Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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14, 21, 302835139, 14, 2217329, 13, 14, 229, 15, 229, 229, 14374622221222228, 9, 14, 22, 23, 3638122279, 14, 16, 229, 34243, 9267, 9, 14, 18, 25...14, 16, 22, 362995, 36331915102011SREBP1A/1C/2 Dimer[nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]SREBP1A/1C:NF-Y:GPAMgene [nucleoplasm]Activated PPARA:RXRAHeterodimer[nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]endoplasmic reticulum membraneNF-Y [nucleoplasm]NF-Y [nucleoplasm]SREBP1A/1C/2:NF-Y:TM7SF2gene [nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]Ligands of PPARA[nucleoplasm]SREBP1A/2:NF-Y:SP1:GGPS1gene [nucleoplasm]SREBP1A/2:NF-Y:SP1:CYP51A1gene [nucleoplasm]SREBP1A/2:NF-Y:HMGCRgene [nucleoplasm]SREBP1A/1C:ACACBgene [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]SREBP1A/2:SQLE gene[nucleoplasm]SREBP1A/2:NF-Y:SP1:DHCR7gene [nucleoplasm]NF-Y [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2:NF-Y:SC5DLgene [nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]Activated PPARA:RXRAHeterodimer[nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]SREBP1A/2:LSS gene[nucleoplasm]SREBF1A,2[nucleoplasm]nucleoplasmSREBP1A/2:MVD gene[nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]SREBP1A/2:NF-Y:SP1:IDI1gene [nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]PPARA: Fatty AcidComplex (ActivatedPPARA) [nucleoplasm]Coactivators ofPPARalpha[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/1C/2:NF-Y:SP1:FDFT1gene [nucleoplasm]SREBF1A,2[nucleoplasm]SREBF1A,2[nucleoplasm]Activated PPARA:RXRAHeterodimer[nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBF1A,2[nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]PPARA:RXRACoactivator Complex[nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]mitochondrial outer membraneSREBF1A,C[nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]Coactivators ofPPARalpha[nucleoplasm]cytosolSREBF1A,C[nucleoplasm]SREBF1A,2[nucleoplasm]SREBF1A,C[nucleoplasm]SREBP1A/1C/2 Dimer[nucleoplasm]SREBF1A,C[nucleoplasm]SREBP1A/1C/2:NF-Y:HMGCS1gene [nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]Coactivators ofPPARalpha[nucleoplasm]SREBP1A/1C:NF-Y:SP1:FASNgene [nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/2:NF-Y:SP1:PMVKgene [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]SREBF1A,1C,2 cleavedby S2P [nucleoplasm]SREBF1A,C[nucleoplasm]SREBF1A,2[nucleoplasm]Ligands of PPARA[nucleoplasm]SREBP1A/2:NF-Y:SP1:MVKgene [nucleoplasm]SREBP1A/1C:ACACAgene [nucleoplasm]SREBF1A,2[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/2 Dimer[nucleoplasm]NF-Y [nucleoplasm]SREBP1A/1C/2:NF-Y:FDPSgene [nucleoplasm]SREBF1A,2[nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]NF-Y [nucleoplasm]Ligands of PPARA[nucleoplasm]SREBP1A/1C Dimer[nucleoplasm]SREBF1A,2[nucleoplasm]SREBP1A/1C/2:ELOVL6gene [nucleoplasm]NF-Y [nucleoplasm]SP1(1-785)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]EPA [nucleoplasm]NCOA2 [nucleoplasm]CHD9 [nucleoplasm]ACACA genePPARA:RXRACoactivator ComplexSREBF1-1(1-490)[nucleoplasm]SQLE geneFDPS gene[nucleoplasm]NFYB [nucleoplasm]TBL1XR1[nucleoplasm]NCOA1 [nucleoplasm]DHCR7NFYA [nucleoplasm]NFYC [nucleoplasm]NCOA6 [nucleoplasm]SREBP1A/1C/2:NF-Y:HMGCS1geneFASN