Heroin metabolism (Homo sapiens)

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122heroin6-acetylmorphinemorphine metabolismCES2morphineCES1


Description

Pathway complementing the morphine metabolism pathway around heroin.

Quality Tags

Ontology Terms

 

Bibliography

  1. Hatfield MJ, Tsurkan L, Hyatt JL, Yu X, Edwards CC, Hicks LD, Wadkins RM, Potter PM; ''Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin.''; Br J Pharmacol, 2010 PubMed Europe PMC Scholia
  2. Maurer HH, Sauer C, Theobald DS; ''Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine.''; Ther Drug Monit, 2006 PubMed Europe PMC Scholia
  3. Redinbo MR, Bencharit S, Potter PM; ''Human carboxylesterase 1: from drug metabolism to drug discovery.''; Biochem Soc Trans, 2003 PubMed Europe PMC Scholia
  4. Sawynok J; ''The therapeutic use of heroin: a review of the pharmacological literature.''; Can J Physiol Pharmacol, 1986 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95179view15:51, 21 November 2017DeSlOntology Term : 'heroin drug pathway' added !
95178view15:50, 21 November 2017DeSlModified description
95177view15:49, 21 November 2017DeSlAdded an enzyme+conversion, literature reference to support this and additional information.
77113view09:35, 20 July 2014EgonwLess whitespace.
77112view09:35, 20 July 2014EgonwThe proper metabolization is in two steps. CES1 is involved in both.
77111view09:30, 20 July 2014EgonwFound another reference that CES1 metabolizes heroin.
77110view09:25, 20 July 2014EgonwOntology Term : 'xenobiotic metabolic pathway' added !
77109view09:24, 20 July 2014EgonwOntology Term : 'drug pathway' added !
77108view09:23, 20 July 2014EgonwModified description
77107view09:22, 20 July 2014EgonwFound an article describing two enzymes that metabolize heroin.
74321view15:33, 12 April 2014EgonwAdded a missing metabolite identifier.
74320view15:32, 12 April 2014EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-acetylmorphineMetabolite5462507 (PubChem-compound)
CES1GeneProductENSG00000198848 (Ensembl)
CES2GeneProductENSG00000172831 (Ensembl)
heroinMetaboliteCHEBI:27808 (ChEBI)
morphine metabolismPathwayWP1604 (WikiPathways)
morphineMetaboliteCHEBI:17303 (ChEBI)

Annotated Interactions

No annotated interactions

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