Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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27, 36, 5843911, 12, 2432, 5659172, 13, 17, 30, 3552415310, 2234311821, 4648, 511, 5542236, 47nucleoplasmcytosolLTB4R,LTB4R2 PALM HRH1 NRAS HTR2A LTB4R OPN4 PMCH(147-165) GNG8 Pentadecanoic acid LTD4 GNA11 GPR65 GNG12 RPS6KA3 FFAR3 MCHR2 TAC1(98-107) OXT(20-28) DDCX KRAS UTS2 CREB1NAd LTB4R2 GPR4 GCG(53-81) MLN(26-47) UDP GPR4 GRM5 HTR2B TRH(227-229) ATPPTGER1 TACR2 HRAS DecS-GHRL-1(24-50) NPFFR2 GNGT1 TRH(135-137) PROKR1 TRH(152-154) PMCH(147-165) GTP thrombin heavy chain CYSLTR1 GHSR AGT(34-41) GNRHR PIK3R2 F2R(27-425) MLNR NPFF(69-76) LPAR5 GTP FFAR1 GNA15 GCG(53-81) TACR2 AGT(34-41) Bombesin-like receptor GCGR LTB4 XCL1 GPRC6A GNAQ TRHR OLEA GNA15 PTAFR XCL2 FFAR1 ligands NMB(47-56) HCRTR2 GRPR QRFP TBXA2R GRK5TXA2 QRFPR PLCB2 H+ G-protein alpha(q/11):PI3K alphaADRA1D DecS-GHRL-1(24-51) TAC1(58-68) Ribosomal protein S6kinaseBDKRB1 BRS3 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)PROKR2 GNG4 UTS2B NMBR UTS2 GNG2 LPAR1 RGS3 GNA15 MT-RNR2 ANXA1 NTS(151-163) HCRTR1 LPAR6 PAF LPAR2 PROK2 pH sensing receptors PROKR1 EDN1 GTP P2RY10 GNA11 ADPGNB4 GPRC6A P2RY2 GNG2 GPR17 LTB4R AGTR1 PIK3R3 GNAQ PRKCAXCL2 LXA4 RGS18 PIK3CA PIK3R1 DDCX NMUR1 FPR2 GPR17 GPR68 GRB2:SOS1:HB-EGF:p-6Y-EGFRPentadecanoic acid TRH(227-229) GNA14 MLNR EDN2 GNG3 NPFFR1 TAC1(98-107) GCGR CCL23-2 Photon GAST(76-92) EtCOO- or C2H5COO- GNA15 ATP HTR2A HBEGF(63-148) GNA11 FFAR3 GPR4 RGS21 SAA1(19-122) Acyl Ghrelin NTS(151-163) RGZ TXA2 MMP3LTE4 AGT(34-41) Pentadecanoic acid PMCH(147-165) PROK2 F2RL3(18-385) Ca2+ ADP CHRM5 GDP GNA11 ADRBK1 OXTR AVP(20-28) LPAR2 GNG8 GNG11 AVP(20-28) PLC beta:G alpha(q/11)CHRM5 HBEGF(20-208)TAC3 P2RY1 F2RL2(22-374) NMS P2RY6 NMB(47-56) GNG10 GNB5 GNB5 P2RY11 PGE2 GPR68 Bradykinin NPFF(69-76) OXTR NMU PTAFR XCL1 PLCB1 GNA11 CYSLTR1 GNA15 BDKRB2 GNA11 TACR3 GNB1 PMCH(147-165) GPRC6A ANXA1 ATP CCK GNB5 PROKR2 GNG12 NMBR UTS2B F2RL1(37-397) PLCB1 ADRA1A GNAQ HTR2C NPSR1 NMUR2 GNGT2 Photon GNRHR TACR1 GAST(76-92)MMP3(100-477)LXA4 H+ HCRT(34-66) GNRH ligands GTPL-Glu HTR2A-C PTAFR HCRT(34-66) F2RL3(18-385) HCRT(70-97) RGSL1 Ligands of GPCRsthat activate Gq/11NPS Valerate NMS p-4S,T231,T365-RPS6KA3 KISS1(68-121) CCKAR,CCKBR EDNRA,EDNRB NMS NPFFR1 MLNR FFAR1 GNA15 EDN3(97-117) HBEGF(149-208)NMUR2 ADRA1B Ca2+ QRFP FPR2 LTE4 MT-RNR2 GNG2 PGF2a HCRTR2 GRM1 LPAR1 PTGER1 PTGFR P2RY10 GNA15 OLEA PGE2 HCRTR1 p-4S,T359,T573-RPS6KA1 F2RL3(18-385) GNGT2 NMBR LXA4 