Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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22, 23, 4353304113, 191521, 40503129282, 5645, 5436, 4737324, 27, 28, 34, 3886, 39329nucleoplasmcytosolNTSR1,NTSR2 FFAR2 P2RY10 RPS6KA2 GNRHR2 TAC1(98-107) CASR GRM1 GNG13 CH3COO- CCKAR GNG3 GHSR GNB3 ADPH+ NMU HeterotrimericG-protein Gq/11(inactive)NPFFR1 F2RL3(18-385) BUT RPS6KA1 OLEA HTR2C TACR2 GAST(76-92) GPRC6A ligands TRH(152-154) Photon GAST(76-92) GNA15 GNRH1(24-33) TRH(84-86) p-ERK1/2/5QRFP NPFFR2 KRAS MCHR2 HCRTR1 GNB5 PROKR1 UTS2 NPSR1 GNG2 GDP PTGFR GPRC6A MCHR1 BRS3 AVPR1A PIK3R2 thrombin light chain FFAR1 NTSR2 TACR1 GTPRGZ GNG4 TBXA2R NPFFR2 BRS3 HTR2A-C LTC4 NTS(151-163) TRH(227-229) EDNRA RGS3 TRH(114-116) EtCOO- or C2H5COO- ADRBK1 TRHR TRHR Acyl Ghrelin BDKRB1 F2RL2(22-374) BDKRB2 MLN(26-47) FPR2 GNA14 FPR2 ligands MLNR GNA14 NMU GTP HTR2A PMCH(147-165) HCRT(34-66) p-4S,T359,T573-RPS6KA1 CHRM3 CHRM1 GRPR UTS2B GNG10 DDCX AcCho OLEA GNG8 LTB4R2 DAG RGS18 CCKBR KISS1(68-121) GPR17 HCRT(70-97) P2RY11 P2RY10 XCL1 LTB4 PALM NMUR2 UTS2 FPR2 PLCB4 P2RY11 Effects of PIP2hydrolysisATPGRP(24-50) EDNRA LPAR4 GNG8 TACR2 TAC1(98-107) HRH1 PIK3R3 GTP HBEGF(149-208)TRHR SAA1(19-122) PRKCA GNA11 GNA14 BUT Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)APP(672-713) LPAR3 DecS-GHRL-1(24-50) HRAS CH3COO- TRH(84-86) PIK3CA TRH(135-137) LXA4 GNGT2 HCRT(34-66) NPFFR1 LTC4 KISS1R CCK O-octanoyl-L-serine-GHRL-1(24-51) FFAR3 DAGP2RY6 GNRHR2 GTP GNG3 NMUR1,NMUR2 GAST(76-92) MMP3LPAR2 G-protein beta-gammacomplexthrombin light chain Valerate CYSLTR1 CCKBR BRS3 CH3COO- GRM1 PALM PTGER1 LTD4 LPA ADR G-protein alpha(q/11)PLC-betaGNAQ F2RL1(37-397) ATP LTB4 GNG13 GNB2 ATP GTP ADR HBEGF(63-148) NTS(151-163) UDP PGE2 GNG3 CASR BDKRB1 GNB1 NMB(47-56) AGT(34-41) GAST(76-92)thrombin heavy chain PTAFR DecS-GHRL-1(24-50) CHRM5 NTSR2 F2RL1(37-397) AGTR1 XCR1 TRH(227-229) GNA11 GNG2 GPRC6A GNG5 ADRA1A ADRBK1NTSR1 Ligand:GPCRcomplexes thatactivate Gq/11GRM1 LPAR1,2,3,5 GPR17 P2RY6 LTB4 CHRM1, 3, 5 UTS2B GNB3 AcCho DDCX PGF2a PLCB1 HRH1 G-protein alpha(q/11):GDPGNRH2(24-33) UTS2R GRM5 GNGT1 TXA2 AVPR1A NPFF(69-76) HB-EGF:p-6Y-EGFRdimerSAA1(19-122) O-octanoyl-L-serine-GHRL-1(24-50) PGE2 UDP GRP(24-50) GNG5 P2RY2 XCR1 OXTR PTGER1 F2R(27-425) HBEGF(20-208)Catecholamine PROK2 GPR65 L-Glu CREB1LTB4R KISS1R LTB4R,LTB4R2 L-Glu HCRT(34-66) TRH(135-137) RGZ PIK3R1 ANXA1 p-6Y-EGFR GRM5 Hist LTD4 MLN(26-47) TACR1 CCKBR KISS1(68-121) GNG8 QRFPR PTAFR AGT(34-41) LTB4R2 QRFP