Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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1, 31, 3791521212, 12, 2913322151, 19, 21, 22644112, 21, 29, 33, 421, 21, 321, 21, 22, 30, 32...3918, 321, 9, 21, 3221, 23, 32441, 10, 22, 24, 32...717282121, 32161, 19, 21, 3211268, 2214, 323361, 322343202521cytosolnucleoplasmmitochondrial outer membraneendoplasmic reticulum membraneSREBF1-1(1-490) SREBF1-3 TGS1 TBL1X SREBF1-1(1-490) FDPSSREBF1-1(1-490) RXRA SREBF1-1(1-490) SP1 NFYA HELZ2 PMVK geneCYP51A1MVDSREBF2(1-484) SREBP1A,2 dimerLSS geneNFYB SREBF1-3 ACACB genePMVK gene SREBF2(1-484) SREBP1A,1C,2:ELOVL6geneSREBP1A,1C:SCD geneSREBP1A,1C:NF-Y:GPAMgenePPARA:RXRACoactivator complexNFYB SC5DNFYA SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneSREBF2(1-484) NFYB NFYB HELZ2 SREBP1A,2:SQLE geneSREBP1A,1C:ACACBgeneSREBF1-1(1-490) SREBF1-1(1-490) SREBF2(1-484) SP1 SREBF2(1-484) TM7SF2 gene SP1 ACACA geneHMGCS1 gene SC5DL gene NFYA GGPS1 gene SREBF1-1(1-490) SREBF1-3 SREBP1A,2:NF-Y:SP1:GGPS1 geneAA SCD gene NFYA SREBP1A,2:NF-Y:SP1:MVK geneACACAIDI1SP1 NFYB SREBP1A,2:NF-Y:SP1:DHCR7 geneNFYC NFYA NFYB MTF1 SREBF1-3 FDFT1SREBP1A,1C:NF-Y:SP1:FASN geneSREBF1-3 FASNNFYB GGPS1NFYB NFYC SREBP1A,1C,2:NF-Y:FDPS geneNFYC SREBP1A,2:NF-Y:SP1:PMVK geneIDI1 gene FDPS gene NFYC LSSCARM1 SREBF1-1(1-490) NCOA2 DHCR7 gene TM7SF2FDPS geneCARM1 SREBF1-1(1-490) NFYA NFYC HMGCR geneIDI1 genePeroxisome Proliferator Receptor Element (PPRE) NFYC SREBP1A,2:NF-Y:SC5DLgeneSREBF2(1-484) FDFT1 gene SREBF1-3 SREBF1-1(1-490) NFYC EPA ELOVL6 geneNFYB PPARA:RXRACoactivator complexNF-YNFYA SREBF1-3 NFYC NFYA CHD9 NFYB CHD9 NFYA SREBF2(1-484) MED1 SREBF2(1-484) SREBF1-1(1-490) NFYB NCOA6 TBL1X HMGCS1 geneNFYC SQLE geneCREBBP ACACA gene ACACBSREBP1A,1C,2:NF-Y:TM7SF2 genePalm SREBP1A,2:NF-Y:SP1:IDI1 geneTBL1XR1 CREBBP SREBP1A,1C:ACACAgeneFASN gene SREBF1-3 NFYC SREBF2(1-484) NFYB SP1 LINA HMGCS1SP1 SQLE gene TGS1 RXRA Zn2+ SREBF1-1(1-490) LINA AA SC5DL geneNFYB NCOA1 NCOA6 DHCR7 geneELOVL6 gene PMVKHMGCR-1NCOA1 SREBF1-1(1-490) ACACB gene SREBP1A,1C,2:NF-Y:HMGCS1 geneSREBP1A,1C,2 dimerSREBF1-1(1-490) TBL1XR1 AA SP1 SREBF2(1-484) SREBF2(1-484) SP1 SREBP1A,1C dimerNFYA GPAM genePPARA:RXRACoactivator complexMVK geneSP1CREBBP PPARA SMARCD3 SREBF2(1-484) Palm FASN geneSREBF1-3 ELOVL6SREBF1-1(1-490) NFYC SREBF2(1-484) SREBF1-1(1-490) HMGCR gene CHD9 SREBF1-3 NFYC MVD geneNFYA NFYA HELZ2 EPA Palm SCD geneSMARCD3 SREBF1-1(1-490) DHCR7HMGCR gene SP1NFYB LSS gene SP1 TM7SF2 geneLINA SREBF1-3 CYP51A1 gene SREBF2(1-484) NCOA2 PPARA NCOA1 NFYA FDFT1 geneMVD gene MED1 TGS1 SCDSREBF1-1(1-490) CYP51A1 geneNF-YEPA NFYA NFYC MVK gene ALA NFYC NFYA SREBF2(1-484) SREBP1A,2:NF-Y:HMGCRgeneSREBF1-1(1-490) NFYA SREBF2(1-484) SREBF1-1(1-490) MED1 NFYC RXRA MVKSREBP1A,2:MVD geneSREBF2(1-484) TBL1X SQLESREBP1A,2:NF-Y:SP1:CYP51A1 geneALA NFYC NFYA ALA NFYB Peroxisome Proliferator Receptor Element (PPRE) SREBF2(1-484) SREBF1-1(1-490) SMARCD3 TBL1XR1 MTF1dimer:12Zn2+:HMGCRgeneGGPS1 geneSREBF1-1(1-490) NCOA6 GPAM(1-828)SREBF1-3 SREBF1-1(1-490) SREBP1A,2:LSS geneSREBF1-1(1-490) NFYB CARM1 PPARA NFYC Peroxisome Proliferator Receptor Element (PPRE) GPAM gene NCOA2 NFYB 2114, 21, 23, 304021212127212127214021, 382121272140212135


