Glycerophospholipid Biosynthetic Pathway (Homo sapiens)

From WikiPathways

Revision as of 22:11, 21 July 2013 by Amanzo (Talk | contribs)
Jump to: navigation, search
Biosynthesis pathwaysR-CH2-CH2-OH(Long chain fatty alcohol)3 (S-adenosyl-methionine)2-acyl-sn-glycero-3-phosphate(Lysophosphatidic acid; LPA)NAD+(Coenzyme I)1,2-diacyl-sn-glycero-3-phosphate(Phosphatidic acid; PA)1,2-diacyl-sn-glycero-3-phosphoserine(PS)Cardiolipin(DPG, CL)Adenosine triphosphate(ATP)sn-glycerol-3-phosphate(glycerol-3-P)EthanolaminePhosphorylethanolaminePIP2[4',5']Glycerol-3-phosphate dehydrogenase (NAD+)EC 1.1.1.8Cytidine diphosphate choline(CDP-choline)InositolPyrimidine MetabolismFatty acid MetabolismSerinetriacyl-sn-glycerol(Triacylglycerol; TAG)Phosphatidylinositol-4-phosphate(PIP)1,2-diacyl-sn-glycero-3-phosphoethanolamine(PE)1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate(CDP-DAG, CMP-PA)NADH + H+Dihydroxyacetone phosphateFatty acyl-CoA1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol)(PI)PPiD-Glucose-6-PAdenosine diphosphate(ADP)1,2-diacyl-sn-glycerol(1,2-diacylglycerol; 1,2-DAG)CTPGlycerolPIP3[3',4',5']1D-myo-Inositol-1-PPhosphocholine(Choline-P)GlycolysisCytidine monophosphate(CMP)PiCoA-SH1,2-diacyl-sn-glycero-3-phosphocholine(PC, Lecithin)1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate)(PGP)Cytidine diphosphate ethanolamine(CDP-ethanolamine)Choline1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)(PG)Glycerol-3-PPiCMPCMPATPADPCTPPPiEthanolamineATPADPATPADPATPADPATPADPGlycerol kinaseEC 2.7.1.30Acyl-CoA2-acylglycerol-3-phosphate O-acyltransferaseEC 2.3.1.52Glycerol-3-phosphate 2-O-acyltransferaseEC 2.3.1.198Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate phosphataseEC 3.1.3.4Diacylglycerol O-acyltransferaseEC 2.3.1.20Acyl coenzyme A(Acyl-CoA)Coenzyme A(CoA-SH)Phosphatidate cytidylyltransferaseEC 2.7.7.41Cytidine triphosphate(CTP)PPiCDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferaseEC 2.7.8.5PhosphatidylglycerophosphataseEC 3.1.3.27H2OCardiolipin synthaseEC 2.7.8.-CDP-DAGCMPCDP-diacylglyreol-inositol 3-phosphatidyltransferaseEC 2.7.8.111-phosphatidylinositol 4-kinaseEC 2.7.1.671-phosphatidylinositol 4-phosphate 5-kinaseEC 2.7.1.68Phosphatidylinositol-4,5-bisphosphate 3-kinaseEC 2.7.1.153Choline kinaseEC 2.7.1.32Choline-phosphate cytidylyltransferaseEC 2.7.7.15Diacylglycerol cholinephosphotransferaseEC 2.7.8.2Ethanolamine kinaseEC 2.7.1.82Ethanolamine-phosphate cytidylyltransferaseEC 2.7.7.14EthanolaminephosphotransferaseEC 2.7.8.1L-serine-phosphatidylethanolamine phosphatidyltransferaseEC 2.7.8.29Phosphatidylethanolamine N-methyltransferaseEC 2.1.1.173 (S-adenosylhomocysteine)CMPGlycolysisGlycolysisDegradation pathwaysPathway originAlkyldihydroxyacetonephosphate synthase(Alkyl-DHAP synthase)EC 2.5.1.261-Alkenyl-2-acylglycerophosphocholine(Plasmenylcholine)1-Alkyldihydroxyacetone phosphate(Octanoyl DHAP)1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine(Plasmanylethanolamine)1-Alkyl-sn-glycerol 3-phosphate1-alkyl-2-acyl-sn-glycero-3-phosphocholine(Plasmanylcholine)1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine(Platelet Activating Factor, PAF)1-alkyl-2-acyl-sn-glycerol 3-phosphate1-Acyl dihydroxyacetone phosphate(Acyl-DHAP)1-alkenyl-2-acylglycerophosphoethanolamine(Plasmenylethanolamine)Acylglycerone-phosphate reductase(1-alkyl-sn-glycerol-3-phosphate dehydrogenase)EC 1.1.1.101Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferaseEC 2.3.1.