Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

From WikiPathways

Revision as of 08:07, 17 July 2014 by ReactomeTeam (Talk | contribs)
Jump to: navigation, search
11, 16, 227, 27, 35, 37, 41312883, 2010, 394, 13353419523143821, 3315, 25181, 264017Gastrin:CCKBR[plasma membrane]EP1 receptor:PGE2[plasma membrane]GPRC6Areceptor:GPRC6Aligands [plasmamembrane]Prokineticin[extracellularregion]Substance Preceptor:Substance Ppeptide [plasmamembrane]FPRL1 ligands[extracellularregion]Cholecystokininreceptors [plasmamembrane]Neuropeptide FFreceptor [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]GPR17:UDP [plasmamembrane]CASR:Calcium [plasmamembrane]Proteinase-activatedreceptors [plasmamembrane]GPRC6Areceptor:GPRC6Aligands [plasmamembrane]pH sensingreceptors:H+ [plasmamembrane]Prokineticinreceptors:prokineticin[plasma membrane]Bradykininreceptor:Bradykinin[plasma membrane]Thrombin:Proteinase-activatedreceptors [plasmamembrane]Motilinreceptor:Motilin[plasma membrane]Cysteinylleukotrienes[extracellularregion]P2RY11 :ATP [plasmamembrane]Neuromedin-S:Neuromedin-Ureceptor 2 [plasmamembrane]CHRM1, 3, 5 [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]P2RY6:UDP [plasmamembrane]Type 1 angiotensinIIreceptor:AngiotensinII [plasma membrane]TPreceptor:ThromboxaneA2 [plasma membrane]Urotensin 2, 2B[extracellularregion]Cholecystokininreceptors [plasmamembrane]Ligand:GPCRcomplexes thatactivate Gq/11[plasma membrane]Activated thrombin(factor IIa)[extracellularregion]Cysteinylleukotrienereceptors [plasmamembrane]Prokineticin[extracellularregion]Alpha-1adrenoceptor:Catecholamine[plasma membrane]Endothelin[extracellularregion]Acyl Ghrelin[extracellularregion]Gastrin:CCKBR[plasma membrane]Bombesin-likereceptor:bombesin-likepeptide [plasmamembrane]G-protein alpha(q/11):GDP [plasmamembrane]5-HT2receptor:Serotonin[plasma membrane]Neurotensin:Neurotensinreceptor [plasmamembrane]XC1 ligands[extracellularregion]FFAR2:Carboxylateligands [plasmamembrane]LTB4 receptors[plasma membrane]Endothelin receptor[plasma membrane]Carboxylate ligandsof FFAR3[extracellularregion]Oxytocin:Oxytocinreceptor [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]Prokineticinreceptors [plasmamembrane]P2RY9:LPA [plasmamembrane]Bradykinin receptor[plasma membrane]Type 1 angiotensinIIreceptor:AngiotensinII [plasma membrane]UTS2R:Urotensin 2,2B [plasma membrane]Urotensin 2, 2B[extracellularregion]P2RY5:LPA [plasmamembrane]QRFP receptor:QRFP[plasma membrane]HB-EGF:p-6Y-EGFR[plasma membrane]NPS:NPSR [plasmamembrane]G-protein alpha(q/11):GDP [plasmamembrane]FFAR3:Carboxylateligands [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]P2RY10:LPA [plasmamembrane]HRH1:Histamine[plasma membrane]Bombesin-likepeptide[extracellularregion]Cholecystokininreceptors [plasmamembrane]5-HT2receptor:Serotonin[plasma membrane]P2RY11 :ATP [plasmamembrane]MCH:Melanin-concentratinghormone receptors[plasma membrane]Substance Kreceptor:NeurokininA peptide [plasmamembrane]CASR:Calcium [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]Thrombin:Proteinase-activatedreceptors [plasmamembrane]Catecholamine[extracellularregion]GPRC6A ligands[extracellularregion]TRH [extracellularregion]p21 RAS [plasmamembrane]PI3K alpha [cytosol]G-protein alpha(q/11) [plasmamembrane]Proteinase-activatedreceptors [plasmamembrane]P2RY2:ATP [plasmamembrane]FFAR2:Carboxylateligands [plasmamembrane]Bombesin-likereceptor:bombesin-likepeptide [plasmamembrane]Orexin 1receptor:Orexin A[plasma membrane]Orexin 1receptor:Orexin A[plasma membrane]Carboxylate ligandsof FFAR3[extracellularregion]G-protein alpha(q/11) [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]Alpha-1 adrenoceptor[plasma membrane]5-HT2 receptor[plasma membrane]Endothelin:Endothelinreceptor [plasmamembrane]FPreceptor:PGF2-alpha[plasma membrane]Neuromedin-U:Neuromedinreceptors [plasmamembrane]Bradykininreceptor:Bradykinin[plasma membrane]Carboxylate ligandsof FFAR2[extracellularregion]LTB4 receptors:LTB4[plasma membrane]Ligands of FFAR1(GPR40) [plasmamembrane]p21 RAS:GTP [plasmamembrane]Carboxylate ligandsof FFAR2[extracellularregion]Chemokine XCreceptor 1: XC1ligands [plasmamembrane]HRH1:Histamine[plasma membrane]FFAR3:Carboxylateligands [plasmamembrane]pH sensingreceptors:H+ [plasmamembrane]Neuromedin-Ureceptors [plasmamembrane]nucleoplasmProkineticinreceptors [plasmamembrane]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(inactive) [plasmamembrane]Cysteinylleukotrienes[extracellularregion]G-protein beta-gammacomplex [plasmamembrane]Neuromedin-U:Neuromedinreceptors [plasmamembrane]LPA-binding EDGreceptors: LPA[plasma membrane]Protein Kinase C,alpha type: DAG[plasma membrane]Oxytocin:Oxytocinreceptor [plasmamembrane]Prokineticinreceptors:prokineticin[plasma membrane]PAF receptor:PAF[plasma membrane]Metastin:KiSS1R[plasma membrane]Group I Metabotropicglutamatereceptors:Glu[plasma membrane]Gastrin:CCKBR[plasma membrane]Vasopressin receptortype 1 [plasmamembrane]M1/M3/M5:acetylcholine[plasma membrane]G-protein beta-gammacomplex [plasmamembrane]Vasopressin receptortype 1:AVP [plasmamembrane]P2RY1:ADP [plasmamembrane]5-HT2 receptor[plasma membrane]Group I Metabotropicglutamate receptors[plasma membrane]HeterotrimericG-protein Gq/11(inactive) [plasmamembrane]Acyl ghrelin:GHSR[plasma membrane]G-protein alpha(q/11):GDP [plasmamembrane]Cysteinylleukotrienes[extracellularregion]pH sensing receptors[plasma membrane]M1/M3/M5:acetylcholine[plasma membrane]Neuromedin-S:Neuromedin-Ureceptor 2 [plasmamembrane]P2RY6:UDP [plasmamembrane]Activated thrombin(factor IIa)[extracellularregion]Cysteinylleukotrienereceptors [plasmamembrane]FFAR1:fatty acid[plasma membrane]P2RY5:LPA [plasmamembrane]PI3K alpha [cytosol]HB-EGF:p-6Y-EGFRdimer [plasmamembrane]CCK:Cholecystokininreceptors [plasmamembrane]GnRH receptor[plasma membrane]GnRH receptor:GNRHligands [plasmamembrane]PAF receptor:PAF[plasma membrane]5-HT2receptor:Serotonin[plasma membrane]Neuropeptide FFreceptor:NeuropeptideFF [plasma membrane]PLC-beta [cytosol]TRIO family RhoGEFs[cytosol]Neuromedin-U:Neuromedinreceptors [plasmamembrane]Motilinreceptor:Motilin[plasma membrane]Thrombin:Proteinase-activatedreceptors [plasmamembrane]Group I Metabotropicglutamatereceptors:Glu[plasma membrane]UTS2R:Urotensin 2,2B [plasma membrane]Endothelin receptor[plasma membrane]Neuromedin Kreceptor:NeurokininB peptide [plasmamembrane]Neurotensin:Neurotensinreceptor [plasmamembrane]HB-EGF:p-6Y-EGFR[plasma membrane]Chemokine XCreceptor 1: XC1ligands [plasmamembrane]P2RY2:ATP [plasmamembrane]GNRH ligands[extracellularregion]LTB4 receptors:LTB4[plasma membrane]P2RY1:ADP [plasmamembrane]Cysteinylleukotrienereceptors [plasmamembrane]cytosolFFAR1:fatty acid[plasma membrane]LTB4 receptors:LTB4[plasma membrane]HRH1:Histamine[plasma membrane]Catecholamine[extracellularregion]XC1 ligands[extracellularregion]Proteinase-activatedreceptors [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]Neurotensin receptor[plasma membrane]QRFP receptor:QRFP[plasma membrane]GnRH receptor:GNRHligands [plasmamembrane]Metastin:KiSS1R[plasma membrane]Group I Metabotropicglutamate receptors[plasma membrane]Bradykinin receptor[plasma membrane]Metastin:KiSS1R[plasma membrane]Glucagon:GCGR[plasma membrane]CCK:Cholecystokininreceptors [plasmamembrane]P2RY10:LPA [plasmamembrane]Group I Metabotropicglutamatereceptors:Glu[plasma membrane]Gastrin:CCKBR[plasma membrane]Orexin 2receptor:Orexin B[plasma membrane]Substance Preceptor:Substance Ppeptide [plasmamembrane]LTB4 receptors[plasma