Cadmium and glutathione (Arabidopsis thaliana)

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CCHATX1CdGSH biosynthesis...transcript levelglycineGSHAPX1CdGSH1MDHARglutamatePCgamma-ECcysteineAsAGSHGSH2Cd chelationCdGSHPCS1CdCdCdCdCdMDHAAPX2DHAGSSGGSHDHARNADPHNADP+H2O22 H2OGR1AsA-GSH cycleMSD1FSD1CCSCSD1CSD2miR398amiR398b/cactivity levelMnSODFeSODCuZnSODSOD regulationGSSGGSH


Picture from Research article: "Jozefczak M., E. Keunen, H. Schat, M. Bliek, L.E. Hernández, R. Carleer, T. Remans, S. Bohler, J. Vangronsveld, and A. Cuypers, Differential response of Arabidopsis leaves and roots to cadmium: Glutathione-related chelating capacity vs antioxidant capacity. Plant Physiology and Biochemistry, 2014. 83: p. 1-9." Caption: Fig. 8. Schematic overview of four studied processes, all activated under Cd stress: GSH biosynthesis, Cd chelation, SOD regulation and the AsA-GSH cycle. There are several indications that the GSH state, including both total GSH content and GSH:GSSG ratio, is involved in the stimulation of these pathways. Data of roots and leaves of Arabidopsis thaliana exposed to 5 or 10 mM CdSO4 for different time periods (2, 24, 48, 72 h) are visualised (significant upregulation, green box; significant downregulation, red box; ANOVA). Data from in-gel activities are presented by and for increased and decreased SOD activity according to visual quantification. Abbreviations: cadmium (Cd), glutathione (GSH), GSH disulfide (GSSG), gglutamylcysteine (g-EC), g-EC synthetase (GSH1), GSH synthetase (GSH2), phytochelatin (PC), PC synthase (PCS1), hydrogen peroxide (H2O2), ascorbate (AsA), AsA peroxidase (APX1, APX2), monodehydroascorbate (MDHA), MDHA reductase (MDHAR), dehydroascorbate (DHA), DHA reductase (DHAR), GSH reductase (GR), nicotinamide adenine dinucleotide phosphate (NADPH, NADPþ), superoxide dismutase (SOD) isoforms: manganese (MSD1, MnSOD), iron (FSD1, FeSOD) and copper/zinc (CSD1, CSD2, CuZnSOD); microRNA398 (miR398a, miR398b/c), copper chaperones (CCH, ATX1, CCS).



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  1. Jozefczak M, Keunen E, Schat H, Bliek M, Hernández LE, Carleer R, Remans T, Bohler S, Vangronsveld J, Cuypers A; ''Differential response of Arabidopsis leavesand roots to cadmium: glutathione-related chelating capacity vs antioxidant capacity.''; Plant Physiol Biochem, 2014 PubMed Europe PMC


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107043view14:11, 17 September 2019MaintBotChEBI identifier normalization
105897view11:36, 16 August 2019MkutmonHMDB identifier normalization
82711view09:46, 23 October 2015EgonwAdded the paper from which the figure was digitized to the reference list.
82710view09:39, 23 October 2015EgonwFixed the identifier for NADP+ (the HMDB id for glutathion was used).
79443view06:51, 22 March 2015EgonwRemoved Entrez Gene xrefs where gene names where used and of which the genes are given by another gene code and identifier too.
77262view01:04, 9 August 2014AlexanderPicoone more shape sent to back
77261view01:03, 9 August 2014AlexanderPicoSet bounding shapes behind datanodes
77260view00:56, 9 August 2014AlexanderPicoModified description
77206view16:14, 5 August 2014Marijke JozefczakModified description
77205view16:11, 5 August 2014Marijke JozefczakModified description
74481view11:29, 25 April 2014Marijke Jozefczakno legend
74132view05:54, 1 April 2014EgonwRemoved a non-existing HMDB ID and cannot figure out based on the name 'DHA' what it should be.
74130view05:22, 1 April 2014EgonwReplaced an unknown HMDB identifier (not on their website) with the ChEBI one.
73612view20:35, 4 February 2014Marijke JozefczakModified title
73611view20:34, 4 February 2014Marijke JozefczakPP
72205view11:49, 27 October 2013EgonwOntology Term : 'cellular detoxification pathway' added !
71886view19:25, 21 October 2013Marijke JozefczakNew pathway

External references


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NameTypeDatabase referenceComment
2 H2OMetaboliteHMDB02111 (HMDB)
APX1GeneProductAT1G07890 (Ensembl)
APX2GeneProductAT3G09640 (Ensembl)
ATX1GeneProductAT1G66240 (Ensembl)
AsAMetaboliteHMDB00044 (HMDB)
CCHGeneProductAT3G56240 (Ensembl)
CCSGeneProductAT1G12520 (Ensembl)
CSD1GeneProductAT1G08830 (Ensembl)
CSD2GeneProductAT2G28190 (Ensembl)
CdMetaboliteHMDB03638 (HMDB)
CuZnSODProteinCuZnSOD (Entrez Gene)
DHARProteinGO:0045174 (GeneOntology)
FSD1GeneProductAT4G25100 (Ensembl)
FeSODProteinFeSOD (Entrez Gene)
GR1GeneProductAT3G24170 (Ensembl)
GSH1GeneProduct828409 (Entrez Gene)
GSH2GeneProductAT5G27380 (Ensembl)
GSHMetaboliteHMDB00125 (HMDB)
GSSGMetaboliteHMDB03337 (HMDB)
H2O2MetaboliteHMDB03125 (HMDB)
MDHAMetaboliteCHEBI:16504 (ChEBI)
MDHARProteinGO:0016656 (GeneOntology)
MSD1GeneProduct820263 (Entrez Gene)
MnSODMnSOD (Entrez Gene)
NADP+MetaboliteHMDB00125 (HMDB)
NADPHMetaboliteHMDB00221 (HMDB)
PCMetabolite60836 (ChEBI)
PCS1ProteinQ9S7Z3 (Uniprot-TrEMBL)
cysteineMetaboliteHMDB00574 (HMDB)
gamma-ECMetaboliteHMDB01049 (HMDB)
glutamateMetaboliteHMDB00148 (HMDB)
glycineMetaboliteHMDB00123 (HMDB)
miR398aGeneProductAT2G03445 (Ensembl)
miR398b/cGeneProductAT5G14545 (Ensembl)

Annotated Interactions

No annotated interactions
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