(26-190)[extracellularregion]p-7Y-KIT [plasmamembrane]CHEK1 [cytosol]GRB7 [cytosol]PIP3 activates AKTsignalingPI(4,5)P2p-7Y-KIT [plasmamembrane]SOS1 [cytosol]LYN(2-512) [cytosol]PI3K:p-KIT:sSCFdimer:p-KITATPHRAS(1-186) [plasmamembrane]p-Y629-SH2B2[cytosol]LCK [cytosol]p21 RAS:GTPADPp-Y546,Y584-PTPN11[cytosol]RAC1-GTPSRC-1 [cytosol]ATPSTAT3 [cytosol]YES1(2-543)[cytosol]SOCS1:p-KIT complexFYN(2-537) [cytosol]Adapter proteinsGRB2-1 [cytosol]KITLG-1(26-190)[extracellularregion]RAC1-GDPLYN(2-512) [cytosol]LYN(2-512) [cytosol]p-7Y-KIT [plasmamembrane]p-Y142,Y160,Y174-VAV1[plasma membrane]SRC-1 [cytosol]KITLG-1(26-190)[extracellularregion]FYN(2-537) [cytosol]LYN(2-512) [cytosol]YES1(2-543)[cytosol]LCK [cytosol]LCK [cytosol]LCK [cytosol]LCK [cytosol]SFKs:p-8Y-KIT:sSCFdimer:p-8Y-KITKITLG-1(26-190)[extracellularregion]YES1(2-543)[cytosol]FYN(2-537) [cytosol]p-Y-GAB2 [cytosol]STAT5B [cytosol]p-S741,S746-KIT[plasma membrane]GDP [cytosol]Endopeptidases forSCF processingp-7Y-KIT [plasmamembrane]LCK [cytosol]LYN(2-512) [cytosol]YES1(2-543)[cytosol]FYN(2-537) [cytosol]LYN(2-512) [cytosol]p-7Y-KIT [plasmamembrane]p-7Y-KIT [plasmamembrane]FYN(2-537) [cytosol]PTPRU(19-1430)SH2B3 [cytosol]PI3K alphaPIK3CA [cytosol]FER [cytosol]p-Y705-STAT3[cytosol]STAT5A [cytosol]p-7Y-KIT [plasmamembrane]PI(3,4,5)P3 [plasmamembrane]SRC-1 [cytosol]HRAS(1-186) [plasmamembrane]FYN(2-537) [cytosol]YES1(2-543)[cytosol]LCK [cytosol]GRB2-1p-Y546,Y584-PTPN11[cytosol]YES1(2-543)[cytosol]GAB2GRB10 [cytosol]RAC1 [cytosol]GRB2:SOS1:p-KITcomplexp-Y705-STAT3[cytosol]FES [cytosol]KRAS(1-186) [plasmamembrane]SOCS6:p-c-Kit:sSCFdimer:p-c-KitYES1(2-543)[cytosol]Adapterproteins:p-KITcomplexPTPRU(19-1430)[plasma membrane]p-7Y-KIT [plasmamembrane]KITLG-1(26-190)[extracellularregion]p-Y699-STAT5B[cytosol]ATPLYN(2-512) [cytosol]SOS1 [cytosol]PTPN11 [cytosol]p-Y694-STAT5A[cytosol]SHP-1:p-c-KitcomplexFYN(2-537) [cytosol]LCK [cytosol]KIT [plasmamembrane]ADPKITLG-1(26-190)[extracellularregion]GRB2-1 [cytosol]LCK [cytosol]SRC-1 [cytosol]p-JAK2:SFKs:p-KITcomplex:p-STATsSRC-1 [cytosol]KIT:sSCF dimerADPKITLG-1(192-273)LYN(2-512) [cytosol]p-7Y-KIT [plasmamembrane]ADPYES1(2-543)[cytosol]p-7Y-KIT [plasmamembrane]p21 RAS:GDPVAV1YES1(2-543)[cytosol]TEC [cytosol]50, 65