Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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11, 30, 584425, 401936273, 18, 233329, 456, 7, 42, 43, 5138, 395424508, 59574, 35561362, 34cytosolnucleoplasmHTR2C GNG11 GNG12 GNA14 GCGR TACR3 DecS-GHRL-1(24-50) AGTR1 RGZ HTR2A HB-EGF:p-6Y-EGFRdimerL-Glu PIK3R3 NRAS NMBR GCG(53-81) UDP UTS2,UTS2B H+ LPAR3 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)GNRHR2 NPS p-4S,T356,T570-RPS6KA2 QRFP CHRM1 DecS-GHRL-1(24-50) HRH1 GNG7 Protein Kinase C,alpha type: DAGL-Glu BDKRB1 RAF/MAP kinasecascadeADP NPFF(69-76) TRHR LTB4 PLCB4 Valerate GNG5 FFAR3 ligands TRH(135-137) NMB(47-56) GNA11 GDPNMBR AVP(20-28) HCRTR2 CCKBR NPS GCGR AGT(34-41) LPAR4 CCK GRM1 GNG12 PLCB1 FFAR3 QRFPR TAC3 O-octanoyl-L-serine-GHRL-1(24-50) OXT(20-28) F2RL3(18-385) G-protein alpha(q/11):Trio familyRhoGEFsp21 RAS:GTPBDKRB2 PAF PTGFR BUT GNA14 PLC-beta:G-alpha(q/11):DAG:IP3ADR NPS HTR2C GTP GNRH1(24-33) I(1,4,5)P3FFAR1 AVPR1A P2RY11 AVPR1A,B GPRC6A ligands GNA14 CCK AcCho PGE2 Bombesin-like receptor GNA14 GNG10 GPCRs that activateGq/11GAST(76-92) NPSR1 EtCOO- or C2H5COO- AcCho DecS-GHRL-1(24-51) 5HT GNGT2 TRH(84-86) OXTR PLC beta:G alpha(q/11)F2RL1(37-397) CASR MCHR1 LPAR2 PROKR1,PROKR2 ADPPTGER1 LPA GNB5 PI(4,5)P2 NAd XCR1 GNB1 GNB1 EDN1 MCHR2 EDNRA,EDNRB FFAR3 GNA14 HCRTR2 TRH(186-188) GNA15 PALM pH sensing receptors AVPR1A TAC1(98-107) Photon QRFP MCHR1 LTB4 KISS1(68-121) RGZ TAC1(58-68) EGFRLigands of GPCRsthat activate Gq/11TACR2 APP(672-713) HCRTR1 MT-RNR2 TRH(135-137) SAA1(19-122) LTE4 GNG5 GRPR CYSLTR2 MLNR QRFP PRKCA ADP GNA11 TBXA2R UTS2B GNGT2 GNAQ TACR1 ANXA1 LPA GNB3 GNB1 XCR1 XCL1,XCL2 GAST(76-92) OPN4 GNB3 GNRHR2 ARHGEF25 GPR68 thrombin heavy chain NMU P2RY10 F2R(27-425) GPR4 DecS-GHRL-1(24-50) TACR1 LPAR1 TXA2 ADRBK1ADR NTSR2 GNRH2(24-33) p-S133-CREB1ATP TRH(114-116) ADRA1A,B,D GNA11 NTSR1 NMU GNA15 GPR17 GRPR OLEA AGT(34-41) OLEA GNB4 KRAS Phospho-Ribosomalprotein S6 kinasePhoton LXA4 GNG10 UDP PLCB1 PGE2 GHSR HCRT(34-66) GNA11 PLCB3 TRH(186-188) CCKAR FPR2 ligands HRAS DecS-GHRL-1(24-51) LTB4R2 LTB4R2 GCGR p-4S,T359,T573-RPS6KA1 PLCB1 GNG13 GNRH ligands GNA15 GNG2 PLCB2 AVP(20-28) GNB4 P2RY11 GNAQ PIK3R2 QRFPR GNRH2(24-33) P2RY6 NMBR GNA11 GNA14 GHSR TAC3 FFAR2 PAF KRAS ADRBK1 Hist NMS HCRT(34-66) P2RY11 LTB4R,LTB4R2 BRS3 Ca2+ LTC4 LXA4 CCK HCOOH Proteinase-activated receptors 5HT SOS1 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)GNA11 GNG3 GNA15 NPFF(69-76) Gastrin:CCKBRCYSLTR1 CCL23-2 HCOOH GNG8 TACR2 GPR4 HBEGF(63-148)NTS(151-163) GRM1,GRM5 FPR2 G-protein