Activation of gene expression by SREBF (SREBP) (Homo sapiens)

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16, 18, 37263, 616, 24, 35, 46102076241, 4-6, 16...303234, 40, 44396, 24411112366, 456, 166, 24, 3622311324196, 16, 24, 46212715, 23, 24, 40, 4424246, 14, 16, 24835, 3824146, 9, 16, 24, 28...2176, 16, 24endoplasmic reticulum membranemitochondrial outer membranecytosolnucleoplasmIDI1 geneHELZ2 SREBP1A,2:NF-Y:SP1:DHCR7 geneNFYC GPAM(1-828)SREBP1A,1C dimerRXRB ELOVL6 geneACACB geneSREBP1A,1C,2:NF-Y:TM7SF2 geneHMGCR gene SP1 NFYA NFYA EPA SREBF2(1-484) NCOA1 SREBP1A,2:MVD geneSQLE gene 24(S),25-epoxycholesterol SREBF1-1(1-490) CYP51A1SREBP1A,2:NF-Y:SP1:IDI1 geneNFYC RXRA SREBF1-1(1-490) SMARCD3 NFYC NFYA SREBF2(1-484) CREBBP NFYA RXRA CHD9 SREBP1A,1C,2 dimerNFYA SREBF2(1-484) SREBP1A,2:NF-Y:SP1:PMVK geneGPAM gene NFYB NFYA NCOA6 NFYC SC5DL gene MVK gene SREBP1A,2:NF-Y:SP1:CYP51A1 geneSREBF1-1(1-490) IDI1 gene LINA NFYB NRIP1 24(S)-hydroxycholesterol LINA SREBF2(1-484) SCD gene NFYA TGS1 SREBP1A,2:NF-Y:SP1:MVK geneTBL1XR1 NFYC Palm MTF1 DHCR7NFYB SQLE geneELOVL6SREBF2(1-484) 27-hydroxycholesterol NFYB TGS1 TM7SF2 geneNR1H3 LSS geneNFYC SREBF1-3 EPA HMGCS1SREBF2(1-484) FDPS gene SREBF2(1-484) TBL1XR1 SREBP1A,1C,2:ELOVL6geneAA NFYB SREBP1A,2:LSS geneNCOA6 SREBF1-3 MED1 NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SCD geneNFYA SREBP1A,2:SQLE geneNFYC PPARA AA NFYA PMVK24(S),25-epoxycholesterol TBL1X SREBF1-1(1-490) NFYC CYP51A1 genePPARA NFYB NFYB SREBP1A,1C,2:NF-Y:FDPS geneSMARCD3 SREBF1-1(1-490) SREBF1-3 SREBF1-3 SREBF1-1(1-490) SREBP1A,2:NF-Y:HMGCRgeneSREBF1-1(1-490) NFYB FDPS genePPARA SREBP1A,2:NF-Y:SC5DLgeneMED1 NCOA2 SREBF1-1(1-490) RXRA ELOVL6 gene MTF1dimer:12Zn2+:HMGCRgeneZn2+ FDFT1DHCR7 geneTBL1XR1 PPARA:RXRACoactivator complexSP1SREBP1A,1C,2:NF-Y:HMGCS1 geneEPA SREBF1-1(1-490) NFYC ALA NFYC HELZ2 NRIP1 GGPS1 geneSREBF2(1-484) SCD geneNFYB CREBBP SP1 SREBF1-1(1-490) HMGCR geneSREBF2(1-484) SREBF1-1(1-490) NF-YPeroxisome Proliferator Receptor Element (PPRE) AA NFYA SREBP1A,2 dimerSP1 NFYC HMGCR gene SREBF1-3 SP1NFYA NFYC ACACA geneNFYA NFYB MED1 Peroxisome Proliferator Receptor Element (PPRE) SREBF2(1-484) CHD9 ACACBGGPS1NR1H3 FASN geneSREBF1-1(1-490) MVDSCDNFYB NR1H2 MVD gene CARM1 GPAM geneCHD9 DHCR7 gene SREBF2(1-484) NFYA SREBF1-1(1-490) NFYC SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneSREBF1-1(1-490) SP1 NFYB SREBF1-3 SREBF2(1-484) SREBF1-3 SREBF1-1(1-490) SREBF2(1-484) SREBF2(1-484) 24(S)-hydroxycholesterol SC5DRXRA NFYA SREBF1-1(1-490) RXRA MVK geneMVD geneNCOA2 NFYB LSSGGPS1 gene NFYC TM7SF222R-hydroxycholesterol TGS1 SC5DL geneNR1H2 CARM1 SMARCD3 NF-YSP1 NFYA PMVK geneCREBBP SREBP1A,1C:NF-Y:SP1:FASN geneSP1 TM7SF2 gene NFYA SREBF2(1-484) ACACB gene FDPSPalm FDFT1 geneSREBF1-1(1-490) CARM1 TBL1X PPARA:RXRACoactivator complexSREBF1-1(1-490) SREBF1-3 RXRB SQLELINA ALA MVKFASN gene ALA NCOA2 TBL1X ACACAFASNSREBP1A,1C:ACACBgeneFASN gene NCOA1 SREBF2(1-484) FDFT1 gene CYP51A1 gene SREBF1-1(1-490) SREBF1-3 HMGCS1 geneSREBF2(1-484) SREBF1-1(1-490) SREBP1A,1C:SCD genePMVK gene SP1 SREBF1-3 NFYC HELZ2 NFYC NFYB PPARA:RXRACoactivator complexNFYB SP1 SREBF1-1(1-490) NCOA1 SREBF2(1-484) NCOA6 NFYC SREBF1-3 SREBP1A,1C:NF-Y:GPAMgeneSREBP1A,2:NF-Y:SP1:GGPS1 geneHMGCS1 gene SREBF1-1(1-490) ACACA gene NFYB Peroxisome Proliferator Receptor Element (PPRE) HMGCR-1SCD gene SREBF1-1(1-490) NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:FASN geneSREBF1-3 NFYB LSS gene 27-hydroxycholesterol SP1 SREBP1A,1C:ACACAgeneIDI1SREBF1-1(1-490) NFYA 22R-hydroxycholesterol Palm 3, 9, 24, 3624242924422442252524242443422529242424241, 2424


After transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2004). SREBPs alone are relatively weak activators of transcription, with SREBP1C being significantly weaker than SREBP1A or SREBP2. In combination with other transcription factors such as SP1 and NF-Y the SREBPs are much stronger activators. SREBP1C seems to more specifically target genes involved in fatty acid synthesis while SREBP2 seems to target genes involved in cholesterol synthesis (Pai et al. 1998). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 2426168
Reactome version: 64
