Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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11, 26, 5528125, 45408, 442723223219, 4221, 392, 9, 24, 35, 46415174814213, 3616, 52cytosolnucleoplasmOXTR BUT P2RY6 p-4S,T359,T573-RPS6KA1 AVP(20-28) TACR3 LTC4 GTP GNB3 Valerate Basic L-amino acids GNG7 O-octanoyl-L-serine-GHRL-1(24-50) GPCRs that activateGq/11p-T185,Y187-MAPK1 DecS-GHRL-1(24-50) L-Glu GNA14 NTSR1 thrombin light chain HCOOH Phospho-Ribosomalprotein S6 kinaseFFAR2 GNRHR2 NPFF(69-76) DecS-GHRL-1(24-51) KISS1(68-121) TRH(84-86) Ca2+ DecS-GHRL-1(24-51) GNG3 AVPR1A PROKR1 CREB1XCL1 NTSR2 GDPNMS OXT(20-28) Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)PROK2 DDCX PROK1 GNG5 GNA15 QRFP EDN2 NMUR2 BDKRB2 P2RY1 GNA11 PGF2a pH sensing receptors HCRT(70-97) TAC3 RPS6KA2 EtCOO- or C2H5COO- GNG8 LTE4 NTSR2 BDKRB2 P2RY1 CYSLTR1 OXT(20-28) TRH(135-137) LXA4 PRKCA NPSR1 HXA GNA14 FFAR1 TRH(152-154) NMU CHRM1 thrombin heavy chain CHRM5 TRH(227-229) LPA-binding EDG receptors TRIO family RhoGEFsTAC1(58-68) TRH(186-188) PI3K alphaGNG2 GNA15 5HT NMUR1 thrombin heavy chain p-ERK1/2/5ADRA1D ADRA1A Bradykinin OLEA GNG13 CH3COO- CHRM3 FFAR2 GNG11 TACR1 HBEGF(63-148)Protein Kinase C,alpha type: DAGGDP LPAR3 LPAR1 OXTR F2RL3(18-385) Glucagon MLNR TAC1(98-107) RGZ GTP DDCX CCL23-2 PLCB2 CASR G-protein alpha(q/11):GDPRAF/MAP kinasecascadeNMBR LXA4 Photon GNG11 Neurotensin receptor TACR3 AVPR1A,B GNA14 GNA15 HB-EGF:p-6Y-EGFRdimerTRH(152-154) KISS1(68-121) HBEGF(149-208)GNAQ Effects of PIP2hydrolysisHCOOH GRP(24-50) KISS1R LTB4R2 O-octanoyl-L-serine-GHRL-1(24-51) p21 RAS:GDPValerate PROKR1 PIK3R3 NPS(1-467) MT-RNR2 GNG12 HCRTR2 NTSR1 CYSLTR1 LPAR2 FPRL1 ligands PMCH(147-165) GPR68 GNA11 OPN4 AVP(20-28) NRAS GNG7 G-protein alpha(q/11): GTPDecS-GHRL-1(24-51) HBEGF(20-62)LTB4R GNG4 PAF FFAR3 CCKAR EDN1 BDKRB2 Valerate GDP RGZ PAF CYSLTR2 LPAR4 Hist GNA15 PLCB3 GRK5 PGE2 LPA TAC1(98-107) GNB3 GNB5 LPA GNA15 Hist SOS1 HCRT(34-66) P2RY10 PTGFR GNG7 Cholecystokinin receptors CHRM1 GNB2 BRS3 GRPR PTGER1 XCL2 O-octanoyl-L-serine-GHRL-1(24-51) ADRA1B HCRT(70-97) PGE2 NMB(47-56) TRHR TRH(135-137) GNAQ GNG5 EDN2 GNGT2 ADR GTP HCRTR1 GRP(24-50) Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)TACR2 LPAR1 OPN4 TAC3 5-HT2 receptor OLEA Ligands of GPCRsthat activate Gq/11CHRM3 CH3COO- PTAFR PLCB4 HTR2B GNA14 AVPR1B FFAR1 GNA11 GNB4 LTD4 P2RY1 NTS(151-163) GRB2-1 KISS1(68-121) MCHR2 QRFP Ca2+ NMBR GNGT2 LPAR4 TRHR F2RL2(22-374) PAF F2RL1(37-397) EGFRGNRH ligands UTS2B H+ GNA14 PI(4,5)P2TAC1(58-68) TACR1 TACR3 AGT(34-41) HCRTR2 