After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 2426168
Reactome version: 61
Reactome Author 
Reactome Author: May, Bruce

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  1. Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.; ''Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells.''; PubMed Europe PMC
  2. Amemiya-Kudo M, Shimano H, Hasty AH, Yahagi N, Yoshikawa T, Matsuzaka T, Okazaki H, Tamura Y, Iizuka Y, Ohashi K, Osuga J, Harada K, Gotoda T, Sato R, Kimura S, Ishibashi S, Yamada N.; ''Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogenic and cholesterogenic genes.''; PubMed Europe PMC
  3. Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M.; ''Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.''; PubMed Europe PMC
  4. Lu B, Jiang YJ, Kim P, Moser A, Elias PM, Grunfeld C, Feingold KR.; ''Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis.''; PubMed Europe PMC
  5. Wilkin DJ, Kutsunai SY, Edwards PA.; ''Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.''; PubMed Europe PMC
  6. Wassif CA, Maslen C, Kachilele-Linjewile S, Lin D, Linck LM, Connor WE, Steiner RD, Porter FD.; ''Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome.''; PubMed Europe PMC
  7. Toth MJ, Huwyler L.; ''Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase.''; PubMed Europe PMC
  8. Choi WI, Jeon BN, Park H, Yoo JY, Kim YS, Koh DI, Kim MH, Kim YR, Lee CE, Kim KS, Osborne TF, Hur MW.; ''Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).''; PubMed Europe PMC
  9. Li J, Ding SF, Habib NA, Fermor BF, Wood CB, Gilmour RS.; ''Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues.''; PubMed Europe PMC
  10. Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F.; ''SREBP transcription factors: master regulators of lipid homeostasis.''; PubMed Europe PMC
  11. Strömstedt M, Rozman D, Waterman MR.; ''The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.''; PubMed Europe PMC
  12. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B.; ''DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region.''; PubMed Europe PMC
  13. Nagai M, Sakakibara J, Nakamura Y, Gejyo F, Ono T.; ''SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase.''; PubMed Europe PMC
  14. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A.; ''ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.''; PubMed Europe PMC
  15. Ericsson J, Jackson SM, Edwards PA.; ''Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene.''; PubMed Europe PMC
  16. Párraga A, Bellsolell L, Ferré-D'Amaré AR, Burley SK.; ''Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.''; PubMed Europe PMC
  17. Inoue J, Sato R, Maeda M.; ''Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase.''; PubMed Europe PMC
  18. Oh SY, Park SK, Kim JW, Ahn YH, Park SW, Kim KS.; ''Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.''; PubMed Europe PMC
  19. Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ.; ''Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.''; PubMed Europe PMC
  20. Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N.; ''Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.''; PubMed Europe PMC
  21. Nakamura Y, Sakakibara J, Izumi T, Shibata A, Ono T.; ''Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells.''; PubMed Europe PMC
  22. Weber LW, Boll M, Stampfl A.; ''Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins.''; PubMed Europe PMC
  23. Chambliss KL, Slaughter CA, Schreiner R, Hoffmann GF, Gibson KM.; ''Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.''; PubMed Europe PMC
  24. Xiong S, Chirala SS, Wakil SJ.; ''Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites.''; PubMed Europe PMC
  25. Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E.; ''Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.''; PubMed Europe PMC
  26. Vallett SM, Sanchez HB, Rosenfeld JM, Osborne TF.; ''A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.''; PubMed Europe PMC
  27. Vock C, Döring F, Nitz I.; ''Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.''; PubMed Europe PMC
  28. Matsushima M, Inazawa J, Takahashi E, Suzumori K, Nakamura Y.; ''Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase.''; PubMed Europe PMC
  29. Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.; ''Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.''; PubMed Europe PMC
  30. Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR.; ''Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells.''; PubMed Europe PMC
  31. Pai JT, Guryev O, Brown MS, Goldstein JL.; ''Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins.''; PubMed Europe PMC
  32. Schiavoni G, Bennati AM, Castelli M, Della Fazia MA, Beccari T, Servillo G, Roberti R.; ''Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box.''; PubMed Europe PMC
  33. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD.; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; PubMed Europe PMC
  34. Bené H, Lasky D, Ntambi JM.; ''Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol.''; PubMed Europe PMC
  35. Horton JD, Goldstein JL, Brown MS.; ''SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.''; PubMed Europe PMC
  36. Jiang G, McKenzie TL, Conrad DG, Shechter I.; ''Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase.''; PubMed Europe PMC
  37. Zhao Y, Yu L, Gao J, Fu Q, Hua Y, Zhang H, Zhao S.; ''cDNA cloning, chromosome mapping and expression characterization of human geranylgeranyl pyrophosphate synthase.''; PubMed Europe PMC
  38. Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ.; ''Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms.''; PubMed Europe PMC
  39. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ.; ''Human fatty acid synthase: properties and molecular cloning.''; PubMed Europe PMC
  40. Wang M, Yang F, Zhang X, Zhao H, Wang Q, Pan Y.; ''Comparative analysis of MTF-1 binding sites between human and mouse.''; PubMed Europe PMC
  41. Xuan JW, Kowalski J, Chambers AF, Denhardt DT.; ''A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase.''; PubMed Europe PMC
  42. Tabor DE, Kim JB, Spiegelman BM, Edwards PA.; ''Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.''; PubMed Europe PMC
  43. Harada N, Fujimoto E, Okuyama M, Sakaue H, Nakaya Y.; ''Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.''; PubMed Europe PMC
  44. Magaña MM, Lin SS, Dooley KA, Osborne TF.; ''Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins.''; PubMed Europe PMC
  45. Bennett MK, Lopez JM, Sanchez HB, Osborne TF.; ''Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways.''; PubMed Europe PMC


