Nifedipine Activity (Homo sapiens)

From WikiPathways

(Difference between revisions)
Jump to: navigation, search
(layout, xrefs, connections)
(fix unconnected lines)
Line 4: Line 4:
Source: Wikipedia ([[wikipedia:Nifedipine]])</Comment>
Source: Wikipedia ([[wikipedia:Nifedipine]])</Comment>
   <Comment Source="WikiPathways-category">Cellular Process</Comment>
   <Comment Source="WikiPathways-category">Cellular Process</Comment>
-
   <Graphics BoardWidth="914.0" BoardHeight="581.2884012539182" />
+
   <Graphics BoardWidth="898.7836990595613" BoardHeight="577.3699059561123" />
   <DataNode TextLabel="Cholesterol" GraphId="fd5" Type="Metabolite">
   <DataNode TextLabel="Cholesterol" GraphId="fd5" Type="Metabolite">
     <Graphics CenterX="81.81191222570531" CenterY="119.62382445141075" Width="80.0" Height="20.0" ZOrder="28672" FontSize="10" Valign="Middle" Color="0000ff" />
     <Graphics CenterX="81.81191222570531" CenterY="119.62382445141075" Width="80.0" Height="20.0" ZOrder="28672" FontSize="10" Valign="Middle" Color="0000ff" />
Line 155: Line 155:
       <Point X="805.6426332288402" Y="314.07523510971754" GraphRef="dec86" RelX="0.0" RelY="1.0" />
       <Point X="805.6426332288402" Y="314.07523510971754" GraphRef="dec86" RelX="0.0" RelY="1.0" />
       <Point X="806.0188087774291" Y="354.42006269592457" GraphRef="c81ef" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
       <Point X="806.0188087774291" Y="354.42006269592457" GraphRef="c81ef" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" />
-
    </Graphics>
 
-
    <Xref Database="" ID="" />
 
-
  </Interaction>
 
-
  <Interaction GraphId="id5bb82af8">
 
-
    <Graphics ZOrder="12288" LineThickness="1.0">
 
-
      <Point X="806.0188087774291" Y="374.42006269592457" GraphRef="c81ef" RelX="0.0" RelY="1.0" />
 
-
      <Point X="805.6426332288398" Y="420.8463949843259" ArrowHead="Arrow" />
 
     </Graphics>
     </Graphics>
     <Xref Database="" ID="" />
     <Xref Database="" ID="" />
Line 310: Line 303:
   <Label TextLabel="79" GraphId="e5e">
   <Label TextLabel="79" GraphId="e5e">
     <Graphics CenterX="816.8260188087771" CenterY="330.7163009404389" Width="29.0" Height="19.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="ff00ff" />
     <Graphics CenterX="816.8260188087771" CenterY="330.7163009404389" Width="29.0" Height="19.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="ff00ff" />
-
  </Label>
 
-
  <Label TextLabel="79" GraphId="ac8">
 
-
    <Graphics CenterX="814.9075235109718" CenterY="394.87617554858923" Width="29.0" Height="19.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" Color="ff00ff" />
 
   </Label>
   </Label>
   <Label TextLabel="ROS" GraphId="d48">
   <Label TextLabel="ROS" GraphId="d48">
Line 410: Line 400:
   <InfoBox CenterX="0.0" CenterY="0.0" />
   <InfoBox CenterX="0.0" CenterY="0.0" />
   <Biopax>
   <Biopax>
 +
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 +
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypertension</bp:TERM>
 +
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:10763</bp:ID>
 +
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
 +
    </bp:openControlledVocabulary>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nifedipine drug pathway</bp:TERM>
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">nifedipine drug pathway</bp:TERM>
Line 432: Line 427:
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heart disease</bp:TERM>
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">heart disease</bp:TERM>
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:114</bp:ID>
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:114</bp:ID>
-
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
 
-
    </bp:openControlledVocabulary>
 
-
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 
-
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">hypertension</bp:TERM>
 
-
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:10763</bp:ID>
 
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
   </Biopax>
   </Biopax>
</Pathway>
</Pathway>