geneSREBP1A/1C:ACACAgeneAA [nucleoplasm]FDFT1SREBP1A/1C/2 DimerSREBF2(1-484)[nucleoplasm]NFYA [nucleoplasm]SP1(1-785)[nucleoplasm]EPA [nucleoplasm]NFYA [nucleoplasm]SREBP1A/2:NF-Y:SC5DLgeneSREBF1-3[nucleoplasm]NFYC [nucleoplasm]SP1(1-785)[nucleoplasm]SREBP1A/1C DimerAA [nucleoplasm]ACACBSP1(1-785)SREBF1-1(1-490)[nucleoplasm]SP1(1-785)[nucleoplasm]SREBF2(1-484)[nucleoplasm]NFYB [nucleoplasm]CYP51A1 gene[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]NFYB [nucleoplasm]SREBF1-3[nucleoplasm]SREBP1A/2:NF-Y:HMGCRgeneGGPS1 gene[nucleoplasm]SREBF2(1-484)[nucleoplasm]NFYA [nucleoplasm]RXRA [nucleoplasm]NFYB [nucleoplasm]NFYC [nucleoplasm]LSSNFYA [nucleoplasm]NCOA1 [nucleoplasm]SREBP1A/1C:ACACBgeneCARM1(2-608)[nucleoplasm]TGS1 [nucleoplasm]FDPS geneNFYC [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SMARCD3[nucleoplasm]NFYB [nucleoplasm]LSS gene[nucleoplasm]NCOA6 [nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]ELOVL6SREBF1-1(1-490)[nucleoplasm]NFYC [nucleoplasm]NFYB [nucleoplasm]NFYA [nucleoplasm]SREBP1A/2:LSS geneCREBBP(2-2442)[nucleoplasm]ALA [nucleoplasm]NFYB [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF1-3[nucleoplasm]NFYC [nucleoplasm]TGS1 [nucleoplasm]HMGCS1 geneTGS1 [nucleoplasm]NFYA [nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBP1A/1C/2:ELOVL6geneFASN gene[nucleoplasm]NFYA [nucleoplasm]SREBP1A/1C/2:NF-Y:FDPSgeneSREBP1A/2:NF-Y:SP1:DHCR7geneSREBF1-1(1-490)[nucleoplasm]Palm [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBP1A/2:NF-Y:SP1:GGPS1genePMVK gene[nucleoplasm]SC5DL gene[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF1-3[nucleoplasm]SREBP1A/1C/2:NF-Y:SP1:FDFT1geneSC5DSREBF1-3[nucleoplasm]NFYB [nucleoplasm]NCOA1 [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBF2(1-484)[nucleoplasm]SP1(1-785)[nucleoplasm]CARM1(2-608)[nucleoplasm]NFYA [nucleoplasm]Palm [nucleoplasm]Palm [nucleoplasm]SP1(1-785)[nucleoplasm]GPAM geneSREBF2(1-484)[nucleoplasm]SREBP1A/2:NF-Y:SP1:CYP51A1geneHELZ2 [nucleoplasm]MVD geneSREBF2(1-484)[nucleoplasm]SP1(1-785)[nucleoplasm]CHD9 [nucleoplasm]MVD gene[nucleoplasm]NFYC [nucleoplasm]ACACANFYA [nucleoplasm]MED1 [nucleoplasm]ELOVL6 gene[nucleoplasm]NF-YSREBF2(1-484)[nucleoplasm]LINA [nucleoplasm]SMARCD3[nucleoplasm]GPAM gene[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]TM7SF2 geneSREBF2(1-484)[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]NF-YFDFT1 geneNFYA [nucleoplasm]PPARA [nucleoplasm]MVD(2-400)SREBF2(1-484)[nucleoplasm]ALA [nucleoplasm]TM7SF2 gene[nucleoplasm]SP1(1-785)[nucleoplasm]GGPS1GGPS1 geneNFYC [nucleoplasm]TBL1X [nucleoplasm]NFYB [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]MED1 [nucleoplasm]CYP51A1 geneNFYC [nucleoplasm]NFYA [nucleoplasm]HMGCR geneELOVL6 geneNFYC [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]RXRA [nucleoplasm]PMVK geneSQLE gene[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]MVK geneNFYC [nucleoplasm]SREBP1A/1C/2:NF-Y:TM7SF2geneFDFT1 gene[nucleoplasm]NFYC [nucleoplasm]SREBF1-3[nucleoplasm]HELZ2 [nucleoplasm]MED1 [nucleoplasm]SREBF1-3[nucleoplasm]NCOA2 [nucleoplasm]SQLEEPA [nucleoplasm]SP1(1-785)PMVKSREBF1-1(1-490)[nucleoplasm]LSS geneCREBBP(2-2442)[nucleoplasm]LINA [nucleoplasm]CARM1(2-608)[nucleoplasm]NFYC [nucleoplasm]NFYB [nucleoplasm]AA [nucleoplasm]NFYA [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]NFYC [nucleoplasm]IDI1 gene[nucleoplasm]SREBF1-3[nucleoplasm]NFYA [nucleoplasm]TBL1X [nucleoplasm]FASNGPAM(1-828)TBL1XR1[nucleoplasm]SREBP1A/2:NF-Y:SP1:PMVKgeneSREBF1-3[nucleoplasm]SREBF1-1(1-490)[nucleoplasm]CREBBP(2-2442)[nucleoplasm]SREBF1-3[nucleoplasm]MVK gene[nucleoplasm]PPARA:RXRACoactivator ComplexNFYB [nucleoplasm]ACACB genePPARA:RXRACoactivator ComplexSREBF2(1-484)[nucleoplasm]MVKNFYC [nucleoplasm]SREBP1A/2:NF-Y:SP1:MVKgeneSREBF2(1-484)[nucleoplasm]HMGCS1SMARCD3[nucleoplasm]SP1(1-785)[nucleoplasm]SC5DL geneACACB gene[nucleoplasm]DHCR7 geneCHD9 [nucleoplasm]LINA [nucleoplasm]SREBP1A/1C:NF-Y:GPAMgeneSREBF2(1-484)[nucleoplasm]ACACA gene[nucleoplasm]HMGCR-1NFYC [nucleoplasm]NCOA2 [nucleoplasm]CYP51A1NFYB [nucleoplasm]SREBF2(1-484)[nucleoplasm]NFYB [nucleoplasm]DHCR7 gene[nucleoplasm]NFYA [nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBP1A/2 DimerSREBF2(1-484)[nucleoplasm]SREBP1A/2:NF-Y:SP1:IDI1geneTM7SF2NFYA [nucleoplasm]NFYA [nucleoplasm]PPARA [nucleoplasm]NFYB [nucleoplasm]SREBF1-3[nucleoplasm]NFYC [nucleoplasm]PPARA [nucleoplasm]HMGCR gene[nucleoplasm]TBL1X [nucleoplasm]FDPSNFYB [nucleoplasm]RXRA [nucleoplasm]NFYB [nucleoplasm]SREBF1-1(1-490)[nucleoplasm]SREBP1A/2:SQLE geneALA [nucleoplasm]SREBF2(1-484)[nucleoplasm]SREBP1A/1C:NF-Y:SP1:FASNgeneSREBF1-1(1-490)[nucleoplasm]NFYB [nucleoplasm]SREBP1A/2:MVD geneNCOA6 [nucleoplasm]HELZ2 [nucleoplasm]IDI1HMGCS1 gene[nucleoplasm]TBL1XR1[nucleoplasm]IDI1 gene222222222222223, 15, 22, 2322227, 2222222222


Description

After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998).Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2426168

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Bibliography

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History

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CompareRevisionActionTimeUserComment
103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA [nucleoplasm]MetaboliteCHEBI:15843 (ChEBI)
ACACA gene [nucleoplasm]ProteinENSG00000132142 (ENSEMBL)
ACACA geneENSG00000132142 (ENSEMBL)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene [nucleoplasm]ProteinENSG00000076555 (ENSEMBL)
ACACB geneENSG00000076555 (ENSEMBL)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA [nucleoplasm]MetaboliteCHEBI:27432 (ChEBI)
CARM1(2-608) [nucleoplasm]ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 [nucleoplasm]ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBP(2-2442) [nucleoplasm]ProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene [nucleoplasm]ProteinENSG00000067064 (ENSEMBL)
CYP51A1 geneENSG00000067064 (ENSEMBL)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene [nucleoplasm]ProteinENSG00000172893 (ENSEMBL)
DHCR7 geneENSG00000172893 (ENSEMBL)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene [nucleoplasm]ProteinENSG00000170522 (ENSEMBL)
ELOVL6 geneENSG00000170522 (ENSEMBL)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA [nucleoplasm]MetaboliteCHEBI:28364 (ChEBI)
FASN gene [nucleoplasm]ProteinENSG00000169710 (ENSEMBL)
FASN geneENSG00000169710 (ENSEMBL)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene [nucleoplasm]ProteinENSG00000079459 (ENSEMBL)
