Iron uptake and transport (Homo sapiens)

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35, 81, 1277812, 37, 1242629, 77, 94, 12513819, 63, 82, 107, 12333, 4733, 58, 14412234, 57, 8710916, 56, 14262, 14165, 113, 11718, 38, 53, 84, 14510511180, 93, 115, 12045, 888510911822, 13913432, 7364, 1477596, 112, 1307, 43, 10128, 89, 91, 1033, 20, 36, 54, 72...64, 14714362, 14110, 11, 21, 44, 46...8, 104, 119116861724, 11430, 5515, 27, 7450, 12631, 59, 8322, 41, 1391, 25, 42, 70, 97...4, 5, 9, 13, 14, 69...39, 40, 61, 68, 95...49223, 51866, 146GLRAGLRBGly mitochondrial matrixRAF1SGKTSC22D3WPP GABRGs Ub-SCNN1A/SCNN1D CYBRD1Heme HTR3 receptors FTH1FTL platelet dense tubular network lumenGABRR pentamerGABA TFRC dimer ATP6V1B GABRA2ARHGEF9 CLCN7OSTM1 ATP2C1/2 endosome lumenFerritin Complex TFRC dimer ATP6V0E TFTFRC dimer 2GABRA2GABRBGABRGGABA HTR35HT ATP6V1C ATP6V0 TFRC dimer GABRR1-3 mitochondrial intermembrane spaceATP6V1E ATP6V1 sarcoplasmic reticulum lumenRYR1 tetramer ABCG2 dimer Golgi lumenGABRAs SGK1/2/3 lysosomal lumenendoplasmic reticulum lumenATP4A/12A ATP6V1G MTP1HEPH6Cu2+ ATP6V0C hexamer late endosome lumenRYR3 tetramer holoTFTFRC SCNN1A/1D RYR2 tetramer ATP6V0D holoTF V-ATPase TFRC dimer ATP6V0A FXYDs TFTFRC holoTFTFRC dimer ATP6V1B trimer cytosolATP1B CASQ polymer holoTF ATP4A/12AATP4B ATP1A ATP1AATP1BFXYD WPP1/NEDD4L TFRC dimer RYR tetramers MTP1CP6Cu2+ ATP6V1A trimer sperm flagellumNALCNUNC79UNC80 ATP2C1/2Mg2+ ATP6V1G dimer holoTF Ub-SCNN channels RYR tetramerCASQ polymerTRDNjunctin SCNN channels GABRBs ATP7AATPNa+CLCN4/5/6ATP6V0E2 Ub-SCNN channelsNSAIDH+Na+ABCG2 dimerATP6V0B GABA SLC11A2FXYD7 Cu2+APLsNa+Fe3+H+UNC79 ATPATP6V0E1 Cu2+ Na+K+RYR1 CYBRD1 MTP1HEPH6Cu2+Fe2+ATP4A PiH2OHEPH AMPH2OPiCa2+ATPATP6V1F H2OCl-TRDNCa2+Na+ATP1A4 H+GABRA4 HCO3-GABRA5 H+H+CP amilorideRYR3 TPCN1/2Cl-K+Ca2+TF Cl-ADPH+RAF1SGKTSC22D3WPPe-SLC9C1ATP6V0D1 ATP2A1-3HTR3E Ca2+p-S56,S534-N-acetyl-L-alanine-FLVCR1H+H+HTR3C OSTM1 Gly hemeNa+Na+Ca2+ATP6V1A TFTFRCP-type ATPases type IVRAF1 TFRCPiholoTFFe3+UrateNADPHHTR3A H2OATPFe3+FXYD2 ATP6V1C1 Na+Fe3+ ATP1B2 ATP2C1 PiSCNN1A FXYD1 SLC46A1ADPRYR tetramerCASQ polymerTRDNjunctinADPFe3+GABRA2 TFRC dimerATP1A3 TF K+NADP+SLC40A1 PiH+Na+ATP6V1G3 H+Cu2+Na+SCNN1D TFRC2GABRA2GABRBGABRGGABAGABRA1 H+holoTFTFRC dimerSLC17A3ATP7BSLC40A1 ADPASIC trimerH+Na+TTYH1-3CLCN7OSTM1Na+ATP6V0D2 ATP2A1-3Ub-SCNN1A O2PiATP6V1B2 ATP4B Fe2+Ferritin ComplexCa2+CLCN1/2/KA/KBH2OATPH+MTP1CP6Cu2+SLC9B2H+Fe3+ Ca2+ATPATP6V0A2 H+Cl-UNC80 Cl-SGK2 hemeATP6V1D PiCa2+NAADPADPFe3+ GABRR1 FXYD6 ATPH+Na+Na+Ca2+HTR3B ATPCl-SCNN1B V-ATPaseRYR2FXYD3 FeHMCl-Cl-Ca2+ATP6V1B1 Fe3+GABRG2 TFRCSTEAP3ATP6V1G1 Fe2+FXYD4 BESTsATP1B3 O2ATP2C2 COATP12A TTYH2/3Cu2+ HMOX1/2GABRR3 Ub-SCNN1G H2OCLCN3UbGLRB TFRCATP6V0A1 UrateGABRR pentamerGABAWWP1 ATP4A/12AATP4BATP6V0A4 H2OTF GABRB1 H+ATP6V0C K+TF5HT HCO3-GABRG3 GABA SLC17A3H2OSCNN channelsNa+/Li+Pie-H2OTCIRG1 NALCN TF Cl-PPiADPATP6V1C2 H+ATP6V1G2 GABRR2 HTR3D ATP1AATP1BFXYDFTL ATP1A1 Ca2+NALCNUNC79UNC80Cl-SGK3 TSC22D3 H+BVAPLsPiCYBRD1HemeTFRCCLIC2SCNN1B H2OARHGEF9 FTH1ANOsATP1A2 GABRB2 WNKsFe2+GABRB3 Cu2+MCOLN1ATPCa2+SCNN1D ATP6V1H Ca2+H+ATP2C1/2Mg2+SGK1 ATP2B1-4H+Ca2+HC-ABCG2 H+O2ADPGABRA3 H+Mg2+ NEDD4LCa2+HTR35HTSLC9B1/C2FeHMATP6V1E2 TF Na+/Li+ASIC4ATP1B1 CLCN7 holoTFTFRCH+heme TFTFRC dimerGABRA6 GLRAGLRBGlyATP6V1E1SCNN1G 135


The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010). Original Pathway at Reactome:

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