Revision as of 19:25, 11 August 2016

CholesterolphosphorylationSerum induced DNA synthesis79phosphorylationFe uptakeZn uptake797777Na balance86818377NifedipinephosphorylationMETABOLISM liver and small intestineAngiogenesisin vivo88Antiprolerative778186Antithrombotic888677Lactam derivate81Ca uptake79Rapid degration by daylightAntioxidative83ROS8183Nitrosonifedipinecell growth inhibition79, 82, 8479Antiartherosclerosis79Vasodilatation8181, 88Delay G0/G1 --> S-phase79KDR/FLK1CYP3A4SODPCNAPKCCYP2C11Cholesterol hydrolaseNOBDKRB2PTK2BMAPK1MAP2K1NADPH oxidaseVEGFCa-channelCholesterol esterase1


Description

Nifedipine (brand names Adalat, Nifediac, Cordipin, Nifedical, and Procardia) is a dihydropyridine calcium channel blocker. Its main uses are as an antianginal (especially in Prinzmetal's angina) and antihypertensive, although a large number of other indications have recently been found for this agent, such as Raynaud's phenomenon, premature labor, and painful spasms of the esophagus in cancer and tetanus patients. It is also commonly used for the small subset of pulmonary hypertension patients whose symptoms respond to calcium channel blockers. Source: Wikipedia (wikipedia:Nifedipine)

Quality Tags

Ontology Terms

 

Bibliography

  1. Hirata A, Igarashi M, Yamaguchi H, Suwabe A, Daimon M, Kato T, Tominaga M; ''Nifedipine suppresses neointimal thickening by its inhibitory effect on vascular smooth muscle cell growth via a MEK-ERK pathway coupling with Pyk2.''; Br J Pharmacol, 2000 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106191view12:08, 16 August 2019MaintBotHMDB identifier normalization
88585view19:25, 11 August 2016Mkutmonfix unconnected lines
75227view19:24, 12 May 2014Khansperslayout, xrefs, connections
74419view12:42, 18 April 2014EgonwConverted two labels into metabolite DataNodes with an identifier.
71991view11:18, 24 October 2013MkutmonChanged Unknown -> GeneProduct for all annotated data nodes
68905view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
67508view11:18, 26 June 2013DdiglesOntology Term : 'nifedipine drug pathway' added !
45358view20:43, 7 October 2011KhanspersModified description
45357view20:42, 7 October 2011KhanspersModified description
45356view20:41, 7 October 2011KhanspersOntology Term : 'heart disease' added !
45355view20:40, 7 October 2011KhanspersOntology Term : 'hypertension' added !
41054view23:17, 1 March 2011MaintBotRemoved redundant pathway information and comments
39776view21:35, 17 January 2011AlexanderPicomore complete title
38868view18:23, 24 September 2010KhanspersChanged line types
34583view22:23, 21 December 2009KhanspersModified categories
34447view18:20, 10 December 2009MaintBotAutomatic update of empty xrefs
26597view19:11, 10 December 2008AlexanderPicoupdate
26595view19:10, 10 December 2008AlexanderPicoadded connectors, database refs and literature ref
26593view19:05, 10 December 2008AlexanderPicoPeriodical save, work in progress
21223view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:test1234]] moved to [[Pathway:WP259]]: Moved to stable identifier
20471view10:39, 7 November 2008RobatwikiNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BDKRB2GeneProduct624 (Entrez Gene)
CYP2C11
CYP3A4GeneProduct1576 (Entrez Gene)
Ca-channelGeneProduct
Cholesterol esterase
Cholesterol hydrolase
CholesterolMetaboliteCHEBI:16113 (ChEBI)
KDR/FLK1GeneProduct3791 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
NADPH oxidaseGeneProduct
NOMetaboliteHMDB03378 (HMDB)
NifedipineMetaboliteCHEBI:7565 (ChEBI)
PCNAGeneProduct5111 (Entrez Gene)
PKCGeneProduct50818 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
SODGeneProduct6647 (Entrez Gene)
VEGFProteinVEGF (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

Personal tools