Iron uptake and transport (Homo sapiens)

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47, 127, 1367612, 1414128, 34, 841341235, 24, 60, 72, 78...4, 9512268120291, 9714, 39, 5686, 102, 131669, 15, 16, 2029, 932114743, 46, 81, 92, 126...33, 10010, 75, 8711, 118, 12512, 1418, 503, 7, 27, 111, 12175, 8722, 36, 45, 62, 73...52, 67, 10542, 54, 1098931, 51, 9138, 74, 112, 14230, 5932, 5818, 85, 12463, 8335, 7133, 10013, 19, 26, 40, 49...1408023, 37, 64, 113, 12910125, 57, 110, 13988, 103, 1451478279, 104, 1321, 6, 17, 44, 53...482CLCN7OSTM1 NALCNUNC79UNC80 GLRAGLRBGly WPP1/NEDD4L MTP1CP6Cu2+ GABRA2ARHGEF9 ABCG2 dimer CASQ polymer lysosomal lumenFerritin Complex holoTF ATP6V1G dimer GABRR pentamerGABA RYR tetramers ATP1B platelet dense tubular network lumenRYR tetramerCASQ polymerTRDNjunctin ATP6V0 ATP6V1B trimer TFRC dimer GABRBs GABRAs ATP6V1G ATP6V0D ATP1AATP1BFXYD FTH1FTL TFTFRC dimer ATP6V1B sperm flagellumSCNN channels holoTF late endosome lumenGABRGs endosome lumenmitochondrial intermembrane spacesarcoplasmic reticulum lumen2GABRA2GABRBGABRGGABA TFTFRC TFRC dimer ATP6V1 CYBRD1Heme mitochondrial matrixUb-SCNN channels holoTFTFRC dimer RAF1SGKTSC22D3WPP SCNN1A/1D ATP6V1A trimer ATP6V0A MTP1HEPH6Cu2+ ATP6V0C hexamer ATP2C1/2Mg2+ ATP6V0E HTR35HT ATP2C1/2 V-ATPase ATP6V1E endoplasmic reticulum lumenATP4A/12A RYR2 tetramer TFRC dimer HTR3 receptors ATP4A/12AATP4B FXYDs cytosolTFRC dimer RYR3 tetramer holoTFTFRC ATP6V1C Golgi lumenATP1A TFRC dimer holoTF SGK1/2/3 RYR1 tetramer Ub-SCNN1A/SCNN1D GABRR1-3 Ca2+H+ATP1AATP1BFXYDCl-ATP6V1B2 Ub-SCNN1A Na+RYR1 Fe3+ATP6V0D2 GABRR2 SLC46A1H+Cu2+5HT SCNN1B HEPH SLC17A3Na+Ca2+ATP6V1B1 H+amiloride2GABRA2GABRBGABRGGABATRDNp-S56,S534-N-acetyl-L-alanine-FLVCR1SLC40A1 TF H+ADPCu2+MTP1CP6Cu2+SGK1 ADPATP2C1/2Mg2+CLCN7OSTM1ATP4A/12AATP4BATP6V1G3 Fe2+NAADPCa2+RYR2K+ATP1B3 TPCN1/2GABRB1 H+GABRB2 FeHMH+Na+H2ONa+CLIC2Cl-H+Cl-Na+Fe2+Fe2+CLCN7 ATP1A2 H+SGK3 heme ASIC trimerH+ATP6V0E2 PiNa+Na+/Li+Fe3+CLCN3Na+Ca2+Na+Ferritin ComplexHC-ABCG2 H+PiNa+/Li+ATP6V1C1 ATPHTR3A Cl-H2OTFRC dimerCu2+ HCO3-BVHTR3D ADPSCNN1B FTL FXYD6 ATP6V1E1Ca2+TF FXYD2 K+H2OUbFXYD4 hemeATP6V0A1 RYR3 Cl-STEAP3GABRA5 TFRCATP1B2 TFRCATP1A1 COCu2+ CLCN4/5/6Na+Cl-TFTFRC dimerSLC11A2Ca2+SCNN1G RAF1SGKTSC22D3WPPholoTFTFRC dimerGABRA2 ARHGEF9 ATP12A Fe3+ RYR tetramerCASQ polymerTRDNjunctinATP2B1-4O2ATPASIC4Ca2+H+TTYH2/3ATP6V1A ATP2A1-3PPiNADP+V-ATPaseATP6V1D APLsFeHMH+Ca2+BESTsFTH1PiPiSLC40A1 SLC9C1TFPiH2ONa+ATP6V0B ATP2A1-3Na+Na+NALCN WWP1 H2OATP6V1F ATP7AK+H+ATP2C2 holoTFTFRCGABA H2OCu2+Cl-TTYH1-3PiH+HTR3E Ca2+GABRA1 SCNN1D ATP6V0A4 ATPFXYD7 NADPHH+GABRA3 Ca2+ATP6V1C2 CYBRD1 GABRR pentamerGABATF TFRCATP6V1H TFTFRCATPSLC17A3FXYD3 H2ONa+e-APLsUrateCP CYBRD1HemeGLRB AMPADPCa2+Ub-SCNN1G Fe3+H2OTCIRG1 HCO3-GABRR3 WNKsATP4B ATP6V0C K+ATPGABRG2 P-type ATPases type IVATP6V0E1 H2OFe3+ HTR3C H+GABRR1 Gly SLC9B1/C2Fe3+SCNN1A H+H+MCOLN1ADPATP6V0D1 Ca2+TFRCNALCNUNC79UNC80SGK2 ATPATP6V1E2 PiH+GLRAGLRBGlyCa2+ATP1A3 ADPATP1A4 UrateUNC80 H+TSC22D3 ANOsH+HMOX1/2HTR35HTPihemee-H+SCNN1D ATP4A GABRA6 O2Ca2+ATP1B1 GABRG3 Cl-GABA PiTF Cl-ATP2C1 Ub-SCNN channelsFe2+TFRCUNC79 NSAIDMg2+ NEDD4LCa2+ATP6V0A2 H+MTP1HEPH6Cu2+OSTM1 holoTFATP7BGABRA4 TF ATPH+RAF1 CLCN1/2/KA/KBHTR3B Na+O2ATP6V1G2 ADPSLC9B2SCNN channelsFXYD1 Cl-Fe3+ ATPABCG2 dimerFe3+GABRB3 H2OATP6V1G1 ATP144


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The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).

Original Pathway at Reactome: http://www.reactome.org/PathwayBrowser/#DB=gk_current&FOCUS_SPECIES_ID=48887&FOCUS_PATHWAY_ID=917937

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