Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)

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2, 21, 399, 32382910235258, 306, 14, 26, 35, 3817, 37204011, 1812, 3311613, 313673Carboxylate ligandsof FFAR3[extracellularregion]Thrombin:Proteinase-activatedreceptors [plasmamembrane]Cysteinylleukotrienereceptors [plasmamembrane]NPS:NPSR [plasmamembrane]LPA-binding EDGreceptors [plasmamembrane]Endothelin[extracellularregion]Cysteinylleukotrienes[extracellularregion]Substance Kreceptor:NeurokininA peptide [plasmamembrane]Gastrin:CCKBR[plasma membrane]Endothelin receptor[plasma membrane]P2RY10:LPA [plasmamembrane]Oxytocin:Oxytocinreceptor [plasmamembrane]Cysteinylleukotrienereceptors [plasmamembrane]Carboxylate ligandsof FFAR2[extracellularregion]TRH:TRHR [plasmamembrane]Type 1 angiotensinIIreceptor:AngiotensinII [plasma membrane]Orexin 2receptor:Orexin B[plasma membrane]QRFP receptor:QRFP[plasma membrane]CASR:Calcium [plasmamembrane]Orexin 1receptor:Orexin A[plasma membrane]Acyl Ghrelin[extracellularregion]Bradykininreceptor:Bradykinin[plasma membrane]Group I Metabotropicglutamate receptors[plasma membrane]P2RY1:ADP [plasmamembrane]Group I Metabotropicglutamate receptors[plasma membrane]Melanospin:photon[plasma membrane]Prokineticinreceptors [plasmamembrane]Cysteinylleukotrienes[extracellularregion]G-protein alpha(q/11):GDP [plasmamembrane]P2RY11 :ATP [plasmamembrane]TPreceptor:ThromboxaneA2 [plasma membrane]NPS:NPSR [plasmamembrane]Bradykinin receptor[plasma membrane]GPRC6A ligands[extracellularregion]pH sensing receptors[plasma membrane]Carboxylate ligandsof FFAR3[extracellularregion]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(active) [plasmamembrane]Group I Metabotropicglutamatereceptors:Glu[plasma membrane]Alpha-1 adrenoceptor[plasma membrane]Neuromedin Kreceptor:NeurokininB peptide [plasmamembrane]PAF receptor:PAF[plasma membrane]Urotensin 2, 2B[extracellularregion]LPA-binding EDGreceptors: LPA[plasma membrane]Basic L-amino acids[extracellularregion]FFAR2:Carboxylateligands [plasmamembrane]Neurotensin receptor[plasma membrane]G-protein alpha(q/11) [plasmamembrane]TRH [extracellularregion]P2RY2:ATP [plasmamembrane]Bombesin-likereceptor:bombesin-likepeptide [plasmamembrane]G-protein beta-gammacomplex [plasmamembrane]Prokineticinreceptors:prokineticin[plasma membrane]Prokineticinreceptors [plasmamembrane]Vasopressin receptortype 1 [plasmamembrane]EP1 receptor:PGE2[plasma membrane]GRB2:SOS1:HB-EGF:p-6Y-EGFR[plasma membrane]Motilinreceptor:Motilin[plasma membrane]Ligands of FFAR1(GPR40) [plasmamembrane]PLC beta:G alpha(q/11) [plasmamembrane]P2RY5:LPA [plasmamembrane]Alpha-1adrenoceptor:Catecholamine[plasma membrane]Ligand:GPCRcomplexes thatactivate Gq/11[plasma membrane]Cysteinylleukotrienes[extracellularregion]Alpha-1 adrenoceptor[plasma membrane]Orexin 1receptor:Orexin A[plasma membrane]Gastrin:CCKBR[plasma membrane]LTB4 receptors:LTB4[plasma membrane]P2RY10:LPA [plasmamembrane]PI3K alpha [cytosol]Orexin 2receptor:Orexin B[plasma membrane]CHRM1, 3, 5 [plasmamembrane]CCK:Cholecystokininreceptors [plasmamembrane]XC1 ligands[extracellularregion]HB-EGF:p-6Y-EGFRdimer [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]G-protein beta-gammacomplex [plasmamembrane]Oxytocin:Oxytocinreceptor [plasmamembrane]Vasopressin receptortype 1:AVP [plasmamembrane]Urotensin 2, 2B[extracellularregion]G-protein beta-gammacomplex [plasmamembrane]Neuropeptide FFreceptor [plasmamembrane]Neuropeptide FFreceptor [plasmamembrane]FFAR2:Carboxylateligands [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]M1/M3/M5:acetylcholine[plasma membrane]Catecholamine[extracellularregion]GPRC6Areceptor:GPRC6Aligands [plasmamembrane]Proteinase-activatedreceptors [plasmamembrane]MCH:Melanin-concentratinghormone receptors[plasma membrane]Type 1 angiotensinIIreceptor:AngiotensinII [plasma membrane]FFAR1:fatty acid[plasma membrane]Metastin:KiSS1R[plasma membrane]UTS2R:Urotensin 2,2B [plasma membrane]GRB2:SOS1 [cytosol]FFAR1:fatty acid[plasma membrane]FPreceptor:PGF2-alpha[plasma membrane]Alpha-1adrenoceptor:Catecholamine[plasma membrane]Ligands of FFAR1(GPR40) [plasmamembrane]Carboxylate ligandsof FFAR2[extracellularregion]Melanin-concentratinghormone receptors[plasma membrane]p21 RAS:GDP [plasmamembrane]TRH [extracellularregion]Neuromedin-Ureceptors [plasmamembrane]CASR:Calcium [plasmamembrane]HeterotrimericG-protein Gq(active) [plasmamembrane]MCH:Melanin-concentratinghormone receptors[plasma membrane]FPRL1 ligands[extracellularregion]G-protein alpha(q/11) [plasmamembrane]Neurotensin receptor[plasma membrane]TRH:TRHR [plasmamembrane]Activated thrombin(factor IIa)[extracellularregion]FPRL1:FPRL1 ligands[plasma membrane]Neuromedin-S:Neuromedin-Ureceptor 2 [plasmamembrane]Carboxylate ligandsof FFAR3[extracellularregion]GnRH receptor[plasma membrane]Bombesin-likepeptide[extracellularregion]HeterotrimericG-protein Gq/11(inactive) [plasmamembrane]GnRH receptor:GNRHligands [plasmamembrane]GNRH ligands[extracellularregion]Catecholamine[extracellularregion]Neuromedin-U:Neuromedinreceptors [plasmamembrane]Neuromedin-Ureceptors [plasmamembrane]pH sensingreceptors:H+ [plasmamembrane]PI3K alpha [cytosol]CASR:Calcium [plasmamembrane]FFAR3:Carboxylateligands [plasmamembrane]Bombesin-likepeptide[extracellularregion]Acyl Ghrelin[extracellularregion]P2RY1:ADP [plasmamembrane]P2RY11 :ATP [plasmamembrane]TPreceptor:ThromboxaneA2 [plasma membrane]Prokineticin[extracellularregion]Vasopressin receptortype 1 [plasmamembrane]PLC-beta [cytosol]G-protein alpha(q/11):GDP [plasmamembrane]Cysteinylleukotrienereceptors:Cysteinylleukotrienes [plasmamembrane]5-HT2receptor:Serotonin[plasma membrane]HRH1:Histamine[plasma membrane]Activated thrombin(factor IIa)[extracellularregion]Alpha-1 adrenoceptor[plasma membrane]Substance Preceptor:Substance Ppeptide [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]MCH:Melanin-concentratinghormone receptors[plasma membrane]QRFP receptor:QRFP[plasma membrane]Orexin 2receptor:Orexin B[plasma membrane]Neuromedin-S:Neuromedin-Ureceptor 2 [plasmamembrane]Prokineticinreceptors:prokineticin[plasma membrane]Basic L-amino acids[extracellularregion]LTB4 receptors[plasma membrane]Neuromedin Kreceptor:NeurokininB peptide [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]FPreceptor:PGF2-alpha[plasma membrane]Vasopressin receptortype 1:AVP [plasmamembrane]5-HT2 receptor[plasma membrane]Metastin:KiSS1R[plasma membrane]GNRH ligands[extracellularregion]TPreceptor:ThromboxaneA2 [plasma membrane]p21 RAS [plasmamembrane]Prokineticin[extracellularregion]Metastin:KiSS1R[plasma membrane]Alpha-1adrenoceptor:Catecholamine[plasma membrane]CHRM1, 3, 5 [plasmamembrane]PAF receptor:PAF[plasma membrane]nucleoplasmOxytocin:Oxytocinreceptor [plasmamembrane]G-protein alpha(q/11):Trio familyRhoGEFs [plasmamembrane]Neuropeptide FFreceptor:NeuropeptideFF [plasma membrane]EP1 receptor:PGE2[plasma membrane]HRH1:Histamine[plasma membrane]FPRL1:FPRL1 ligands[plasma membrane]Neuromedin-U:Neuromedinreceptors [plasmamembrane]Bombesin-likereceptor:bombesin-likepeptide [plasmamembrane]FPRL1:FPRL1 ligands[plasma membrane]P2RY9:LPA [plasmamembrane]Cysteinylleukotrienereceptors:Cysteinylleukotrienes [plasmamembrane]P2RY5:LPA [plasmamembrane]Neuromedin-S:Neuromedin-Ureceptor 2 [plasmamembrane]Neurotensin:Neurotensinreceptor [plasmamembrane]LPA-binding EDGreceptors [plasmamembrane]LPA-binding EDGreceptors: LPA[plasma membrane]P2RY1:ADP [plasmamembrane]Endothelin