-1-alkyl-2-acyl-sn-glycero-3-phosphate phosphatase(Phosphatidate phosphatase)EC 3.1.3.4CDP-ethanolamine:1-alkyl-2-acyl-sn-glycerophosphoethanolamine transferase(Ethanolaminephosphotransferase)EC 2.7.8.11-alkyl-2-acyl-sn-glycerophoethanolamine desaturase(Plasmanylethanolamine desaturase)EC 1.14.99.19CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase(Diacylglycerol cholinephosphotransferase)EC 2.7.8.2CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase(Diacylglycerol cholinephosphotransferase)EC 2.7.8.2Coenzyme A(CoA-SH)R'-COOH1-alkyl-2-acyl-sn-glycerolNADPH + H+NADP(Coenzyme II)Acyl-CoACoA-SHPiCytidine diphosphate ethanolamine(CDP-ethanolamine)CMPO2 + NADH + H+2H2OCytochrome b


Description

Glycerophospholipids or phosphoglycerides, in which the hydrophobic regions are composed of two fatty acids joined to glycerol; and sphingolipids, in which a single fatty acid is joined to a fatty amine, sphingosine, are glycerol-based phospholipids and the main component of biological membranes. The hydrophilic moieties in these amphipathic compounds may be as a simple as a single -OH at one end of the sterol ring system, or they may be more complex. Glycerophospholipds, as well as sphingolipids, contained polar or charged alcohols at their polar ends; some also contain phosphate groups.

In glycerophospholipids, two fatty acids are ester-linked to glycerol at C-1 and C-2, and a highly polar or charged (and therefore hydrophilic) head group is attached to C-3 through a phosphodiester bond. All glycerophospholipds are derivatives of phosphatidic acid and are named for their polar head groups (e.g., phosphatidylethanolamine and phosphatidylcholine). All have a negative charge on the phosphate group at pH 7.0. The head-goup alcohol may also contribute one or more charges at pH near 7.0. The fatty acids in glycerophospholipds can be any of a wide variety. They are different in different species, in different tissues of the same species, and in different types of glycerophospholipids in the same cell or tissue. In general, glycerophospholipids contain a saturated fatty acid at C-1 and an unsaturated fatty acid at C-2, and, in general terms, the fatty acyl groups are generally 16 or 18 carbons long.

Eukaryotic membranes contain significant amounts of two other types of glycerophospholipids: Plasmalogens and Alkylacylglycerophospholipids. Plasmalogens contain a hydrocarbon chain linked to glycerol C-1 via vinyl ether linkage whereas alkylacylglycerophospholipids the alkyl substituent at glycerol C-1 is attached via an ether linkage. About 20% of mammalian glycerophospholipids are plasmalogens, this percentage varies both from species to species and from tissue to tissue within a given organism. While plasmalogens comprise only about 0.8% of the phospholipids in human liver, they account for around 23% of those in human nervous tissue. The alkylacylglycerophospholipids are less abundant than the plasmalogens, e.g., about 59% of ethanolamine glycerophospholipids of human heart are plasmalogens, whereas only 3.6% are alkylacylglycerophospholipids. However, in bovine erythrocytes, 75% of the ethanolamine glycerophospholipids are of alkylacyl type.