GAST(76-92) PLCB3 GNAQ P2RY6 GDP CCKBR GNG7 OXTR XCR1 HCRT(70-97) Basic L-amino acids NPSR1 AVPR1B TACR2 CHRM5 GNB4 HRH1 FFAR3 TRH(114-116) MCHR2 AVPR1B GPR65 CASR TRH(227-229) I(1,4,5)P3TRH(135-137) GRB2-1:SOS1Hist TRHR GDPCa2+ LPAR5 p-6Y-EGFR PGF2a AGTR1 EtCOO- or C2H5COO- HBEGF(20-62)P2RY6 Proteinase-activated receptors BUT AVP(20-28) GNA14 CCK TBXA2R AcCho NTS(151-163) CCKAR DAGGNB2 FFAR3 ligands SAA1(19-122) Protein Kinase C,alpha type: DAGP2RY11 OPN4 GNA14 GRB2-1 LPAR1 GNAQ CYSLTR1,CYSLTR2 KISS1R TRHR GNA14 TRH(152-154) AVPR1B Hist GNG11 GNG5 NMUR1 DecS-GHRL-1(24-50) GAST(76-92) HB-EGF:p-6Y-EGFRdimerGHSR GNA11 HBEGF(63-148)UTS2R EDN1 p-T185,Y187-MAPK1 NMU UDP MCHR1 5HT HCRTR1 BDKRB2 CYSLTR2 GNA15 GNA14 P2RY2 GNB3 GCG(53-81) Ligand:GPCRcomplexes thatactivate Gq/11Bradykinin receptor CCKAR G-protein alpha(q/11)L-Glu MT-RNR2 GNAQ p-T202,Y204-MAPK3 ATPGRPR PROK1 GPR17 O-octanoyl-L-serine-GHRL-1(24-50) TXA2 Photon AVP(20-28) GNG7 CASR CCL23-2 SOS1 TAC3 HBEGF(63-148) GRP(24-50) GNRHR AcCho GPR68 ATP GNG10 GRB2-1 GNG2 GNB2 p21 RAS:GDPTXA2 XCL1 KISS1(68-121) LTB4R NPSR1 BDKRB1 Ca2+ NMB(47-56) TRIO NPFF(69-76) NPFF(69-76) P2RY11 MCHR1 FFAR2 LTB4 O-octanoyl-L-serine-GHRL-1(24-50) NTS(151-163) UTS2B F2RL2(22-374) NPS GCGR TAC1(58-68) CHRM1, 3, 5 GNG11 HTR2C p-S133-CREB1LPAR4 ADR EGFROPN4 Phospho-Ribosomalprotein S6 kinaseEDNRB GNA11 FPR2 NPSR1 ARHGEF25 G-protein alpha(q):GRK2HRAS XCL2 GTP O-octanoyl-L-serine-GHRL-1(24-50) PALM LPAR2 GNGT2 GNG12 NTSR2 P2RY6 EDN3(97-117) TRH(114-116) CYSLTR2 CHRM1 LPA QRFPR GNG8 NPFFR2 PI(4,5)P2GNG4 KALRN PAF P2RY1 NTSR1 thrombin heavy chain TRH(186-188) LPAR6 GNG11 5HT XCL1,XCL2 ANXA1 GNG7 ATP P2RY2 ADRA1B Hist TACR3 Bradykinin GNG5 ADR GNG3 CHRM3 PAF LPA GAST(76-92) thrombin light chain CCKBR BDKRB2 Valerate EDNRB CYSLTR1 CCKBR GTP UDP PGE2 O-octanoyl-L-serine-GHRL-1(24-51) KISS1(68-121) Valerate GRM1 PTGER1 GPR132 ADRA1D GnRH receptor APP(672-713) GRM5 H+ GNAQ p-4S,T356,T570-RPS6KA2 QRFP PROK1 LTC4 TAC3 CYSLTR2 GRM1,GRM5 GNG13 NPFFR1,NPFFR2 TACR1 BRS3 ADRA1B GNAQ DecS-GHRL-1(24-50) GNAQ Bombesin-like peptide GNRH2(24-33) HCRT(70-97) PROKR1 PALM NPS p-6Y-EGFR EDN3(97-117) PLCB2 AVPR1A,B UTS2,UTS2B PROK1 GNA15 HTR2B GPCRs that activateGq/11Basic L-amino acids EDNRA HCRT(34-66) FFAR2 ligands FPR2 ligands HTR2B GPR132 PTGER1 GTP GNA11 MCHR1 LPAR4 TAC1(98-107) G-protein alpha(q/11): GTPBDKRB1 Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)LPAR3 LPA FFAR1 HCOOH 5HT PTGFR DDCX GNRH1(24-33) AVPR1A CASR NMUR1,NMUR2 TAC1(98-107) BUT