Signaling by SCF-KIT (Homo sapiens)

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3, 47, 48, 63, 68...635, 6121, 5311, 29, 34, 36, 49...1, 11, 22, 23, 6733, 4344, 6411, 26, 54468, 11, 13, 22, 366, 40, 55, 5911, 22, 3914, 19, 4637, 53462, 9, 13, 15, 16, 25...5212, 48, 6819, 4632, 58, 62, 686150, 51, 61, 6520244318, 6611, 17, 48, 5624414327, 28, 30, 427, 10, 2427, 31sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]SFKs:p-KIT complex[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]p21 RAS [plasmamembrane]SFKs:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]Adapter proteins[cytosol]Src family tyrosinekinases (SFKs)[cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]STATs [cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]p-STAT dimer[cytosol]p-STATs [cytosol]SHP2:SFKs:p-KIT:sSCFdimer:p-KIT [plasmamembrane]PI3K alpha [cytosol]p-KIT (S741,746):PKCalpha [plasmamembrane]P13K:p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-APS dimer:p-KITcomplex [plasmamembrane]p-SHP2:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]SOCS6:p-c-Kit:sSCFdimer:p-c-Kit[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]GRB2:SOS1 [cytosol]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]PI3K alpha [cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]GRB2:SOS1:p-KITcomplex [plasmamembrane]Src family tyrosinekinases (SFKs)[cytosol]SFKs:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]sSCF dimer[extracellularregion]KIT:sSCF dimer:KIT[plasma membrane]RAC1-GDP [cytosol]PI3K:p-KIT:sSCFdimer:p-KIT [plasmamembrane]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Adapterproteins:p-KITcomplex [plasmamembrane]SOCS1:p-KIT complex[plasma membrane]GRB2:SOS1 [cytosol]p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplex [plasmamembrane]KIT:sSCF dimer[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]sSCF dimer[extracellularregion]p-JAK2:SFKs:p-KITcomplex [plasmamembrane]APS dimer [cytosol]Src family tyrosinekinases (SFKs)[cytosol]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-STATs [cytosol]p21 RAS [plasmamembrane]Tyrosinekinases:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]sSCF dimer[extracellularregion]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]sSCF dimer[extracellularregion]p-8Y-KIT:sSCFdimer:p-8Y-KIT[plasma membrane]sSCF dimer[extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]SFKs:p-KIT complex[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]APS dimer [cytosol]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]sSCF dimer[extracellularregion]p-VAV1:PIP3 [plasmamembrane]SFKs:p-KIT complex[plasma membrane]RAC1-GTP [cytosol]p-SHP2:p-KIT complex[plasma membrane]SFKs:p-KIT complex[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]p-APS dimer[cytosol]p-APS dimer[cytosol]CBL:Grb2/p-APS:p-c-Kitcomplex [plasmamembrane]p21 RAS:GDP [plasmamembrane]Grb2:SOS:p-c-Kit/p-APS:p-c-Kitcomplex [plasmamembrane, cytosol,extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]SFKs:p-KIT complex[plasma membrane]GRB2:SOS1:p-KITcomplex [plasmamembrane]sSCF dimer[extracellularregion]p-APS dimer[cytosol]sSCF dimer[extracellularregion]SFKs:p-8Y-KIT:sSCFdimer:p-8Y-KIT[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]p-JAK2:SFKs:p-KITcomplex:STATs[plasma membrane]p-STATs[nucleoplasm]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]SFKs:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]SFKs:p-KIT complex[plasma membrane]SFKs:p-KIT complex[plasma membrane]SFKs:p-KIT complex[plasma membrane]p-SHP2:p-KIT complex[plasma membrane]sSCF dimer[extracellularregion]JAK2:SFKS:p-KITcomplex [plasmamembrane]Src family tyrosinekinases (SFKs)[cytosol]sSCF dimer[extracellularregion]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SFKs:p-KIT complex[plasma membrane]nucleoplasmcytosolGRB2:SOS1:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Src family tyrosinekinases (SFKs)[cytosol]p-JAK2:SFKs:p-KITcomplex:p-STATdimers [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]SHP-1:p-c-Kitcomplex [plasmamembrane]p-STAT dimers[nucleoplasm]p21 RAS:GTP [plasmamembrane]GRB2:p-SHP2:p-KITcomplex [plasmamembrane]sSCF dimer[extracellularregion]p-SHP2:p-KIT complex[plasma membrane]APSdimer:p-c-Kit:SFKscomplex [plasmamembrane]Src family tyrosinekinases (SFKs)[cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-APS dimer:p-KITcomplex [plasmamembrane]GRB2:SOS1 [cytosol]sSCF dimer[extracellularregion]Tyrosine kinases[cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]PI3K alpha [cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]PTPRO:KIT [plasmamembrane]p-APS dimer:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-JAK2:SFKs:p-KITcomplex:p-STATs[plasma membrane]GAB2:GRB2:p-SHP2:p-KITcomplex [plasmamembrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]sSCF dimer[extracellularregion]p-SHP2:p-KIT complex[plasma membrane]GRB2:SOS1 [cytosol]SFKs:p-KIT complex[plasma membrane]SFKs:p-KIT complex[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]Grb2:SOS:p-c-Kit/p-APS:p-c-Kitcomplex [plasmamembrane, cytosol,extracellularregion]Src family tyrosinekinases (SFKs)[cytosol]LNK:p-7Y-KIT:sSCFdimer:p-7Y-KIT[plasma membrane]sSCF dimer[extracellularregion]p-7Y-KIT [plasmamembrane]p-S741,S746-KIT[plasma membrane]p-JAK2:SFKs:p-KITcomplex:p-STATdimersGRB2-1 [cytosol]p-8Y-KIT [plasmamembrane]SOS1 [cytosol]PTPN6 [cytosol]p-Y629-SH2B2[cytosol]LCK [cytosol]p-7Y-KIT [plasmamembrane]YES1(2-543)[cytosol]GRB2-1p-7Y-KIT [plasmamembrane]GRB2-1 [cytosol]KITLG-1(26-190)[extracellularregion]SOCS6GRB2-1 [cytosol]APSdimer:p-c-Kit:SFKscomplexATPADPPIP3 activates