Reactome Author 
Reactome Author: May, Bruce

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  1. Ishimoto K, Tachibana K, Hanano I, Yamasaki D, Nakamura H, Kawai M, Urano Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Doi T.; ''Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells.''; PubMed Europe PMC
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  3. Reed BD, Charos AE, Szekely AM, Weissman SM, Snyder M.; ''Genome-wide occupancy of SREBP1 and its partners NFY and SP1 reveals novel functional roles and combinatorial regulation of distinct classes of genes.''; PubMed Europe PMC
  4. Lu B, Jiang YJ, Kim P, Moser A, Elias PM, Grunfeld C, Feingold KR.; ''Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis.''; PubMed Europe PMC
  5. Wilkin DJ, Kutsunai SY, Edwards PA.; ''Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester.''; PubMed Europe PMC
  6. Wassif CA, Maslen C, Kachilele-Linjewile S, Lin D, Linck LM, Connor WE, Steiner RD, Porter FD.; ''Mutations in the human sterol delta7-reductase gene at 11q12-13 cause Smith-Lemli-Opitz syndrome.''; PubMed Europe PMC
  7. Toth MJ, Huwyler L.; ''Molecular cloning and expression of the cDNAs encoding human and yeast mevalonate pyrophosphate decarboxylase.''; PubMed Europe PMC
  8. Choi WI, Jeon BN, Park H, Yoo JY, Kim YS, Koh DI, Kim MH, Kim YR, Lee CE, Kim KS, Osborne TF, Hur MW.; ''Proto-oncogene FBI-1 (Pokemon) and SREBP-1 synergistically activate transcription of fatty-acid synthase gene (FASN).''; PubMed Europe PMC
  9. Li J, Ding SF, Habib NA, Fermor BF, Wood CB, Gilmour RS.; ''Partial characterization of a cDNA for human stearoyl-CoA desaturase and changes in its mRNA expression in some normal and malignant tissues.''; PubMed Europe PMC
  10. Eberlé D, Hegarty B, Bossard P, Ferré P, Foufelle F.; ''SREBP transcription factors: master regulators of lipid homeostasis.''; PubMed Europe PMC
  11. Strömstedt M, Rozman D, Waterman MR.; ''The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha-demethylase, a cytochrome P450 whose expression is regulated by oxysterols.''; PubMed Europe PMC
  12. Juge-Aubry C, Pernin A, Favez T, Burger AG, Wahli W, Meier CA, Desvergne B.; ''DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region.''; PubMed Europe PMC
  13. Nagai M, Sakakibara J, Nakamura Y, Gejyo F, Ono T.; ''SREBP-2 and NF-Y are involved in the transcriptional regulation of squalene epoxidase.''; PubMed Europe PMC
  14. Ohno Y, Suto S, Yamanaka M, Mizutani Y, Mitsutake S, Igarashi Y, Sassa T, Kihara A.; ''ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.''; PubMed Europe PMC
  15. Ericsson J, Jackson SM, Edwards PA.; ''Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene.''; PubMed Europe PMC
  16. Párraga A, Bellsolell L, Ferré-D'Amaré AR, Burley SK.; ''Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.''; PubMed Europe PMC
  17. Inoue J, Sato R, Maeda M.; ''Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase.''; PubMed Europe PMC
  18. Oh SY, Park SK, Kim JW, Ahn YH, Park SW, Kim KS.; ''Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory element-binding protein-1 in liver.''; PubMed Europe PMC
  19. Abu-Elheiga L, Almarza-Ortega DB, Baldini A, Wakil SJ.; ''Human acetyl-CoA carboxylase 2. Molecular cloning, characterization, chromosomal mapping, and evidence for two isoforms.''; PubMed Europe PMC
  20. Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, Gotoda T, Ishibashi S, Yamada N.; ''Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes.''; PubMed Europe PMC
  21. Nakamura Y, Sakakibara J, Izumi T, Shibata A, Ono T.; ''Transcriptional regulation of squalene epoxidase by sterols and inhibitors in HeLa cells.''; PubMed Europe PMC
  22. Weber LW, Boll M, Stampfl A.; ''Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins.''; PubMed Europe PMC
  23. Chambliss KL, Slaughter CA, Schreiner R, Hoffmann GF, Gibson KM.; ''Molecular cloning of human phosphomevalonate kinase and identification of a consensus peroxisomal targeting sequence.''; PubMed Europe PMC
  24. Xiong S, Chirala SS, Wakil SJ.; ''Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites.''; PubMed Europe PMC