Quality Tags

Ontology Terms

 

Bibliography

View all...
  1. Koynova R, Caffrey M; ''Phases and phase transitions of the hydrated phosphatidylethanolamines.''; Chem Phys Lipids, 1994 PubMed Europe PMC
  2. Hoch FL; ''Cardiolipins and biomembrane function.''; Biochim Biophys Acta, 1992 PubMed Europe PMC
  3. van den Bosch H, de Vet EC; ''Alkyl-dihydroxyacetonephosphate synthase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  4. Nikawa J, Yamashita S; ''Molecular cloning of the gene encoding CDPdiacylglycerol-inositol 3-phosphatidyl transferase in Saccharomyces cerevisiae.''; Eur J Biochem, 1984 PubMed Europe PMC
  5. Snyder F; ''Metabolism of platelet activating factor and related ether lipids: enzymatic pathways, subcellular sites, regulation, and membrane processing.''; Prog Clin Biol Res, 1988 PubMed Europe PMC
  6. Kay JG, Grinstein S; ''Phosphatidylserine-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed Europe PMC
  7. Rüstow B, Kunze D; ''Diacylglycerol synthesized in vitro from sn-glycerol 3-phosphate and the endogenous diacylglycerol are different substrate pools for the biosynthesis of phosphatidylcholine in rat lung microsomes.''; Biochim Biophys Acta, 1985 PubMed Europe PMC
  8. Detopoulou P, Nomikos T, Fragopoulou E, Antonopoulou S, Kotroyiannis I, Vassiliadou C, Panagiotakos DB, Chrysohoou C, Pitsavos C, Stefanadis C; ''Platelet activating factor (PAF) and activity of its biosynthetic and catabolic enzymes in blood and leukocytes of male patients with newly diagnosed heart failure.''; Clin Biochem, 2009 PubMed Europe PMC
  9. Hullin-Matsuda F, Kawasaki K, Delton-Vandenbroucke I, Xu Y, Nishijima M, Lagarde M, Schlame M, Kobayashi T; ''De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate.''; J Lipid Res, 2007 PubMed Europe PMC
  10. Heilmeyer LM Jr, Vereb G Jr, Vereb G, Kakuk A, Szivák I; ''Mammalian phosphatidylinositol 4-kinases.''; IUBMB Life, 2003 PubMed Europe PMC
  11. Stremmel W, Ehehalt R, Staffer S, Stoffels S, Mohr A, Karner M, Braun A; ''Mucosal protection by phosphatidylcholine.''; Dig Dis, 2012 PubMed Europe PMC
  12. Das AK, Milam JE, Reddy RC, Hajra AK; ''Facile syntheses of acyl dihydroxyacetone phosphates and lysophosphatidic acids having different acyl groups.''; J Lipid Res, 2006 PubMed Europe PMC
  13. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver. Modulation of diacylglycerol acyltransferase activity in vitro.''; J Biol Chem, 1982 PubMed Europe PMC
  14. Hsuan JJ, Minogue S, dos Santos M; ''Phosphoinositide 4- and 5-kinases and the cellular roles of phosphatidylinositol 4,5-bisphosphate.''; Adv Cancer Res, 1998 PubMed Europe PMC
  15. Houtkooper RH, Vaz FM; ''Cardiolipin, the heart of mitochondrial metabolism.''; Cell Mol Life Sci, 2008 PubMed Europe PMC
  16. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC
  17. Jiang F, Kelly BL, Hagopian K, Greenberg ML; ''Purification and characterization of phosphatidylglycerolphosphate synthase from Schizosaccharomyces pombe.''; J Biol Chem, 1998 PubMed Europe PMC
  18. Nojima S; ''Platelet-activating factor (PAF): an introduction.''; Lipids, 1991 PubMed Europe PMC
  19. Honda Z, Ishii S, Shimizu T; ''Platelet-activating factor receptor.''; J Biochem, 2002 PubMed Europe PMC
  20. Spencer DA; ''An update on PAF.''; Clin Exp Allergy, 1992 PubMed Europe PMC