AKTsignalingKITLG-1(26-190)[extracellularregion]p-VAV1:PIP3KIT:sSCF dimerSOCS1:p-KIT complexSRC-1 [cytosol]SRC-1 [cytosol]RAC1-GTPKITLG-1(26-190)[extracellularregion]ATPp-Y701-STAT1-1[cytosol]SOCS1 [cytosol]SOCS6 [cytosol]CHEK1 [cytosol]p-SHP2:p-KIT complexPRKCA [cytosol]LYN(2-512) [cytosol]YES1(2-543)[cytosol]P13K:p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplexPTPRU(19-1430)FYN(2-537) [cytosol]KIT [plasmamembrane]LCK [cytosol]FER [cytosol]p-Y699-STAT5B[nucleoplasm]p-7Y-KIT [plasmamembrane]YES1(2-543)[cytosol]p-Y546,Y584-PTPN11[cytosol]LYN(2-512) [cytosol]SRC-1 [cytosol]RAC1-GDPKITLG-1(192-273)FYN(2-537) [cytosol]GRB2-1 [cytosol]LCK [cytosol]LYN(2-512) [cytosol]SH2B2 [cytosol]p-Y705-STAT3[nucleoplasm]KIT:sSCF dimer:KITp-Y694-STAT5A[nucleoplasm]FYN(2-537) [cytosol]GDP [cytosol]PIK3CA [cytosol]SRC-1 [cytosol]LCK [cytosol]CBL:Grb2/p-APS:p-c-KitcomplexKITLG-1(26-190)[extracellularregion]RAF/MAP kinasecascadeSHP-1:p-c-KitcomplexFYN(2-537) [cytosol]FYN(2-537) [cytosol]p-7Y-KIT [plasmamembrane]GDPPTPN6Tyrosine kinasesYES1(2-543)[cytosol]p-7Y-KIT [plasmamembrane]p-7Y-KIT [plasmamembrane]PIK3CA [cytosol]KITLG-1(26-190)p-JAK2:SFKs:p-KITcomplex:p-STATsp-Y-GAB2 [cytosol]p-7Y-KIT:sSCFdimer:p-7Y-KITp-Y1007-JAK2[cytosol]p-Y142,Y160,Y174-VAV1[plasma membrane]YES1(2-543)[cytosol]GRB2:SOS1:p-KITcomplexp-7Y-KIT [plasmamembrane]SOCS1STAT1 [cytosol]LNK:p-7Y-KIT:sSCFdimer:p-7Y-KITGRB2-1 [cytosol]Tyrosinekinases:p-KITcomplexSOCS6:p-c-Kit:sSCFdimer:p-c-Kitp-Y546,Y584-PTPN11[cytosol]LYN(2-512) [cytosol]VAV1SRC-1 [cytosol]LCK [cytosol]LYN(2-512) [cytosol]ADPSOS1 [cytosol]FYN(2-537) [cytosol]p-KIT (S741,746):PKCalphaKITLG-1(26-190)[extracellularregion]KITLG-1(26-190)[extracellularregion]KITLG-1LYN(2-512) [cytosol]GRB2-1 [cytosol]p-JAK2:SFKs:p-KITcomplex:STATsp-7Y-KIT [plasmamembrane]GRB7 [cytosol]p-Y546,Y584-PTPN11[cytosol]p-JAK2:SFKs:p-KITcomplexFYN(2-537) [cytosol]p-7Y-KIT [plasmamembrane]LCK [cytosol]ATPp21 RAS:GTPGDPLYN(2-512) [cytosol]ADPLYN(2-512) [cytosol]ATPKITLG-1(26-190)[extracellularregion]PI3K alphaSTAT5B [cytosol]KITLG-1(26-190)[extracellularregion]p-Y701-STAT1-1[nucleoplasm]KIT [plasmamembrane]YES1(2-543)[cytosol]p-Y1007-JAK2[cytosol]PTPN11GAB2:GRB2:p-SHP2:p-KITcomplexLYN(2-512) [cytosol]KITLG-1(26-190)[extracellularregion]FYN(2-537) [cytosol]LYN(2-512) [cytosol]GRB10 [cytosol]LCK [cytosol]p-Y694-STAT5A[cytosol]SHP2:SFKs:p-KIT:sSCFdimer:p-KITYES1(2-543)[cytosol]SH2B2 [cytosol]p-Y705-STAT3[cytosol]KITCBL [cytosol]SFKs:p-KIT complexSRC-1 [cytosol]p-Y1007-JAK2[cytosol]SOS1 [cytosol]FYN(2-537) [cytosol]Endopeptidases forSCF processingGTPp-7Y-KIT [plasmamembrane]p-7Y-KIT [plasmamembrane]SRC-1 [cytosol]KITLG-1(26-190)[extracellularregion]PI(4,5)P2KITLG-1(26-190)[extracellularregion]YES1(2-543)[cytosol]p-Y699-STAT5B[cytosol]APS dimerLYN(2-512) [cytosol]p-Y629-SH2B2[cytosol]p-7Y-KIT [plasmamembrane]SRC-1 [cytosol]RAC1 [cytosol]YES1(2-543)[cytosol]FYN(2-537) [cytosol]KITLG-1(26-190)[extracellularregion]STAT5A [cytosol]SRC-1 [cytosol]LCK [cytosol]p-STAT dimersJAK2 [cytosol]GRB2-1 [cytosol]KITLG-1(26-190)[extracellularregion]ATPADPYES1(2-543)[cytosol]ADPKIT [plasmamembrane]PTPN11 [cytosol]ADPRAC1 [cytosol]p-Y699-STAT5B[cytosol]SH2B3 [cytosol]FYN(2-537) [cytosol]p-7Y-KIT [plasmamembrane]GRB2-1 [cytosol]STATsTEC [cytosol]KITLG-1(26-190)[extracellularregion]ADPPI(3,4,5)P3KITLG-1(26-190)[extracellularregion]SRC-1 [cytosol]KITLG-1(26-190)[extracellularregion]p-APS dimer:p-KITcomplexNRAS [plasmamembrane]PTPRO:KITKITLG-1(26-190)[extracellularregion]KRAS(1-186) [plasmamembrane]p-7Y-KIT [plasmamembrane]p-Y-GAB2 [cytosol]GTP [cytosol]p-7Y-KIT [plasmamembrane]SFKs:p-8Y-KIT:sSCFdimer:p-8Y-KITLYN(2-512) [cytosol]LCK [cytosol]p-7Y-KIT [plasmamembrane]YES1(2-543)[cytosol]GRAP2 [cytosol]FYN(2-537) [cytosol]Grb2:SOS:p-c-Kit/p-APS:p-c-KitcomplexGDP [cytosol]SRC-1 [cytosol]SRC-1 [cytosol]Adapter proteinsPI3K:p-KIT:sSCFdimer:p-KITp-7Y-KIT [plasmamembrane]LYN(2-512) [cytosol]YES1(2-543)[cytosol]SRC-1 [cytosol]LCK [cytosol]KITLG-1(26-190)[extracellularregion]KITLG-1(26-190)[extracellularregion]KITLG-1(26-190)[extracellularregion]CBLLYN(2-512) [cytosol]JAK2:SFKS:p-KITcomplexLCK [cytosol]YES1(2-543)[cytosol]SH2B3FYN(2-537) [cytosol]Src family tyrosinekinases (SFKs)HRAS(1-186) [plasmamembrane]KITLG-1(26-190)[extracellularregion]JAK2KITLG-1(26-190)[extracellularregion]SRC-1 [cytosol]LCK [cytosol]YES1(2-543)[cytosol]SRC-1 [cytosol]ATPp-Y546,Y584-PTPN11[cytosol]YES1(2-543)[cytosol]PTPRU(19-1430)[plasma membrane]KITLG-1(26-190)[extracellularregion]GAB2p(Y)-GAB2:GRB2:p-SHP2:p-KITcomplexFES [cytosol]LYN(2-512) [cytosol]STAT3 [cytosol]p-Y546,Y584-PTPN11[cytosol]ADPp-7Y-KIT [plasmamembrane]NRAS [plasmamembrane]YES1(2-543)[cytosol]LCK [cytosol]KITLG-1(26-190)[extracellularregion]FYN(2-537) [cytosol]GRB2:p-SHP2:p-KITcomplexLCK [cytosol]FYN(2-537) [cytosol]p-7Y-KIT [plasmamembrane]GRB2:SOS1SOS1 [cytosol]LYN(2-512) [cytosol]KITLG-1(26-190)[extracellularregion]GTP [cytosol]p-7Y-KIT [plasmamembrane]LCK [cytosol]GRAP [cytosol]p21 RAS:GDPATPAdapterproteins:p-KITcomplexp-Y705-STAT3[cytosol]p-7Y-KIT [plasmamembrane]SRC-1 [cytosol]KITLG-1(26-190)[extracellularregion]LYN(2-512) [cytosol]p-Y701-STAT1-1[cytosol]p-7Y-KIT [plasmamembrane]YES1(2-543)[cytosol]KITLG-1(26-190)[extracellularregion]HRAS(1-186) [plasmamembrane]FYN(2-537) [cytosol]p-Y1007-JAK2[cytosol]PIK3CA [cytosol]KITLG-1(26-190)[extracellularregion]p-Y629-SH2B2[cytosol]p-Y694-STAT5A[cytosol]p-7Y-KIT [plasmamembrane]KITLG-1(26-190)[extracellularregion]GAB2 [cytosol]sSCF dimerSRC-1 [cytosol]GTPFYN(2-537) [cytosol]LCK [cytosol]PRKCAKRAS(1-186) [plasmamembrane]PI(3,4,5)P3 [plasmamembrane]LCK [cytosol]p-7Y-KIT [plasmamembrane]4, 5