receptor[plasma membrane]G-protein alpha(q):GRK5 [plasmamembrane]Protein Kinase C,alpha type: DAG[plasma membrane]Vasopressin receptortype 1:AVP [plasmamembrane]GnRH receptor:GNRHligands [plasmamembrane]HB-EGF:p-6Y-EGFR[plasma membrane]QRFP receptor:QRFP[plasma membrane]Group I Metabotropicglutamate receptors[plasma membrane]Group I Metabotropicglutamatereceptors:Glu[plasma membrane]Activated thrombin(factor IIa)[extracellularregion]Substance Kreceptor:NeurokininA peptide [plasmamembrane]GPR17:UDP [plasmamembrane]Vasopressin receptortype 1 [plasmamembrane]GnRH receptor[plasma membrane]Acyl ghrelin:GHSR[plasma membrane]HB-EGF:p-6Y-EGFRdimer [plasmamembrane]Melanin-concentratinghormone receptors[plasma membrane]PAF receptor:PAF[plasma membrane]P2RY6:UDP [plasmamembrane]P2RY6:UDP [plasmamembrane]Neurotensin:Neurotensinreceptor [plasmamembrane]EP1 receptor:PGE2[plasma membrane]P2RY10:LPA [plasmamembrane]Neurotensin:Neurotensinreceptor [plasmamembrane]Glucagon:GCGR[plasma membrane]Bombesin-likereceptor:bombesin-likepeptide [plasmamembrane]Cysteinylleukotrienereceptors:Cysteinylleukotrienes [plasmamembrane]Acyl ghrelin:GHSR[plasma membrane]Motilinreceptor:Motilin[plasma membrane]M1/M3/M5:acetylcholine[plasma membrane]GNRH ligands[extracellularregion]5-HT2 receptor[plasma membrane]FFAR1:fatty acid[plasma membrane]cytosolp21 RAS:GTP [plasmamembrane]GPRC6Areceptor:GPRC6Aligands [plasmamembrane]Bradykininreceptor:Bradykinin[plasma membrane]LTB4 receptors[plasma membrane]LPA-binding EDGreceptors [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]CCK:Cholecystokininreceptors [plasmamembrane]FPRL1 ligands[extracellularregion]Proteinase-activatedreceptors [plasmamembrane]Substance Preceptor:Substance Ppeptide [plasmamembrane]Group I Metabotropicglutamatereceptors:Glu[plasma membrane]Ligands of FFAR1(GPR40) [plasmamembrane]Chemokine XCreceptor 1: XC1ligands [plasmamembrane]P2RY6:UDP [plasmamembrane]Ligand:GPCRcomplexes thatactivate Gq/11[plasma membrane]GPRC6A ligands[extracellularregion]pH sensingreceptors:H+ [plasmamembrane]5-HT2 receptor[plasma membrane]G-protein alpha(q/11) [plasmamembrane]Endothelin[extracellularregion]Gastrin:CCKBR[plasma membrane]Endothelin receptor[plasma membrane]G-protein alpha(q/11): GTP [plasmamembrane]Ligand:GPCRcomplexes thatactivate Gq/11[plasma membrane]G-protein alpha(q/11) [plasmamembrane]Orexin 1receptor:Orexin A[plasma membrane]P2RY9:LPA [plasmamembrane]P2RY2:ATP [plasmamembrane]Motilinreceptor:Motilin[plasma membrane]Chemokine XCreceptor 1: XC1ligands [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]FFAR3:Carboxylateligands [plasmamembrane]GnRH receptor:GNRHligands [plasmamembrane]P2RY11 :ATP [plasmamembrane]TRH:TRHR [plasmamembrane]Prokineticinreceptors [plasmamembrane]G-protein alpha(q/11) [plasmamembrane]CCK:Cholecystokininreceptors [plasmamembrane]UTS2R:Urotensin 2,2B [plasma membrane]Cholecystokininreceptors [plasmamembrane]Thrombin:Proteinase-activatedreceptors [plasmamembrane]G-protein alpha(q/11): GTP [plasmamembrane]Thrombin:Proteinase-activatedreceptors [plasmamembrane]Bradykinin receptor[plasma membrane]FFAR3:Carboxylateligands [plasmamembrane]Bombesin-likepeptide[extracellularregion]FPreceptor:PGF2-alpha[plasma membrane]pH sensing receptors[plasma membrane]NPS:NPSR [plasmamembrane]Melanospin:photon[plasma membrane]GPR17:UDP [plasmamembrane]Endothelin:Endothelinreceptor [plasmamembrane]Glucagon:GCGR[plasma membrane]Endothelin[extracellularregion]GPR17:UDP [plasmamembrane]LTB4 receptors:LTB4[plasma membrane]Neurotensin receptor[plasma membrane]LTB4 receptors[plasma membrane]TRH [extracellularregion]G-protein alpha(q/11): GTP [plasmamembrane]Catecholamine[extracellularregion]Neuropeptide FFreceptor:NeuropeptideFF [plasma