Delta-Notch Signaling Pathway (Mus musculus)

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ERRecruitmentEndoplasmic reticulumNucleusNU->CYControlDInhibitionNU->CYICDMethylationProteins in a complex interactionCY->NUICDICDDephosphorylationCY->NUDNUIntracellular DomainPM->NUReactioin through unknown mechanisms/moleculesSumoylationCY->NUAcetylationReceptor(Protein-protein interaction)CY->NUAutophosphorylationMTPM->CYICDEnzyme complexDesumoylationGO->PMPlasma membranePM->NUICDMitochondrionTranslocationDCYUbiquitinationEndosomeProteolytic CleavageGO->PMAccession Number: NetPath 3; cellmap:3ICDMolecular associationPalmitoylationDPhosphorylationDeacetylationGolgi apparatusMolecule in the pathwayGamma secretase complexExtracellularGlycosylationGODPM->NUDeubiquitinationDDemethylationPM->NUECLigandActivationENGene Symbol-- ICDCY->NUNU->CYPMCytoplasmNcor2Notch2Hes1NovNcstnHivep3Notch1Ncor1Fhl1Jag2NfkbiaRelaGsk3bEgfJunNumblDll1Adam10Notch1PsenenSin3aJag2PcafLef1AppSkp1aNotch2Notch4Zfpm1Skp2Aph1aHey1EgfrRbx1Ep3001700023B02RikTcfe2aSmad4Hdac1SPENDll1FurinNcor2Pofut1Gsk3bCntfPIK3R1Notch2RbpsuhMef2cSmad1Mapk3Notch3Hey2MfngYy1Dll4LckRing1Hes5Notch1Ascl1Trp53Maml1Adam17Mapk1Jag1Dll1Maml2CntfrTle1Jag1Stat3Notch2Jak2Notch1Jag1MAML3Jag2MAGEA1ItchNotch4Dll4Wdr12RelaSmad3Notch1Ep300NumbPik3r2Skp1aLfngAph1bNcor1Notch1Notch3Hdac2Skp2Hes6SNW1Notch3Cntn1Dtx1Psen2Cul1Akt1Fbxw7Sap30Stat3CDK2Dtx1Psen1


