Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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1, 5, 1817, 18, 21, 3473618, 21, 25, 27, 31...282437817, 213417, 18, 2120121716, 213519, 321714, 17, 18, 21, 32...171718, 21923622117, 18, 32, 3413221721, 302915108, 17, 18, 212, 17, 2111SREBF1A,1C,2 cleaved by S2P mitochondrial outer membraneSREBF1A,C NF-Y Activated PPARARXRA Heterodimer SREBP1A/1CNF-YSP1FASN gene SREBP1A/2NF-YSC5DL gene SREBP1A/1C/2 Dimer cytosolSREBF1A,1C,2 cleaved by S2P PPARARXRA Coactivator Complex SREBP1A/1C Dimer Ligands of PPARA SREBP1A/2NF-YSP1GGPS1 gene Ligands of PPARA NF-Y SREBP1A/1C Dimer SREBP1A/1CACACB gene NF-Y NF-Y SREBP1A/1C Dimer SREBP1A/2 Dimer SREBP1A/1C/2NF-YTM7SF2 gene SREBF1A,C SREBF1A,2 SREBF1A,2 SREBP1A/2NF-YSP1PMVK gene NF-Y SREBP1A/1C/2NF-YFDPS gene NF-Y PPARA Fatty Acid Complex SREBP1A/1C/2 Dimer PPARA Fatty Acid Complex PPARARXRA Coactivator Complex SREBF1A,1C,2 cleaved by S2P NF-Y SREBP1A/1C/2 Dimer SREBP1A/1CNF-YGPAM gene NF-Y SREBP1A/2NF-YSP1MVK gene SREBF1A,2 NF-Y SREBP1A/2NF-YSP1CYP51A1 gene SREBF1A,2 SREBP1A/1C/2 Dimer NF-Y SREBP1A/2NF-YHMGCR gene SREBF1A,1C,2 cleaved by S2P SREBF1A,2 SREBF1A,2 NF-Y Coactivators of PPARalpha SREBP1A/2NF-YSP1IDI1 gene SREBP1A/2 Dimer SREBF1A,C SREBF1A,C SREBP1A/2 Dimer Coactivators of PPARalpha NF-Y SREBP1A/2 Dimer SREBP1A/1C/2NF-YHMGCS1 gene PPARARXRA Coactivator Complex SREBP1A/1C/2 Dimer SREBP1A/2NF-YSP1DHCR7 gene SREBP1A/2LSS gene NF-Y SREBF1A,2 Activated PPARARXRA Heterodimer SREBP1A/2 Dimer SREBP1A/1C Dimer SREBF1A,C SREBP1A/2 Dimer SREBF1A,2 SREBF1A,2 nucleoplasmSREBP1A/2SQLE gene SREBF1A,2 SREBP1A/1C/2NF-YSP1FDFT1 gene SREBF1A,2 SREBP1A/2 Dimer SREBP1A/2 Dimer SREBP1A/2 Dimer SREBP1A/1CACACA gene NF-Y SREBP1A/2 Dimer SREBP1A/2MVD gene SREBF1A,1C,2 cleaved by S2P NF-Y SREBF1A,1C,2 cleaved by S2P Activated PPARARXRA Heterodimer SREBP1A/1C/2 Dimer Ligands of PPARA SREBP1A/2 Dimer SREBF1A,2 SREBP1A/2 Dimer Coactivators of PPARalpha NF-Y SREBP1A/1C Dimer NF-Y PPARA Fatty Acid Complex endoplasmic reticulum membraneSREBP1A/1C/2ELOVL6 gene ALA SREBF2SREBP1A/1C/2NF-YHMGCS1 geneFASN