MLNR Ca2+ GRK5 EtCOO- or C2H5COO- PTAFR PTGER1 p-T202,Y204-MAPK3 PTGER1 GNGT1 AcCho SAA1(19-122) O-octanoyl-L-serine-GHRL-1(24-51) PLCB3 GNG5 GCG(53-81) GNG2 GNA14 GNG12 QRFPR TRH(186-188) F2R(27-425) EDNRB UTS2R LPAR6 NPFFR2 ADR Bradykinin 5HT H+ PROKR2 NMU LPAR6 GHSR LTE4 TRH(84-86) GNA14 PROKR1 HBEGF(63-148) GNRHR FFAR3 NMB(47-56) Endothelin TACR1 SOS1 TRH NMBR FFAR3 GRB2-1 GCG(53-81) XCR1 GPR4 Photon RGS19 EDN1 CYSLTR2 ADRA1B HCRT(70-97) EDN2 GNA15 AGT(34-41) NMS LPAR2 HBEGF(63-148)thrombin heavy chain CASR GNA14 KRAS LTB4R2 GTP GPR17 LPAR5 TRH(114-116) G-protein alpha(q):GRK2NPSR1 LPAR6 ATP GNB2 GNG11 GTP MCHR2 L-Glu GRB2:SOS1:HB-EGF:p-6Y-EGFRG-protein alpha(q/11): GTPPI3K alphaGRB2-1:SOS1Pentadecanoic acid FPR2 RAF/MAP kinasecascadeGNA11 Photon NMUR1 LPA P2RY11 ADRA1A Basic L-amino acids GNA15 GNG4 OPN4 Bombesin-like peptide TBXA2R GRPR GnRH receptor EDN2 RGS proteins activefor G alpha (q)GNAQ KISS1(68-121) KALRN PI(4,5)P2BDKRB2 FFAR1 LPAR3 NMUR2 CYSLTR1 TXA2 ATP GNG12 LTE4 KISS1R p21 RAS:GTPNTS(151-163) GRB2-1 Bradykinin AVPR1A ADRA1B DecS-GHRL-1(24-50) P2RY6 GNB1 p-6Y-EGFR GNG8 GDPGDPCYSLTR1 TRH(227-229) LTB4R TAC1(98-107) UTS2R CHRM3 LTD4 BDKRB1 GNA14 NTSR2 thrombin heavy chain thrombin heavy chain NMUR1 MCHR1,MCHR2 TAC3 NMUR2 HCRT(70-97) DDCX PGE2 PROK2 LTC4 TACR3 AVPR1A,B GNB2 GNRH2(24-33) GCGR HTR2B SOS1 CASR p-T218,Y220-MAPK7 MT-RNR2 RGS2 APP(672-713) FFAR2 KALRN GNA15 Ribosomal protein S6kinaseTRHR GNA11 NMUR2 FFAR2 LTB4 GNGT1 GNB3 OXT(20-28) GCG(53-81) ANXA1 PROKR2 Basic L-amino acids ADRA1D TXA2 MLNR GNG13 HCRTR1 GNG10 GNAQ XCL1 UDP HCRTR2 PTGFR NPS P2RY10 GNB2 AVP(20-28) UTS2,UTS2B GPR17 GNG12 Ca2+ LPAR4 Hist GNRHR NTSR1 CHRM5 GNG11 HTR2B GNGT2 NAd NPS OPN4 GNA15 XCL1,XCL2 EDN3(97-117) ADRA1A GPR65 MT-RNR2 GPRC6A EDN3(97-117) PIK3R3 Cysteinyl leukotrienes PTAFR NMS LTB4R GPR65 GNA14 NPSR1 DecS-GHRL-1(24-51) HTR2A LPAR6 LPAR1 GRP(24-50) O-octanoyl-L-serine-GHRL-1(24-50) PLCB3 p-T185,Y187-MAPK1 PROK1,PROK2 FFAR1 CCK NTS(151-163) Basic L-amino acids GNA15 GNB4 Proteinase-activated receptors NPFF(69-76) CHRM1 Hist GNAQ MCHR2 PIK3R2 5HT P2RY1 F2R(27-425) UTS2 FFAR2 FFAR3 ligands p21 RAS:GDPANXA1 PLCB2 P2RY6 GAST(76-92) FFAR1 GNG5 GNRH1(24-33) ADRA1A,B,D EDNRB CCL23-2 OXTR PMCH(147-165) TAC3 GNRH1(24-33) DecS-GHRL-1(24-51) QRFP GNA11 GNA11 NMUR1 TBXA2R HCRT(70-97) GNAQ CHRM3 GRPR TAC1(58-68) OPN4 RGZ GPR132 AVP(20-28) XCL2 BUT ADP P2RY2 LTE4 GNA11 NPFFR1 GPR4 Hist GNB5 PAF NAd HTR2B I(1,4,5)P3LPAR5 GNG4 TRIO GNRH2(24-33) TXA2 ADRA1B pH