Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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17, 47, 585341222916, 35, 4828, 5014, 425744, 4623, 36211126, 53383, 6, 7, 39, 593449274, 30cytosolnucleoplasmEDNRA NMU GNA15 AcCho GPR17 OXT(20-28) GHSR FFAR3 CYSLTR1 UDP HCOOH NMUR2 TRH(135-137) F2R(27-425) TACR3 GNB2 PMCH(147-165) GRM1 GRM5 GPR132 AVPR1B Pentadecanoic acid PROKR2 PI(4,5)P2 GPR65 L-Glu thrombin heavy chain Proteinase-activated receptors P2RY10 ADR GNG2 PTGER1 OPN4 thrombin light chain APP(672-713) LPAR1,2,3,5 GNA15 GRPR TRH(84-86) PTGFR BDKRB1 OXT(20-28) GNG2 MMP3GNGT2 HTR2A LPA PROK1 MLNR ADRA1A OLEA CYSLTR2 NPFF(69-76) F2RL3(18-385) TRH(227-229) PLCB1 AVPR1A SOS1 PLCB2 TRH(114-116) UTS2R thrombin heavy chain FFAR1 GNA11 HTR2B TRHR DDCX NPS BRS3 H+ CASR NMS FFAR2 CHRM3 p-6Y-EGFR QRFPR thrombin light chain GRB2-1 TACR2 XCL2 OXTR PLCB1 NMU GNAQ HBEGF(63-148)ANXA1 NPS GRK5EDNRA QRFP BUT KALRN GNB1 MT-RNR2 ATPGNA14 CHRM1 LTB4R CCKAR,CCKBR QRFP HTR2A-C NTSR2 GAST(76-92) HRAS LPAR1 LTB4R,LTB4R2 GCG(53-81) Phospho-Ribosomalprotein S6 kinasePROKR2 GNG11 TRH(227-229) HTR2A O-octanoyl-L-serine-GHRL-1(24-51) TBXA2R PAF FFAR3 AGT(34-41) P2RY1 FPR2 KISS1R LPAR3 NPFFR1 EDN3(97-117) GNG12 FFAR1 ligands PLC-beta:G-alpha(q/11):DAG:IP3TRH(135-137) GNB1 TBXA2R GNA15 GNA14 GHSR PRKCAO-octanoyl-L-serine-GHRL-1(24-51) TRH(186-188) PLCB3 GNG12 TXA2 HTR2C GNB2 FFAR1 TXA2 GTP GNAQ GNB1 GNG8 G-protein alpha(q/11):Trio familyRhoGEFsNTSR1,NTSR2 BRS3 MLN(26-47) GNG13 GNG10 PGF2a P2RY11 QRFPR UTS2 HCRTR2 FFAR2 MCHR2 ANXA1 CCKBR 5HT EtCOO- or C2H5COO- UTS2 HCRTR2 GRM5 RPS6KA1 OPN4 Ca2+ GPR132 PLCB4 MCHR1,MCHR2 GNAQ Basic L-amino acids XCL2 PLCB3 GNGT2 PGE2 NMB(47-56) Endothelin CCKAR PLCB4 GRM5 LTB4R FFAR1 GNG11 NMUR1 NMBR F2RL3(18-385) CHRM5 CHRM1, 3, 5 GHSR PTGER1 PLC beta:G alpha(q/11)PIK3R3 GAST(76-92) GNG10 GNRH1(24-33) 5HT Ligands of GPCRsthat activate Gq/11AcCho BDKRB1 DecS-GHRL-1(24-50) OLEA TAC1(58-68) PTAFR LPAR2 PGE2 APP(672-713) PTGER1 GNRH ligands NPSR1 P2RY2 p-4S,T356,T570-RPS6KA2 OXTR O-octanoyl-L-serine-GHRL-1(24-50) QRFPR MCHR2 TRHR F2RL2(22-374) PLCB2 GHSR Bradykinin DecS-GHRL-1(24-51) HTR2A MLN(26-47) GNAQ GNG3 GNAQ GNA11 FFAR2 ligands GNG2 Acyl Ghrelin NMU GNRH2(24-33) GNB2 GTP L-Glu LTE4 UDP AGT(34-41) GNGT1 ARHGEF25 G-protein alpha(q):GRK5GTP ADR NMUR2 UTS2R Ca2+ CYSLTR1 GPR4 KISS1R GNA15 PROK1 ADRA1D SAA1(19-122) OLEA GTP G-protein alpha(q/11):GDPAPP(672-713) AVP(20-28) PIK3R3 Valerate GPRC6A GNRH2(24-33) ADRA1B GNG8 GCGR CH3COO- P2RY1 P2RY2 EtCOO- or C2H5COO- EDN3(97-117) GRB2:SOS1:HB-EGF:p-6Y-EGFRGNG3 