geneNFYC LSSNFYB SREBF2MVD gene NFYB NCOA1 MED1 FDPS gene GPAM gene NCOA1 NFYA NFYA SREBF1-3 GGPS1 gene DHCR7SREBF1-1CARM1SP1SREBP1A/1C/2ELOVL6 geneNFYA PPARA SC5DL gene SQLE geneRXRA SREBF2SC5DL geneSP1HMGCS1SP1SC5DMVD geneCARM1NFYA TGS1 NFYC SREBF1-1FDFT1 geneSREBF2EPA NFYC MVK geneCHD9 SQLESREBF2SREBF2FDFT1 gene NFYA ACACB gene SREBP1A/2LSS geneNFYC GPAMDHCR7 gene NFYC SREBF1-1GPAM geneTM7SF2 gene NCOA6 SREBF1-3 TM7SF2MED1 TBL1X SREBF2CYP51A1 geneNFYB IDI1 geneNCOA6 NFYB IDI1PPARARXRA Coactivator ComplexSP1CREBBPNFYC ELOVL6NFYB MED1 NFYC FDFT1SREBF1-1SREBF2SREBF1-1NFYA SREBP1A/2NF-YSP1GGPS1 geneSREBF1-3 SREBF2LINA NFYC SREBP1A/1C/2 DimerPMVKRXRA EPA SREBF1-1SREBF1-3 HMGCR gene NFYA ALA RXRA FASNNFYB NFYA PMVK gene NFYB SP1HELZ2 NCOA6 SREBF2NFYC NCOA1 SMARCD3 SREBF2SMARCD3 SREBP1A/1C/2NF-YFDPS geneGGPS1NFYC SQLE gene SREBF1-1SREBF1-1SREBP1A/2NF-YSP1MVK geneSREBP1A/2NF-YSP1CYP51A1 genePPARA SREBP1A/2NF-YSC5DL geneSP1HMGCR-1SREBF2CREBBPNFYA TBL1XR1 SREBP1A/2NF-YSP1PMVK geneNFYB NFYA NFYB IDI1 gene ACACAELOVL6 geneACACB geneSREBF1-1SREBP1A/1C/2NF-YSP1FDFT1 geneSREBF1-1MVKSP1ACACA geneNF-YSREBF1-1SREBP1A/2 DimerSREBF2SREBP1A/1C DimerFDPSSREBP1A/2MVD geneSREBF1-1NFYC NCOA2 PMVK geneSREBP1A/2NF-YSP1IDI1 geneTGS1 SREBP1A/1C/2NF-YTM7SF2 geneSP1LINA SREBF2NFYA SREBF1-1NFYB SREBF1-1SREBP1A/1CACACB geneSREBF1-1GGPS1 geneSREBF1-1AA CREBBPNFYC CHD9 AA TGS1 ACACBPPARA SREBF1-1Palm TBL1X NFYC SMARCD3 LSS geneSREBF1-3 ACACA gene NF-YSP1SP1CYP51A1 gene LSS gene SREBF1-3 NFYB CHD9 SREBF1-1ELOVL6 gene NFYB SREBF1-3 FASN gene SREBP1A/2NF-YSP1DHCR7 geneSREBF1-1SREBP1A/2SQLE geneNFYB LINA NFYA SREBP1A/1CNF-YGPAM geneNFYA NFYB CYP51A1SREBF1-3 Palm SREBF2NFYA EPA SP1SREBF1-3 SREBF1-1DHCR7 geneTM7SF2 geneHELZ2 SREBF1-3 TBL1XR1 PPARARXRA Coactivator ComplexPalm AA MVDCARM1TBL1XR1 SREBP1A/2NF-YHMGCR geneSREBF1-1NFYA NFYC SREBP1A/1CACACA geneNFYC ALA HMGCR geneTBL1X NFYA HMGCS1 gene NFYB SREBF1-1SREBF2NFYC HMGCS1 geneNFYA SREBF2NFYB PPARARXRA Coactivator ComplexSREBF2SREBF1-1HELZ2 MVK gene SREBP1A/1CNF-YSP1FASN geneNCOA2 FDPS geneSREBF1-3 NCOA2 NFYC NFYB 171717171717, 3817172617172, 14, 17, 3017261717


