Glucose-1-phosphate metabolism (Saccharomyces cerevisiae)

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1-4H2OUTPNADPbeta-D-Glucosedelta-Glucono-delta-lactoneUDP-D-glucosephosphatefructosea glucosylated glycogeninGlycogen(1,4-alpha-D-glucosyl)n - RUDP-D-glucoseglucose-1-phosphatePGM1UDPpyrophosphateglucose-6-phosphatePGM2GSY1UGP1GLC3NADPHYHL012WGSY2(1,4-alpha-D-Glucosyl)n+1 - RUDP-D-glucoseUDPUDP-D-glucoseUDP


Glycogen, a branched polymer of glucose, is a storage molecule whose accumulation is under rigorous control in many cells. In Saccharomyces cerevisiae, glycogen biosynthesis involves three processes: nucleation, elongation, and branching (also known as ramification). The formation of glycogen begins when either Glg1p or Glg2p uses UDP-glucose to self-glucosylate to produce a short alpha (1,4)-glucosyl chain covalently attached to one of their internal tyrosine residues. After the self-glucosylation of Glg1p or Glg2p, glycogen synthase is able to extend the linear alpha (1,4)-glucosyl chains of glycogen by catalyzing the formation of alpha (1,4)-glucosidic bonds from UDP- glucose at the non-reducing ends. Branches can be added into the glycogen molecule by Glc3p, which is the glycogen branching enzyme (EC: in S. cerevisiae.

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Ontology Terms



  1. Mu J, Cheng C, Roach PJ; ''Initiation of glycogen synthesis in yeast. Requirement of multiple tyrosine residues for function of the self-glucosylating Glg proteins in vivo.''; J Biol Chem, 1996 PubMed Europe PMC Scholia
  2. Thon VJ, Vigneron-Lesens C, Marianne-Pepin T, Montreuil J, Decq A, Rachez C, Ball SG, Cannon JF; ''Coordinate regulation of glycogen metabolism in the yeast Saccharomyces cerevisiae. Induction of glycogen branching enzyme.''; J Biol Chem, 1992 PubMed Europe PMC Scholia
  3. Farkas I, Hardy TA, Goebl MG, Roach PJ; ''Two glycogen synthase isoforms in Saccharomyces cerevisiae are coded by distinct genes that are differentially controlled.''; J Biol Chem, 1991 PubMed Europe PMC Scholia
  4. Fran├žois J, Parrou JL; ''Reserve carbohydrates metabolism in the yeast Saccharomyces cerevisiae.''; FEMS Microbiol Rev, 2001 PubMed Europe PMC Scholia


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107252view14:35, 17 September 2019MaintBotChEBI identifier normalization
96372view09:40, 10 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94487view13:54, 13 September 2017Mkutmonfix literature references
94486view13:52, 13 September 2017Mkutmonlayout fix
94485view13:51, 13 September 2017Mkutmonupdated layout
94484view12:35, 13 September 2017Mkutmonupdate layout
94483view12:34, 13 September 2017Mkutmonupdated layout
94482view12:33, 13 September 2017Mkutmonupdated layout
94481view12:32, 13 September 2017Mkutmonupdated layout
94173view09:32, 25 August 2017DeSlChanged width of several data nodes, so text is readable in download file.
94172view09:30, 25 August 2017DeSlChanged appearance of nodes
94143view09:59, 24 August 2017DeSlOntology Term : 'glycogen biosynthetic pathway' added !
94142view09:59, 24 August 2017DeSlOntology Term : 'glucose conversion pathway' added !
94141view09:57, 24 August 2017DeSlAdded literature references, added part to PW (after UDP-D-glucose)
94140view09:25, 24 August 2017DeSlModified description
94139view09:23, 24 August 2017DeSlModified description
94138view09:21, 24 August 2017DeSlAdded last missing ID for UDP-D-Glucose
94137view09:19, 24 August 2017DeSlAnnotated all nodes which previously were textlabel; changed wrong glucose-1-phosphate annotation.
94136view09:11, 24 August 2017DeSlConnected all reactions which were displayed in this PW, so it is a real PW.
89691view10:10, 26 September 2016EgonwReplace the CAS number of the salt with that of just the metabolite.
69835view15:14, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69578view20:28, 8 July 2013MaintBotUpdated to 2013 gpml schema
67287view10:32, 26 June 2013Christine ChichesterOntology Term : 'glucose utilization pathway' added !
41800view04:48, 2 March 2011MaintBotRemoved redundant pathway information and comments
21227view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Gucose-1-phosphate Metabolism]] moved to [[Pathway:WP260]]: Moved to stable identifier
12740view08:00, 17 May 2008MaintBotautomated metabolite conversion
8771view14:08, 7 January 2008MaintBotAdded to category $category
8769view14:08, 7 January 2008J.HeckmanUploaded new pathway

External references


View all...
NameTypeDatabase referenceComment
(1,4-alpha-D-Glucosyl)n+1 - RMetaboliteCHEBI:28102 (ChEBI) R = a glycogenin
(1,4-alpha-D-glucosyl)n - RMetaboliteCHEBI:15444 (ChEBI) R = a glycogenin
GLC3GeneProductYEL011W (Ensembl)
GSY1GeneProductYFR015C (Ensembl)
GSY2GeneProductYLR258W (Ensembl)
GlycogenMetaboliteCHEBI:28087 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
NADPMetaboliteCHEBI:44409 (ChEBI)
NADPHMetabolite53-57-6 (CAS)
PGM1GeneProductS000001610 (SGD)
PGM2GeneProductS000004711 (SGD)
UDP-D-glucoseMetaboliteCHEBI:46229 (ChEBI)
UDPMetaboliteCHEBI:17659 (ChEBI)
UGP1GeneProductS000001518 (SGD)
UTPMetaboliteCHEBI:46398 (ChEBI)
YHL012WGeneProductS000001004 (SGD)
a glucosylated glycogeninMetabolite
beta-D-GlucoseMetaboliteCHEBI:15903 (ChEBI)
delta-Glucono-delta-lactoneMetaboliteCHEBI:16217 (ChEBI)
fructoseMetabolite7776-48-9 (CAS)
glucose-1-phosphateMetaboliteCHEBI:16077 (ChEBI)
glucose-6-phosphateMetaboliteCHEBI:75150 (ChEBI)
phosphateMetabolite14265-44-2 (CAS)
pyrophosphateMetabolite2466-09-3 (CAS)

Annotated Interactions

No annotated interactions

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