NMUR1,NMUR2 CHRM3 TACR1 GNAQ XCR1 NAd LPAR6 HTR2B GNGT1 GNA14 EDN2 F2RL1(37-397) RPS6KA2 GNG13 Hist GPR68 KISS1(68-121) GNA11 PTAFR GNG12 EDN1 GNAQ GNG11 GNG4 thrombin light chain TRH(186-188) TRH(152-154) GRP(24-50) NTS(151-163) TBXA2R HCRTR2 TXA2 PGF2a BDKRB2 SOS1 BDKRB2 UTS2B Valerate GNA14 GNAQ GNG7 LPAR4 HB-EGF:p-6Y-EGFRdimerPRKCA MCHR1 HCRT(70-97) GPR17 LTD4 Effects of PIP2hydrolysisGCGR GNA15 GNRHR2 PTGFR ATPp-6Y-EGFR GPRC6A F2RL2(22-374) TAC1(98-107) AcCho LPA GTPATP LPAR3 GNG3 DecS-GHRL-1(24-51) RGS proteins activefor G alpha (q)NPFFR1,NPFFR2 GNA11 LPAR6 O-octanoyl-L-serine-GHRL-1(24-50) TRH(135-137) QRFP BDKRB1 GNA14 GNA11 RGZ MCHR2 GNAQ Hist GNB1 LTB4R2 ATP Ribosomal protein S6kinasePMCH(147-165) GAST(76-92) QRFP TAC1(58-68) HCOOH GNA15 FFAR3 Pentadecanoic acid p-T185,Y187-MAPK1 GNG4 NTS(151-163) GDPF2RL2(22-374) MMP3(100-477)UTS2B TAC1(98-107) GNA11 KRAS Photon PLCB3 H+ NMUR2 RAF/MAP kinasecascadeGNGT1 Ca2+ BRS3 ADPLTB4R2 HBEGF(63-148) GAST(76-92) NTSR1 PGF2a GNRH1(24-33) ADRA1D CYSLTR2 GNG12 NPFFR2 p-T202,Y204-MAPK3 P2RY2 TAC3 AVPR1B HBEGF(149-208)LXA4 KISS1(68-121) PROK1,PROK2 RGS2 HCRTR1 XCL1 MLNR CCL23-2 GNB2 GNB5 GNGT1 P2RY2 NPFF(69-76) GNAQ AVP(20-28) LTB4 CYSLTR1 NPSR1 GCG(53-81) UTS2R BDKRB2 EtCOO- or C2H5COO- GDP 5HT LTB4 p-S133-CREB1PLC-beta:G-alpha(q/11):PIP2TAC1(58-68) PROKR1 RGS21 I(1,4,5)P3 RGS19 XCL1 GNA11 LPAR5 GNA11 BUT LTB4R CCK PAF GNG7 GNA15 GnRH receptor TACR2 GNG3 PIK3R1 ADP TRHR EDN1 LTE4 HXA RGZ ADRBK1 p21 RAS:GTPPROK2 HCRT(70-97) GNRH1(24-33) LTB4R2 PLCB1 G-protein alpha(q):GRK2p-ERK1/2/5RGZ G-protein alpha(q/11)OPN4 GNRHR2 F2RL3(18-385) GNG5 GNAQ NTS(151-163) GNG2 LTD4 CHRM1 LTB4 GTP GPR68 HCRTR1 LPAR4 TACR2 pH sensing receptors HCOOH AVP(20-28) P2RY1 NMS PIK3R2 LTD4 GNA15 OXTR NMU GDP GNA11 GNA11 AVPR1A,B thrombin heavy chain GNG7 GNB4 UDP TAC1(98-107) EDNRB GNAQ GRPR F2R(27-425) GNRH2(24-33) GNB3 EGFRGNA11 HCRTR1 GTP PROK1 GTP NTSR1 LPAR1 FFAR2 CYSLTR2 p-T218,Y220-MAPK7 NPFFR2 ATP Bombesin-like receptor NPFFR2 GRK5 NAd GNG5 GNB3 GNB5 GNA15 GNG7 XCR1 CCL23-2 HRH1 TAC1(98-107) ADRA1B LPAR4 P2RY10 Bradykinin HCRT(34-66) GNRHR2 SAA1(19-122) LTB4 RGS3 GNB5 AVPR1A GNGT2 DecS-GHRL-1(24-50) HRH1 PMCH(147-165) GNG4 PLCB3 CASR GRM1 OXTR NPS TAC3 GPCRs that activateGq/11CH3COO- GCGR GNA14 GRPR CREB1GAST(76-92)TACR3 KISS1(68-121) GNGT2 TACR3 MLNR HTR2C EDN2 p-4S,T359,T573-RPS6KA1 CH3COO- G-protein alpha(q/11): GTPthrombin light chain GNA14 TRH(114-116) GRM1,GRM5 PTAFR PLCB4 HCRT(34-66) MLNR TACR1 LXA4 CHRM5 LTC4 Photon FPR2 GTP AGTR1 CCL23-2 CCKBR ADPG-protein alpha(q/11):PI3K