NPS(1-467) EtCOO- or C2H5COO- G-protein alpha(q/11):PI3K alphaAPP(672-713) GRB2:SOS1:HB-EGF:p-6Y-EGFRGNA11 HTR2C CYSLTR2 TRH(227-229) Neuropeptide FF receptor EDN1 LPAR3 GNG11 XCR1 MLNR GRPR TACR1 XCL1 Prokineticin receptors TBXA2R GNA14 HXA XCL2 XCR1 p-S133-CREB1PAF GNB4 CHRM3 KISS1(68-121) PMCH(147-165) GNA11 GNGT2 CASR GNG5 GNG2 GNB1 NPSR1 TRH(114-116) F2RL1(37-397) ANXA1 FFAR1 P2RY6 NTSR2 Hist Hist GNRH1(24-33) DecS-GHRL-1(24-50) UTS2R L-Glu P2RY6 O-octanoyl-L-serine-GHRL-1(24-50) CCK PROKR1 G-protein alpha(q/11)PROK2 KRAS GNRH2(24-33) GHSR BRS3 LTB4 TAC3 HRAS Urotensin 2, 2B BDKRB1 GPR68 SOS1 CASR TRHR GPR132 TXA2 PRKCAEDNRA CCKBR NAd OXTR EDNRB GNA11 AcCho G-protein beta-gammacomplexLTB4R HBEGF(63-148) PTGER1 LTC4 RGS proteins activefor G alpha (q)HRAS TACR1 GNA15 LTB4 receptors LTB4 NPSR1 GNA11 PROK1 P2RY6 Photon GNB5 GNGT1 GNA15 NMS GNG3 p-6Y-EGFR GNA14 PIK3R2 GRB2-1 PALM CCL23-2 GNAQ Ca2+ GRM5 Glucagon F2RL3(18-385) ADR EDN3(97-117) RGS2 GNG8 TBXA2R Catecholamine LTE4 Bradykinin P2RY10 EDNRB RGS18 GNG4 LPAR3 ARHGEF25 CHRM5 Pentadecanoic acid LTB4R2 NMU CCKAR LTD4 LPA GNB1 CCK LPAR2 GTP HCRT(34-66) p21 RAS:GTPAcCho P2RY1 NAd O-octanoyl-L-serine-GHRL-1(24-51) OPN4 GNB2 NRAS GNG11 AGT(34-41) RPS6KA3 CCKAR TRH(135-137) TAC1(58-68) TACR3 FFAR1 ADRA1D CYSLTR2 CHRM1 PLC-betaHCRT(70-97) PGF2a PTGER1 GRM5 Group I Metabotropic glutamate receptors NPFFR1 NMU OXTR CH3COO- PTGFR UTS2B CYSLTR1 NPFFR2 P2RY2 GNB5 AVPR1B TXA2 GNRHR HBEGF(63-148) LTC4 ATPGPR17 RGS21 KISS1R CCKBR GNA14 G-protein alpha(q):GRK5ATPTRH(152-154) GNAQ NMU BUT TAC1(98-107) GNB4 Ligand:GPCRcomplexes thatactivate Gq/11F2R(27-425) CASR APP(672-713) UTS2R EDN3(97-117) HRH1 GPRC6A ligands TRH(186-188) GNB3 OXT(20-28) GNG13 PLCB2 MLNR P2RY10 P2RY11 QRFP PROKR2 Glucagon GNB5 ADP Carboxylate ligands of FFAR3 LPAR1 GNB1 CCK Photon HTR2C GNRH2(24-33) HCRTR1 ADRA1B GNGT1 GNRHR CCKBRGNG12 HTR2A Ligands of FFAR1 (GPR40) GCGR GNG3 NPS(1-467) FPR2 ADR H+ GPR17 EDN2 FPR2 PIK3R1 Endothelin XCL2 GRM1 CCKBR TAC1(58-68) H+ GNG2 UTS2R MCHR1 5HT P2RY11 LPAR5 NMBR MCHR2 PLCB1 ADPCarboxylate ligands of FFAR2 Pentadecanoic acid GPRC6A HCRT(34-66) EDN3(97-117) G-protein alpha(q):GRK2AGTR1 PTAFR NTS(151-163) ADRA1A HTR2C RGS19 NMS PIK3CA ADP LPAR6 F2RL1(37-397) DDCX BUT Acyl Ghrelin GDP APP(672-713) GTP OPN4 NMS Pentadecanoic acid GNGT2 AVPR1A GnRH receptor ANXA1 SAA1(19-122) F2RL2(22-374) L-Glu HCRT(34-66) AVPR1A MCHR1 XCL1 GNAQ GNAQ GRM5 GPRC6A thrombin light chain ADRBK1 ADRA1D Bradykinin TACR2 GCGR EtCOO- or C2H5COO- GHSR ADP MLN(26-47) HCOOH P2RY2 UDP CCK GNAQ NTSR1 GPR132 AVP(20-28) Bombesin-like