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Wikipathways-description 
After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998).

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=2426168

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AA MetaboliteCHEBI:15843 (ChEBI)
ACACA gene ProteinENSG00000132142 (ENSEMBL)
ACACA geneENSG00000132142 (ENSEMBL)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene ProteinENSG00000076555 (ENSEMBL)
ACACB geneENSG00000076555 (ENSEMBL)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
CARM1ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBPProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene ProteinENSG00000067064 (ENSEMBL)
CYP51A1 geneENSG00000067064 (ENSEMBL)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene ProteinENSG00000172893 (ENSEMBL)
DHCR7 geneENSG00000172893 (ENSEMBL)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene ProteinENSG00000170522 (ENSEMBL)
ELOVL6 geneENSG00000170522 (ENSEMBL)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
FASN gene ProteinENSG00000169710 (ENSEMBL)
FASN geneENSG00000169710 (ENSEMBL)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (ENSEMBL)
FDFT1 geneENSG00000079459 (ENSEMBL)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene ProteinENSG00000160752 (ENSEMBL)
FDPS geneENSG00000160752 (ENSEMBL)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene ProteinENSG00000152904 (ENSEMBL)
GGPS1 geneENSG00000152904 (ENSEMBL)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene ProteinENSG00000119927 (ENSEMBL)
GPAM geneENSG00000119927 (ENSEMBL)
GPAMProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (ENSEMBL)
HMGCR geneENSG00000113161 (ENSEMBL)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (ENSEMBL)
HMGCS1 geneENSG00000112972 (ENSEMBL)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene ProteinENSG00000067064 (ENSEMBL)
IDI1 geneENSG00000067064 (ENSEMBL)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA MetaboliteCHEBI:17351 (ChEBI)
LSS gene ProteinENSG00000160285 (ENSEMBL)
LSS geneENSG00000160285 (ENSEMBL)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.
MVD gene ProteinENSG00000167508 (ENSEMBL)
MVD geneENSG00000167508 (ENSEMBL)
MVDProteinP53602 (Uniprot-TrEMBL)
MVK gene ProteinENSG00000110921 (ENSEMBL)
MVK geneENSG00000110921 (ENSEMBL)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexREACT_26721 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
PMVK gene ProteinENSG00000163344 (ENSEMBL)
PMVK geneENSG00000163344 (ENSEMBL)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA RXRA Coactivator ComplexComplexREACT_20439 (Reactome)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
Palm MetaboliteCHEBI:15756 (ChEBI)
RXRA ProteinP19793 (Uniprot-TrEMBL)
SC5DL gene ProteinENSG00000109929 (ENSEMBL)
SC5DL geneENSG00000109929 (ENSEMBL)
SC5DProteinO75845 (Uniprot-TrEMBL)
SMARCD3 ProteinQ6STE5 (Uniprot-TrEMBL)
SP1ProteinP08047 (Uniprot-TrEMBL)
SQLE gene ProteinENSG00000104549 (ENSEMBL)
SQLE geneENSG00000104549 (ENSEMBL)
SQLEProteinQ14534 (Uniprot-TrEMBL)
SREBF1-1ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A/1C ACACA geneComplexREACT_148537 (Reactome)
SREBP1A/1C ACACB geneComplexREACT_148190 (Reactome)
SREBP1A/1C

NF-Y

GPAM gene
ComplexREACT_148505 (Reactome)
SREBP1A/1C

NF-Y SP1

FASN gene
ComplexREACT_116518 (Reactome)
SREBP1A/1C DimerComplexREACT_148003 (Reactome)
SREBP1A/1C/2 ELOVL6 geneComplexREACT_148436 (Reactome)
SREBP1A/1C/2

NF-Y

FDPS gene
ComplexREACT_148195 (Reactome)
SREBP1A/1C/2

NF-Y

HMGCS1 gene
ComplexREACT_148333 (Reactome)
SREBP1A/1C/2

NF-Y SP1

FDFT1 gene
ComplexREACT_148107 (Reactome)
SREBP1A/1C/2

NF-Y

TM7SF2 gene
ComplexREACT_148435 (Reactome)
SREBP1A/1C/2 DimerComplexREACT_117119 (Reactome)
SREBP1A/2 LSS geneComplexREACT_148445 (Reactome)
SREBP1A/2 MVD geneComplexREACT_148564 (Reactome)
SREBP1A/2