membrane]FPRL1 ligands[extracellularregion]Bradykininreceptor:Bradykinin[plasma membrane]5-HT2receptor:Serotonin[plasma membrane]Substance Preceptor:Substance Ppeptide [plasmamembrane]Cholecystokininreceptors [plasmamembrane]P2RY9:LPA [plasmamembrane]Cholecystokininreceptors [plasmamembrane]pH sensing receptors[plasma membrane]GnRH receptor[plasma membrane]P2RY5:LPA [plasmamembrane]Bradykinin receptor[plasma membrane]Gastrin:CCKBR[plasma membrane]G-protein alpha(q/11):PI3K alpha[plasma membrane]Glucagon:GCGR[plasma membrane]Neuropeptide FFreceptor:NeuropeptideFF [plasma membrane]G-protein alpha(q):GRK2 [plasmamembrane]5-HT2receptor:Serotonin[plasma membrane]LTB4 receptors:LTB4[plasma membrane]Substance Kreceptor:NeurokininA peptide [plasmamembrane]Melanospin:photon[plasma membrane]Cysteinylleukotrienereceptors [plasmamembrane]Neuromedin Kreceptor:NeurokininB peptide [plasmamembrane]Basic L-amino acids[extracellularregion]XC1 ligands[extracellularregion]Neuromedin-U:Neuromedinreceptors [plasmamembrane]M1/M3/M5:acetylcholine[plasma membrane]TRIO family RhoGEFs[cytosol]Urotensin 2, 2B[extracellularregion]G-protein alpha(q/11) [plasmamembrane]Neuropeptide FFreceptor [plasmamembrane]Chemokine XCreceptor 1: XC1ligands [plasmamembrane]GPRC6A ligands[extracellularregion]HeterotrimericG-protein Gq/11(inactive) [plasmamembrane]HB-EGF:p-6Y-EGFR[plasma membrane]Neuromedin-Ureceptors [plasmamembrane]Acyl Ghrelin[extracellularregion]HRH1:Histamine[plasma membrane]GRB2:SOS1 [cytosol]GPRC6Areceptor:GPRC6Aligands [plasmamembrane]FFAR2:Carboxylateligands [plasmamembrane]P2RY2:ATP [plasmamembrane]Proteinase-activatedreceptors [plasmamembrane]G-protein beta-gammacomplex [plasmamembrane]G-protein alpha(q/11):GDP [plasmamembrane]UTS2R:Urotensin 2,2B [plasma membrane]Melanin-concentratinghormone receptors[plasma membrane]LPA-binding EDGreceptors: LPA[plasma membrane]Type 1 angiotensinIIreceptor:AngiotensinII [plasma membrane]Prokineticinreceptors:prokineticin[plasma membrane]CHRM1, 3, 5 [plasmamembrane]Prokineticin[extracellularregion]Endothelin:Endothelinreceptor [plasmamembrane]Carboxylate ligandsof FFAR2[extracellularregion]Acyl ghrelin:GHSR[plasma membrane]p21 RAS [plasmamembrane]pH sensingreceptors:H+ [plasmamembrane]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(inactive) [plasmamembrane]Endothelin:Endothelinreceptor [plasmamembrane]XC1 ligands[extracellularregion]PGE2 [extracellularregion]NMS(109-141)[extracellularregion]AcCho [extracellularregion]NPSR1 [plasmamembrane]LPA [extracellularregion]XCL2 [extracellularregion]Glu [extracellularregion]KISS1R [plasmamembrane]TBXA2R(1-369)[plasma membrane]DDCX [plasmamembrane]HB-EGF:p-6Y-EGFRdimerO-octanoyl-L-serine-GHRL-1(24-50)[extracellularregion]L-Lys [extracellularregion]Ca2+ [extracellularregion]PRKCAL-Arg [extracellularregion]FFAR1 [plasmamembrane]BDKRB1 [plasmamembrane]LTD4 [extracellularregion]NTSR1 [plasmamembrane]F2RL1(37-397)[plasma membrane]NMUR1 [plasmamembrane]GNA15 [plasmamembrane]MLNR [plasmamembrane]L-Orn [extracellularregion]HBEGF(63-148)F2RL3(18-385)[plasma membrane]AVPR1B [plasmamembrane]NAd [extracellularregion]GDP [plasmamembrane]CYSLTR2 [plasmamembrane]BDKRB1 [plasmamembrane]EDN3(97-117)[extracellularregion]MCHR1 [plasmamembrane]LXA4 [extracellularregion]GTP [cytosol]ATP [extracellularregion]PROK2 [extracellularregion]ARHGEF25 [cytosol]HTR2C(1-458) [plasmamembrane]HTR2C(1-458) [plasmamembrane]G-protein alpha(q):GRK2UTS2(114-124)[extracellularregion]FPR2 [plasmamembrane]TACR3 [plasmamembrane]thrombin light chain[extracellularregion]GAST(76-92)[extracellularregion]CHRM1 [plasmamembrane]LPAR2 [plasmamembrane]Pentadecanoic acid[plasma membrane]CASR [plasmamembrane]TRH(114-116)[extracellularregion]Substance P