  21. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed Europe PMC
  22. Pagès C, Simon M, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release(1).''; Prostaglandins, 2001 PubMed Europe PMC
  23. Graham TR, Burd CG; ''Coordination of Golgi functions by phosphatidylinositol 4-kinases.''; Trends Cell Biol, 2011 PubMed Europe PMC
  24. Moolenaar WH, van Meeteren LA, Giepmans BN; ''The ins and outs of lysophosphatidic acid signaling.''; Bioessays, 2004 PubMed Europe PMC
  25. Sinha Roy S, Mukhopadhyay S, Mukherjee S, Das SK; ''Breast cancer is associated with an increase in the activity and expression of cholinephosphotransferase in rats.''; Life Sci, 2008 PubMed Europe PMC
  26. Carman GM; ''Phosphatidate phosphatases and diacylglycerol pyrophosphate phosphatases in Saccharomyces cerevisiae and Escherichia coli.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  27. Roberti R, Mancini A, Freysz L, Binaglia L; ''Reversibility of the reactions catalyzed by cholinephosphotransferase and ethanolaminephosphotransferase solubilized from rat-brain microsomes.''; Biochim Biophys Acta, 1992 PubMed Europe PMC
  28. Jackowski S, Fagone P; ''CTP: Phosphocholine cytidylyltransferase: paving the way from gene to membrane.''; J Biol Chem, 2005 PubMed Europe PMC
  29. Dobrowsky RT, Ballas LM; ''Peroxisomal dihydroxyacetone phosphate acyltransferase. Effect of acetaldehyde on the intact and solubilized activity.''; J Biol Chem, 1987 PubMed Europe PMC
  30. Rock CO, Snyder F; ''Biosynthesis of 1-alkyl-sn-glycero-3-phosphate via adenosine triphosphate:1-alkyl-sn-glycerol phosphotransferase.''; J Biol Chem, 1974 PubMed Europe PMC
  31. Ide H, Miller JC, Weinhold PA; ''Ethanolaminephosphotransferase in rat lung: selectivity for endogenous and exogenous diacylglycerol.''; Biochim Biophys Acta, 1988 PubMed Europe PMC
  32. Yamashita S, Hosaka K; ''Choline kinase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  33. Claypool SM, Koehler CM; ''The complexity of cardiolipin in health and disease.''; Trends Biochem Sci, 2012 PubMed Europe PMC
  34. Chao W, Olson MS; ''Platelet-activating factor: receptors and signal transduction.''; Biochem J, 1993 PubMed Europe PMC
  35. Kawasaki K, Nishijima M; ''[Biosynthesis and function of phosphatidylglycerol and cardiolipin in animal cells].''; Tanpakushitsu Kakusan Koso, 1999 PubMed Europe PMC
  36. D'Angelo G, Vicinanza M, Di Campli A, De Matteis MA; ''The multiple roles of PtdIns(4)P -- not just the precursor of PtdIns(4,5)P2.''; J Cell Sci, 2008 PubMed Europe PMC
  37. Ofman R, Hogenhout EM, Wanders RJ; ''Identification and characterization of the mouse cDNA encoding acyl-CoA:dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1999 PubMed Europe PMC
  38. Ueda H, Matsunaga H, Olaposi OI, Nagai J; ''Lysophosphatidic acid: chemical signature of neuropathic pain.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  39. Quest AF, Ghosh S, Xie WQ, Bell RM; ''DAG second messengers: molecular switches and growth control.''; Adv Exp Med Biol, 1997 PubMed Europe PMC
  40. Shin J, Thompson DH; ''Direct synthesis of plasmenylcholine from allyl-substituted glycerols.''; J Org Chem, 2003 PubMed Europe PMC
  41. De Matteis MA, Wilson C, D'Angelo G; ''Phosphatidylinositol-4-phosphate: The Golgi and beyond.''; Bioessays, 2013 PubMed Europe PMC
