Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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1, 31, 3791521212, 12, 2913322151, 19, 21, 22644112, 21, 29, 33, 421, 21, 321, 21, 22, 30, 32...3918, 321, 9, 21, 3221, 23, 32441, 10, 22, 24, 32...717282121, 32161, 19, 21, 3211268, 2214, 323361, 322343202521cytosolnucleoplasmmitochondrial outer membraneendoplasmic reticulum membraneSREBF1-1(1-490) SREBF1-3 TGS1 TBL1X SREBF1-1(1-490) FDPSSREBF1-1(1-490) RXRA SREBF1-1(1-490) SP1 NFYA HELZ2 PMVK geneCYP51A1MVDSREBF2(1-484) SREBP1A,2 dimerLSS geneNFYB SREBF1-3 ACACB genePMVK gene SREBF2(1-484) SREBP1A,1C,2:ELOVL6geneSREBP1A,1C:SCD geneSREBP1A,1C:NF-Y:GPAMgenePPARA:RXRACoactivator complexNFYB SC5DNFYA SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneSREBF2(1-484) NFYB NFYB HELZ2 SREBP1A,2:SQLE geneSREBP1A,1C:ACACBgeneSREBF1-1(1-490) SREBF1-1(1-490) SREBF2(1-484) SP1 SREBF2(1-484) TM7SF2 gene SP1 ACACA geneHMGCS1 gene SC5DL gene NFYA GGPS1 gene SREBF1-1(1-490) SREBF1-3 SREBP1A,2:NF-Y:SP1:GGPS1 geneAA SCD gene NFYA SREBP1A,2:NF-Y:SP1:MVK geneACACAIDI1SP1 NFYB SREBP1A,2:NF-Y:SP1:DHCR7 geneNFYC NFYA NFYB MTF1 SREBF1-3 FDFT1SREBP1A,1C:NF-Y:SP1:FASN geneSREBF1-3 FASNNFYB GGPS1NFYB NFYC SREBP1A,1C,2:NF-Y:FDPS geneNFYC SREBP1A,2:NF-Y:SP1:PMVK geneIDI1 gene FDPS gene NFYC LSSCARM1 SREBF1-1(1-490) NCOA2 DHCR7 gene TM7SF2FDPS geneCARM1 SREBF1-1(1-490) NFYA NFYC HMGCR geneIDI1 genePeroxisome Proliferator Receptor Element (PPRE) NFYC SREBP1A,2:NF-Y:SC5DLgeneSREBF2(1-484) FDFT1 gene SREBF1-3 SREBF1-1(1-490) NFYC EPA ELOVL6 geneNFYB PPARA:RXRACoactivator complexNF-YNFYA SREBF1-3 NFYC NFYA CHD9 NFYB CHD9 NFYA SREBF2(1-484) MED1 SREBF2(1-484) SREBF1-1(1-490) NFYB NCOA6 TBL1X HMGCS1 geneNFYC SQLE geneCREBBP ACACA gene ACACBSREBP1A,1C,2:NF-Y:TM7SF2 genePalm SREBP1A,2:NF-Y:SP1:IDI1 geneTBL1XR1 CREBBP SREBP1A,1C:ACACAgeneFASN gene SREBF1-3 NFYC SREBF2(1-484) NFYB SP1 LINA HMGCS1SP1 SQLE gene TGS1 RXRA Zn2+ SREBF1-1(1-490) LINA AA SC5DL geneNFYB NCOA1 NCOA6 DHCR7 geneELOVL6 gene PMVKHMGCR-1NCOA1 SREBF1-1(1-490) ACACB gene SREBP1A,1C,2:NF-Y:HMGCS1 geneSREBP1A,1C,2 dimerSREBF1-1(1-490) TBL1XR1 AA SP1 SREBF2(1-484) SREBF2(1-484) SP1 SREBP1A,1C dimerNFYA GPAM genePPARA:RXRACoactivator complexMVK geneSP1CREBBP PPARA SMARCD3 SREBF2(1-484) Palm FASN geneSREBF1-3 ELOVL6SREBF1-1(1-490) NFYC SREBF2(1-484) SREBF1-1(1-490) HMGCR gene CHD9 SREBF1-3 NFYC MVD geneNFYA NFYA HELZ2 EPA Palm SCD geneSMARCD3 SREBF1-1(1-490) DHCR7HMGCR gene SP1NFYB LSS gene SP1 TM7SF2 geneLINA SREBF1-3 CYP51A1 gene SREBF2(1-484) NCOA2 PPARA NCOA1 NFYA FDFT1 geneMVD gene MED1 TGS1 SCDSREBF1-1(1-490) CYP51A1 geneNF-YEPA NFYA NFYC MVK gene ALA NFYC NFYA SREBF2(1-484) SREBP1A,2:NF-Y:HMGCRgeneSREBF1-1(1-490) NFYA SREBF2(1-484) SREBF1-1(1-490) MED1 NFYC RXRA MVKSREBP1A,2:MVD geneSREBF2(1-484) TBL1X SQLESREBP1A,2:NF-Y:SP1:CYP51A1 geneALA NFYC NFYA ALA NFYB Peroxisome Proliferator Receptor Element (PPRE) SREBF2(1-484) SREBF1-1(1-490) SMARCD3 TBL1XR1 MTF1dimer:12Zn2+:HMGCRgeneGGPS1 geneSREBF1-1(1-490) NCOA6 GPAM(1-828)SREBF1-3 SREBF1-1(1-490) SREBP1A,2:LSS geneSREBF1-1(1-490) NFYB CARM1 PPARA NFYC Peroxisome Proliferator Receptor Element (PPRE) GPAM gene NCOA2 NFYB 2114, 21, 23, 304021212127212127214021, 382121272140212135


