Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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27, 36, 5811, 12, 2448, 511, 55593441422, 13, 17, 30, 354318539522332, 5621, 46311710, 226, 47cytosolnucleoplasmLPAR1,2,3,5 FFAR1 ADRA1A,B,D KRAS Hist LPAR5 P2RY10 MCHR2 GNG7 PALM LTC4 GDP GPR4 GNG11 RPS6KA2 HCOOH MCHR1 TACR1 HCRTR2 OLEA HRAS UTS2R p-T185,Y187-MAPK1 ADR LTB4R FFAR3 Photon XCR1 LPA FFAR3 GRM1 HTR2A TRHR RPS6KA3 PGE2 TAC1(98-107) p21 RAS:GTPGHSR NPFFR1 GNG13 TRH(152-154) NPSR1 TRH(186-188) Acyl Ghrelin GNAQ F2RL1(37-397) LTE4 GAST(76-92) AGTR1 5HT PIK3R1 P2RY11 XCR1 MMP3TACR3 LPAR3 NRAS UTS2B GNA14 Photon TAC1(98-107) AGTR1 AGTR1 GCG(53-81) KISS1(68-121) XCL2 CCKBR GNA15 MLNR Pentadecanoic acid GNA14 PTGER1 QRFPR UTS2,UTS2B GRP(24-50) HCRT(70-97) NMB(47-56) PTAFR CASR GTP Ca2+ QRFP PLCB1 FFAR3 ligands PIK3R3 ADRA1B DecS-GHRL-1(24-50) LTB4 GDPBradykinin NMBR L-Glu PROKR1 GNG3 UTS2 GRPR UTS2R GTP KISS1(68-121) RGS18 GNA14 CCL23-2 LXA4 NPFFR2 HCRT(34-66) P2RY2 PTGFR LPAR1 PROK1 FFAR3 NPSR1 Basic L-amino acids GNAQ P2RY1 PIK3R3 p-4S,T231,T365-RPS6KA3 GNB3 CCKBR ATP G-protein beta-gammacomplexFPR2 LPAR5 GPCRs that activateGq/11PIK3R2 GNA15 RGSL1 QRFPR FPR2 RGS19 G-protein alpha(q/11):PI3K alphaPIK3CA OLEA NMS EDNRB SAA1(19-122) GPR65 SOS1 PALM TRHR GNA11 MLN(26-47) EDN1 GNG2 NPFF(69-76) TACR1 GCG(53-81) ANXA1 UDP H+ CH3COO- GNA14 P2RY1 Hist SOS1 GDP FFAR2 FFAR3 RGS3 APP(672-713) GAST(76-92) NPFF(69-76) DDCX CASR RAF/MAP kinasecascadeLTD4 AGTR1 PALM MCHR2 PROK1 F2RL2(22-374) GCGR AVPR1B CHRM1 G-protein alpha(q/11):GDPKALRN G-protein alpha(q):GRK2OXT(20-28) GNRH2(24-33) LPAR1 GNG7 GNG10 GNRH2(24-33) PLCB4 CHRM1 MMP3(100-477)TACR2 ADP F2R(27-425) PMCH(147-165) LPAR6 GRP(24-50) GNGT2 GNB4 GNB4 OXTR thrombin light chain GPR65 BRS3 TACR3 OXT(20-28) NMUR1 PAF XCL2 PLC beta:G alpha(q/11)L-Glu LTE4 GNA14 BDKRB1 G-protein alpha(q/11): GTPTAC3 GNGT1 MCHR2 CCKAR,CCKBR LXA4 P2RY1 Cysteinyl leukotrienes GNB4 PROKR1 GNG11 GRPR UTS2 F2RL3(18-385) PLC-betaCHRM3 GNA15 HTR2B NPS PMCH(147-165) GNG8 OPN4 5HT TAC1(58-68) DAG FPR2 GPR132 NTS(151-163) 5HT GNB5 NMU HRH1 PAF NTSR2 F2RL2(22-374) HCRTR1 RGS21 GNB5 TRH(84-86) BUT NMUR2 p-4S,T356,T570-RPS6KA2 KISS1R CYSLTR1,CYSLTR2 GPRC6A NMUR2 NPFF(69-76) MLN(26-47) UTS2B GNA14 EDN2 HBEGF(20-208)PMCH(147-165) ADRA1A GCGR PTAFR EDNRA,EDNRB LTD4 CCL23-2 GNAQ PTGER1 HCRTR1 NMU KISS1(68-121) PGE2 Proteinase-activated receptors LPAR4 GNA14 Pentadecanoic acid thrombin light chain NTSR1,NTSR2 Phospho-Ribosomalprotein S6 