FDFT1 geneENSG00000079459 (ENSEMBL)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene [nucleoplasm]ProteinENSG00000160752 (ENSEMBL)
FDPS geneENSG00000160752 (ENSEMBL)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene [nucleoplasm]ProteinENSG00000152904 (ENSEMBL)
GGPS1 geneENSG00000152904 (ENSEMBL)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene [nucleoplasm]ProteinENSG00000119927 (ENSEMBL)
GPAM geneENSG00000119927 (ENSEMBL)
GPAM(1-828)ProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 [nucleoplasm]ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene [nucleoplasm]ProteinENSG00000113161 (ENSEMBL)
HMGCR geneENSG00000113161 (ENSEMBL)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene [nucleoplasm]ProteinENSG00000112972 (ENSEMBL)
HMGCS1 geneENSG00000112972 (ENSEMBL)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene [nucleoplasm]ProteinENSG00000067064 (ENSEMBL)
IDI1 geneENSG00000067064 (ENSEMBL)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA [nucleoplasm]MetaboliteCHEBI:17351 (ChEBI)
LSS gene [nucleoplasm]ProteinENSG00000160285 (ENSEMBL)
LSS geneENSG00000160285 (ENSEMBL)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 [nucleoplasm]ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MVD gene [nucleoplasm]ProteinENSG00000167508 (ENSEMBL)
MVD geneENSG00000167508 (ENSEMBL)
MVD(2-400)ProteinP53602 (Uniprot-TrEMBL)
MVK gene [nucleoplasm]ProteinENSG00000110921 (ENSEMBL)
MVK geneENSG00000110921 (ENSEMBL)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 [nucleoplasm]ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 [nucleoplasm]ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 [nucleoplasm]ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexREACT_26721 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA [nucleoplasm]ProteinP23511 (Uniprot-TrEMBL)
NFYB [nucleoplasm]ProteinP25208 (Uniprot-TrEMBL)
NFYC [nucleoplasm]ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene [nucleoplasm]ProteinENSG00000163344 (ENSEMBL)
PMVK geneENSG00000163344 (ENSEMBL)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA [nucleoplasm]ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator ComplexComplexREACT_20439 (Reactome)
Palm [nucleoplasm]MetaboliteCHEBI:15756 (ChEBI)
RXRA [nucleoplasm]ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene [nucleoplasm]ProteinENSG00000109929 (ENSEMBL)
SC5DL geneENSG00000109929 (ENSEMBL)
SC5DProteinO75845 (Uniprot-TrEMBL)
SMARCD3 [nucleoplasm]ProteinQ6STE5 (Uniprot-TrEMBL)
SP1(1-785) [nucleoplasm]ProteinP08047 (Uniprot-TrEMBL)
SP1(1-785)ProteinP08047 (Uniprot-TrEMBL)
SQLE gene [nucleoplasm]ProteinENSG00000104549 (ENSEMBL)
SQLE geneENSG00000104549 (ENSEMBL)
SQLEProteinQ14534 (Uniprot-TrEMBL)
SREBF1-1(1-490) [nucleoplasm]ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 [nucleoplasm]ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2(1-484) [nucleoplasm]ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A/1C DimerComplexREACT_148003 (Reactome)
SREBP1A/1C/2 DimerComplexREACT_117119 (Reactome)
SREBP1A/1C/2:ELOVL6 geneComplexREACT_148436 (Reactome)
SREBP1A/1C/2:NF-Y:FDPS geneComplexREACT_148195 (Reactome)
SREBP1A/1C/2:NF-Y:HMGCS1 geneComplexREACT_148333 (Reactome)
SREBP1A/1C/2:NF-Y:SP1:FDFT1 geneComplexREACT_148107 (Reactome)
SREBP1A/1C/2:NF-Y:TM7SF2 geneComplexREACT_148435 (Reactome)