  42. Balla T; ''Phosphatidylinositol 4-kinases.''; Biochim Biophys Acta, 1998 PubMed Europe PMC
  43. MacDonald PM, McMurray WC; ''Partial purification and properties of mammalian phosphatidylglycerophosphatase.''; Biochim Biophys Acta, 1980 PubMed Europe PMC
  44. Goñi FM, Alonso A; ''Structure and functional properties of diacylglycerols in membranes.''; Prog Lipid Res, 1999 PubMed Europe PMC
  45. Taguchi T, Arai H; ''[Emerging roles of intracellular phosphatidylserine (PS) in membrane traffic].''; Seikagaku, 2012 PubMed Europe PMC
  46. Blank ML, Fitzgerald V, Lee TC, Snyder F; ''Evidence for biosynthesis of plasmenylcholine from plasmenylethanolamine in HL-60 cells.''; Biochim Biophys Acta, 1993 PubMed Europe PMC
  47. Kawasaki K, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from cultured mammalian cells.''; Methods Mol Biol, 2003 PubMed Europe PMC
  48. Lucken-Ardjomande Hasler S; ''Cholesterol, cardiolipin, and mitochondria permeabilisation.''; Anticancer Agents Med Chem, 2012 PubMed Europe PMC
  49. Polokoff MA, Bell RM; ''Solubilization, partial purification and characterization of rat liver microsomal diacylglycerol acyltransferase.''; Biochim Biophys Acta, 1980 PubMed Europe PMC
  50. Li Z, Vance DE; ''Phosphatidylcholine and choline homeostasis.''; J Lipid Res, 2008 PubMed Europe PMC
  51. Longmuir KJ, Johnston JM; ''Changes in CTP:phosphatidate cytidylyltransferase activity during rabbit lung development.''; Biochim Biophys Acta, 1980 PubMed Europe PMC
  52. Kocsis MG, Weselake RJ; ''Phosphatidate phosphatases of mammals, yeast, and higher plants.''; Lipids, 1996 PubMed Europe PMC
  53. Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  54. Sims SM, Panupinthu N, Lapierre DM, Pereverzev A, Dixon SJ; ''Lysophosphatidic acid: a potential mediator of osteoblast-osteoclast signaling in bone.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  55. Snyder F, Fitzgerald V, Blank ML; ''Biosynthesis of platelet-activating factor and enzyme inhibitors.''; Adv Exp Med Biol, 1996 PubMed Europe PMC
  56. de Vet EC, Ijlst L, Oostheim W, Wanders RJ, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Fate in peroxisome biogenesis disorders and identification of the point mutation underlying a single enzyme deficiency.''; J Biol Chem, 1998 PubMed Europe PMC
  57. Czech MP; ''PIP2 and PIP3: complex roles at the cell surface.''; Cell, 2000 PubMed Europe PMC
  58. Kulikov VI, Muzya GI; ''The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions.''; Biochemistry (Mosc), 1998 PubMed Europe PMC
  59. Saulnier-Blache JS; ''[Lysophosphatidic acid: a "bioactive" phospholipid].''; Med Sci (Paris), 2004 PubMed Europe PMC
  60. Huang CL; ''Complex roles of PIP2 in the regulation of ion channels and transporters.''; Am J Physiol Renal Physiol, 2007 PubMed Europe PMC
  61. Garcia C, Montero M, Alvarez J, Sanchez Crespo M; ''Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid.''; J Biol Chem, 1993 PubMed Europe PMC
  62. Carman GM, Han GS; ''Roles of phosphatidate phosphatase enzymes in lipid metabolism.''; Trends Biochem Sci, 2006 PubMed Europe PMC
  63. Chang J, Musser JH, McGregor H; ''Phospholipase A2: function and pharmacological regulation.''; Biochem Pharmacol, 1987 PubMed Europe PMC
