Nanoparticle-mediated activation of receptor signaling (Homo sapiens)

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Current revision (21:19, 12 September 2019) (view source)
(Modified description)
 
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   <Comment Source="WikiPathways-description">Nanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as proliferation, apoptosis, differentiation, and migration. In lung epithelial cells, NPs interact with both EGFR and integrins, leading to cell proliferation via activation of PI3K and AKT. NPs were shown to activate the EGFR, leading in parallel to apoptosis and proliferation, and oncogenic Ras mutations might influence these effects. Interestingly, while integrin-mediated activation of ERK was instrumental for proliferation, apoptosis was mediated via activation of JNK. In addition, NPs (PM2.5) are able to bind the EGFR to activate the MAPK signaling cascade. Activation of ERK leads to the expression and secretion of the epidermal growth factor amphiregulin, thus forming an autocrine loop, which might be instrumental for sustained inflammatory responses. Nanoparticles are depicted as red circles.
   <Comment Source="WikiPathways-description">Nanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as proliferation, apoptosis, differentiation, and migration. In lung epithelial cells, NPs interact with both EGFR and integrins, leading to cell proliferation via activation of PI3K and AKT. NPs were shown to activate the EGFR, leading in parallel to apoptosis and proliferation, and oncogenic Ras mutations might influence these effects. Interestingly, while integrin-mediated activation of ERK was instrumental for proliferation, apoptosis was mediated via activation of JNK. In addition, NPs (PM2.5) are able to bind the EGFR to activate the MAPK signaling cascade. Activation of ERK leads to the expression and secretion of the epidermal growth factor amphiregulin, thus forming an autocrine loop, which might be instrumental for sustained inflammatory responses. Nanoparticles are depicted as red circles.
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP2643 CPTAC Assay Portal].</Comment>
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Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP2643 CPTAC Assay Portal]</Comment>
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   <BiopaxRef>a61</BiopaxRef>
   <Graphics BoardWidth="801.8820861678005" BoardHeight="666.0"/>
   <Graphics BoardWidth="801.8820861678005" BoardHeight="666.0"/>

Current revision

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Pathway history

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CompareRevisionActionTimeUserComment
106660view21:19, 12 September 2019KhanspersModified description
105661view05:17, 10 August 2019KhanspersModified description
102132view09:12, 2 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
95473view08:43, 16 December 2017EgonwOh, there were two nodes :(
95472view08:42, 16 December 2017EgonwReplace a Wikipedia ID with the matching Wikidata ID (with more mappings).
92317view08:50, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
87898view12:53, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
74251view08:45, 11 April 2014ElisaUsing label type for text elements
74250view08:40, 11 April 2014ElisaUsing label type for text elements
74187view11:00, 3 April 2014Bart SmeetsModified title
74186view11:00, 3 April 2014Bart SmeetsModified description
74185view10:56, 3 April 2014Bart SmeetsModified description
74184view10:55, 3 April 2014Bart SmeetsModified description
74183view10:55, 3 April 2014Bart SmeetsNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/6/6d/WP2643_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/6/6d/WP2643_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106660)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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