alphaATP PLCB2 F2RL1(37-397) LPAR2 DAG I(1,4,5)P3TACR3 PROKR1,PROKR2 PLCB4 Ligand:GPCRcomplexes thatactivate Gq/11HTR2C F2R(27-425) NMBR O-octanoyl-L-serine-GHRL-1(24-51) HXA FFAR3 HBEGF(20-208)NPFFR1 XCL2 CASR ANXA1 KISS1R GNG10 NTSR2 GNA14 P2RY11 GTPH+ PROKR1 OPN4 GNA11 XCR1 O-octanoyl-L-serine-GHRL-1(24-50) PTGFR GPR65 PLCB1 LPAR3 GNG8 NMB(47-56) H+ MT-RNR2 TRIO family RhoGEFsBradykinin CCKBR XCL1,XCL2 UTS2B TRH(84-86) TRH Photon CHRM3 GCGR GNAQ BUT PAF GNG13 KALRN ADRA1A AGT(34-41) GPRC6A ligands GRB2-1 EDNRB Valerate AVP(20-28) NMBR NTSR2 LPAR1 RGSL1 GNG13 CCK CCK KISS1(68-121) Bradykinin receptor TRH(84-86) FPR2 P2RY10 Ca2+ GNRHR Bradykinin TRIO TACR1 GNA11 Pentadecanoic acid LTE4 ADRBK1GNA15 P2RY6 NPSR1 FFAR2 GPRC6A GPR17 Bombesin-like peptide NRAS NTS(151-163) MCHR1 PIK3CA TXA2 GCG(53-81) LPA CCKAR KISS1R GNA15 RGS18 p-4S,T231,T365-RPS6KA3 HBEGF(20-62)HXA GNRHR GNG5 ADRA1B Hist PROKR1 AVPR1A DAGTRHR UTS2 p21 RAS:GDPCYSLTR1,CYSLTR2 PTGER1 GNB4 LXA4 ADP HCRT(34-66) UTS2R thrombin heavy chain CASR EDNRA FFAR3 ligands LTC4 TRH(152-154) NPSR1 MCHR1 NPS GTP FFAR1 P2RY6 HeterotrimericG-protein Gq/11(inactive)GPR65 GRM1 P2RY6 NPFF(69-76) ADR EDN3(97-117) HCRT(70-97) P2RY1 PTGFR LPA GNB4 GNA15 CCKBRGRB2-1:SOS1TAC3 GNG11 MLN(26-47) L-Glu PGE2 GNG4 SAA1(19-122) AcCho LPAR4 CCK Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)EDN1 ADP TRH(152-154) FPR2 EDNRA,EDNRB NMS GDP CHRM5 AGT(34-41) GDPPROK2 P2RY6 HBEGF(63-148) AVPR1B NRAS TRH(114-116) G-protein beta-gammacomplexEDNRB P2RY11 PGE2 LTC4 PROK2 QRFPR TRH(186-188) CCKBR GNRHR HCRTR1 NPFFR1 GTP NAd 5HT CCKAR PLC-betaADRA1A,B,D ADP NPFF(69-76) GNA14 GNG8 ADRA1A GNA14 Protein Kinase C,alpha type: DAGLPAR5 TRIO F2RL1(37-397) ADR, NAd DecS-GHRL-1(24-50) LPAR5 GNG10 DDCX XCR1 UDP HCRT(34-66) GNA14 GNA14 TBXA2R PI3K alphaGNG5 Hist CHRM1 GNA15 NMB(47-56) PMCH(147-165) NTSR1 HCRT(70-97) ARHGEF25 GRP(24-50) TACR2 RPS6KA3 HRH1 HCRTR2 GNB3 TRH(227-229) PALM GDP ADRA1D P2RY10 GRP(24-50) GCG(53-81) Cysteinyl leukotrienes PAF DecS-GHRL-1(24-51) NMUR2 MLN(26-47) OXT(20-28) TAC1(58-68) Basic L-amino acids GPR68 GNB4 CCKBR HRH1 AGTR1 GPR4 HTR2B PLCB2 Photon MT-RNR2 Gastrin:CCKBRPROKR2 PALM PIK3R2 NMUR1 GNA14 GPR4 LPAR6 GPR132 FPR2 ligands PTAFR GNB5 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)NMUR1 TAC3 GNB3 GPR17 TACR1 DAG KRAS PIK3CA NMS OXT(20-28) DDCX PALM Basic L-amino acids UTS2,UTS2B AGTR1 GAST(76-92) PGF2a PIK3R1 AGTR1 HRAS XCL1 L-Glu P2RY11 LPAR2 EDN2 GPRC6A LPAR6 311, 2, 12, 18-20, 24...55, 5655, 5610, 1315, 4555, 5655, 5655, 56318, 9, 33, 5155, 5655, 5655, 56