  64. Klingenberg M; ''Cardiolipin and mitochondrial carriers.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  65. Thompson DH, Inerowicz HD, Grove J, Sarna T; ''Structural characterization of plasmenylcholine photooxidation products.''; Photochem Photobiol, 2003 PubMed Europe PMC
  66. Brindley DN, Pilquil C, Sariahmetoglu M, Reue K; ''Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  67. Paoletti L, Elena C, Domizi P, Banchio C; ''Role of phosphatidylcholine during neuronal differentiation.''; IUBMB Life, 2011 PubMed Europe PMC
  68. Zhang Y, Du G; ''Phosphatidic acid signaling regulation of Ras superfamily of small guanosine triphosphatases.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  69. Bru R, Blöchliger E, Luisi PL; ''sn-1,2-diacylglycerol cholinephosphotransferase from pig liver: mixed micellar assay and kinetic analysis of the partially pure enzyme.''; Arch Biochem Biophys, 1993 PubMed Europe PMC
  70. Schlegel RA, Williamson P; ''P.S. to PS (phosphatidylserine)--pertinent proteins in apoptotic cell clearance.''; Sci STKE, 2007 PubMed Europe PMC
  71. Diagne A, Fauvel J, Record M, Chap H, Douste-Blazy L; ''Studies on ether phospholipids. II. Comparative composition of various tissues from human, rat and guinea pig.''; Biochim Biophys Acta, 1984 PubMed Europe PMC
  72. de Vet EC, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase.''; Cell Biochem Biophys, 2000 PubMed Europe PMC
  73. Francescangeli E, Goracci G; ''The de novo biosynthesis of platelet-activating factor in rat brain.''; Biochem Biophys Res Commun, 1989 PubMed Europe PMC
  74. Mrá�ek T, Drahota Z, Houštěk J; ''The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  75. Bleijerveld OB, Brouwers JF, Vaandrager AB, Helms JB, Houweling M; ''The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species.''; J Biol Chem, 2007 PubMed Europe PMC
  76. Carrasco S, Mérida I; ''Diacylglycerol, when simplicity becomes complex.''; Trends Biochem Sci, 2007 PubMed Europe PMC
  77. Nakagawa T, Harada N, Miyamoto A, Kawanishi Y, Yoshida M, Shono M, Mawatari K, Takahashi A, Sakaue H, Nakaya Y; ''Membrane topology of murine glycerol-3-phosphate acyltransferase 2.''; Biochem Biophys Res Commun, 2012 PubMed Europe PMC
  78. Fariss MW, Chan CB, Patel M, Van Houten B, Orrenius S; ''Role of mitochondria in toxic oxidative stress.''; Mol Interv, 2005 PubMed Europe PMC
  79. Schlame M, Ren M; ''The role of cardiolipin in the structural organization of mitochondrial membranes.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  80. Ishidate K, Matsuo R, Nakazawa Y; ''CDP-choline: 1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. II. Photoaffinity labeling by radioactive CDP-choline analogs.''; Biochim Biophys Acta, 1992 PubMed Europe PMC
  81. Nikawa J, Yamashita S; ''Yeast mutant defective in synthesis of phosphatidylinositol. Isolation and characterization of a CDPdiacylglycerol--inositol 3-phosphatidyltransferase Km mutant.''; Eur J Biochem, 1982 PubMed Europe PMC
  82. Zhang L, Mao YS, Janmey PA, Yin HL; ''Phosphatidylinositol 4, 5 bisphosphate and the actin cytoskeleton.''; Subcell Biochem, 2012 PubMed Europe PMC
  83. Kay JG, Grinstein S; ''Sensing phosphatidylserine in cellular membranes.''; Sensors (Basel), 2011 PubMed Europe PMC