Description

After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998). View original pathway at:Reactome.

Comments

Reactome-Converter 
Pathway is converted from Reactome ID: 2426168
Reactome-version 
Reactome version: 61
Reactome Author 
Reactome Author: May, Bruce

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA MetaboliteCHEBI:15843 (ChEBI)
ACACA gene ProteinENSG00000132142 (Ensembl)
ACACA geneGeneProductENSG00000132142 (Ensembl)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene ProteinENSG00000076555 (Ensembl)
ACACB geneGeneProductENSG00000076555 (Ensembl)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
CARM1 ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBP ProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene ProteinENSG00000001630 (Ensembl)
CYP51A1 geneGeneProductENSG00000001630 (Ensembl)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene ProteinENSG00000172893 (Ensembl)
DHCR7 geneGeneProductENSG00000172893 (Ensembl)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene ProteinENSG00000170522 (Ensembl)
ELOVL6 geneGeneProductENSG00000170522 (Ensembl)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
FASN gene ProteinENSG00000169710 (Ensembl)
FASN geneGeneProductENSG00000169710 (Ensembl)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (Ensembl)
FDFT1 geneGeneProductENSG00000079459 (Ensembl)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene ProteinENSG00000160752 (Ensembl)
FDPS geneGeneProductENSG00000160752 (Ensembl)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene ProteinENSG00000152904 (Ensembl)
GGPS1 geneGeneProductENSG00000152904 (Ensembl)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene ProteinENSG00000119927 (Ensembl)
GPAM geneGeneProductENSG00000119927 (Ensembl)
GPAM(1-828)ProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (Ensembl)
HMGCR geneGeneProductENSG00000113161 (Ensembl)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (Ensembl)
HMGCS1 geneGeneProductENSG00000112972 (Ensembl)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene ProteinENSG00000067064 (Ensembl)
IDI1 geneGeneProductENSG00000067064 (Ensembl)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA MetaboliteCHEBI:17351 (ChEBI)
LSS gene ProteinENSG00000160285 (Ensembl)
LSS geneGeneProductENSG00000160285 (Ensembl)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MTF1

dimer:12Zn2+:HMGCR

gene
ComplexR-HSA-5660440 (Reactome)
MTF1 ProteinQ14872 (Uniprot-TrEMBL)
MVD gene ProteinENSG00000167508 (Ensembl)
MVD geneGeneProductENSG00000167508 (Ensembl)
MVDProteinP53602 (Uniprot-TrEMBL)
MVK gene ProteinENSG00000110921 (Ensembl)
MVK geneGeneProductENSG00000110921 (Ensembl)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexR-HSA-381204 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene ProteinENSG00000163344 (Ensembl)
PMVK geneGeneProductENSG00000163344 (Ensembl)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator complexComplexR-HSA-400154 (Reactome)
Palm MetaboliteCHEBI:15756 (ChEBI)
Peroxisome Proliferator Receptor Element (PPRE) R-NUL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RXRA ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene ProteinENSG00000109929 (Ensembl)