peptide[extracellularregion]TRH(84-86)[extracellularregion]GNA11 [plasmamembrane]Pentadecanoic acid[plasma membrane]TRIO family RhoGEFsL-Arg [extracellularregion]LPAR6 [plasmamembrane]GTP [plasmamembrane]NPFFR1 [plasmamembrane]Bradykinin[extracellularregion]NPFFR2 [plasmamembrane]G-protein alpha(q):GRK5GNAQ [plasmamembrane]GRK5 [cytosol]HCRTR2 [plasmamembrane]NPFFR1 [plasmamembrane]p-S133-CREB1LTB4R2 [plasmamembrane]LPAR4 [plasmamembrane]APP(672-713)[extracellularregion]NMB(47-56)[extracellularregion]NTS(151-163)[extracellularregion]PLCB3(2-1234)[cytosol]PTGFR [plasmamembrane]GNRHR [plasmamembrane]MCHR1 [plasmamembrane]TRH(84-86)[extracellularregion]CCKBR [plasmamembrane]GAST(76-92)[extracellularregion]HCOOH [extracellularregion]CCK [extracellularregion]GDPTRH(186-188)[extracellularregion]DecS-GHRL-1(24-50)[extracellularregion]GNAQ [plasmamembrane]Valerate[extracellularregion]TACR1 [plasmamembrane]TRH(186-188)[extracellularregion]FFAR2 [plasmamembrane]DDCX [plasmamembrane]KISS1R [plasmamembrane]GCGR [plasmamembrane]GNRHR [plasmamembrane]TRH(227-229)[extracellularregion]LPAR1 [plasmamembrane]Valerate[extracellularregion]DecS-GHRL-1(24-51)[extracellularregion]DAGGNA14 [plasmamembrane]GNAQ [plasmamembrane]FFAR2 [plasmamembrane]MT-RNR2(1-714)[extracellularregion]GNAQ [plasmamembrane]Neurokinin A peptide[extracellularregion]NMS(109-141)[extracellularregion]LPAR6 [plasmamembrane]TACR2 [plasmamembrane]FFAR3 [plasmamembrane]PIK3CA [cytosol]EDNRB [plasmamembrane]Effects of PIP2hydrolysisGPR4 [plasmamembrane]DecS-GHRL-1(24-51)[extracellularregion]PALM [plasmamembrane]TRH(135-137)[extracellularregion]PI3K alphaUTS2(114-124)[extracellularregion]MLN(26-47)[extracellularregion]Phospho-Ribosomalprotein S6 kinaseProtein Kinase C,alpha type: DAGPLCB1 [cytosol]CHRM3 [plasmamembrane]NPS(1-467)[extracellularregion]KISS1(68-121)[extracellularregion]QRFP(91-133)[extracellularregion]NTSR2 [plasmamembrane]GPR17 [plasmamembrane]GTP [plasmamembrane]XCL2 [extracellularregion]MCHR2 [plasmamembrane]LPAR2 [plasmamembrane]PTGFR [plasmamembrane]OXT(20-28)[extracellularregion]NMU(142-166)[extracellularregion]QRFPR [plasmamembrane]CHRM5 [plasmamembrane]NPS(1-467)[extracellularregion]P2RY6 [plasmamembrane]HXA [extracellularregion]BDKRB1 [plasmamembrane]H+ [extracellularregion]HTR2B [plasmamembrane]Neurokinin A peptide[extracellularregion]LPAR1 [plasmamembrane]APP(672-713)[extracellularregion]BUT [extracellularregion]Neurokinin A peptide[extracellularregion]XCR1 [plasmamembrane]GDP [cytosol]UDP [extracellularregion]EDN2(49-69)[extracellularregion]CCL23-2[extracellularregion]NTSR2 [plasmamembrane]GNA15 [plasmamembrane]BDKRB2 [plasmamembrane]PROK1 [extracellularregion]LPAR2 [plasmamembrane]HTR2B [plasmamembrane]Pentadecanoic acid[plasma membrane]p-6Y-EGFR [plasmamembrane]NPFFR2 [plasmamembrane]GNA14 [plasmamembrane]P2RY11 [plasmamembrane]LTB4R2 [plasmamembrane]GPR17 [plasmamembrane]GPR132 [plasmamembrane]P2RY1 [plasmamembrane]Valerate[extracellularregion]TRHR [plasmamembrane]TAC3(81-90)[extracellularregion]PLCB4 [cytosol]ADRA1A [plasmamembrane]HCRTR1 [plasmamembrane]GDP [plasmamembrane]EDNRA [plasmamembrane]PRKCA [plasmamembrane]ADRA1B [plasmamembrane]GNA11 [plasmamembrane]TRH(135-137)[extracellularregion]GRM5 [plasmamembrane]Glucagon[extracellularregion]HXA [extracellularregion]TBXA2R(1-369)[plasma membrane]GDP [plasmamembrane]GTPGNAQ [plasmamembrane]NMB(47-56)[extracellularregion]GNA14 [plasmamembrane]CCKBR [plasmamembrane]DAG [plasmamembrane]P2RY1 [plasmamembrane]KISS1(68-121)[extracellularregion]LXA4 [extracellularregion]Glu [extracellularregion]5HT [extracellularregion]GRM1 [plasmamembrane]F2RL2(22-374)[plasma membrane]LTC4 [extracellularregion]UTS2(114-124)[extracellularregion]HCRT(70-97)[extracellularregion]LTC4 [extracellularregion]CASR [plasmamembrane]UTS2R [plasmamembrane]GPR4 [plasmamembrane]CCL23-2[extracellularregion]AVP(20-28)[extracellularregion]GNA14 [plasmamembrane]AGTR1 [plasmamembrane]LPAR3 [plasmamembrane]GHSR [plasmamembrane]TRH(186-188)[extracellularregion]LTC4 [extracellularregion]GTP [plasmamembrane]NMUR1 [plasmamembrane]TBXA2R(1-369)[plasma membrane]GNAQ [plasmamembrane]KISS1(68-121)[extracellularregion]ATPGPR68 [plasmamembrane]GNA11 [plasmamembrane]TRHR [plasmamembrane]EDNRA [plasmamembrane]EDN1(53-73)[extracellularregion]GNA14 [plasmamembrane]G-protein beta-gammacomplexGNA15 [plasmamembrane]PTAFR [plasmamembrane]NMUR1 [plasmamembrane]OLEA [plasmamembrane]GNAQ [plasmamembrane]QRFP(91-133)[extracellularregion]P2RY2 [plasmamembrane]CCKBRI(1,4,5)P3Substance P peptide[extracellularregion]G-protein alpha(q/11):Trio familyRhoGEFsKALRN [cytosol]F2R(27-425) [plasmamembrane]GDPO-octanoyl-L-serine-GHRL-1(24-50)[extracellularregion]LTB4 [extracellularregion]Glucagon[extracellularregion]TRH(114-116)[extracellularregion]CCKAR [plasmamembrane]UDP [extracellularregion]PALM [plasmamembrane]PROKR2 [plasmamembrane]HCRT(70-97)[extracellularregion]FFAR2 [plasmamembrane]PTAFR [plasmamembrane]GPR68 [plasmamembrane]LPAR1 [plasmamembrane]GPR68 [plasmamembrane]AcCho [extracellularregion]TRH(152-154)[extracellularregion]CHRM1 [plasmamembrane]MCHR2 [plasmamembrane]O-octanoyl-L-serine-GHRL-1(24-50)[extracellularregion]AVPR1A [plasmamembrane]GRP(24-50)[extracellularregion]P2RY1 [plasmamembrane]XCR1 [plasmamembrane]LTB4R [plasmamembrane]GRB2-1 [cytosol]PLCB2 [cytosol]HBEGF(20-208)LTB4R2 [plasmamembrane]TRH(135-137)[extracellularregion]CCKBR [plasmamembrane]RAF/MAP kinasecascadeUTS2B(112-119)[extracellularregion]GRP(24-50)[extracellularregion]CHRM5 [plasmamembrane]RGZ [plasmamembrane]HBEGF(63-148)[extracellularregion]PROKR2 [plasmamembrane]TACR2 [plasmamembrane]Ligand:GPCRcomplexes thatactivate Gq/11DecS-GHRL-1(24-50)[extracellularregion]GNRH1(24-33)[extracellularregion]DDCX [plasmamembrane]HBEGF(20-62)GCGR [plasmamembrane]PROKR1 [plasmamembrane]GNRHR2(1-178)[plasma membrane]TACR2 [plasmamembrane]GPR132 [plasmamembrane]CCL23-2[extracellularregion]HRH1 [plasmamembrane]AGT(34-41)[extracellularregion]UTS2R [plasmamembrane]ADPL-Orn [extracellularregion]PAF [extracellularregion]NTS(151-163)[extracellularregion]XCL2 [extracellularregion]GRB2-1 [cytosol]HRAS(1-186) [plasmamembrane]PROKR1 [plasmamembrane]GNRHR2(1-178)[plasma membrane]F2RL3(18-385)[plasma membrane]O-octanoyl-L-serine-GHRL-1(24-51)[extracellularregion]O-octanoyl-L-serine-GHRL-1(24-51)[extracellularregion]NAd [extracellularregion]UDP [extracellularregion]PI(4,5)P2GNRH2(24-33)[extracellularregion]PROK2 [extracellularregion]p-ERK1/2/5F2R(27-425) [plasmamembrane]GNA15 [plasmamembrane]GRM5 [plasmamembrane]GNA11 [plasmamembrane]P2RY6 [plasmamembrane]MCHR2 [plasmamembrane]GNA11 [plasmamembrane]Ca2+ [extracellularregion]GNA15 [plasmamembrane]PROK1 [extracellularregion]GPR65 [plasmamembrane]HTR2A [plasmamembrane]PMCH(147-165)[extracellularregion]ATP [extracellularregion]HRAS(1-186) [plasmamembrane]F2RL1(37-397)[plasma membrane]OXT(20-28)[extracellularregion]ADRA1D [plasmamembrane]UTS2R [plasmamembrane]GPR65 [plasmamembrane]5HT [extracellularregion]G-protein alpha(q/11)TXA2 [extracellularregion]HRH1 [plasmamembrane]p-6Y-EGFR [plasmamembrane]LPAR3 [plasmamembrane]GNA15 [plasmamembrane]AcCho [extracellularregion]HCOOH [extracellularregion]GTP [plasmamembrane]HCRTR2 [plasmamembrane]5HT [extracellularregion]HBEGF(63-148)[extracellularregion]GTP [plasmamembrane]GRB2:SOS1:HB-EGF:p-6Y-EGFRGNAQ [plasmamembrane]TXA2 [extracellularregion]Bradykinin[extracellularregion]TRIO [cytosol]SAA1(19-122)[extracellularregion]XCR1 [plasmamembrane]GPR132 [plasmamembrane]SOS1 [cytosol]TRH(227-229)[extracellularregion]TRH(114-116)[extracellularregion]GNRH1(24-33)[extracellularregion]F2R(27-425) [plasmamembrane]thrombin light chain[extracellularregion]ADPHCRT(34-66)[extracellularregion]CYSLTR1 [plasmamembrane]GRP(24-50)[extracellularregion]LTE4 [extracellularregion]SOS1 [cytosol]OXTR [plasmamembrane]MLNR [plasmamembrane]P2RY10 [plasmamembrane]EDN2(49-69)[extracellularregion]LPAR4 [plasmamembrane]OLEA [plasmamembrane]HCRTR1 [plasmamembrane]GNA11 [plasmamembrane]GPR4 [plasmamembrane]CH3COO-[extracellularregion]CHRM3 [plasmamembrane]ADR [extracellularregion]CYSLTR2 [plasmamembrane]GAST(76-92)[extracellularregion]ANXA1 [extracellularregion]CH3COO-[extracellularregion]G-protein alpha(q/11):GDPLPAR3 [plasmamembrane]GHSR [plasmamembrane]LPAR5 [plasmamembrane]EDNRA [plasmamembrane]NMUR2 [plasmamembrane]RGZ [plasmamembrane]LTD4 [extracellularregion]P2RY10 [plasmamembrane]FFAR1 [plasmamembrane]GNA11 [plasmamembrane]UTS2B(112-119)[extracellularregion]QRFPR [plasmamembrane]LPAR5 [plasmamembrane]NTSR1 [plasmamembrane]LPAR5 [plasmamembrane]LTD4 [extracellularregion]GNA15 [plasmamembrane]TRH(152-154)[extracellularregion]GAST(76-92)NPFFR2 [plasmamembrane]P2RY6 [plasmamembrane]GNA11 [plasmamembrane]GAST(76-92)[extracellularregion]CCKBR [plasmamembrane]CH3COO-[extracellularregion]PLC beta:G alpha(q/11)LTE4 [extracellularregion]LXA4 [extracellularregion]PTGER1 [plasmamembrane]RGZ [plasmamembrane]AGT(34-41)[extracellularregion]AVPR1B [plasmamembrane]TXA2 [extracellularregion]EDN3(97-117)[extracellularregion]GNA11 [plasmamembrane]APP(672-713)[extracellularregion]PGE2 [extracellularregion]AVPR1A [plasmamembrane]L-Lys [extracellularregion]AVP(20-28)[extracellularregion]HCRT(34-66)[extracellularregion]HCRT(70-97)[extracellularregion]Ribosomal protein S6kinaseDecS-GHRL-1(24-51)[extracellularregion]TRH(152-154)[extracellularregion]GTP [plasmamembrane]PTGFR [plasmamembrane]Hist [extracellularregion]GNAQ [plasmamembrane]QRFP(91-133)[extracellularregion]XCL1 [extracellularregion]NPSR1 [plasmamembrane]AGTR1 [plasmamembrane]Glu [extracellularregion]F2RL3(18-385)[plasma membrane]H+ [extracellularregion]FPR2 [plasmamembrane]PGF2a [extracellularregion]PROKR1 [plasmamembrane]TRHR [plasmamembrane]NPFF(69-76)[extracellularregion]PROK2 [extracellularregion]GRM5 [plasmamembrane]NPS(1-467)[extracellularregion]OXTR [plasmamembrane]ADP [extracellularregion]ADRA1B [plasmamembrane]NTSR2 [plasmamembrane]CHRM3 [plasmamembrane]CCKAR [plasmamembrane]GPRC6A [plasmamembrane]OPN4 [plasmamembrane]P2RY2 [plasmamembrane]TACR3 [plasmamembrane]HTR2C(1-458) [plasmamembrane]HBEGF(149-208)P2RY11 [plasmamembrane]EDN1(53-73)[extracellularregion]ADP [extracellularregion]FFAR3 [plasmamembrane]GPRC6A [plasmamembrane]GCGR [plasmamembrane]G-protein alpha(q/11): GTPLPAR6 [plasmamembrane]GNA15 [plasmamembrane]ATPFPR2 [plasmamembrane]GNA14 [plasmamembrane]EDNRB [plasmamembrane]P2RY2 [plasmamembrane]NTS(151-163)[extracellularregion]MLN(26-47)[extracellularregion]HCRTR2 [plasmamembrane]NMUR2 [plasmamembrane]ANXA1 [extracellularregion]SAA1(19-122)[extracellularregion]ATP [extracellularregion]PMCH(147-165)[extracellularregion]FFAR3 [plasmamembrane]GNRH1(24-33)[extracellularregion]OPN4 [plasmamembrane]G-protein alpha(q/11):PI3K alphaGRB2:SOS1Gastrin:CCKBRADP [extracellularregion]PAF [extracellularregion]NMB(47-56)[extracellularregion]GRK5CCK [extracellularregion]MLN(26-47)[extracellularregion]EtCOO- or C2H5COO-[extracellularregion]HTR2B [plasmamembrane]SAA1(19-122)[extracellularregion]EtCOO- or C2H5COO-[extracellularregion]CYSLTR1 [plasmamembrane]NAd [extracellularregion]Bradykinin[extracellularregion]GTP [plasmamembrane]PTGER1 [plasmamembrane]AVP(20-28)[extracellularregion]KRAS(1-186) [plasmamembrane]thrombin