  25. Rome S, Lecomte V, Meugnier E, Rieusset J, Debard C, Euthine V, Vidal H, Lefai E.; ''Microarray analyses of SREBP-1a and SREBP-1c target genes identify new regulatory pathways in muscle.''; PubMed Europe PMC
  26. Vallett SM, Sanchez HB, Rosenfeld JM, Osborne TF.; ''A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene.''; PubMed Europe PMC
  27. Vock C, Döring F, Nitz I.; ''Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP.''; PubMed Europe PMC
  28. Matsushima M, Inazawa J, Takahashi E, Suzumori K, Nakamura Y.; ''Molecular cloning and mapping of a human cDNA (SC5DL) encoding a protein homologous to fungal sterol-C5-desaturase.''; PubMed Europe PMC
  29. Villagra A, Ulloa N, Zhang X, Yuan Z, Sotomayor E, Seto E.; ''Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression.''; PubMed Europe PMC
  30. Shin ES, Lee HH, Cho SY, Park HW, Lee SJ, Lee TR.; ''Genistein downregulates SREBP-1 regulated gene expression by inhibiting site-1 protease expression in HepG2 cells.''; PubMed Europe PMC
  31. Pai JT, Guryev O, Brown MS, Goldstein JL.; ''Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins.''; PubMed Europe PMC
  32. Schiavoni G, Bennati AM, Castelli M, Della Fazia MA, Beccari T, Servillo G, Roberti R.; ''Activation of TM7SF2 promoter by SREBP-2 depends on a new sterol regulatory element, a GC-box, and an inverted CCAAT-box.''; PubMed Europe PMC
  33. Schafer BL, Bishop RW, Kratunis VJ, Kalinowski SS, Mosley ST, Gibson KM, Tanaka RD.; ''Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria.''; PubMed Europe PMC
  34. Bené H, Lasky D, Ntambi JM.; ''Cloning and characterization of the human stearoyl-CoA desaturase gene promoter: transcriptional activation by sterol regulatory element binding protein and repression by polyunsaturated fatty acids and cholesterol.''; PubMed Europe PMC
  35. Horton JD, Goldstein JL, Brown MS.; ''SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.''; PubMed Europe PMC
  36. Jiang G, McKenzie TL, Conrad DG, Shechter I.; ''Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase.''; PubMed Europe PMC
  37. Zhao Y, Yu L, Gao J, Fu Q, Hua Y, Zhang H, Zhao S.; ''cDNA cloning, chromosome mapping and expression characterization of human geranylgeranyl pyrophosphate synthase.''; PubMed Europe PMC
  38. Abu-Elheiga L, Jayakumar A, Baldini A, Chirala SS, Wakil SJ.; ''Human acetyl-CoA carboxylase: characterization, molecular cloning, and evidence for two isoforms.''; PubMed Europe PMC
  39. Jayakumar A, Tai MH, Huang WY, al-Feel W, Hsu M, Abu-Elheiga L, Chirala SS, Wakil SJ.; ''Human fatty acid synthase: properties and molecular cloning.''; PubMed Europe PMC
  40. Wang M, Yang F, Zhang X, Zhao H, Wang Q, Pan Y.; ''Comparative analysis of MTF-1 binding sites between human and mouse.''; PubMed Europe PMC
  41. Xuan JW, Kowalski J, Chambers AF, Denhardt DT.; ''A human promyelocyte mRNA transiently induced by TPA is homologous to yeast IPP isomerase.''; PubMed Europe PMC
  42. Tabor DE, Kim JB, Spiegelman BM, Edwards PA.; ''Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2.''; PubMed Europe PMC
  43. Harada N, Fujimoto E, Okuyama M, Sakaue H, Nakaya Y.; ''Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.''; PubMed Europe PMC
  44. Magaña MM, Lin SS, Dooley KA, Osborne TF.; ''Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins.''; PubMed Europe PMC
  45. Bennett MK, Lopez JM, Sanchez HB, Osborne TF.; ''Sterol regulation of fatty acid synthase promoter. Coordinate feedback regulation of two major lipid pathways.''; PubMed Europe PMC


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103006view15:08, 31 January 2019Mkutmonupdated outdated Ensembl identifiers
101249view11:14, 1 November 2018ReactomeTeamreactome version 66
100788view20:41, 31 October 2018ReactomeTeamreactome version 65
100330view19:18, 31 October 2018ReactomeTeamreactome version 64
99875view16:02, 31 October 2018ReactomeTeamreactome version 63
99432view14:36, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
93743view13:33, 16 August 2017ReactomeTeamreactome version 61
93257view11:18, 9 August 2017ReactomeTeamreactome version 61
87078view14:22, 18 July 2016MkutmonOntology Term : 'transcription pathway' added !