NF-Y

HMGCR gene
ComplexREACT_148301 (Reactome)
SREBP1A/2

NF-Y

SC5DL gene
ComplexREACT_148446 (Reactome)
SREBP1A/2

NF-Y SP1

CYP51A1 gene
ComplexREACT_148151 (Reactome)
SREBP1A/2

NF-Y SP1

DHCR7 gene
ComplexREACT_148543 (Reactome)
SREBP1A/2

NF-Y SP1

GGPS1 gene
ComplexREACT_147937 (Reactome)
SREBP1A/2

NF-Y SP1

IDI1 gene
ComplexREACT_148432 (Reactome)
SREBP1A/2

NF-Y SP1

MVK gene
ComplexREACT_148095 (Reactome)
SREBP1A/2

NF-Y SP1

PMVK gene
ComplexREACT_148481 (Reactome)
SREBP1A/2 SQLE geneComplexREACT_148275 (Reactome)
SREBP1A/2 DimerComplexREACT_119740 (Reactome)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TGS1 ProteinQ96RS0 (Uniprot-TrEMBL)
TM7SF2 gene ProteinENSG00000149809 (ENSEMBL)
TM7SF2 geneENSG00000149809 (ENSEMBL)
TM7SF2ProteinO76062 (Uniprot-TrEMBL)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ACACA geneREACT_147714 (Reactome)
ACACB geneREACT_147803 (Reactome)
CYP51A1 geneREACT_147786 (Reactome)
DHCR7 geneREACT_147715 (Reactome)
ELOVL6 geneREACT_147877 (Reactome)
FASN geneREACT_147842 (Reactome)
FDFT1 geneREACT_147835 (Reactome)
FDPS geneREACT_147735 (Reactome)
GGPS1 geneREACT_147815 (Reactome)
GPAM geneREACT_147903 (Reactome)
HMGCR geneREACT_147894 (Reactome)
HMGCS1 geneREACT_147710 (Reactome)
IDI1 geneREACT_147783 (Reactome)
LSS geneREACT_147766 (Reactome)
MVD geneREACT_147898 (Reactome)
MVK geneREACT_147804 (Reactome)
NF-YREACT_147699 (Reactome)
NF-YREACT_147710 (Reactome)
NF-YREACT_147715 (Reactome)
NF-YREACT_147735 (Reactome)
NF-YREACT_147752 (Reactome)
NF-YREACT_147783 (Reactome)
NF-YREACT_147786 (Reactome)
NF-YREACT_147804 (Reactome)
NF-YREACT_147815 (Reactome)
NF-YREACT_147835 (Reactome)
NF-YREACT_147842 (Reactome)
NF-YREACT_147859 (Reactome)
NF-YREACT_147861 (Reactome)
NF-YREACT_147894 (Reactome)
NF-YREACT_147903 (Reactome)
PMVK geneREACT_147861 (Reactome)
PPARA RXRA Coactivator ComplexArrowREACT_115739 (Reactome)
PPARA RXRA Coactivator ComplexArrowREACT_115945 (Reactome)
PPARA RXRA Coactivator ComplexArrowREACT_115997 (Reactome)
REACT_115739 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115784 (Reactome) The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115945 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_115997 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147699 (Reactome) SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
REACT_147710 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
REACT_147714 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind two sites in the promoter of the ACACA gene (Magana et al. 1997, Rome et al. 2008). Each site is required for activation of transcription.
REACT_147715 (Reactome) SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
REACT_147725 (Reactome) The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147728 (Reactome) The TM7SF2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147735 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).
REACT_147743 (Reactome) The ACACB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147752 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the SQLE gene (Reed et al. 2008). The promoter also contains a consensus binding site for NF-Y (Nagai et al. 2002).
REACT_147766 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the LSS gene (Pai et al. 1998, Rome et al. 2008). SREBP1A and SREBP2 activate LSS equally (Pai et al. 1998).
REACT_147771 (Reactome) The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147783 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the IDI1 gene (Reed et al. 2008).
REACT_147786 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
REACT_147803 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with SP1, bind and transactivate promoter II of the ACACB gene in human HepG2 cells (Oh et al. 2003).
REACT_147804 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the MVK gene (Reed et al. 2008).
REACT_147807 (Reactome) The FDPS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147810 (Reactome) The GPAM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147815 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
REACT_147816 (Reactome) The ACACA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147826 (Reactome) The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147835 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).
REACT_147842 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
REACT_147844 (Reactome) The LSS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147859 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the SC5DL gene (Reed et al. 2008, Rome et al. 2008).
REACT_147861 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the PMVK gene (Reed et al. 2008).
REACT_147863 (Reactome) The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147864 (Reactome) The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147875 (Reactome) The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147877 (Reactome) As inferred from mouse, SREBP1A/1C/2 (SREBF1A/1C/2) binds and transactivates the promoter of the ELOVL6 gene.
REACT_147880 (Reactome) The IDI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147888 (Reactome) The ELOVL6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147894 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996).
REACT_147898 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the MVD gene (Rome et al. 2008).
REACT_147899 (Reactome) The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147902 (Reactome) The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
REACT_147903 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012). Promoter II is active in lipogenic tissues. As inferred from mouse, NF-Y also binds the GPAM promoter with SREBP1A/1C.
SC5DL geneREACT_147859 (Reactome)
SP1REACT_147715 (Reactome)
SP1REACT_147783 (Reactome)
SP1REACT_147786 (Reactome)
SP1REACT_147803 (Reactome)
SP1REACT_147804 (Reactome)
SP1REACT_147815 (Reactome)
SP1REACT_147835 (Reactome)
SP1REACT_147842 (Reactome)
SP1REACT_147861 (Reactome)
SQLE geneREACT_147752 (Reactome)
SREBP1A/1C ACACA geneArrowREACT_147816 (Reactome)
SREBP1A/1C ACACB geneArrowREACT_147743 (Reactome)
SREBP1A/1C