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103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references


View all...
NameTypeDatabase referenceComment
AA MetaboliteCHEBI:15843 (ChEBI)
ACACA gene ProteinENSG00000132142 (Ensembl)
ACACA geneGeneProductENSG00000132142 (Ensembl)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene ProteinENSG00000076555 (Ensembl)
ACACB geneGeneProductENSG00000076555 (Ensembl)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
CARM1 ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBP ProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene ProteinENSG00000001630 (Ensembl)
CYP51A1 geneGeneProductENSG00000001630 (Ensembl)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene ProteinENSG00000172893 (Ensembl)
DHCR7 geneGeneProductENSG00000172893 (Ensembl)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene ProteinENSG00000170522 (Ensembl)
ELOVL6 geneGeneProductENSG00000170522 (Ensembl)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
FASN gene ProteinENSG00000169710 (Ensembl)
FASN geneGeneProductENSG00000169710 (Ensembl)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (Ensembl)
FDFT1 geneGeneProductENSG00000079459 (Ensembl)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene ProteinENSG00000160752 (Ensembl)
FDPS geneGeneProductENSG00000160752 (Ensembl)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene ProteinENSG00000152904 (Ensembl)
GGPS1 geneGeneProductENSG00000152904 (Ensembl)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene ProteinENSG00000119927 (Ensembl)
GPAM geneGeneProductENSG00000119927 (Ensembl)
GPAM(1-828)ProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (Ensembl)
HMGCR geneGeneProductENSG00000113161 (Ensembl)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (Ensembl)
HMGCS1 geneGeneProductENSG00000112972 (Ensembl)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene ProteinENSG00000067064 (Ensembl)
IDI1 geneGeneProductENSG00000067064 (Ensembl)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA MetaboliteCHEBI:17351 (ChEBI)
LSS gene ProteinENSG00000160285 (Ensembl)
LSS geneGeneProductENSG00000160285 (Ensembl)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.


ComplexR-HSA-5660440 (Reactome)
MTF1 ProteinQ14872 (Uniprot-TrEMBL)
MVD gene ProteinENSG00000167508 (Ensembl)
MVD geneGeneProductENSG00000167508 (Ensembl)
MVDProteinP53602 (Uniprot-TrEMBL)
MVK gene ProteinENSG00000110921 (Ensembl)
MVK geneGeneProductENSG00000110921 (Ensembl)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexR-HSA-381204 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene ProteinENSG00000163344 (Ensembl)
PMVK geneGeneProductENSG00000163344 (Ensembl)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator complexComplexR-HSA-400154 (Reactome)
Palm MetaboliteCHEBI:15756 (ChEBI)
Peroxisome Proliferator Receptor Element (PPRE) R-NUL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RXRA ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene ProteinENSG00000109929 (Ensembl)