peptide QRFPR HTR2A GNRHR GDP LTB4 GNG8 G-protein alpha(q/11):Trio familyRhoGEFsAVPR1B LTD4 NAd Melanin-concentrating hormone receptors AcCho Basic L-amino acids PLCB4 TBXA2R LTB4 PGF2a Glucagon HCRTR2 QRFP GNG3 HeterotrimericG-protein Gq/11(inactive)AGT(34-41) HTR2B p-4S,T356,T570-RPS6KA2 LPAR5 RGZ TRH(227-229) GNG2 GNRH1(24-33) GNG12 PTGFR GNA15 TRH(114-116) SAA1(19-122) GAST(76-92) FFAR2 thrombin light chain PIK3R1 PTAFR UTS2 GHSR BDKRB1 GAST(76-92) PMCH(147-165) Bradykinin receptor GAST(76-92)LPAR4 UTS2R FPR2 Basic L-amino acids NTS(151-163) GRK5FFAR3 GNG10 GNG10 TRH(84-86) L-Glu Bradykinin PGE2 Proteinase-activated receptors HRH1 Cysteinyl leukotrienes TRH TRH(114-116) GPR65 GNRHR2 GTP GNG10 PTGER1 GNA11 PROKR2 GNG13 UDP TRHR NPFF(69-76) NPFFR1 GAST(76-92) GNA14 GTPH+ GCGR SAA1(19-122) GNGT1 MLN(26-47) GTP PIK3R2 LXA4 Gastrin:CCKBRGPR132 HCRTR2 ADRBK1NPS(1-467) GTPLPAR6 Endothelin receptor NMUR2 GPR68 PROK2 PTAFR P2RY2 XCR1 GNG10 TAC1(98-107) NPFF(69-76) ARHGEF25 GPR4 ATP F2RL2(22-374) p-4S,T231,T365-RPS6KA3 UDP GNA15 LPAR6 CHRM5 UTS2 PROK1 GNB2 EDNRB LPAR5 GDPPROKR2 MCHR1 thrombin heavy chain NMB(47-56) TXA2 PIK3CA Ca2+ GNRHR2 GPR65 Neuromedin-U receptors GNAQ F2R(27-425) HCRT(70-97) GCGR XCR1 PTGFR GNAQ GPR17 Ribosomal protein S6kinaseGNAQ AGTR1 GPR17 KALRN GNA11 LPAR4 ANXA1 AGT(34-41) thrombin heavy chain HTR2A GNG13 TACR2 NMUR1 GNB4 QRFPR GPR4 TACR2 NPFFR1 LTB4R GNA14 Bombesin-like receptor FPR2 CCKBR AGTR1 GRM1 GNA11 HRH1 TXA2 GNB3 p-6Y-EGFR GNA15 NMUR2 ADP UTS2B PLC beta:G alpha(q/11)GNG8 UTS2 F2RL3(18-385) PMCH(147-165) GNB2 EDNRA PGF2a KALRN HCRTR1 LPA GNA14 AcCho GPR65 QRFPR Prokineticin KISS1R LTB4R2 GAST(76-92) GNG4 ATP PALM MCHR2 HXA GNG5 LPAR2 GRB2-1:SOS1HTR2B TBXA2R RPS6KA1 OXT(20-28) NPFF(69-76) O-octanoyl-L-serine-GHRL-1(24-50) CCKBR LTE4 PLCB3 MLN(26-47) NPSR1 AGTR1 ATP BRS3 GNAQ CHRM1, 3, 5 NPFFR2 GTP GRP(24-50) P2RY11 NMUR1 AVP(20-28) HRH1 TRIO GPRC6A 5HT Alpha-1 adrenoceptor TRH(186-188) thrombin light chain NPFFR2 GRM1 GNRH2(24-33) DecS-GHRL-1(24-50) OLEA ATP GNA11 BDKRB1 p-T218,Y220-MAPK7 Photon NMUR2 GPRC6A FFAR3 HBEGF(20-208)GNG4 GNRH1(24-33) Cysteinyl leukotriene receptors ADRA1A TRIO DAG MT-RNR2 FFAR3 QRFPR F2R(27-425) GHSR GRPR XC1 ligands TRH(84-86) MT-RNR2 ADPKRAS LPAR6 MLN(26-47) P2RY10 GAST(76-92) P2RY11 MMP3GNG7 UDP DAGCCL23-2 PLCB1 P2RY2 GNGT1 NTS(151-163) KISS1R PGE2 I(1,4,5)P3PALM GNA15 GNG12 MLNR NMB(47-56) EDN1 HCRTR1 GPR4 ADRA1B 5HT EDNRA TAC3 FFAR2 p-T202,Y204-MAPK3 PIK3R3 GNB1 10, 3010, 301, 37, 5410, 3010, 302034, 4310, 3025, 4110, 3010, 303, 6, 7, 18, 29...10, 3020