AGT(34-41) GNGT1 thrombin light chain CHRM3 ADR GNA14 KISS1R GNA14 GNA14 HTR2C Photon AcCho PROKR1,PROKR2 GRP(24-50) LTD4 GNA14 P2RY10 KISS1R p-ERK1/2/5F2R(27-425) LPAR6 NPFFR1 thrombin heavy chain GRM5 GNG13 ADRA1A GDP APP(672-713) PROK2 QRFP GRM1 HRH1 GNG3 F2RL2(22-374) KALRN XCR1 EDNRA HXA UTS2 OXT(20-28) PLCB4 F2RL1(37-397) TRH(84-86) HCOOH AGTR1 HXA GAST(76-92) GNB1 ADP TRH(114-116) CCKBR LTD4 TACR1 ADRBK1XCR1 GNAQ G-protein beta-gammacomplexMLN(26-47) MCHR2 GNB1 OXTR TACR1 CHRM1 ADP thrombin heavy chain XCR1 CH3COO- NAd TRIO family RhoGEFsGNAQ TACR3 TRIO TRH(186-188) GNG4 AVPR1A PTAFR GPRC6A ligands LTB4 PLCB4 p21 RAS:GTPMLN(26-47) LPA EDNRA GNG5 PTGFR PIK3R1 PI3K alphaGPRC6A BUT LPAR1,2,3,5 NMUR2 MLNR GNG12 ADRA1A,B,D P2RY11 GHSR EtCOO- or C2H5COO- TRH(135-137) F2RL1(37-397) GNRH1(24-33) PGF2a GTP Cysteinyl leukotrienes LTB4R2 GRK5 FFAR2 GNRHR2 HCRT(34-66) GTPADR, NAd NMUR1 GNRH2(24-33) GRPR TRH(84-86) TRH(152-154) GNG10 CCKAR APP(672-713) GNG13 TRH(186-188) GPR132 HCRTR2 GNB2 LPAR4 PLCB3 UDP NAd CH3COO- UTS2R Effects of PIP2hydrolysisNTSR2 KISS1(68-121) P2RY1 PGF2a TACR2 NMU GCGR KRAS G-protein alpha(q/11):Trio familyRhoGEFsGNB1 EDNRB GTP GNA14 ADP Basic L-amino acids GNGT1 HCRTR2 CHRM3 GNG4 LPAR3 DecS-GHRL-1(24-51) GNGT2 thrombin light chain FFAR2 LPAR3 p-T218,Y220-MAPK7 LTB4 SAA1(19-122) NMS RAF/MAP kinasecascadeGNGT1 OPN4 TBXA2R NMUR2 O-octanoyl-L-serine-GHRL-1(24-51) CCKBR GNB4 LPAR4 GNG8 PRKCA MCHR1,MCHR2 GHSR 5HT NPS GNA15 NMU TRH(84-86) HCRTR1 PROK1,PROK2 GNG10 CCK F2R(27-425) GNA11 TACR3 AcCho G-protein alpha(q/11):GDPGRP(24-50) CH3COO- thrombin light chain PGE2 FPR2 GPR17 TRH HeterotrimericG-protein Gq/11(inactive)GNRHR2 UTS2R H+ OLEA GDP CCL23-2 DAG ADRA1A P2RY10 NRAS NPFFR2 LTB4R2 GPR65 TBXA2R GCG(53-81) PLC-betaOXT(20-28) TRHR GNG13 Bradykinin L-Glu Gastrin:CCKBRGNB2 TAC1(58-68) GNA11 GNB3 NTSR1 DecS-GHRL-1(24-51) HTR2A CHRM1 G-protein alpha(q):GRK5LTC4 ADRA1D GNB3 QRFPR OXT(20-28) TAC1(58-68) O-octanoyl-L-serine-GHRL-1(24-51) Hist FFAR3 PROKR2 GNRHR2 AGTR1 RPS6KA1 P2RY2 FFAR1 LTC4 RGZ RGS19 L-Glu HRH1 ADPLPAR6 BRS3 GNA15 RGS proteins activefor G alpha (q)EDN2 RGZ NTSR1,NTSR2 NTSR2 HCOOH GNB3 HCRT(70-97) MLN(26-47) EDN2 GDPSOS1 GNRH2(24-33) PTGFR P2RY1 HXA NTSR1 RGS2 GNA14 AVPR1A PIK3R3 EDN1 ARHGEF25 GNRH1(24-33) GNG5 Endothelin CASR TAC3 PIK3R2 UTS2R CCKBRGNG3 PAF GNB4 LTE4 KISS1R FFAR2 Bradykinin GNB5 CCK LPAR5 QRFPR RPS6KA2 PIK3CA GNG7 15, 5415, 5425, 4015, 54885, 1915, 5415, 5414, 16, 37, 5015, 543, 4, 7, 20, 26...15, 5415, 54