Polycystic Kidney Disease Pathway (Homo sapiens)

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(Ontology Term : 'kidney disease pathway' added !)
(added annotations)
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   <Comment Source="WikiPathways-description">A putative PKD pathway proposed in Torres 2009 (Figure 2), showing up or down regulated genes.</Comment>
   <Comment Source="WikiPathways-description">A putative PKD pathway proposed in Torres 2009 (Figure 2), showing up or down regulated genes.</Comment>
   <BiopaxRef>ccd</BiopaxRef>
   <BiopaxRef>ccd</BiopaxRef>
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   <DataNode TextLabel="TNF" GraphId="a6ed4" Type="GeneProduct">
   <DataNode TextLabel="TNF" GraphId="a6ed4" Type="GeneProduct">
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   <DataNode TextLabel="AMPK" GraphId="abd7f" Type="GeneProduct">
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     <Comment>Also known as PKD1.</Comment>
     <Comment>Also known as PKD1.</Comment>
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     <Xref Database="HMDB" ID="HMDB00058" />
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   <DataNode TextLabel="mTOR inhibitors" GraphId="bf5e1" Type="Metabolite">
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   <DataNode TextLabel="ADP" GraphId="b9e32" Type="Metabolite">
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     <Xref Database="ChEBI" ID="CHEBI:16761"/>
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     <Xref Database="ChEBI" ID="CHEBI:16761" />
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   <DataNode TextLabel="ATP" GraphId="e9c9d" Type="Metabolite">
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     <Xref Database="ChEBI" ID="CHEBI:15422"/>
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     <Xref Database="ChEBI" ID="CHEBI:15422" />
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   <DataNode TextLabel="ATPase" GraphId="bebac">
   <DataNode TextLabel="ATPase" GraphId="bebac">
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     <Xref Database="" ID="" />
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   <DataNode TextLabel="LKB1" GraphId="fa788" Type="GeneProduct">
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     <Xref Database="Ensembl" ID="ENSG00000118046" />
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   <DataNode TextLabel="Na+" GraphId="b791f" Type="Metabolite">
   <DataNode TextLabel="Na+" GraphId="b791f" Type="Metabolite">
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     <Xref Database="PubChem-compound" ID="923" />
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   <DataNode TextLabel="K+" GraphId="ff43c" Type="Metabolite">
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     <Xref Database="Chemspider" ID="791"/>
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     <Xref Database="Chemspider" ID="791" />
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     <Graphics CenterX="752.5876323655797" CenterY="347.7024666692345" Width="80.00000000000001" Height="19.99999999999997" ZOrder="32839" FontSize="10" Valign="Middle" />
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     <Xref Database="" ID="" />
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   <DataNode TextLabel="JUN" GraphId="f5959" Type="GeneProduct">
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     <Xref Database="Ensembl" ID="ENSG00000177606"/>
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     <Xref Database="Ensembl" ID="ENSG00000177606" />
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     <Xref Database="Ensembl" ID="ENSG00000136997"/>
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     <Xref Database="Ensembl" ID="ENSG00000136997" />
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   <DataNode TextLabel="ATPase" GraphId="db92e">
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     <Xref Database="" ID="" />
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   <DataNode TextLabel="Na+" GraphId="bfda2" Type="Metabolite" GroupRef="dab57">