SREBP1A/1C:ACACA geneComplexREACT_148537 (Reactome)
SREBP1A/1C:ACACB geneComplexREACT_148190 (Reactome)
SREBP1A/1C:NF-Y:GPAM geneComplexREACT_148505 (Reactome)
SREBP1A/1C:NF-Y:SP1:FASN geneComplexREACT_116518 (Reactome)
SREBP1A/2 DimerComplexREACT_119740 (Reactome)
SREBP1A/2:LSS geneComplexREACT_148445 (Reactome)
SREBP1A/2:MVD geneComplexREACT_148564 (Reactome)
SREBP1A/2:NF-Y:HMGCR geneComplexREACT_148301 (Reactome)
SREBP1A/2:NF-Y:SC5DL geneComplexREACT_148446 (Reactome)
SREBP1A/2:NF-Y:SP1:CYP51A1 geneComplexREACT_148151 (Reactome)
SREBP1A/2:NF-Y:SP1:DHCR7 geneComplexREACT_148543 (Reactome)
SREBP1A/2:NF-Y:SP1:GGPS1 geneComplexREACT_147937 (Reactome)
SREBP1A/2:NF-Y:SP1:IDI1 geneComplexREACT_148432 (Reactome)
SREBP1A/2:NF-Y:SP1:MVK geneComplexREACT_148095 (Reactome)
SREBP1A/2:NF-Y:SP1:PMVK geneComplexREACT_148481 (Reactome)
SREBP1A/2:SQLE geneComplexREACT_148275 (Reactome)
TBL1X [nucleoplasm]ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 [nucleoplasm]ProteinQ9BZK7 (Uniprot-TrEMBL)
TGS1 [nucleoplasm]ProteinQ96RS0 (Uniprot-TrEMBL)
TM7SF2 gene [nucleoplasm]ProteinENSG00000149809 (ENSEMBL)
TM7SF2 geneENSG00000149809 (ENSEMBL)
TM7SF2ProteinO76062 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ACACA geneREACT_147714 (Reactome)
ACACAArrowREACT_147816 (Reactome)
ACACB geneREACT_147803 (Reactome)
ACACBArrowREACT_147743 (Reactome)
CYP51A1 geneREACT_147786 (Reactome)
CYP51A1ArrowREACT_147899 (Reactome)
DHCR7 geneREACT_147715 (Reactome)
DHCR7ArrowREACT_147864 (Reactome)
ELOVL6 geneREACT_147877 (Reactome)
ELOVL6ArrowREACT_147888 (Reactome)
FASN geneREACT_147842 (Reactome)
FASNArrowREACT_115784 (Reactome)
FDFT1 geneREACT_147835 (Reactome)
FDFT1ArrowREACT_115945 (Reactome)
FDPS geneREACT_147735 (Reactome)
FDPSArrowREACT_147807 (Reactome)
GGPS1 geneREACT_147815 (Reactome)
GGPS1ArrowREACT_147826 (Reactome)
GPAM geneREACT_147903 (Reactome)
GPAM(1-828)ArrowREACT_147810 (Reactome)
HMGCR geneREACT_147894 (Reactome)
HMGCR-1ArrowREACT_115997 (Reactome)
HMGCS1 geneREACT_147710 (Reactome)
HMGCS1ArrowREACT_115739 (Reactome)
IDI1 geneREACT_147783 (Reactome)
IDI1ArrowREACT_147880 (Reactome)
LSS geneREACT_147766 (Reactome)
LSSArrowREACT_147844 (Reactome)
MVD geneREACT_147898 (Reactome)
MVD(2-400)ArrowREACT_147863 (Reactome)
MVK geneREACT_147804 (Reactome)
MVKArrowREACT_147902 (Reactome)
NF-YREACT_147699 (Reactome)
NF-YREACT_147710 (Reactome)
NF-YREACT_147715 (Reactome)
NF-YREACT_147735 (Reactome)
NF-YREACT_147752 (Reactome)
NF-YREACT_147783 (Reactome)
NF-YREACT_147786 (Reactome)
NF-YREACT_147804 (Reactome)
NF-YREACT_147815 (Reactome)
NF-YREACT_147835 (Reactome)
NF-YREACT_147842 (Reactome)
NF-YREACT_147859 (Reactome)
NF-YREACT_147861 (Reactome)
NF-YREACT_147894 (Reactome)
NF-YREACT_147903 (Reactome)
PMVK geneREACT_147861 (Reactome)
PMVKArrowREACT_147771 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115739 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115945 (Reactome)
PPARA:RXRA Coactivator ComplexArrowREACT_115997 (Reactome)
REACT_115739 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115784 (Reactome) The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115945 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115997 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147699 (Reactome) SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