kinaseF2RL2(22-374) GNG8 GRPR FPR2 H+ PLCB2 GNA15 UDP HeterotrimericG-protein Gq/11(inactive)Gastrin:CCKBRGNG5 HCRTR2 XCL1 HCRTR1 GPRC6A NPS AVPR1A TAC1(98-107) CHRM1 GNB3 NAd HCOOH TRH(135-137) MCHR1 AVPR1A GPR4 Ca2+ TRHR Effects of PIP2hydrolysisTRH(152-154) p-6Y-EGFR HRH1 NPSR1 GTPGCG(53-81) LPAR3 HBEGF(63-148) PGE2 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)CH3COO- HBEGF(63-148)UDP OXTR EtCOO- or C2H5COO- GNRH ligands GNA11 CYSLTR2 TXA2 BDKRB2 NPFFR2 CCK I(1,4,5)P3GNB1 FFAR2 ligands APP(672-713) PRKCAOXTR P2RY10 GNA11 GRB2:SOS1:HB-EGF:p-6Y-EGFRKISS1(68-121) GNA15 TBXA2R GPR17 MLNR GNA11 TRH(186-188) AVPR1A ADR, NAd GNG10 GNG4 NMS GHSR H+ EGFRCCKBR PLCB4 HBEGF(149-208)PROK2 Basic L-amino acids p-T202,Y204-MAPK3 NMUR1 LPA O-octanoyl-L-serine-GHRL-1(24-51) Hist HCRT(34-66) BDKRB1 CYSLTR1 GNA14 GNA11 P2RY10 GNB2 Photon GNB5 Bombesin-like receptor CCK GNAQ GRM5 GAST(76-92)CCL23-2 GNA15 p-T218,Y220-MAPK7 CREB1NMB(47-56) PROKR2 SAA1(19-122) DecS-GHRL-1(24-51) CASR OPN4 GNRH2(24-33) GNG5 Ca2+ ANXA1 GRB2-1 TACR2 HB-EGF:p-6Y-EGFRdimerAGT(34-41) 5HT BDKRB2 GPR65 P2RY1 GNGT2 GRB2-1:SOS1GNAQ GNB1 GTP CASR XCL2 KISS1R LPAR5 NPS Bradykinin GCGR GRP(24-50) G-protein alpha(q/11):Trio familyRhoGEFsTACR3 TAC3 OXTR O-octanoyl-L-serine-GHRL-1(24-51) FFAR1 LTB4R2 DecS-GHRL-1(24-51) NPFFR2 UTS2 F2R(27-425) TRH(84-86) GCG(53-81) LTB4 Bradykinin receptor GNG10 HTR2B ATPP2RY6 ADRA1D HBEGF(20-62)P2RY10 ATPEDNRA G-protein alpha(q/11)EDNRB MLNR TRIO ADRBK1p21 RAS:GDPQRFPR GNAQ DecS-GHRL-1(24-51) FFAR1 LPAR1 GNG8 GNG11 NTSR1 UDP EDN2 TRH(135-137) CYSLTR1 AcCho ATP QRFP GNG7 NPFFR1 ADPGNG3 ARHGEF25 PTGFR ADP NTS(151-163) F2RL1(37-397) TRH(227-229) P2RY2 GNG10 HTR2C QRFP LXA4 GNG5 ADP ATP ADRA1A HRH1 TAC3 BRS3 GNG4 ADRA1D GNG2 CHRM5 PGF2a LPAR6 CCKBR thrombin heavy chain CCKAR BDKRB1 BUT EDNRA LTE4 CCKAR GNAQ LPA thrombin light chain O-octanoyl-L-serine-GHRL-1(24-50) KISS1R BUT NMU PTGFR GPR68 ADRA1B HTR2A-C MT-RNR2 GRM1 GPR132 GNA15 p-4S,T359,T573-RPS6KA1 PAF PROKR2 TBXA2R TACR2 CYSLTR1 NMUR2 GNG12 TACR3 TAC1(58-68) NMBR ADRA1A GNA15 GHSR GNA15 AGT(34-41) GNRH1(24-33) HCRTR1 NPSR1 FFAR1 TRH HBEGF(63-148) EDN2 PLCB1 GnRH receptor PROK1,PROK2 PROKR2 GNA14 HTR2A GNB5 GPRC6A EDN3(97-117) NTSR2 FFAR1 ligands Endothelin HTR2A GPR68 PGE2 GNAQ GDP O-octanoyl-L-serine-GHRL-1(24-51) P2RY6 TAC1(58-68) GRM1,GRM5 Bradykinin GDPLPAR2 LPAR6 UTS2B HXA HTR2C PGF2a OLEA GNRHR2 AVP(20-28) Ca2+ MCHR1,MCHR2 TACR1 EtCOO- or C2H5COO- Ligands of GPCRsthat activate Gq/11GNG13 thrombin heavy chain