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     <Xref Database="ChEBI" ID="CHEBI:29101"/>
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     <Xref Database="ChEBI" ID="CHEBI:29101" />
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   <DataNode TextLabel="K+" GraphId="da49a" Type="Metabolite" GroupRef="dab57">
   <DataNode TextLabel="K+" GraphId="da49a" Type="Metabolite" GroupRef="dab57">
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     <Xref Database="Chemspider" ID="791"/>
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     <Xref Database="Chemspider" ID="791" />
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   <DataNode TextLabel="Na+" GraphId="c765b" Type="Metabolite">
   <DataNode TextLabel="Na+" GraphId="c765b" Type="Metabolite">
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     <Xref Database="ChEBI" ID="CHEBI:29101"/>
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     <Xref Database="ChEBI" ID="CHEBI:29101" />
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   <DataNode TextLabel="NKCC1" GraphId="c970f">
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     <Xref Database="" ID="" />
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   <DataNode TextLabel="K+" GraphId="b3145" Type="Metabolite">
   <DataNode TextLabel="K+" GraphId="b3145" Type="Metabolite">
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     <Xref Database="Chemspider" ID="791"/>
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     <Xref Database="Chemspider" ID="791" />
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   <DataNode TextLabel="KCa3.1" GraphId="d6da4" Type="GeneProduct">
   <DataNode TextLabel="KCa3.1" GraphId="d6da4" Type="GeneProduct">
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     <Xref Database="Ensembl" ID="ENSG00000104783" />
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   <DataNode TextLabel="KCa3.1 inh" GraphId="c24f6" Type="Metabolite">
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     <Xref Database="" ID="" />
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   <DataNode TextLabel=" beta-Catenin" GraphId="d507e">
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   <DataNode TextLabel="PC1" GraphId="dbdb3" Type="GeneProduct" GroupRef="c73fe">
     <Comment>Also known as PKD1.</Comment>
     <Comment>Also known as PKD1.</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000008710" />
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   <DataNode TextLabel="PC2" GraphId="b6360" Type="GeneProduct" GroupRef="c73fe">
     <Comment>Also known as PKD2.</Comment>
     <Comment>Also known as PKD2.</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000118762" />
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   <DataNode TextLabel="PC2" GraphId="e8dcd" Type="GeneProduct" GroupRef="c73fe">
     <Comment>Also known as PKD2.</Comment>
     <Comment>Also known as PKD2.</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000118762" />
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   <DataNode TextLabel="PC1" GraphId="ff114" Type="GeneProduct" GroupRef="b2448">
     <Comment>Also known as PKD1.</Comment>
     <Comment>Also known as PKD1.</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000008710" />
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   <DataNode TextLabel="PC1" GraphId="cd426" Type="GeneProduct" GroupRef="b2448">
     <Comment>Also known as PKD1.</Comment>
     <Comment>Also known as PKD1.</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000008710" />
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   <DataNode TextLabel="PC2" GraphId="fade0" Type="GeneProduct">
     <Comment>Also known as PKD2.</Comment>
     <Comment>Also known as PKD2.</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000118762" />
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   <DataNode TextLabel="ATP" GraphId="e1f07" Type="Metabolite">
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Revision as of 13:49, 23 May 2018