Description

No description

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
69189view18:22, 8 July 2013MaintBotUpdated to 2013 gpml schema
67151view10:13, 26 June 2013Christine ChichesterOntology Term : 'Notch signaling pathway' added !
41380view00:28, 2 March 2011MaintBotRemoved redundant pathway information and comments
35709view23:19, 12 February 2010AlexanderPico
34421view23:17, 9 December 2009MaintBotAutomatic update of empty xrefs
31415view20:55, 13 August 2009MaintBotFixed text labels
30896view00:22, 30 July 2009MaintBotConverted from Homo sapiens
21237view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:Delta-Notch NetPath 3]] moved to [[Pathway:WP265]]: Moved to stable identifier
7986view13:46, 7 January 2008MaintBot[[Pathway:Mouse:Delta-Notch NetPath 3]] moved to [[Pathway:Mus musculus:Delta-Notch NetPath 3]]: Renaming species
7617view16:04, 18 December 2007MaintBotfixed category names
7213view12:33, 4 November 2007MaintBotAdded categories to GPML
6431view22:18, 22 May 2007A.Pandeygpml file for [[Mouse:Delta-Notch_NetPath_3]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1700023B02RikGeneProduct66935 (Entrez Gene)
Adam10GeneProduct11487 (Entrez Gene)
Adam17GeneProduct11491 (Entrez Gene)
Akt1GeneProduct11651 (Entrez Gene)
Aph1aGeneProduct226548 (Entrez Gene)
Aph1bGeneProduct208117 (Entrez Gene)
AppGeneProduct11820 (Entrez Gene)
Ascl1GeneProduct17172 (Entrez Gene)
CDK2GeneProduct
CntfGeneProduct12803 (Entrez Gene)
CntfrGeneProduct12804 (Entrez Gene)
Cntn1GeneProduct12805 (Entrez Gene)
Cul1GeneProduct26965 (Entrez Gene)
Dll1GeneProduct13388 (Entrez Gene)
Dll4GeneProduct54485 (Entrez Gene)
Dtx1GeneProduct14357 (Entrez Gene)
EgfGeneProduct13645 (Entrez Gene)
EgfrGeneProduct13649 (Entrez Gene)
Ep300GeneProduct328572 (Entrez Gene)
Fbxw7GeneProduct50754 (Entrez Gene)
Fhl1GeneProduct14199 (Entrez Gene)
FurinGeneProduct18550 (Entrez Gene)
Gsk3bGeneProduct56637 (Entrez Gene)
Hdac1GeneProduct433759 (Entrez Gene)
Hdac2GeneProduct15182 (Entrez Gene)
Hes1GeneProduct15205 (Entrez Gene)
Hes5GeneProduct15208 (Entrez Gene)
Hes6GeneProduct55927 (Entrez Gene)
Hey1GeneProduct15213 (Entrez Gene)
Hey2GeneProduct15214 (Entrez Gene)
Hivep3GeneProduct16656 (Entrez Gene)
ItchGeneProduct16396 (Entrez Gene)
Jag1GeneProduct16449 (Entrez Gene)
Jag2GeneProduct16450 (Entrez Gene)
Jak2GeneProduct16452 (Entrez Gene)
JunGeneProduct16476 (Entrez Gene)
LckGeneProduct16818 (Entrez Gene)
Lef1GeneProduct16842 (Entrez Gene)
LfngGeneProduct16848 (Entrez Gene)
MAGEA1GeneProduct
MAML3GeneProduct
Maml1GeneProduct103806 (Entrez Gene)
Maml2GeneProduct270118 (Entrez Gene)
Mapk1GeneProduct26413 (Entrez Gene)
Mapk3GeneProduct26417 (Entrez Gene)
Mef2cGeneProduct17260 (Entrez Gene)
MfngGeneProduct17305 (Entrez Gene)
Ncor1GeneProduct20185 (Entrez Gene)
Ncor2GeneProduct20602 (Entrez Gene)
NcstnGeneProduct59287 (Entrez Gene)
NfkbiaGeneProduct18035 (Entrez Gene)
Notch1GeneProduct18128 (Entrez Gene)
Notch2GeneProduct18129 (Entrez Gene)
Notch3GeneProduct18131 (Entrez Gene)
Notch4GeneProduct18132 (Entrez Gene)
NovGeneProduct18133 (Entrez Gene)
NumbGeneProduct18222 (Entrez Gene)
NumblGeneProduct18223 (Entrez Gene)
PIK3R1GeneProduct
PcafGeneProduct18519 (Entrez Gene)
Pik3r2GeneProduct18709 (Entrez Gene)
Pofut1GeneProduct140484 (Entrez Gene)
Psen1GeneProduct19164 (Entrez Gene)
Psen2GeneProduct19165 (Entrez Gene)
PsenenGeneProduct66340 (Entrez Gene)
RbpsuhGeneProduct19664 (Entrez Gene)
Rbx1GeneProduct56438 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
Ring1GeneProduct19763 (Entrez Gene)
SNW1GeneProduct
SPENGeneProduct
Sap30GeneProduct60406 (Entrez Gene)
Sin3aGeneProduct20466 (Entrez Gene)
Skp1aGeneProduct21402 (Entrez Gene)
Skp2GeneProduct27401 (Entrez Gene)
Smad1GeneProduct17125 (Entrez Gene)
Smad3GeneProduct17127 (Entrez Gene)
Smad4GeneProduct17128 (Entrez Gene)
Stat3GeneProduct20848 (Entrez Gene)
Tcfe2aGeneProduct21423 (Entrez Gene)
Tle1GeneProduct21885 (Entrez Gene)
Trp53GeneProduct22059 (Entrez Gene)
Wdr12GeneProduct57750 (Entrez Gene)
Yy1GeneProduct22632 (Entrez Gene)
Zfpm1GeneProduct22761 (Entrez Gene)

Annotated Interactions

No annotated interactions
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