Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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6, 31, 501217, 19, 24, 41, 422026315, 4328, 4991475, 1416, 273748, 521339242, 463525nucleoplasmcytosolHist SOS1 NMUR1 ADPXCL1 ADR HCRTR1 PROKR2 GPR4 PIK3CA Pentadecanoic acid G-protein alpha(q):GRK5GNA11 XCL1 TACR2 TRH(114-116) AVP(20-28) GPR17 p-6Y-EGFR LXA4 P2RY1 NMUR2 Glucagon PALM TACR3 PTAFR GNA11 AGTR1 PROKR1 HCRTR1 GNA14 UTS2B CHRM1 AcCho GPRC6A MLNR LTB4 NPFFR1 P2RY11 UDP ADRA1D GNAQ G-protein alpha(q/11)DecS-GHRL-1(24-50) GNA15 NPFFR2 GAST(76-92) RGS proteins activefor G alpha (q)NPFFR2 GRP(24-50) LPAR6 Ligand:GPCRcomplexes thatactivate Gq/11thrombin light chainGNRHR2 CCKAR KALRN ATP GDP Pentadecanoic acid HCRTR2 NMB(47-56) DAGF2RL2(22-374) TRH(186-188) XCR1 LPA CCK AVPR1A 5HT BDKRB2 F2R(27-425) ADRA1D CCKBR GNA14 EDNRB ADRBK1FPR2 P2RY1 FPR2 EDN3 PLCB2 PROKR2 HCRT(34-66) OLEA TRH(227-229) F2RL1(37-397) PI(4,5)P2OXT(20-28) CCKAR CYSLTR2 KRAS GTP EDN2 HXA HBEGF(149-208)PGE2 HRH1 GRP(24-50) NPS(1-467) DecS-GHRL-1(24-50) LTB4R UTS2 NPS(1-467) Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (active)PIK3CA LTE4 TRH(114-116) G-protein alpha(q/11):GDPTAC1(98-107) HCRTR2 ADRBK1 CYSLTR2 LTC4 Protein Kinase C,alpha type: DAGPAF LTB4R2 GNAQ TACR1 ATP UTS2R CHRM3 TRH(84-86) PROK1 KRAS GPR132 GCGR NMUR2 H+ GNAQ GNA11 GNRH1(24-33) F2RL2(22-374) NPFF(69-76) GNA14 SAA1(19-122) TXA2 P2RY2 AGT(34-41) HCOOH TAC1(58-68) AVP(20-28) UTS2 QRFPR PTGFR GNA14 GNRHR2 CCK GNA11 BDKRB2 O-octanoyl-L-serine-GHRL-1(24-50) Valerate GNRH2(24-33) G-protein alpha(q/11):PI3K alphaHTR2C PLCB1 MT-RNR2 GNAQ MLN(26-47) TXA2 ADP L-Orn Ligand:GPCRcomplexesthatactivateGq/11:Heterotrimeric G-protein Gq (inactive)GNA14 MLN(26-47) NTSR2 HCOOH EDN3 AGTR1 thrombin heavy chainHTR2C Ribosomal protein S6kinaseF2RL3(18-385) NAd KISS1R MMP3NTSR1 NTSR1 PROK2 CCKBR FFAR2 EDNRA NMU FFAR2 CHRM3 H+ PTGER1 GTP L-Orn ADRA1B EDN1 GDPLPAR6 CASR PAF XCL2 GRM1 CCKBRAGT(34-41) HCRT(70-97) CREB1GDP DecS-GHRL-1(24-51) DDCX Ligands of GPCRsthat activate Gq/11GRK5PGF2a GNAQ NPSR1 GNAQ GPR132 APP(672-713) XCR1 UTS2R GAST(76-92)ADPLPAR4 HBEGF(63-148) EDNRB BDKRB1 TACR1 GNA15 G-protein