87077view14:21, 18 July 2016MkutmonOntology Term : 'sterol regulatory element-binding protein signaling pathway' added !
86336view09:15, 11 July 2016ReactomeTeamreactome version 56
83318view10:46, 18 November 2015ReactomeTeamVersion54
81757view09:58, 26 August 2015ReactomeTeamVersion53
76917view08:18, 17 July 2014ReactomeTeamFixed remaining interactions
76622view11:59, 16 July 2014ReactomeTeamFixed remaining interactions
75953view10:01, 11 June 2014ReactomeTeamRe-fixing comment source
75655view10:55, 10 June 2014ReactomeTeamReactome 48 Update
75010view13:52, 8 May 2014AnweshaFixing comment source for displaying WikiPathways description
74843view10:07, 30 April 2014ReactomeTeamReactome46
74654view08:42, 30 April 2014ReactomeTeamNew pathway

External references


View all...
NameTypeDatabase referenceComment
22R-hydroxycholesterol MetaboliteCHEBI:67237 (ChEBI)
24(S),25-epoxycholesterol MetaboliteCHEBI:41633 (ChEBI)
24(S)-hydroxycholesterol MetaboliteCHEBI:34310 (ChEBI)
27-hydroxycholesterol MetaboliteCHEBI:76591 (ChEBI)
AA MetaboliteCHEBI:15843 (ChEBI)
ACACA gene ProteinENSG00000132142 (Ensembl)
ACACA geneGeneProductENSG00000132142 (Ensembl)
ACACAProteinQ13085 (Uniprot-TrEMBL)
ACACB gene ProteinENSG00000076555 (Ensembl)
ACACB geneGeneProductENSG00000076555 (Ensembl)
ACACBProteinO00763 (Uniprot-TrEMBL)
ALA MetaboliteCHEBI:27432 (ChEBI)
CARM1 ProteinQ86X55 (Uniprot-TrEMBL)
CHD9 ProteinQ3L8U1 (Uniprot-TrEMBL)
CREBBP ProteinQ92793 (Uniprot-TrEMBL)
CYP51A1 gene ProteinENSG00000001630 (Ensembl)
CYP51A1 geneGeneProductENSG00000001630 (Ensembl)
CYP51A1ProteinQ16850 (Uniprot-TrEMBL)
DHCR7 gene ProteinENSG00000172893 (Ensembl)
DHCR7 geneGeneProductENSG00000172893 (Ensembl)
DHCR7ProteinQ9UBM7 (Uniprot-TrEMBL)
ELOVL6 gene ProteinENSG00000170522 (Ensembl)
ELOVL6 geneGeneProductENSG00000170522 (Ensembl)
ELOVL6ProteinQ9H5J4 (Uniprot-TrEMBL)
EPA MetaboliteCHEBI:28364 (ChEBI)
FASN gene ProteinENSG00000169710 (Ensembl)
FASN geneGeneProductENSG00000169710 (Ensembl)
FASNProteinP49327 (Uniprot-TrEMBL)
FDFT1 gene ProteinENSG00000079459 (Ensembl)
FDFT1 geneGeneProductENSG00000079459 (Ensembl)
FDFT1ProteinP37268 (Uniprot-TrEMBL)
FDPS gene ProteinENSG00000160752 (Ensembl)
FDPS geneGeneProductENSG00000160752 (Ensembl)
FDPSProteinP14324 (Uniprot-TrEMBL)
GGPS1 gene ProteinENSG00000152904 (Ensembl)
GGPS1 geneGeneProductENSG00000152904 (Ensembl)
GGPS1ProteinO95749 (Uniprot-TrEMBL)
GPAM gene ProteinENSG00000119927 (Ensembl)
GPAM geneGeneProductENSG00000119927 (Ensembl)
GPAM(1-828)ProteinQ9HCL2 (Uniprot-TrEMBL)
HELZ2 ProteinQ9BYK8 (Uniprot-TrEMBL)
HMGCR gene ProteinENSG00000113161 (Ensembl)
HMGCR geneGeneProductENSG00000113161 (Ensembl)
HMGCR-1ProteinP04035-1 (Uniprot-TrEMBL)
HMGCS1 gene ProteinENSG00000112972 (Ensembl)
HMGCS1 geneGeneProductENSG00000112972 (Ensembl)
HMGCS1ProteinQ01581 (Uniprot-TrEMBL)
IDI1 gene ProteinENSG00000067064 (Ensembl)
IDI1 geneGeneProductENSG00000067064 (Ensembl)
IDI1ProteinQ13907 (Uniprot-TrEMBL)
LINA MetaboliteCHEBI:17351 (ChEBI)
LSS gene ProteinENSG00000160285 (Ensembl)
LSS geneGeneProductENSG00000160285 (Ensembl)
LSSProteinP48449 (Uniprot-TrEMBL)
MED1 ProteinQ15648 (Uniprot-TrEMBL) MED1 is a component of each of the various Mediator complexes, that function as transcription co-activators. The MED1-containing compolexes include the DRIP, ARC, TRIP and CRSP compllexes.