1PC1cyclinDTNFMTORDvlAMP cAMP AMPKIncreased in PKDProtein SynthesisNucleusSOCIKK2Ca2+mTOR inhibitorsRHEBTSC2RSKDecreased in PKDTSC1ERKMEKCDK inhibitorsMEK inhGSK3betaMetforminCa2+Ca2+Ca2+PDEAc-VIPKATNFalphaTNF anatagonistBRAFRasSRCSrc inhPKAPC2IP3TriptolidePLCgammaTKIsEGFIGF1VEGFPKACl-CTFR inhRGqRGiV2RGsSomatostatinVasopressinV2RAFrizzledWntsFRP4AMPADPATPATPaseLKB1Na+K+phosJUNMYCATPaseNa+K+Na+NKCC1K+KCa3.1KCa3.1 inh beta-CateninProteasomePC1PC2PC2PC1PC1PC2ATP


Description

A putative PKD pathway proposed in Torres 2009 (Figure 2), showing up or down regulated genes.

Quality Tags

Ontology Terms

 

Bibliography

  1. Torres VE, Harris PC; ''Autosomal dominant polycystic kidney disease: the last 3 years.''; Kidney Int, 2009 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
108308view19:54, 4 December 2019AgustinGV
108307view19:51, 4 December 2019AgustinGV
108306view19:43, 4 December 2019AgustinGV
108305view19:43, 4 December 2019AgustinGV
108304view19:40, 4 December 2019AgustinGV
108303view19:39, 4 December 2019AgustinGVAdd identifiers B-catenin/GSK3B
108302view19:35, 4 December 2019AgustinGVFix lables
108301view19:31, 4 December 2019AgustinGV
108300view19:30, 4 December 2019AgustinGV
106188view12:08, 16 August 2019MaintBotHMDB identifier normalization
97490view13:49, 23 May 2018Fehrhartadded annotations
88333view15:54, 1 August 2016FehrhartOntology Term : 'kidney disease pathway' added !
84489view23:15, 25 February 2016KhanspersQuick edit to datanode annotation or property
79790view16:02, 16 April 2015Mkutmonfixed unconnected line
78508view10:29, 7 January 2015MaintBotadded missing graphIds
78125view16:17, 4 December 2014Mkutmonadded more xrefs and some layout changes
78124view15:48, 4 December 2014Mkutmonadded some xrefs
78123view15:23, 4 December 2014Mkutmonremoved fill color since it is not ideal for visualization
74333view21:14, 12 April 2014EgonwModified description
71048view18:21, 25 September 2013EgonwAdded several identifiers.
71047view17:19, 25 September 2013EgonwCompleted entering all entities.
71046view13:06, 25 September 2013EgonwAdded identifiers for two PKD genes.
71045view11:47, 25 September 2013EgonwMore pathway content.
71044view11:16, 25 September 2013EgonwMore entities. Prob. 20% done now, excl identifiers.
71043view10:49, 25 September 2013EgonwModified description
71042view10:47, 25 September 2013EgonwNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
beta-Catenin
ADPMetaboliteCHEBI:16761 (ChEBI)
AMP MetaboliteCHEBI:16027 (ChEBI)
AMPMetaboliteCHEBI:16027 (ChEBI)
AMPKGeneProduct
ATPMetaboliteCHEBI:15422 (ChEBI)
ATPase
Ac-VI
BRAFGeneProductENSG00000157764 (Ensembl)
CDK inhibitorsMetabolite
CTFR inhMetabolite
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Cl-Metabolite
Decreased in PKD
Dvl
EGFGeneProductENSG00000138798 (Ensembl)
ERKGeneProduct
Frizzled
GSK3betaGeneProduct
Gi
Gq
Gs
IGF1GeneProductENSG00000017427 (Ensembl)
IKK2GeneProductENSG00000104365 (Ensembl)
IP3MetaboliteCHEBI:16595 (ChEBI)
Increased in PKD
JUNGeneProductENSG00000177606 (Ensembl)
K+Metabolite791 (Chemspider)
KCa3.1 inhMetabolite
KCa3.1GeneProductENSG00000104783 (Ensembl)
LKB1GeneProductENSG00000118046 (Ensembl)
MEK inhMetabolite
MEKGeneProductENSG00000095015 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MetforminMetabolite
NKCC1
Na+Metabolite923 (PubChem-compound)
Na+MetaboliteCHEBI:29101 (ChEBI)
Nucleus
PC1GeneProductENSG00000008710 (Ensembl) Also known as PKD1.
PC2GeneProductENSG00000118762 (Ensembl) Also known as PKD2.
PDEGeneProduct
PKA
PLCgammaGeneProduct
ProteasomePathway
Protein SynthesisPathway
R
RHEBGeneProductENSG00000106615 (Ensembl)
RSKGeneProduct
RasGeneProduct
SOCGeneProduct
SRCGeneProductENSG00000197122 (Ensembl)
SomatostatinMetaboliteHMDB13072 (HMDB)
Src inhMetabolite
TKIsMetabolite
TNF anatagonistMetabolite
TNFGeneProductENSG00000232810 (Ensembl)
TNFalphaGeneProductENSG00000204490 (Ensembl)
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
Triptolide
V2R
V2RA
VEGFGeneProduct
VasopressinMetaboliteHMDB01980 (HMDB)
Wnt
cAMP MetaboliteHMDB00058 (HMDB)
cyclinDGeneProductENSG00000110092 (Ensembl)
mTOR inhibitorsMetabolite
phos
sFRP4

Annotated Interactions

No annotated interactions

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