sensing receptors Bradykinin CCKAR PLCB1 Ca2+ LPAR5 p-S133-CREB1thrombin light chain P2RY10 HCRT(34-66) PTGFR GNA15 Gastrin:CCKBRGNB4 HRH1 RPS6KA3 LPAR1 PALM MLN(26-47) GNA14 5HT GNGT2 PGE2 GTP TRH(186-188) CCL23-2 GPR68 OLEA F2RL3(18-385) GNAQ PGF2a PROK1 GPR132 NMBR GPR68 O-octanoyl-L-serine-GHRL-1(24-51) GPCRs that activateGq/11LPA PROKR2 EDN3(97-117) CCKAR NPFF(69-76) GNA14 UTS2R GNG7 GNG7 TRH(152-154) NMU Ligands of GPCRsthat activate Gq/11F2RL1(37-397) HCRTR1 ADRA1D GCG(53-81) QRFP TRH(186-188) HCOOH HTR2C TRIO GNG7 OXTR ARHGEF25 NPS GNG10 P2RY2 XCR1 TAC1(58-68) TAC3 CCKBRPLCB4 HRAS FFAR1 ligands OPN4 CCL23-2 GNG11 XCL2 PIK3R1 G-protein alpha(q/11):PI3K alphaEDNRA GPR4 NPFFR1,NPFFR2 GNA14 TRH(135-137) GNB3 P2RY1 CYSLTR1,CYSLTR2 MCHR1 FFAR3 PROKR1 PGF2a ADP QRFPR GNG7 KISS1(68-121) TACR2 GNAQ HXA AVPR1B OXTR ATPADP GDP P2RY1 BDKRB2 PROK1 NPSR1 GNB1 EDN2 LPAR1 GNB4 NPS DecS-GHRL-1(24-51) F2RL2(22-374) AGTR1 GCGR GNA15 Photon HTR2C HCOOH CCKBR GNA11 OXT(20-28) NPFF(69-76) LPAR4 QRFPR HCRTR2 GNA11 GPRC6A NRAS GNA11 GTPMT-RNR2 G-protein alpha(q/11):Trio familyRhoGEFsG-protein alpha(q):GRK5LPA EDNRB GNB5 F2RL2(22-374) NAd GNG10 TAC1(58-68) PMCH(147-165) GNGT1 PAF HXA TAC1(58-68) ADPTAC3 LPAR2 L-Glu GNB5 CCKAR,CCKBR CYSLTR2 GRM5 NMS GRM1,GRM5 Bradykinin receptor GCGR GNG13 HBEGF(20-62)GTP MCHR1 AVP(20-28) PROK2 PLCB2 GNG4 PROK1 P2RY11 H+ GNB1 EDN1 thrombin light chain TRIO family RhoGEFsNTSR1 AVP(20-28) GNAQ Bradykinin HCOOH PAF MLN(26-47) APP(672-713) LPAR3 FFAR2 ligands GNAQ AVPR1B Pentadecanoic acid O-octanoyl-L-serine-GHRL-1(24-50) EtCOO- or C2H5COO- GNG2 KISS1R EGFRHRH1 Ca2+ GDP HCRTR1 TACR2 GHSR CYSLTR2 TBXA2R PLC beta:G alpha(q/11)PAF TRH(114-116) GNB4 GNRH ligands NMB(47-56) GNA11 AGTR1 TACR3 GRK5Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)HCRTR2 PMCH(147-165) GNRHR2 ADRA1D GNA15 CCK HTR2A Bombesin-like receptor MLNR F2RL3(18-385) TACR3 NMS GNRHR H+ UTS2B AVPR1B GAST(76-92) NMBR p-4S,T356,T570-RPS6KA2 LPAR4 GHSR CCK Valerate Protein Kinase C,alpha type: DAGGNAQ 5HT GCGR CHRM1 ARHGEF25 RGS21 LXA4 Valerate PTGFR OXT(20-28) GPR132 AGT(34-41) PGF2a TRH(152-154) LXA4 Phospho-Ribosomalprotein S6 kinaseNRAS P2RY1 XCL2 UDP GPR68 HCRTR2 PRKCAGNG3 P2RY2 GNAQ FPR2 GNA15 ADP GNG11 TAC1(98-107) EDNRA,EDNRB OXT(20-28) GNA15 Pentadecanoic acid GDP GNGT2 XCL1 AGTR1 CCKBR TACR3 HXA CHRM5 AcCho EDN1 TACR1 PROKR1,PROKR2 p-4S,T231,T365-RPS6KA3 PIK3CA GNG12 251, 4, 5, 7, 12...10, 5133, 5733, 5733, 5733, 5733, 5733, 5711, 1733, 572516, 42, 46, 4933, 57