ComplexR-HSA-5660440 (Reactome)
MTF1 ProteinQ14872 (Uniprot-TrEMBL)
MVD gene ProteinENSG00000167508 (Ensembl)
MVD geneGeneProductENSG00000167508 (Ensembl)
MVDProteinP53602 (Uniprot-TrEMBL)
MVK gene ProteinENSG00000110921 (Ensembl)
MVK geneGeneProductENSG00000110921 (Ensembl)
MVKProteinQ03426 (Uniprot-TrEMBL)
NCOA1 ProteinQ15788 (Uniprot-TrEMBL)
NCOA2 ProteinQ15596 (Uniprot-TrEMBL)
NCOA6 ProteinQ14686 (Uniprot-TrEMBL)
NF-YComplexR-HSA-381204 (Reactome) NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA ProteinP23511 (Uniprot-TrEMBL)
NFYB ProteinP25208 (Uniprot-TrEMBL)
NFYC ProteinQ13952 (Uniprot-TrEMBL)
NR1H2 ProteinP55055 (Uniprot-TrEMBL)
NR1H3 ProteinQ13133 (Uniprot-TrEMBL)
NRIP1 ProteinP48552 (Uniprot-TrEMBL)
NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:FASN geneComplexR-HSA-9028534 (Reactome)
NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SCD geneComplexR-HSA-9028535 (Reactome)
PMVK gene ProteinENSG00000163344 (Ensembl)
PMVK geneGeneProductENSG00000163344 (Ensembl)
PMVKProteinQ15126 (Uniprot-TrEMBL)
PPARA ProteinQ07869 (Uniprot-TrEMBL)
PPARA:RXRA Coactivator complexComplexR-HSA-400154 (Reactome)
Palm MetaboliteCHEBI:15756 (ChEBI)
Peroxisome Proliferator Receptor Element (PPRE) R-ALL-422139 (Reactome) Peroxisome proliferator receptor elements bind heterodimers containing a peroxisome proliferator receptor and a retinoic acid receptor. The consensus sequence is TGAMCTTTGNCCTAGWTYYG.
RXRA ProteinP19793 (Uniprot-TrEMBL)
RXRB ProteinP28702 (Uniprot-TrEMBL)
SC5DL gene ProteinENSG00000109929 (Ensembl)
SC5DL geneGeneProductENSG00000109929 (Ensembl)
SC5DProteinO75845 (Uniprot-TrEMBL)
SCD gene ProteinENSG00000099194 (Ensembl)
SCD geneGeneProductENSG00000099194 (Ensembl)
SCDProteinO00767 (Uniprot-TrEMBL)
SMARCD3 ProteinQ6STE5 (Uniprot-TrEMBL)
SP1 ProteinP08047 (Uniprot-TrEMBL)
SP1ProteinP08047 (Uniprot-TrEMBL)
SQLE gene ProteinENSG00000104549 (Ensembl)
SQLE geneGeneProductENSG00000104549 (Ensembl)
SQLEProteinQ14534 (Uniprot-TrEMBL)
SREBF1-1(1-490) ProteinP36956-1 (Uniprot-TrEMBL)
SREBF1-3 ProteinP36956-3 (Uniprot-TrEMBL)
SREBF2(1-484) ProteinQ12772 (Uniprot-TrEMBL)
SREBP1A,1C dimerComplexR-HSA-2065537 (Reactome)
SREBP1A,1C,2 dimerComplexR-HSA-1655744 (Reactome)
SREBP1A,1C,2:ELOVL6 geneComplexR-HSA-1655762 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneComplexR-HSA-2426134 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneComplexR-HSA-2426129 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneComplexR-HSA-2426135 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneComplexR-HSA-1655714 (Reactome)
SREBP1A,1C:ACACA geneComplexR-HSA-2426141 (Reactome)
SREBP1A,1C:ACACB geneComplexR-HSA-2426125 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneComplexR-HSA-2426131 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneComplexR-HSA-1655738 (Reactome)
SREBP1A,1C:SCD geneComplexR-HSA-1655743 (Reactome)
SREBP1A,2 dimerComplexR-HSA-2065551 (Reactome)
SREBP1A,2:LSS geneComplexR-HSA-2426137 (Reactome)
SREBP1A,2:MVD geneComplexR-HSA-2426130 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneComplexR-HSA-2426128 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneComplexR-HSA-2426140 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneComplexR-HSA-2426132 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneComplexR-HSA-2426124 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneComplexR-HSA-2426126 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneComplexR-HSA-2426138 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneComplexR-HSA-2426127 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneComplexR-HSA-2426139 (Reactome)
SREBP1A,2:SQLE geneComplexR-HSA-2426136 (Reactome)
TBL1X ProteinO60907 (Uniprot-TrEMBL)
TBL1XR1 ProteinQ9BZK7 (Uniprot-TrEMBL)
TGS1 ProteinQ96RS0 (Uniprot-TrEMBL)
TM7SF2 gene ProteinENSG00000149809 (Ensembl)
TM7SF2 geneGeneProductENSG00000149809 (Ensembl)
TM7SF2ProteinO76062 (Uniprot-TrEMBL)
Zn2+ MetaboliteCHEBI:29105 (ChEBI)

Annotated Interactions

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SourceTargetTypeDatabase referenceComment
ACACA geneR-HSA-1655845 (Reactome)
ACACA geneR-HSA-2426160 (Reactome)
ACACAArrowR-HSA-1655845 (Reactome)
ACACB geneR-HSA-1655830 (Reactome)