REACT_147710 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
REACT_147714 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind two sites in the promoter of the ACACA gene (Magana et al. 1997, Rome et al. 2008). Each site is required for activation of transcription.
REACT_147715 (Reactome) SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
REACT_147725 (Reactome) The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147728 (Reactome) The TM7SF2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147735 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).
REACT_147743 (Reactome) The ACACB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147752 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the SQLE gene (Reed et al. 2008). The promoter also contains a consensus binding site for NF-Y (Nagai et al. 2002).
REACT_147766 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the LSS gene (Pai et al. 1998, Rome et al. 2008). SREBP1A and SREBP2 activate LSS equally (Pai et al. 1998).
REACT_147771 (Reactome) The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147783 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the IDI1 gene (Reed et al. 2008).
REACT_147786 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
REACT_147803 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with SP1, bind and transactivate promoter II of the ACACB gene in human HepG2 cells (Oh et al. 2003).
REACT_147804 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the MVK gene (Reed et al. 2008).
REACT_147807 (Reactome) The FDPS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147810 (Reactome) The GPAM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147815 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
REACT_147816 (Reactome) The ACACA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147826 (Reactome) The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147835 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).
REACT_147842 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
REACT_147844 (Reactome) The LSS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147859 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the SC5DL gene (Reed et al. 2008, Rome et al. 2008).
REACT_147861 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the PMVK gene (Reed et al. 2008).
REACT_147863 (Reactome) The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147864 (Reactome) The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147875 (Reactome) The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147877 (Reactome) As inferred from mouse, SREBP1A/1C/2 (SREBF1A/1C/2) binds and transactivates the promoter of the ELOVL6 gene.
REACT_147880 (Reactome) The IDI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147888 (Reactome) The ELOVL6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147894 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996).
REACT_147898 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the MVD gene (Rome et al. 2008).
REACT_147899 (Reactome) The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147902 (Reactome) The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147903 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012)