CHRM5 ADRA1D GNA11 GPR17 GNA11 GNA11 HTR2B OPN4 BDKRB2 TRHR AGT(34-41) LTC4 GNA11 LPAR4 GPR17 ADPP2RY11 P2RY2 NPFF(69-76) F2RL1(37-397) GRM1 GNG12 CHRM3 NRAS MT-RNR2 PROK1 PTAFR NMU NAd GNG2 F2R(27-425) ARHGEF25 XCL1 EDN3(97-117) Valerate UTS2R HCRTR2 PLCB3 F2RL3(18-385) TRH(114-116) HXA Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)Valerate H+ GNGT1 AVPR1B TRH(135-137) CCKAR LTC4 TAC1(58-68) GTP QRFPR GNA15 L-Glu XCR1 MCHR1 GNGT1 OXT(20-28) LTB4R,LTB4R2 AcCho AVP(20-28) OXT(20-28) XCL1 FFAR2 ADR GTP GNA15 TACR2 TRIO family RhoGEFsTRH(227-229) GNG3 AVP(20-28) PAF CCK LTB4R2 PLCB3 p-6Y-EGFR XCL1,XCL2 LPAR6 EDN3(97-117) GNG4 PGF2a PIK3CA GTP CCKBR EtCOO- or C2H5COO- KISS1R NMUR1,NMUR2 MLN(26-47) GNG11 CHRM1, 3, 5 LPAR4 GAST(76-92) CH3COO- TRH(152-154) F2RL3(18-385) GNRHR2 PTGER1 GNAQ TXA2 LTB4R G-protein alpha(q):GRK5RGZ GNRHR NTSR2 GDP AcCho NMS GNRH1(24-33) NMB(47-56) TRH(114-116) TRH(186-188) GNGT2 CCK MT-RNR2 GNG12 TRH(227-229) GPR68 HCRT(70-97) GNB1 P2RY6 PLCB2 LPA ADR FFAR2 PROKR1,PROKR2 GTP NTSR1 FPR2 ligands AVPR1A,B PTGER1 TACR1 NMUR1 OPN4 HRAS KALRN GNGT1 EDNRA GNAQ GNA11 AVPR1B GPRC6A GNG13 HCRT(70-97) CHRM5 GNG3 LPAR2 DecS-GHRL-1(24-50) GNG8 thrombin heavy chain RGZ LPAR2 p-ERK1/2/5LTB4R2 APP(672-713) NMUR2 PI(4,5)P2GNG13 P2RY11 TXA2 PMCH(147-165) O-octanoyl-L-serine-GHRL-1(24-50) pH sensing receptors GNB3 P2RY6 GNG7 Protein Kinase C,alpha type: DAGGHSR GAST(76-92) HTR2C TRH(84-86) GNA14 NMS TRH(114-116) HCRT(34-66) NPS GNGT2 CYSLTR2 P2RY11 GRK5 TAC3 Bradykinin DAGAGT(34-41) FFAR2 thrombin heavy chain thrombin light chain EDNRB SAA1(19-122) MLN(26-47) GAST(76-92) GNRHR PROK2 GPR132 Pentadecanoic acid L-Glu ANXA1 PRKCA CHRM3 LPAR4 KRAS NPFFR1 LTB4R GPR4 TXA2 Photon GTP HCRT(70-97) MLNR GNG12 Bombesin-like peptide GRM5 CCKBRGNB1 LTB4 ADRBK1 GNB2 NTS(151-163) DecS-GHRL-1(24-50) Hist AcCho GRK5TBXA2R ADRA1B GNB2 QRFP HCRTR2 LTB4 O-octanoyl-L-serine-GHRL-1(24-50) HRH1 HCOOH PROKR1 GNRHR Ligand:GPCRcomplexes thatactivate Gq/11Ribosomal protein S6kinaseATP UTS2R TBXA2R DDCX RGS2 GRM5 NAd p-S133-CREB1P2RY2 NMBR GNA14 GNAQ EDN1 DDCX NPFFR1,NPFFR2 NTSR1 HXA GNB2 HCRT(34-66) XCR1 EDN1 GTPGRB2-1 GNRH1(24-33) PGF2a ADP Valerate NTS(151-163) RGS proteins activefor G alpha (q)GNA11 AVP(20-28) PIK3R2 Basic L-amino acids TRIO GNRHR2 GNG4 GPRC6A ligands GCGR TAC1(98-107) PIK3R1 PROK2 GNG2 PTGFR GNB3 LTD4 GPR17 RGZ BRS3 GNB4 CYSLTR2 LPAR3 PTAFR RPS6KA1 PI3K alphaGNG5 15, 5415, 543, 4, 7, 20, 26...815, 545, 19815, 5415, 5425, 4015, 5414, 16, 37, 5015, 5415, 54