membrane]P2RY6:UDP [plasmamembrane]GPR17:UDP [plasmamembrane]G-protein alpha(q/11):Trio familyRhoGEFs [plasmamembrane]GRB2:SOS1 [cytosol]P2RY2:ATP [plasmamembrane]Vasopressin receptortype 1:AVP [plasmamembrane]p21 RAS:GDP [plasmamembrane]Motilinreceptor:Motilin[plasma membrane]HeterotrimericG-protein Gq/11(inactive) [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]Ligand:GPCRcomplexes thatactivate Gq/11[plasma membrane]PAF receptor:PAF[plasma membrane]Neuropeptide FFreceptor [plasmamembrane]LPA-binding EDGreceptors [plasmamembrane]P2RY5:LPA [plasmamembrane]Vasopressin receptortype 1 [plasmamembrane]Melanin-concentratinghormone receptors[plasma membrane]GRB2:SOS1:HB-EGF:p-6Y-EGFR[plasma membrane]Neuromedin-Ureceptors [plasmamembrane]XC1 ligands[extracellularregion]Melanospin:photon[plasma membrane]Melanospin:photon[plasma membrane]Orexin 2receptor:Orexin B[plasma membrane]QRFP receptor:QRFP[plasma membrane]CASR:Calcium [plasmamembrane]Orexin 2receptor:Orexin B[plasma membrane]Cysteinylleukotrienereceptors:Cysteinylleukotrienes [plasmamembrane]Bradykinin receptor[plasma membrane]CCK:Cholecystokininreceptors [plasmamembrane]Melanin-concentratinghormone receptors[plasma membrane]NPS:NPSR [plasmamembrane]Alpha-1 adrenoceptor[plasma membrane]P2RY1:ADP [plasmamembrane]GNRH ligands[extracellularregion]Carboxylate ligandsof FFAR2[extracellularregion]p21 RAS [plasmamembrane]Endothelin:Endothelinreceptor [plasmamembrane]CHRM1, 3, 5 [plasmamembrane]Neuromedin Kreceptor:NeurokininB peptide [plasmamembrane]Substance Preceptor:Substance Ppeptide [plasmamembrane]G-protein beta-gammacomplex [plasmamembrane]GPRC6A ligands[extracellularregion]LPA-binding EDGreceptors: LPA[plasma membrane]FPreceptor:PGF2-alpha[plasma membrane]Neuropeptide FFreceptor:NeuropeptideFF [plasma membrane]G-protein alpha(q/11): GTP [plasmamembrane]FFAR3:Carboxylateligands [plasmamembrane]TRH:TRHR [plasmamembrane]Melanospin:photon[plasma membrane]Bombesin-likepeptide[extracellularregion]Endothelin[extracellularregion]Acyl ghrelin:GHSR[plasma membrane]GNRH ligands[extracellularregion]G-protein alpha(q/11): GTP [plasmamembrane]FPRL1 ligands[extracellularregion]MCH:Melanin-concentratinghormone receptors[plasma membrane]GPR17:UDP [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]Bombesin-likepeptide[extracellularregion]G-protein alpha(q/11) [plasmamembrane]P2RY11 :ATP [plasmamembrane]Glucagon:GCGR[plasma membrane]P2RY9:LPA [plasmamembrane]NPS:NPSR [plasmamembrane]TRH:TRHR [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]pH sensing receptors[plasma membrane]Vasopressin receptortype 1:AVP [plasmamembrane]Activated thrombin(factor IIa)[extracellularregion]Prokineticinreceptors:prokineticin[plasma membrane]Urotensin 2, 2B[extracellularregion]Type 1 angiotensinIIreceptor:AngiotensinII [plasma membrane]GPRC6A ligands[extracellularregion]Ligands of FFAR1(GPR40) [plasmamembrane]Basic L-amino acids[extracellularregion]EP1 receptor:PGE2[plasma membrane]G-protein alpha(q/11):PI3K alpha[plasma membrane]EP1 receptor:PGE2[plasma membrane]Alpha-1adrenoceptor:Catecholamine[plasma membrane]pH sensing receptors[plasma membrane]M1/M3/M5:acetylcholine[plasma membrane]Chemokine XCreceptor 1: XC1ligands [plasmamembrane]Acyl Ghrelin[extracellularregion]Prokineticin[extracellularregion]TPreceptor:ThromboxaneA2 [plasma membrane]LPA-binding EDGreceptors [plasmamembrane]FPRL1:FPRL1 ligands[plasma membrane]Cysteinylleukotrienereceptors:Cysteinylleukotrienes [plasmamembrane]FPRL1 ligands[extracellularregion]LPA-binding EDGreceptors [plasmamembrane]Substance Kreceptor:NeurokininA peptide [plasmamembrane]Oxytocin:Oxytocinreceptor [plasmamembrane]Neuromedin Kreceptor:NeurokininB peptide [plasmamembrane]Prokineticinreceptors [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]5-HT2 receptor[plasma membrane]Neurotensin receptor[plasma membrane]LPA-binding EDGreceptors: LPA[plasma membrane]CHRM1, 3, 5 [plasmamembrane]GnRH receptor[plasma membrane]Neuropeptide FFreceptor:NeuropeptideFF [plasma membrane]Basic L-amino acids[extracellularregion]Glucagon:GCGR[plasma membrane]Basic L-amino acids[extracellularregion]Acyl Ghrelin[extracellularregion]Vasopressin receptortype 1 [plasmamembrane]P2RY10:LPA [plasmamembrane]Alpha-1adrenoceptor:Catecholamine[plasma membrane]MCH:Melanin-concentratinghormone receptors[plasma membrane]G-protein alpha(q/11) [plasmamembrane]Cysteinylleukotrienereceptors:Cysteinylleukotrienes [plasmamembrane]Neurotensin receptor[plasma membrane]G-protein alpha(q):GRK5 [plasmamembrane]GnRH receptor[plasma membrane]Substance Kreceptor:NeurokininA peptide [plasmamembrane]Neuropeptide FFreceptor [plasmamembrane]TPreceptor:ThromboxaneA2 [plasma membrane]GPRC6Areceptor:GPRC6Aligands [plasmamembrane]Neurotensin:Neurotensinreceptor [plasmamembrane]Endothelin receptor[plasma membrane]TRH [extracellularregion]Group I Metabotropicglutamate receptors[plasma membrane]Alpha-1 adrenoceptor[plasma membrane]PLC beta:G alpha(q/11) [plasmamembrane]FFAR2:Carboxylateligands [plasmamembrane]Ligand:GPCRcomplexes thatactivate Gq/11[plasma membrane]Orexin 1receptor:Orexin A[plasma membrane]TRH:TRHR [plasmamembrane]Endothelin[extracellularregion]G-protein beta-gammacomplex [plasmamembrane]GRB2:SOS1 [cytosol]HeterotrimericG-protein Gq(active) [plasmamembrane]Neuromedin-S:Neuromedin-Ureceptor 2 [plasmamembrane]GnRH receptor:GNRHligands [plasmamembrane]HB-EGF:p-6Y-EGFRdimer [plasmamembrane]Endothelin:Endothelinreceptor [plasmamembrane]Carboxylate ligandsof FFAR3[extracellularregion]P2RY9:LPA [plasmamembrane]FPreceptor:PGF2-alpha[plasma membrane]G-protein alpha(q):GRK2 [plasmamembrane]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(active) [plasmamembrane]Ligands of FFAR1(GPR40) [plasmamembrane]Neuromedin-Ureceptors [plasmamembrane]LTB4 receptors[plasma membrane]Bradykininreceptor:Bradykinin[plasma membrane]UTS2R:Urotensin 2,2B [plasma membrane]Catecholamine[extracellularregion]FFAR1:fatty acid[plasma membrane]FPRL1:FPRL1 ligands[plasma membrane]pH sensingreceptors:H+ [plasmamembrane]Melanin-concentratinghormone receptors[plasma membrane]Acyl ghrelin:GHSR[plasma membrane]Bombesin-likereceptor:bombesin-likepeptide [plasmamembrane]FPRL1:FPRL1 ligands[plasma membrane]TRH [extracellularregion]PTGFR [plasmamembrane]GRM1 [plasmamembrane]CHRM3 [plasmamembrane]PROK1 [extracellularregion]LPAR4 [plasmamembrane]MLN(26-47)[extracellularregion]AGT(34-41)[extracellularregion]LPAR2 [plasmamembrane]LTE4 [extracellularregion]RGZ [plasmamembrane]GRB2:SOS1MCHR2 [plasmamembrane]EDN2(49-69)[extracellularregion]TBXA2R(1-369)[plasma membrane]DAG [plasmamembrane]EDN1(53-73)[extracellularregion]Pentadecanoic acid[plasma membrane]CHRM1 [plasmamembrane]CYSLTR2 [plasmamembrane]HCRTR1 [plasmamembrane]PGE2 [extracellularregion]GRM5 [plasmamembrane]G-protein alpha(q/11):Trio familyRhoGEFsTRH(186-188)[extracellularregion]EDN3(97-117)[extracellularregion]HB-EGF:p-6Y-EGFRdimerthrombin light chain[extracellularregion]ATP [extracellularregion]HTR2A [plasmamembrane]GNA15 [plasmamembrane]CCKBR [plasmamembrane]CHRM1 [plasmamembrane]FPR2 [plasmamembrane]NMUR2 [plasmamembrane]MT-RNR2(1-714)[extracellularregion]KRAS(1-186) [plasmamembrane]LPA [extracellularregion]UTS2B(112-119)[extracellularregion]GNA11 [plasmamembrane]GNRHR2(1-178)[plasma membrane]GNRHR2(1-178)[plasma membrane]GAST(76-92)GNA11 [plasmamembrane]DDCX [plasmamembrane]CCL23-2[extracellularregion]NPFFR2 [plasmamembrane]PGF2a [extracellularregion]DecS-GHRL-1(24-51)[extracellularregion]ADRA1A [plasmamembrane]LTB4R [plasmamembrane]FFAR2 [plasmamembrane]LTC4 [extracellularregion]NPSR1 [plasmamembrane]TACR2 [plasmamembrane]PROKR1 [plasmamembrane]GNAQ [plasmamembrane]FFAR2 [plasmamembrane]ARHGEF25 [cytosol]EDN1(53-73)[extracellularregion]P2RY6 [plasmamembrane]GNA15 [plasmamembrane]NTSR1 [plasmamembrane]AcCho [extracellularregion]NTSR2 [plasmamembrane]GNA11 [plasmamembrane]AGT(34-41)[extracellularregion]GNA14 [plasmamembrane]P2RY11 [plasmamembrane]NTSR1 [plasmamembrane]TACR1 [plasmamembrane]Glucagon[extracellularregion]KISS1R [plasmamembrane]BDKRB2 [plasmamembrane]HCRT(34-66)[extracellularregion]GNA11 [plasmamembrane]QRFP(91-133)[extracellularregion]GNRH2(24-33)[extracellularregion]NMUR2 [plasmamembrane]PROKR1 [plasmamembrane]L-Lys [extracellularregion]DecS-GHRL-1(24-51)[extracellularregion]GPR65 [plasmamembrane]GPRC6A [plasmamembrane]AGT(34-41)[extracellularregion]TRH(114-116)[extracellularregion]O-octanoyl-L-serine-GHRL-1(24-51)[extracellularregion]PLCB1 [cytosol]FFAR3 [plasmamembrane]TAC3(81-90)[extracellularregion]TRH(114-116)[extracellularregion]BUT [extracellularregion]RGZ [plasmamembrane]LPAR2 [plasmamembrane]TXA2 [extracellularregion]GNRH2(24-33)[extracellularregion]TRH(135-137)[extracellularregion]LPAR5 [plasmamembrane]FFAR3 [plasmamembrane]MCHR1 [plasmamembrane]GNA11 [plasmamembrane]PI3K alphaTRIO [cytosol]BUT [extracellularregion]GPR17 [plasmamembrane]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(active)TACR3 [plasmamembrane]GRM1 [plasmamembrane]P2RY6 [plasmamembrane]NPFF(69-76)[extracellularregion]GPR68 [plasmamembrane]GNA14 [plasmamembrane]ANXA1 [extracellularregion]G-protein alpha(q/11):GDPGPR132 [plasmamembrane]MCHR1 [plasmamembrane]EtCOO- or C2H5COO-[extracellularregion]NPS(1-467)[extracellularregion]PIK3CA [cytosol]DDCX [plasmamembrane]TRH(227-229)[extracellularregion]CREB1MMP3PLCB4 [cytosol]ADRA1D [plasmamembrane]PROKR2 [plasmamembrane]LPAR3 [plasmamembrane]XCL1 [extracellularregion]HCRT(70-97)[extracellularregion]LPAR1 [plasmamembrane]GNA15 [plasmamembrane]MLN(26-47)[extracellularregion]NMS(109-141)[extracellularregion]LTB4R [plasmamembrane]CCKBR [plasmamembrane]QRFP(91-133)[extracellularregion]F2R(27-425) [plasmamembrane]Glu [extracellularregion]XCR1 [plasmamembrane]ADRA1B [plasmamembrane]PROKR2 [plasmamembrane]OPN4 [plasmamembrane]GPR4 [plasmamembrane]CHRM1 [plasmamembrane]DecS-GHRL-1(24-50)[extracellularregion]GNRHR [plasmamembrane]TACR3 [plasmamembrane]LPAR5 [plasmamembrane]KISS1R [plasmamembrane]HCOOH [extracellularregion]TACR3 [plasmamembrane]TRHR [plasmamembrane]Ribosomal protein S6kinaseP2RY10 [plasmamembrane]EDNRB [plasmamembrane]SAA1(19-122)[extracellularregion]HCRT(70-97)[extracellularregion]GDPCHRM5 [plasmamembrane]UTS2(114-124)[extracellularregion]LTB4R [plasmamembrane]GNRHR [plasmamembrane]FFAR2 [plasmamembrane]SOS1 [cytosol]NTSR2 [plasmamembrane]GTPF2RL3(18-385)[plasma membrane]TACR1 [plasmamembrane]LPAR1 [plasmamembrane]GHSR [plasmamembrane]LPAR6 [plasmamembrane]FFAR3 [plasmamembrane]TRH(152-154)[extracellularregion]NPFFR1 [plasmamembrane]GNA14 [plasmamembrane]ADR [extracellularregion]OXT(20-28)[extracellularregion]GNA15 [plasmamembrane]LXA4 [extracellularregion]HBEGF(20-208)NAd [extracellularregion]GNAQ [plasmamembrane]NPS(1-467)[extracellularregion]GNA11 [plasmamembrane]CASR [plasmamembrane]GPR4 [plasmamembrane]LTE4 [extracellularregion]GNA15 [plasmamembrane]ATPGPCRs that activateGq/11BDKRB2 [plasmamembrane]PLC-betaL-Lys [extracellularregion]HBEGF(149-208)LPAR6 [plasmamembrane]LPAR3 [plasmamembrane]MT-RNR2(1-714)[extracellularregion]GNA14 [plasmamembrane]GNRH1(24-33)[extracellularregion]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(inactive)thrombin heavy chain[extracellularregion]CYSLTR1 [plasmamembrane]DDCX [plasmamembrane]OXTR [plasmamembrane]CYSLTR1 [plasmamembrane]LTC4 [extracellularregion]FFAR1 [plasmamembrane]GPR132 [plasmamembrane]SAA1(19-122)[extracellularregion]ADP [extracellularregion]GRK5NMB(47-56)[extracellularregion]LTB4R2 [plasmamembrane]O-octanoyl-L-serine-GHRL-1(24-50)[extracellularregion]TRH(114-116)[extracellularregion]CYSLTR1 [plasmamembrane]GNA15 [plasmamembrane]GRM5 [plasmamembrane]LTE4 [extracellularregion]ADRBK1(2-689)[plasma membrane]LPAR3 [plasmamembrane]PI(4,5)P2GAST(76-92)[extracellularregion]GNAQ [plasmamembrane]TRH(152-154)[extracellularregion]LXA4 [extracellularregion]EDNRA [plasmamembrane]TRIO family RhoGEFsGTP [plasmamembrane]PLC beta:G alpha(q/11)XCL2 [extracellularregion]GRM5 [plasmamembrane]PALM [plasmamembrane]DAGXCL1 [extracellularregion]UDP [extracellularregion]GAST(76-92)[extracellularregion]GDP [plasmamembrane]TACR2 [plasmamembrane]KALRN [cytosol]GNA14 [plasmamembrane]F2RL1(37-397)[plasma membrane]Phospho-Ribosomalprotein S6 kinaseMCHR2 [plasmamembrane]Neurokinin A peptide[extracellularregion]CASR [plasmamembrane]NPSR1 [plasmamembrane]L-Arg [extracellularregion]P2RY10 [plasmamembrane]EtCOO- or C2H5COO-[extracellularregion]UTS2R [plasmamembrane]OXTR [plasmamembrane]BUT [extracellularregion]XCL2 [extracellularregion]GAST(76-92)[extracellularregion]LPAR5 [plasmamembrane]GAST(76-92)[extracellularregion]CHRM3 [plasmamembrane]TRH(84-86)[extracellularregion]ADRA1A [plasmamembrane]NMS(109-141)[extracellularregion]MCHR2 [plasmamembrane]P2RY1 [plasmamembrane]BDKRB1 [plasmamembrane]LPAR6 [plasmamembrane]TRHR [plasmamembrane]Substance P peptide[extracellularregion]p-6Y-EGFR [plasmamembrane]GTP [plasmamembrane]HBEGF(20-62)TACR1 [plasmamembrane]NPS(1-467)[extracellularregion]L-Lys [extracellularregion]PRKCA [plasmamembrane]OLEA [plasmamembrane]BDKRB1 [plasmamembrane]ADRA1B [plasmamembrane]CH3COO-[extracellularregion]GRB2-1 [cytosol]UTS2R [plasmamembrane]NPFF(69-76)[extracellularregion]GRP(24-50)[extracellularregion]O-octanoyl-L-serine-GHRL-1(24-51)[extracellularregion]AVPR1A [plasmamembrane]RGZ [plasmamembrane]HBEGF(63-148)[extracellularregion]TXA2 [extracellularregion]PROK2 [extracellularregion]AVP(20-28)[extracellularregion]NPFF(69-76)[extracellularregion]GHSR [plasmamembrane]SAA1(19-122)[extracellularregion]HTR2B [plasmamembrane]Bradykinin[extracellularregion]FFAR1 [plasmamembrane]ATPEDN3(97-117)[extracellularregion]QRFPR [plasmamembrane]HCRT(34-66)[extracellularregion]MLN(26-47)[extracellularregion]GRB2-1 [cytosol]GDP [cytosol]PROK2 [extracellularregion]AVP(20-28)[extracellularregion]thrombin light chain[extracellularregion]PMCH(147-165)[extracellularregion]PMCH(147-165)[extracellularregion]HTR2A [plasmamembrane]P2RY10 [plasmamembrane]AVPR1B [plasmamembrane]UTS2B(112-119)[extracellularregion]p-S133-CREB1F2RL1(37-397)[plasma membrane]AGTR1 [plasmamembrane]GNA11 [plasmamembrane]GNAQ [plasmamembrane]OPN4 [plasmamembrane]NMS(109-141)[extracellularregion]GNAQ [plasmamembrane]TBXA2R(1-369)[plasma membrane]G-protein alpha(q):GRK2UTS2(114-124)[extracellularregion]H+ [extracellularregion]5HT [extracellularregion]NMUR1 [plasmamembrane]LPA [extracellularregion]GTP [cytosol]PGE2 [extracellularregion]F2R(27-425) [plasmamembrane]HRH1 [plasmamembrane]FFAR1 [plasmamembrane]H+ [extracellularregion]GNRH1(24-33)[extracellularregion]PRKCALTD4 [extracellularregion]HTR2B [plasmamembrane]KRAS(1-186) [plasmamembrane]LTB4R2 [plasmamembrane]G-protein beta-gammacomplexCHRM3 [plasmamembrane]GPR65 [plasmamembrane]GNA15 [plasmamembrane]P2RY11 [plasmamembrane]GNRH1(24-33)[extracellularregion]HRAS(1-186) [plasmamembrane]GNA15 [plasmamembrane]HBEGF(63-148)[extracellularregion]GRK5 [cytosol]LTD4 [extracellularregion]AcCho [extracellularregion]GTP [plasmamembrane]KISS1(68-121)[extracellularregion]TRHR [plasmamembrane]GHSR [plasmamembrane]p21 RAS:GTPTRH(135-137)[extracellularregion]NPSR1 [plasmamembrane]AVPR1A [plasmamembrane]F2RL1(37-397)[plasma membrane]PGF2a [extracellularregion]HCRTR2 [plasmamembrane]CCKAR [plasmamembrane]BDKRB1 [plasmamembrane]CCK [extracellularregion]SOS1 [cytosol]F2RL2(22-374)[plasma membrane]TRH(186-188)[extracellularregion]GCGR [plasmamembrane]EDNRB [plasmamembrane]Glucagon[extracellularregion]PALM [plasmamembrane]OXT(20-28)[extracellularregion]GNAQ [plasmamembrane]GPR132 [plasmamembrane]Valerate[extracellularregion]ADRA1D [plasmamembrane]Hist [extracellularregion]CCKBR [plasmamembrane]DecS-GHRL-1(24-51)[extracellularregion]APP(672-713)[extracellularregion]Valerate[extracellularregion]GNA14 [plasmamembrane]LTB4R2 [plasmamembrane]O-octanoyl-L-serine-GHRL-1(24-50)[extracellularregion]LTB4 [extracellularregion]LXA4 [extracellularregion]NMU(142-166)[extracellularregion]CH3COO-[extracellularregion]CYSLTR2 [plasmamembrane]GCGR [plasmamembrane]Pentadecanoic acid[plasma membrane]GNAQ [plasmamembrane]OLEA [plasmamembrane]XCR1 [plasmamembrane]LTB4 [extracellularregion]HCRTR1 [plasmamembrane]LTB4 [extracellularregion]CYSLTR2 [plasmamembrane]RGS proteins activefor G alpha (q)TRH(84-86)[extracellularregion]NTSR2 [plasmamembrane]OPN4 [plasmamembrane]GNAQ [plasmamembrane]GNA11 [plasmamembrane]GDP [plasmamembrane]Valerate[extracellularregion]PLCB3(2-1234)[cytosol]CCK [extracellularregion]MT-RNR2(1-714)[extracellularregion]PAF [extracellularregion]CH3COO-[extracellularregion]Bradykinin[extracellularregion]ATP [extracellularregion]LTD4 [extracellularregion]FPR2 [plasmamembrane]GNAQ [plasmamembrane]KISS1R [plasmamembrane]PTGFR [plasmamembrane]P2RY1 [plasmamembrane]EDN2(49-69)[extracellularregion]ADP [extracellularregion]HCRTR2 [plasmamembrane]OXTR [plasmamembrane]ADPMCHR1 [plasmamembrane]TRH(84-86)[extracellularregion]GNA15 [plasmamembrane]QRFP(91-133)[extracellularregion]HTR2C(1-458) [plasmamembrane]G-protein alpha(q/11):PI3K alphaXCL1 [extracellularregion]MLNR [plasmamembrane]PROK1 [extracellularregion]NMB(47-56)[extracellularregion]GNA14 [plasmamembrane]thrombin light chain[extracellularregion]DecS-GHRL-1(24-50)[extracellularregion]CCL23-2[extracellularregion]PTAFR [plasmamembrane]PROK2 [extracellularregion]TRH(152-154)[extracellularregion]NTS(151-163)[extracellularregion]UTS2B(112-119)[extracellularregion]AGTR1 [plasmamembrane]PROKR2 [plasmamembrane]F2RL2(22-374)[plasma membrane]P2RY2 [plasmamembrane]NAd [extracellularregion]HCRT(70-97)[extracellularregion]ADRA1D [plasmamembrane]L-Arg [extracellularregion]L-Orn [extracellularregion]Ca2+ [extracellularregion]UDP [extracellularregion]NPFFR2 [plasmamembrane]GNRHR2(1-178)[plasma membrane]EGFRF2RL3(18-385)[plasma membrane]EDNRA [plasmamembrane]P2RY2 [plasmamembrane]GPR68 [plasmamembrane]L-Orn [extracellularregion]TXA2 [extracellularregion]GNA14 [plasmamembrane]P2RY6 [plasmamembrane]I(1,4,5)P3p-ERK1/2/5CCL23-2[extracellularregion]Effects of PIP2hydrolysisANXA1 [extracellularregion]UDP [extracellularregion]HCRT(34-66)[extracellularregion]TRH(227-229)[extracellularregion]P2RY11 [plasmamembrane]NMU(142-166)[extracellularregion]APP(672-713)[extracellularregion]KISS1(68-121)[extracellularregion]LPA [extracellularregion]NMUR1 [plasmamembrane]GPR68 [plasmamembrane]AVPR1A [plasmamembrane]Ca2+ [extracellularregion]GNA11 [plasmamembrane]GRB2:SOS1:HB-EGF:p-6Y-EGFRHeterotrimericG-protein Gq/11(inactive)P2RY2 [plasmamembrane]QRFPR [plasmamembrane]BDKRB2 [plasmamembrane]GTP [plasmamembrane]GPRC6A [plasmamembrane]TRH(227-229)[extracellularregion]HXA [extracellularregion]GNRHR [plasmamembrane]KISS1(68-121)[extracellularregion]HXA [extracellularregion]CCKAR [plasmamembrane]HTR2A [plasmamembrane]AcCho [extracellularregion]GNA15 [plasmamembrane]PAF [extracellularregion]ADP [extracellularregion]p21 RAS:GDPPGF2a [extracellularregion]OXT(20-28)[extracellularregion]GPR17 [plasmamembrane]Glucagon[extracellularregion]GPRC6A [plasmamembrane]PTGER1 [plasmamembrane]GTP [plasmamembrane]GCGR [plasmamembrane]PAF [extracellularregion]HTR2B [plasmamembrane]NMUR2 [plasmamembrane]P2RY1 [plasmamembrane]5HT [extracellularregion]HBEGF(63-148)PTAFR [plasmamembrane]ADPMLNR [plasmamembrane]ADRA1A [plasmamembrane]H+ [extracellularregion]HRAS(1-186) [plasmamembrane]Neurokinin A peptide[extracellularregion]PROKR1 [plasmamembrane]F2RL2(22-374)[plasma membrane]ADR [extracellularregion]Hist [extracellularregion]EDNRB [plasmamembrane]PTAFR [plasmamembrane]NRAS [plasmamembrane]HCOOH [extracellularregion]Gastrin:CCKBRHCOOH [extracellularregion]Substance P peptide[extracellularregion]HXA [extracellularregion]GNA11 [plasmamembrane]HCRTR2 [plasmamembrane]NMUR1 [plasmamembrane]APP(672-713)[extracellularregion]HRH1 [plasmamembrane]GRP(24-50)[extracellularregion]L-Arg [extracellularregion]CCKAR [plasmamembrane]Glu [extracellularregion]TAC3(81-90)[extracellularregion]O-octanoyl-L-serine-GHRL-1(24-51)[extracellularregion]PGE2 [extracellularregion]Hist [extracellularregion]Ca2+ [extracellularregion]NTS(151-163)[extracellularregion]HRH1 [plasmamembrane]OLEA [plasmamembrane]LPAR2 [plasmamembrane]Protein Kinase C,alpha type: DAGNTSR1 [plasmamembrane]TRH(135-137)[extracellularregion]Bradykinin[extracellularregion]G-protein alpha(q/11)PTGER1 [plasmamembrane]LPAR4 [plasmamembrane]GNA14 [plasmamembrane]QRFPR [plasmamembrane]AVP(20-28)[extracellularregion]GNAQ [plasmamembrane]G-protein alpha(q/11): GTPGlu [extracellularregion]NRAS [plasmamembrane]Pentadecanoic acid[plasma membrane]ADRBK1(2-689)HTR2C(1-458) [plasmamembrane]GTP [plasmamembrane]TAC3(81-90)[extracellularregion]CCKBR [plasmamembrane]GNA14 [plasmamembrane]O-octanoyl-L-serine-GHRL-1(24-50)[extracellularregion]FPR2 [plasmamembrane]PTGFR [plasmamembrane]CASR [plasmamembrane]PIK3CA [cytosol]p-6Y-EGFR [plasmamembrane]AVPR1B [plasmamembrane]DecS-GHRL-1(24-50)[extracellularregion]F2RL3(18-385)[plasma membrane]CHRM5 [plasmamembrane]NAd [extracellularregion]AGTR1 [plasmamembrane]EDNRA [plasmamembrane]Substance P peptide[extracellularregion]EDN3(97-117)[extracellularregion]ADR [extracellularregion]PROK1 [extracellularregion]GTPGRP(24-50)[extracellularregion]CHRM5 [plasmamembrane]RAF/MAP kinasecascadethrombin heavy chain[extracellularregion]Neurokinin A peptide[extracellularregion]HCRTR1 [plasmamembrane]thrombin heavy chain[extracellularregion]LTC4 [extracellularregion]ATP [extracellularregion]ADRA1B [plasmamembrane]GNRH2(24-33)[extracellularregion]GDP [plasmamembrane]GPR17 [plasmamembrane]PLCB2 [cytosol]XCL2 [extracellularregion]L-Orn [extracellularregion]NPFFR1 [plasmamembrane]ANXA1 [extracellularregion]MLNR [plasmamembrane]LPAR4 [plasmamembrane]Ligand:GPCRcomplexes thatactivate Gq/11UTS2(114-124)[extracellularregion]CCK [extracellularregion]PTGER1 [plasmamembrane]NPFFR2 [plasmamembrane]GPR4 [plasmamembrane]NMB(47-56)[extracellularregion]EDN1(53-73)[extracellularregion]TACR2 [plasmamembrane]AVPR1B [plasmamembrane]XCR1 [plasmamembrane]GPR65 [plasmamembrane]PMCH(147-165)[extracellularregion]G-protein alpha(q):GRK5TBXA2R(1-369)[plasma membrane]TRH(186-188)[extracellularregion]UTS2R [plasmamembrane]Ligands of GPCRsthat activate Gq/11HTR2C(1-458) [plasmamembrane]EtCOO- or C2H5COO-[extracellularregion]CCKBREDN2(49-69)[extracellularregion]5HT [extracellularregion]GDPNPFFR1 [plasmamembrane]PALM [plasmamembrane]GTP [plasmamembrane]NTS(151-163)[extracellularregion]NMU(142-166)[extracellularregion]F2R(27-425) [plasmamembrane]LPAR1 [plasmamembrane]GRM1 [plasmamembrane]6, 1230, 362, 24, 326, 126, 126, 126, 129, 296, 12