ACACB geneR-HSA-2426153 (Reactome)
ACACBArrowR-HSA-1655830 (Reactome)
CYP51A1 geneR-HSA-1655847 (Reactome)
CYP51A1 geneR-HSA-2426163 (Reactome)
CYP51A1ArrowR-HSA-1655847 (Reactome)
DHCR7 geneR-HSA-1655827 (Reactome)
DHCR7 geneR-HSA-2426155 (Reactome)
DHCR7ArrowR-HSA-1655827 (Reactome)
ELOVL6 geneR-HSA-1655835 (Reactome)
ELOVL6 geneR-HSA-2426149 (Reactome)
ELOVL6ArrowR-HSA-1655835 (Reactome)
FASN geneR-HSA-1655843 (Reactome)
FASN geneR-HSA-2426148 (Reactome)
FASNArrowR-HSA-1655843 (Reactome)
FDFT1 geneR-HSA-1655850 (Reactome)
FDFT1 geneR-HSA-2426146 (Reactome)
FDFT1ArrowR-HSA-1655850 (Reactome)
FDPS geneR-HSA-1655824 (Reactome)
FDPS geneR-HSA-2426147 (Reactome)
FDPSArrowR-HSA-1655824 (Reactome)
GGPS1 geneR-HSA-1655832 (Reactome)
GGPS1 geneR-HSA-2426161 (Reactome)
GGPS1ArrowR-HSA-1655832 (Reactome)
GPAM geneR-HSA-1655837 (Reactome)
GPAM geneR-HSA-2426158 (Reactome)
GPAM(1-828)ArrowR-HSA-1655837 (Reactome)
HMGCR geneR-HSA-1655826 (Reactome)
HMGCR geneR-HSA-2426162 (Reactome)
HMGCR-1ArrowR-HSA-1655826 (Reactome)
HMGCS1 geneR-HSA-1655848 (Reactome)
HMGCS1 geneR-HSA-2426150 (Reactome)
HMGCS1ArrowR-HSA-1655848 (Reactome)
IDI1 geneR-HSA-1655823 (Reactome)
IDI1 geneR-HSA-2426152 (Reactome)
IDI1ArrowR-HSA-1655823 (Reactome)
LSS geneR-HSA-1655828 (Reactome)
LSS geneR-HSA-2426154 (Reactome)
LSSArrowR-HSA-1655828 (Reactome)


TBarR-HSA-1655826 (Reactome)
MVD geneR-HSA-1655836 (Reactome)
MVD geneR-HSA-2426144 (Reactome)
MVDArrowR-HSA-1655836 (Reactome)
MVK geneR-HSA-1655846 (Reactome)
MVK geneR-HSA-2426157 (Reactome)
MVKArrowR-HSA-1655846 (Reactome)
NF-YR-HSA-2065966 (Reactome)
NF-YR-HSA-2426146 (Reactome)
NF-YR-HSA-2426147 (Reactome)
NF-YR-HSA-2426148 (Reactome)
NF-YR-HSA-2426150 (Reactome)
NF-YR-HSA-2426151 (Reactome)
NF-YR-HSA-2426152 (Reactome)
NF-YR-HSA-2426155 (Reactome)
NF-YR-HSA-2426156 (Reactome)
NF-YR-HSA-2426157 (Reactome)
NF-YR-HSA-2426158 (Reactome)
NF-YR-HSA-2426161 (Reactome)
NF-YR-HSA-2426162 (Reactome)
NF-YR-HSA-2426163 (Reactome)
NF-YR-HSA-2426164 (Reactome)
NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:FASN geneArrowR-HSA-1655843 (Reactome)
NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SCD geneArrowR-HSA-1655849 (Reactome)
PMVK geneR-HSA-1655839 (Reactome)
PMVK geneR-HSA-2426156 (Reactome)
PMVKArrowR-HSA-1655839 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655826 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655848 (Reactome)
PPARA:RXRA Coactivator complexArrowR-HSA-1655850 (Reactome)
R-HSA-1655823 (Reactome) The IDI1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655824 (Reactome) The FDPS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655826 (Reactome) The HMGCR gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655827 (Reactome) The DHCR7 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655828 (Reactome) The LSS gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655830 (Reactome) The ACACB gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655832 (Reactome) The GGPS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655833 (Reactome) The TM7SF2 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655835 (Reactome) The ELOVL6 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655836 (Reactome) The MVD gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655837 (Reactome) The GPAM gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655839 (Reactome) The PMVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655843 (Reactome) The FASN gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655844 (Reactome) The SQLE gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655845 (Reactome) The ACACA gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655846 (Reactome) The MVK gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655847 (Reactome) The CYP51A1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655848 (Reactome) The HMGCS1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655849 (Reactome) The SCD gene is transcribed to yield mRNA (Li et al. 1994) and the mRNA is translated to yield protein. The SREBP1A (SREBF1A) and SREBP1C (SREBF1C) transcription factors bind the promoter of the SCD gene and activate transcription in response to low cellular cholesterol (Tabor et al. 1999, Bee et al. 2001).