alpha(q/11):PI3K alphaMLNR HCRTR1 ADP PROK1 FFAR3 GNGT2 CASR PLCB4 GNAQ HRH1 EDN1 GNG12 HCRT(70-97) GNG3 DAG DAG p-6Y-EGFR NMU HBEGF(63-148) EDN3(97-117) thrombin light chain LTB4 FFAR1 EDN2 DecS-GHRL-1(24-51) LPAR2 TRH(152-154) P2RY6 Pentadecanoic acid PROK1 p-6Y-EGFR GTP HTR2B NMUR2 CH3COO- GDP GNGT1 PROK1 GNB3 HRH1 KISS1(68-121) thrombin heavy chain TACR2 AVPR1B GAST(76-92) XCL1 GNG3 HTR2A NMUR2 CCKBR GTP GDPPGF2a LPAR4 thrombin heavy chain BRS3 GNAQ GNRHR OXTR GPRC6A TACR3 GNG8 HBEGF(63-148) CHRM3 EDN2 GNA11 O-octanoyl-L-serine-GHRL-1(24-51) EDN3(97-117) LPAR2 SAA1(19-122) LPAR6 FFAR1 RPS6KA1 5HT GNAQ EDNRA H+ UTS2B GNB4 RGS21 PIK3CA TRIO family RhoGEFsGNA15 EDN1 HCRTR2 ADRA1D ATPNMUR1 HBEGF(149-208)MLNR H+ OPN4 NAd TAC1(58-68) F2RL3(18-385) AVPR1A GHSR QRFPR HCRT(34-66) APP(672-713) ADRA1B Bradykinin OXT(20-28) GNA14 NMUR1,NMUR2 GDP AVP(20-28) PLCB3 PLCB2 Bradykinin TRH(114-116) p-T218,Y220-MAPK7 FFAR2 PMCH(147-165) GPR17 HTR2C GPR65 TAC3 TBXA2R CCKAR AGT(34-41) PTGER1 PTAFR TRHR GRK5 LTB4R RGS proteins activefor G alpha (q)5HT EDNRA G-protein alpha(q):GRK2NMB(47-56) GNA15 FFAR1 AGTR1 PROKR1 GNG12 CHRM1, 3, 5 HCRTR1 NPFF(69-76) MLN(26-47) P2RY2 FFAR2 ligands NPFFR2 CHRM5 GTP GNA11 FFAR2 HeterotrimericG-protein Gq/11(inactive)UTS2R TRH(152-154) TACR3 L-Glu XCR1 NTSR2 OPN4 TACR2 RGS18 AVPR1B P2RY11 TRH(135-137) HCOOH CYSLTR1,CYSLTR2 Basic L-amino acids GAST(76-92)HXA PGF2a F2R(27-425) GNA11 AGTR1 NPFFR1 CHRM3 GNG7 GNAQ PIK3R1 PMCH(147-165) PIK3R2 BDKRB2 PROK2 NPFF(69-76) EDNRA HTR2A-C HTR2B NMS GPR17 Effects of PIP2hydrolysisGNG13 GRP(24-50) MLN(26-47) UTS2 LPAR3 HCRT(70-97) GNA15 LPAR1 NTSR1 NTSR1,NTSR2 ADP GNA11 DDCX NRAS P2RY10 GNA14 GNRHR HTR2A ATP GNB5 NMS AVP(20-28) OXTR CCKBR TRH(84-86) UTS2 GNG5 GRB2:SOS1:HB-EGF:p-6Y-EGFRDDCX PGE2 GNA14 MCHR2 GRM5 LTC4 Ca2+ LPAR4 QRFPR PLCB2 F2RL1(37-397) NMB(47-56) TRH(186-188) GNB4 G-protein alpha(q/11):GDPPLCB3 NTSR2 GNG11 Valerate HCRT(34-66) PLCB1 LPA PTAFR PLCB4 GNG7 P2RY1 LXA4 GNGT1 CHRM5 GNB3 KALRN HCRT(70-97) RGS3 GNG3 ANXA1 TRIO ANXA1 LTC4 GTP TAC1(58-68) GNRH1(24-33) NPFFR1 GNRH1(24-33) OLEA PIK3CA KISS1(68-121) NPSR1 GPR132 TRHR GRK5AGTR1 F2RL3(18-385) MMP3Basic L-amino acids ADR GPRC6A LPAR6 Hist NPFFR1,NPFFR2 GPR65 GNRHR P2RY2 GRM5 GTPO-octanoyl-L-serine-GHRL-1(24-50) Basic L-amino acids RPS6KA3 GNGT1 NPFFR2 EDN3(97-117) TRH(152-154) BUT XCL2 F2R(27-425) p-4S,T231,T365-RPS6KA3 LTB4R HCRTR2 GNB2 LTE4 Bombesin-like peptide LPAR1 GNAQ GCG(53-81) LPAR6 PMCH(147-165) GRM5 PGF2a GRP(24-50) GNG8 TRH(227-229) TAC1(98-107) MLNR OPN4 P2RY1 PLCB2 MCHR1,MCHR2 