NF-Y

GPAM gene
ArrowREACT_147810 (Reactome)
SREBP1A/1C

NF-Y SP1

FASN gene
ArrowREACT_115784 (Reactome)
SREBP1A/1C DimerREACT_147714 (Reactome)
SREBP1A/1C DimerREACT_147803 (Reactome)
SREBP1A/1C DimerREACT_147842 (Reactome)
SREBP1A/1C DimerREACT_147903 (Reactome)
SREBP1A/1C/2 ELOVL6 geneArrowREACT_147888 (Reactome)
SREBP1A/1C/2

NF-Y

FDPS gene
ArrowREACT_147807 (Reactome)
SREBP1A/1C/2

NF-Y

HMGCS1 gene
ArrowREACT_115739 (Reactome)
SREBP1A/1C/2

NF-Y SP1

FDFT1 gene
ArrowREACT_115945 (Reactome)
SREBP1A/1C/2

NF-Y

TM7SF2 gene
ArrowREACT_147728 (Reactome)
SREBP1A/1C/2 DimerREACT_147699 (Reactome)
SREBP1A/1C/2 DimerREACT_147710 (Reactome)
SREBP1A/1C/2 DimerREACT_147735 (Reactome)
SREBP1A/1C/2 DimerREACT_147835 (Reactome)
SREBP1A/1C/2 DimerREACT_147877 (Reactome)
SREBP1A/2 LSS geneArrowREACT_147844 (Reactome)
SREBP1A/2 MVD geneArrowREACT_147863 (Reactome)
SREBP1A/2

NF-Y

HMGCR gene
ArrowREACT_115997 (Reactome)
SREBP1A/2

NF-Y

SC5DL gene
ArrowREACT_147875 (Reactome)
SREBP1A/2

NF-Y SP1

CYP51A1 gene
ArrowREACT_147899 (Reactome)
SREBP1A/2

NF-Y SP1

DHCR7 gene
ArrowREACT_147864 (Reactome)
SREBP1A/2

NF-Y SP1

GGPS1 gene
ArrowREACT_147826 (Reactome)
SREBP1A/2

NF-Y SP1

IDI1 gene
ArrowREACT_147880 (Reactome)
SREBP1A/2

NF-Y SP1

MVK gene
ArrowREACT_147902 (Reactome)
SREBP1A/2

NF-Y SP1

PMVK gene
ArrowREACT_147771 (Reactome)
SREBP1A/2 SQLE geneArrowREACT_147725 (Reactome)
SREBP1A/2 DimerREACT_147715 (Reactome)
SREBP1A/2 DimerREACT_147752 (Reactome)
SREBP1A/2 DimerREACT_147766 (Reactome)
SREBP1A/2 DimerREACT_147783 (Reactome)
SREBP1A/2 DimerREACT_147786 (Reactome)
SREBP1A/2 DimerREACT_147804 (Reactome)
SREBP1A/2 DimerREACT_147815 (Reactome)
SREBP1A/2 DimerREACT_147859 (Reactome)
SREBP1A/2 DimerREACT_147861 (Reactome)
SREBP1A/2 DimerREACT_147894 (Reactome)
SREBP1A/2 DimerREACT_147898 (Reactome)
TM7SF2 geneREACT_147699 (Reactome)
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