R-HSA-1655850 (Reactome) The FDFT1 gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-1655852 (Reactome) The SC5D gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
R-HSA-2065966 (Reactome) SREBP2 (SREBF2) binds and transactivates an unusual sterol regulatory element in the promoter of the TM7SF2 gene (Schiavoni et al. 2010). NF-Y binds the promoter and is important for activation by SREBP2. SREBP1A and SREBP1C can also bind the TM7SF2 promoter (Reed et al. 2008, Rome et al. 2008).
R-HSA-2426144 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the MVD gene (Rome et al. 2008).
R-HSA-2426146 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y and SP1, bind and transactivate the promoter of the FDFT1 gene (Inoue et al. 1998, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates FDFT1 more strongly than does SREBP1A (Pai et al. 1998).
R-HSA-2426147 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the FDPS gene (Ericsson et al. 1996, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008, Rome et al. 2008, Ishimoto et al. 2010). The binding of NF-Y synergistically enhances the binding of SREBP1 (Ericsson et al. 1996). SREBP1A activates FDPS more strongly than does SREBP2 or SREBP1C (Amemiya-Kudo et al. 2002).
R-HSA-2426148 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with NF-Y and SP1, bind and transactivate the promoter of the FASN gene (Bennett et al. 1995, Pai et al. 1998, Xiong et al. 2000, Amemiya-Kudo et al. 2002, Shin et al. 2007, Choi et al. 2008, Rome et al. 2008). NF-Y is required for response to cholesterol (Xiong et al. 2000). SREBP1A activates FASN more strongly than does SREBP1C or SREBP2 (Pai et al. 1998, Amemiya-Kudo et al. 2002).
R-HSA-2426149 (Reactome) As inferred from mouse, SREBP1A/1C/2 (SREBF1A/1C/2) binds and transactivates the promoter of the ELOVL6 gene.
R-HSA-2426150 (Reactome) SREBP1A/1C/2 (SREBF1A/1C/2), together with NF-Y, bind and transactivate the promoter of the HMGCS1 gene (Maeda et al. 1998, Pai et al. 1998, Amemiya-Kudo et al. 2002, Reed et al. 2008). SREBP1A and SREBP2 activate HMGCS1 equally (Pai et al. 1998).
R-HSA-2426151 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the SQLE gene (Reed et al. 2008). The promoter also contains a consensus binding site for NF-Y (Nagai et al. 2002).
R-HSA-2426152 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the IDI1 gene (Reed et al. 2008).
R-HSA-2426153 (Reactome) SREBP1A (SREBF1A) or SREBP1C, together with SP1, bind and transactivate promoter II of the ACACB gene in human HepG2 cells (Oh et al. 2003).
R-HSA-2426154 (Reactome) SREBP1A (SREBF1A) or SREBP2 binds and transactivates the promoter of the LSS gene (Pai et al. 1998, Rome et al. 2008). SREBP1A and SREBP2 activate LSS equally (Pai et al. 1998).
R-HSA-2426155 (Reactome) SREBP1A (SREBF1A) and SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the DHCR7 gene (Reed et al. 2008).
R-HSA-2426156 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the PMVK gene (Reed et al. 2008).
R-HSA-2426157 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the MVK gene (Reed et al. 2008).
R-HSA-2426158 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind and transactivate promoter II of the GPAM gene (Harada et al. 2012). Promoter II is active in lipogenic tissues. As inferred from mouse, NF-Y also binds the GPAM promoter with SREBP1A/1C.
R-HSA-2426160 (Reactome) SREBP1A (SREBF1A) or SREBP1C bind two sites in the promoter of the ACACA gene (Magana et al. 1997, Rome et al. 2008). Each site is required for activation of transcription.
R-HSA-2426161 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the GGPS1 gene (Reed et al. 2008).
R-HSA-2426162 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the HMGCR gene (Vallett et al. 1996, Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP2 activates HMGCR slightly more than does SREBP1A (Pai et al. 1998). SREBP1A/2 binds 2 main sites and 2 auxiliary sites in the HMGCR promoter (Vallett et al. 1996).
R-HSA-2426163 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y and SP1, bind and transactivate the promoter of the CYP51A1 gene (Pai et al. 1998, Reed et al. 2008, Rome et al. 2008). SREBP1A and SREBP2 activate CYP51A1 equally (Pai et al. 1998).
R-HSA-2426164 (Reactome) SREBP1A (SREBF1A) or SREBP2, together with NF-Y, bind and transactivate the promoter of the SC5DL gene (Reed et al. 2008, Rome et al. 2008).
R-HSA-6800052 (Reactome) SREBF1A (SREBP1A) and SREBF1C (SREBP1C) bind the promoter of the Stearoyl CoA Desaturase 1 (SCD1) gene and enhance transcription (Pai et al. 1998, Shimao et al. 1999, Tabor et al. 1999, Bene et al. 2001, reviewed in Horton et al. 2002).