PTGER1 CCL23-2 NTSR1 GNGT2 HCRT(70-97) Cysteinyl leukotrienes GCG(53-81) TRH(227-229) PMCH(147-165) Bradykinin FFAR1 ligands XCR1 P2RY1 TRIO LTD4 GNG2 LTB4R2 EtCOO- or C2H5COO- NMUR2 ADPCCKAR AGT(34-41) GNRHR2 CYSLTR1 PROKR2 PTAFR ADRA1A MT-RNR2 GNAQ F2RL1(37-397) L-Glu GNA14 NPSR1 GNAQ GNB2 PROKR1 XCL2 thrombin light chain CREB1XCL2 CHRM1 NMUR1 UTS2R GRP(24-50) GNA15 GNB5 GPRC6A CCKBR UTS2R FPR2 GTP TACR3 PAF NAd CCKAR,CCKBR GNA14 EDNRB GNG5 HRAS GCG(53-81) BDKRB1 GTPGAST(76-92) BDKRB1 GNG4 TAC1(98-107) Acyl Ghrelin TBXA2R CH3COO- PTGFR PROKR1 CCKBR GNG13 GPR17 GNA14 MMP3(100-477)CHRM3 GPR68 F2RL2(22-374) HBEGF(20-62)CCKBRRibosomal protein S6kinaseADRA1B GNAQ XCL1 PROKR2 GNG2 GNGT1 RGS19 NTS(151-163) GNRH2(24-33) LPAR1,2,3,5 NTS(151-163) GDP O-octanoyl-L-serine-GHRL-1(24-50) LPA Endothelin TAC1(58-68) GNG13 CHRM1 BUT DAGH+ LTD4 PTGER1 thrombin heavy chain TXA2 PTGFR GAST(76-92) UDP G-protein alpha(q/11)GNAQ ADRA1B G-protein alpha(q/11): GTPCASR GnRH receptor GNB5 RGZ UDP KALRN TAC3 NPFFR2 RGSL1 GHSR GNG10 GNG7 GDP KISS1R BDKRB2 GTP PROK1,PROK2 GRM1 GNA11 GPR65 AcCho O-octanoyl-L-serine-GHRL-1(24-51) PLCB4 HBEGF(20-208)LTD4 I(1,4,5)P3 p-ERK1/2/5GNG10 NPFFR1 FPR2 TRH(84-86) FPR2 KISS1(68-121) EDN2 PLC-betaG-protein alpha(q):GRK5GNA15 NTS(151-163) GTP GNA14 F2RL2(22-374) CYSLTR1 GNA15 Hist TRH(227-229) MLN(26-47) NMUR1 QRFP LPAR6 CH3COO- CHRM5 LPAR3 GPRC6A AVPR1B GNG11 ATP TAC1(98-107) Ligand:GPCRcomplexes thatactivate Gq/11PTAFR TRHR P2RY1 SAA1(19-122) TACR1 GRM1 LPAR5 PROK2 ADR, NAd OXT(20-28) O-octanoyl-L-serine-GHRL-1(24-51) Ca2+ PGF2a GNB1 MCHR1 LPAR5 FFAR2 HXA Photon GPR68 ATPGNA15 GNG8 CCL23-2 EDNRB OXTR ADRA1A MCHR2 GNA15 NMS G-protein beta-gammacomplexp-T202,Y204-MAPK3 PROK2 P2RY2 PIK3R3 Photon Pentadecanoic acid LTB4 ADRA1D CYSLTR2 GRPR TACR1 GTP PI3K alphaF2RL2(22-374) GRB2-1 GNB2 P2RY6 DDCX GNA11 MLN(26-47) PGE2 MT-RNR2 CCK GNAQ GNAQ TRH(114-116) PLC-beta:G-alpha(q/11):PIP2thrombin light chain GNG2 P2RY2 TBXA2R PALM P2RY10 TXA2 PALM CASR TXA2 GRB2-1 ADRA1D HCRTR1 ARHGEF25 KISS1R Hist p21 RAS:GDPP2RY10 GPR132 KISS1R GPR4 GNG11 OXT(20-28) LTB4R HTR2B BRS3 PIK3R1 NPS PROKR2 NPSR1 PRKCAPAF GNG4 Pentadecanoic acid CYSLTR2 GNG4 KISS1R P2RY6 PTGFR APP(672-713) GNG4 GNB2 FFAR3 SOS1 UTS2 XCL1 AcCho GRB2-1:SOS1thrombin light chain RPS6KA2 GNA11 Bradykinin HXA Ca2+ Valerate UTS2R p-T185,Y187-MAPK1 GNA15 Bradykinin receptor ATP LPAR5 LTE4 EDNRB PLCB3 NMU ADRA1A GTP LPAR4 NMUR2 GCGR EtCOO- or C2H5COO- TRH GPR132 UTS2B HRH1 RGS2 5, 9, 12, 14, 16...1, 171, 171, 171, 173231, 4610, 15, 48, 531, 171, 1741, 47321, 171, 17