beta-gammacomplexp-S133-CREB1LTB4 GHSR GTP ATPNTSR2 PROK1 OXT(20-28) QRFPR GDPADRA1A TRH(186-188) GNA11 QRFP AVPR1B GNA14 GRM1 GNA11 O-octanoyl-L-serine-GHRL-1(24-50) HBEGF(20-208)GPR17 FFAR1 GTP PMCH(147-165) CYSLTR1 CYSLTR1 NRAS thrombin heavy chainBradykinin EGFRF2RL1(37-397) GRB2-1 KISS1(68-121) ADP MCHR1 CHRM5 GNAQ HBEGF(63-148)OXTR GNA14 PLC-betaGNA11 Gastrin:CCKBRDAG GRM5 G-protein alpha(q/11):Trio familyRhoGEFsTBXA2R TRH(152-154) L-Arg EtCOO- or C2H5COO- TRHR L-Arg TRHR AVPR1A CCL23-2 HCRT(34-66) UDP LTC4 GNA14 PRKCAL-Lys GNA15 F2RL3(18-385) PROK2 LPAR5 APP(672-713) thrombin light chainGPR65 RGZ HTR2A GPR4 AVPR1B PLCB4 GRB2:SOS1:HB-EGF:p-6Y-EGFRGTP GNRH1(24-33) TACR3 AcCho LPAR2 P2RY6 GPCRs that activateGq/11PRKCA NTS(151-163) LPAR3 LPAR2 GTPSOS1 GCGR p21 RAS:GTPNRAS GPR68 GNRHR HBEGF(63-148) PLCB3 XCL2 GRB2-1 CCKBR NAd OPN4 p-ERK1/2/5P2RY11 GNA15 FFAR3 Phospho-Ribosomalprotein S6 kinaseLTB4R PTAFR TRH(227-229) GNA11 KISS1R MCHR2 ARHGEF25 LPA TRH(152-154) ADRA1B QRFP ANXA1 L-Lys P2RY10 TRH(84-86) CHRM5 LTE4 F2R(27-425) ADR CASR GNAQ SAA1(19-122) p21 RAS:GDPLPAR3 GTP GNA15 LPAR1 CH3COO- PROKR1 GNA15 FFAR3 LTD4 GNA15 MCHR2 TRH(135-137) TRIO GTP PGF2a GNAQ GNRH2(24-33) TRIO family RhoGEFsGNAQ NMU GHSR NPFF(69-76) HTR2B UTS2B TAC3 PALM LPAR1 LTD4 Hist TACR2 HTR2A G-protein alpha(q/11): GTPL-Glu HCRT(70-97) O-octanoyl-L-serine-GHRL-1(24-51) P2RY6 Effects of PIP2hydrolysisATPPMCH(147-165) GNA14 KISS1(68-121) OPN4 NPFFR1 LTB4R2 Valerate HeterotrimericG-protein Gq/11(inactive)GNA15 GPRC6A TRH(135-137) GPR65 P2RY2 5HT GNA11 EDNRA TAC1(98-107) NMUR1 HTR2B CCL23-2 NMS TBXA2R RAF/MAP kinasecascadeMT-RNR2 O-octanoyl-L-serine-GHRL-1(24-51) P2RY10 GPR68 NTS(151-163) NMB(47-56) HRH1 HXA Ca2+ CH3COO- GRM5 FFAR1 PLC beta:G alpha(q/11)BDKRB1 Glucagon HBEGF(20-62)DecS-GHRL-1(24-51) GDP GDP MLNR GNA15 GAST(76-92) L-Glu TAC3 PTGER1 OXTR NMS EDN2 EtCOO- or C2H5COO- HB-EGF:p-6Y-EGFRdimerGRK5 CHRM1 EDN1 MCHR1 GNA15 p-6Y-EGFR GTP GNA11 Ca2+ G-protein alpha(q):GRK2ANXA1 OLEA GAST(76-92) Bradykinin GRB2-1:SOS1ADRA1A I(1,4,5)P3HRAS NPSR1 RGZ GNRHR HRAS PTGFR PGE2 GTPTAC1(58-68) BUT GNA14 LXA4 LPAR5 DDCX PI3K alphaBUT LPAR4 4, 18, 3421, 3621, 3610, 1121, 3621, 367, 8, 22, 23, 29...