TCA Cycle (Krebs Cycle) (Arabidopsis thaliana)

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CoAAcetyl-CoA2-oxoglutarate dehydrogenasepyruvate dehydrogenasesuccinatecitrate synthase2-oxoglutarateisocitrate dehydrogenaseoxaloacetateSuccinyl-CoAaconitaseGlycolysisisocitratesuccinyl-CoA synthetasemalate dehydrogenasesuccinate dehydrogenasecitratefumarateFADH2malic enzymefumaraseFAD+pyruvateCoACO2NAD+NADHNAD+NADHCoACO2NAD+NADHCoAH2OATPADPmalateH2ONAD+NADHNAD+NADHisocitrateisocitrate dehydrogenase2-oxoglutarateNADP+NADPHCO2CO2Glutamate BiosynthesisMitochondrionCO2


This pathway describes TCA cycle (Krebs Cycle) reactions in A. thaliana mitochondria.The metabolic links with the Glycolysis and Glutamate Biosynthesis are indicated. Protein identifiers for A. thaliana are from UNIPROT. The pathway is inspired from information drawn for Plant Physiology (Taiz and Zeiger) Third Edition and KEGG Pathways.

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111813view19:05, 8 September 2020EgonwCorrected the data source to match the identifier
105902view11:36, 16 August 2019MkutmonHMDB identifier normalization
79786view15:54, 16 April 2015Mkutmonfixed unconnected line
78386view10:22, 7 January 2015MaintBotadded missing graphIds
76230view13:45, 19 June 2014SbohlerAll protein nodes are now annotated with UNIPROT IDs. Information about protein isoforms has been added.
75332view14:48, 19 May 2014SbohlerCorrected translation destination of NAD-ME1 and 2.
75325view13:35, 19 May 2014SbohlerAdapted font of "Mitochondrion" to match other pathways from same authors. Added RNA for CICDH.
75323view13:10, 19 May 2014SbohlerAdded cell border, organelle label and mRNAs for NAD-ME1 and NAD-ME2
74204view07:28, 5 April 2014EgonwRemoved a data source where no ID was given.
73921view10:09, 4 March 2014Anwesha
73920view10:08, 4 March 2014AnweshaModified description
73919view09:59, 4 March 2014SbohlerModified description
73917view09:52, 4 March 2014AnweshaAdded metabolite identifiers
73910view09:03, 4 March 2014Anweshaadded metabolite and pathway identifiers
73909view09:01, 4 March 2014AnweshaPeriodical save, work in progress
73908view08:51, 4 March 2014AnweshaPeriodical save, work in progress
73882view21:55, 26 February 2014MaintBotOntology Term : 'citric acid cycle pathway' added !
73877view21:45, 26 February 2014MaintBotFixed scaling issue
73609view13:43, 4 February 2014Sbohlerremoval of excess objects
73608view13:23, 4 February 2014AnweshaNew pathway

External references


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NameTypeDatabase referenceComment
2-oxoglutarate dehydrogenaseProtein1.2.4.2 (Enzyme Nomenclature)
2-oxoglutarateMetaboliteC00026 (KEGG Compound)
ADPMetaboliteC00008 (KEGG Compound)
ATPMetaboliteHMDB00538 (HMDB)
Acetyl-CoAMetaboliteHMDB01206 (HMDB)
CO2MetaboliteHMDB01967 (HMDB)
CoAMetaboliteC00010 (KEGG Compound)
FAD+MetaboliteHMDB01248 (HMDB)
FADH2MetaboliteHMDB01197 (HMDB)
Glutamate BiosynthesisPathway
GlycolysisPathwayWP2621 (WikiPathways)
H2OMetaboliteHMDB02111 (HMDB)
NAD+MetaboliteHMDB00902 (HMDB)
NADHMetaboliteHMDB01487 (HMDB)
NADP+MetaboliteHMDB00902 (HMDB)
NADPHMetaboliteHMDB01487 (HMDB)
Succinyl-CoAMetaboliteHMDB01022 (HMDB)
aconitaseProtein4.2.1.3 (Enzyme Nomenclature)
citrate synthaseProtein2.3.3.1 (Enzyme Nomenclature)
citrateMetaboliteC00158 (KEGG Compound)
fumaraseProtein4.2.1.2 (Enzyme Nomenclature)
fumarateMetaboliteC00122 (KEGG Compound)
isocitrate dehydrogenaseProtein1.1.1.41 (Enzyme Nomenclature)
isocitrate dehydrogenaseProteinQ9SRZ6 (Uniprot-TrEMBL)
isocitrateMetaboliteC00311 (KEGG Compound)
malate dehydrogenaseProtein1.1.1.37 (Enzyme Nomenclature)
malateMetaboliteC00149 (KEGG Compound)
malic enzymeProtein1.1.1.38 (Enzyme Nomenclature)
oxaloacetateMetaboliteC00036 (KEGG Compound)
pyruvate dehydrogenaseProtein1.2.1.51 (Enzyme Nomenclature)
pyruvateMetaboliteCHEBI:15361 (ChEBI)
succinate dehydrogenaseProtein1.3.99.1 (Enzyme Nomenclature)
succinateMetaboliteC00042 (KEGG Compound)
succinyl-CoA synthetaseProtein6.2.1.5 (Enzyme Nomenclature)

Annotated Interactions

No annotated interactions

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