SC5DArrowR-HSA-1655852 (Reactome)
SC5DL geneR-HSA-1655852 (Reactome)
SC5DL geneR-HSA-2426164 (Reactome)
SCD geneR-HSA-1655849 (Reactome)
SCD geneR-HSA-6800052 (Reactome)
SCDArrowR-HSA-1655849 (Reactome)
SP1R-HSA-2426146 (Reactome)
SP1R-HSA-2426148 (Reactome)
SP1R-HSA-2426152 (Reactome)
SP1R-HSA-2426153 (Reactome)
SP1R-HSA-2426155 (Reactome)
SP1R-HSA-2426156 (Reactome)
SP1R-HSA-2426157 (Reactome)
SP1R-HSA-2426161 (Reactome)
SP1R-HSA-2426163 (Reactome)
SQLE geneR-HSA-1655844 (Reactome)
SQLE geneR-HSA-2426151 (Reactome)
SQLEArrowR-HSA-1655844 (Reactome)
SREBP1A,1C dimerR-HSA-2426148 (Reactome)
SREBP1A,1C dimerR-HSA-2426153 (Reactome)
SREBP1A,1C dimerR-HSA-2426158 (Reactome)
SREBP1A,1C dimerR-HSA-2426160 (Reactome)
SREBP1A,1C dimerR-HSA-6800052 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2065966 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426146 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426147 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426149 (Reactome)
SREBP1A,1C,2 dimerR-HSA-2426150 (Reactome)
SREBP1A,1C,2:ELOVL6 geneArrowR-HSA-1655835 (Reactome)
SREBP1A,1C,2:ELOVL6 geneArrowR-HSA-2426149 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneArrowR-HSA-1655824 (Reactome)
SREBP1A,1C,2:NF-Y:FDPS geneArrowR-HSA-2426147 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-1655848 (Reactome)
SREBP1A,1C,2:NF-Y:HMGCS1 geneArrowR-HSA-2426150 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-1655850 (Reactome)
SREBP1A,1C,2:NF-Y:SP1:FDFT1 geneArrowR-HSA-2426146 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneArrowR-HSA-1655833 (Reactome)
SREBP1A,1C,2:NF-Y:TM7SF2 geneArrowR-HSA-2065966 (Reactome)
SREBP1A,1C:ACACA geneArrowR-HSA-1655845 (Reactome)
SREBP1A,1C:ACACA geneArrowR-HSA-2426160 (Reactome)
SREBP1A,1C:ACACB geneArrowR-HSA-1655830 (Reactome)
SREBP1A,1C:ACACB geneArrowR-HSA-2426153 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneArrowR-HSA-1655837 (Reactome)
SREBP1A,1C:NF-Y:GPAM geneArrowR-HSA-2426158 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneArrowR-HSA-1655843 (Reactome)
SREBP1A,1C:NF-Y:SP1:FASN geneArrowR-HSA-2426148 (Reactome)
SREBP1A,1C:SCD geneArrowR-HSA-1655849 (Reactome)
SREBP1A,1C:SCD geneArrowR-HSA-6800052 (Reactome)
SREBP1A,2 dimerR-HSA-2426144 (Reactome)
SREBP1A,2 dimerR-HSA-2426151 (Reactome)
SREBP1A,2 dimerR-HSA-2426152 (Reactome)
SREBP1A,2 dimerR-HSA-2426154 (Reactome)
SREBP1A,2 dimerR-HSA-2426155 (Reactome)
SREBP1A,2 dimerR-HSA-2426156 (Reactome)
SREBP1A,2 dimerR-HSA-2426157 (Reactome)
SREBP1A,2 dimerR-HSA-2426161 (Reactome)
SREBP1A,2 dimerR-HSA-2426162 (Reactome)
SREBP1A,2 dimerR-HSA-2426163 (Reactome)
SREBP1A,2 dimerR-HSA-2426164 (Reactome)
SREBP1A,2:LSS geneArrowR-HSA-1655828 (Reactome)
SREBP1A,2:LSS geneArrowR-HSA-2426154 (Reactome)
SREBP1A,2:MVD geneArrowR-HSA-1655836 (Reactome)
SREBP1A,2:MVD geneArrowR-HSA-2426144 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-1655826 (Reactome)
SREBP1A,2:NF-Y:HMGCR geneArrowR-HSA-2426162 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneArrowR-HSA-1655852 (Reactome)
SREBP1A,2:NF-Y:SC5DL geneArrowR-HSA-2426164 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneArrowR-HSA-1655847 (Reactome)
SREBP1A,2:NF-Y:SP1:CYP51A1 geneArrowR-HSA-2426163 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneArrowR-HSA-1655827 (Reactome)
SREBP1A,2:NF-Y:SP1:DHCR7 geneArrowR-HSA-2426155 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneArrowR-HSA-1655832 (Reactome)
SREBP1A,2:NF-Y:SP1:GGPS1 geneArrowR-HSA-2426161 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneArrowR-HSA-1655823 (Reactome)
SREBP1A,2:NF-Y:SP1:IDI1 geneArrowR-HSA-2426152 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneArrowR-HSA-1655846 (Reactome)
SREBP1A,2:NF-Y:SP1:MVK geneArrowR-HSA-2426157 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneArrowR-HSA-1655839 (Reactome)
SREBP1A,2:NF-Y:SP1:PMVK geneArrowR-HSA-2426156 (Reactome)
SREBP1A,2:SQLE geneArrowR-HSA-1655844 (Reactome)
SREBP1A,2:SQLE geneArrowR-HSA-2426151 (Reactome)
TM7SF2 geneR-HSA-1655833 (Reactome)
TM7SF2 geneR-HSA-2065966 (Reactome)
TM7SF2ArrowR-HSA-1655833 (Reactome)
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