light chain[extracellularregion]HCRTR1 [plasmamembrane]MT-RNR2(1-714)[extracellularregion]LPAR4 [plasmamembrane]CCK [extracellularregion]thrombin heavy chain[extracellularregion]ADRBK1(2-689)P2RY10 [plasmamembrane]PTGER1 [plasmamembrane]HRH1 [plasmamembrane]MCHR1 [plasmamembrane]AVPR1A [plasmamembrane]HTR2A [plasmamembrane]MMP3PGF2a [extracellularregion]CREB1XCL1 [extracellularregion]CHRM1 [plasmamembrane]GPR65 [plasmamembrane]NRAS [plasmamembrane]LTB4 [extracellularregion]TRH(84-86)[extracellularregion]OXTR [plasmamembrane]ADRA1A [plasmamembrane]ADR [extracellularregion]EDN2(49-69)[extracellularregion]PGF2a [extracellularregion]p21 RAS:GDPBUT [extracellularregion]BUT [extracellularregion]LTB4R [plasmamembrane]EtCOO- or C2H5COO-[extracellularregion]GPCRs that activateGq/11HCRT(34-66)[extracellularregion]PMCH(147-165)[extracellularregion]ANXA1 [extracellularregion]ADRA1D [plasmamembrane]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(inactive)CCKAR [plasmamembrane]CYSLTR1 [plasmamembrane]NMU(142-166)[extracellularregion]TACR1 [plasmamembrane]DecS-GHRL-1(24-50)[extracellularregion]F2RL1(37-397)[plasma membrane]ADR [extracellularregion]OPN4 [plasmamembrane]NPFF(69-76)[extracellularregion]ADRA1D [plasmamembrane]UTS2B(112-119)[extracellularregion]KISS1R [plasmamembrane]RGS proteins activefor G alpha (q)NPFFR1 [plasmamembrane]TRH(227-229)[extracellularregion]AGT(34-41)[extracellularregion]GNA14 [plasmamembrane]thrombin heavy chain[extracellularregion]LPA [extracellularregion]HeterotrimericG-protein Gq/11(inactive)PAF [extracellularregion]GNRHR2(1-178)[plasma membrane]GNA11 [plasmamembrane]Ligands of GPCRsthat activate Gq/11NMU(142-166)[extracellularregion]p21 RAS:GTPFFAR1 [plasmamembrane]GNA14 [plasmamembrane]Hist [extracellularregion]GRM1 [plasmamembrane]TACR1 [plasmamembrane]CYSLTR2 [plasmamembrane]ADRBK1(2-689)[plasma membrane]GHSR [plasmamembrane]EDN3(97-117)[extracellularregion]PGE2 [extracellularregion]Glucagon[extracellularregion]GNA15 [plasmamembrane]EGFRGNRH2(24-33)[extracellularregion]H+ [extracellularregion]P2RY11 [plasmamembrane]BDKRB2 [plasmamembrane]ADRA1B [plasmamembrane]GTPEDN1(53-73)[extracellularregion]LTB4R [plasmamembrane]L-Orn [extracellularregion]ADRA1A [plasmamembrane]NPSR1 [plasmamembrane]KRAS(1-186) [plasmamembrane]Ligand:GPCRcomplexes thatactivateGq/11:HeterotrimericG-protein Gq(active)BDKRB2 [plasmamembrane]GNAQ [plasmamembrane]F2RL2(22-374)[plasma membrane]LTB4 [extracellularregion]NTSR1 [plasmamembrane]F2RL2(22-374)[plasma membrane]CASR [plasmamembrane]AVPR1B [plasmamembrane]CHRM5 [plasmamembrane]GNRHR [plasmamembrane]GRM1 [plasmamembrane]MT-RNR2(1-714)[extracellularregion]PLC-betaPTAFR [plasmamembrane]GPRC6A [plasmamembrane]TAC3(81-90)[extracellularregion]EDNRB [plasmamembrane]XCL1 [extracellularregion]LPA [extracellularregion]GNA14 [plasmamembrane]PROK1 [extracellularregion]LTE4 [extracellularregion]thrombin heavy chain[extracellularregion]TACR3 [plasmamembrane]HXA [extracellularregion]AGTR1 [plasmamembrane]L-Arg [extracellularregion]Substance P peptide[extracellularregion]GNRH2(24-33)[extracellularregion]QRFPR [plasmamembrane]HCOOH [extracellularregion]O-octanoyl-L-serine-GHRL-1(24-51)[extracellularregion]GNA15 [plasmamembrane]Ca2+ [extracellularregion]MLNR [plasmamembrane]PROKR2 [plasmamembrane]GNA14 [plasmamembrane]Hist [extracellularregion]PALM [plasmamembrane]L-Lys [extracellularregion]HTR2A [plasmamembrane]NRAS [plasmamembrane]TAC3(81-90)[extracellularregion]OLEA [plasmamembrane]PIK3CA [cytosol]NPFF(69-76)[extracellularregion]NMUR2 [plasmamembrane]OXT(20-28)[extracellularregion]GPR17 [plasmamembrane]NMS(109-141)[extracellularregion]15, 1915, 1915, 194, 22, 3415, 1924, 2715, 1915, 1928, 41