  84. Clayton EL, Minogue S, Waugh MG; ''Phosphatidylinositol 4-kinases and PI4P metabolism in the nervous system: roles in psychiatric and neurological diseases.''; Mol Neurobiol, 2013 PubMed Europe PMC
  85. Dircks LK, Sul HS; ''Mammalian mitochondrial glycerol-3-phosphate acyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  86. Shin JJ, Loewen CJ; ''Putting the pH into phosphatidic acid signaling.''; BMC Biol, 2011 PubMed Europe PMC
  87. Clark JD, Schievella AR, Nalefski EA, Lin LL; ''Cytosolic phospholipase A2.''; J Lipid Mediat Cell Signal, 1995 PubMed Europe PMC
  88. Pagès C, Simon MF, Valet P, Saulnier-Blache JS; ''Lysophosphatidic acid synthesis and release.''; Prostaglandins Other Lipid Mediat, 2001 PubMed Europe PMC
  89. Hosaka K, Schiele U, Numa S; ''Diacylglycerol acyltransferase from rat liver microsomes. Separation and acyl-donor specificity.''; Eur J Biochem, 1977 PubMed Europe PMC
  90. Cabezas MC, Erkelens DW; ''Triglycerides and atherosclerosis: to feast or fast.''; Neth J Med, 2000 PubMed Europe PMC
  91. Lewis RN, McElhaney RN; ''The physicochemical properties of cardiolipin bilayers and cardiolipin-containing lipid membranes.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  92. Hirasawa K, Nishizuka Y; ''Phosphatidylinositol turnover in receptor mechanism and signal transduction.''; Annu Rev Pharmacol Toxicol, 1985 PubMed Europe PMC
  93. Moolenaar WH; ''Lysophosphatidic acid, a multifunctional phospholipid messenger.''; J Biol Chem, 1995 PubMed Europe PMC
  94. Waku K, Sugiura T, Nakagawa Y; ''Metabolism of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a precursor of platelet-activating factor in macrophages.''; Adv Prostaglandin Thromboxane Leukot Res, 1985 PubMed Europe PMC
  95. Farese RV Jr, Cases S, Smith SJ; ''Triglyceride synthesis: insights from the cloning of diacylglycerol acyltransferase.''; Curr Opin Lipidol, 2000 PubMed Europe PMC
  96. Farooqui AA, Yang HC, Horrocks LA; ''Plasmalogens, phospholipases A2 and signal transduction.''; Brain Res Brain Res Rev, 1995 PubMed Europe PMC
  97. van den Bosch H, Aarsman AJ, van Schaik RH, Schalkwijk CG, Neijs FW, Sturk A; ''Structural and enzymological properties of cellular phospholipases A2.''; Biochem Soc Trans, 1990 PubMed Europe PMC
  98. Arienti G, Goracci G, Porcellati G; ''Glycerophospholipid metabolism in neuronal and glial cell-enriched fractions.''; Neurochem Res, 1981 PubMed Europe PMC
  99. Qiu Q, Liu G, Li W, Shi Q, Zhu F, Lu G; ''Glycerol-3-phosphate acyltransferase 4 gene is involved in mouse spermatogenesis.''; Acta Biochim Biophys Sin (Shanghai), 2009 PubMed Europe PMC
  100. Arthur G, Page L, Mock T, Choy PC; ''The catabolism of plasmenylcholine in the guinea pig heart.''; Biochem J, 1986 PubMed Europe PMC
  101. Zhao Y, Natarajan V; ''Lysophosphatidic acid (LPA) and its receptors: role in airway inflammation and remodeling.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  102. Rüdiger M, Kolleck I, Putz G, Wauer RR, Stevens P, Rüstow B; ''Plasmalogens effectively reduce the surface tension of surfactant-like phospholipid mixtures.''; Am J Physiol, 1998 PubMed Europe PMC
  103. Roberti R, Binaglia L, Francescangeli E, Goracci G, Porcellati G; ''Enzymic synthesis of 1-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine through ethanolaminephosphotransferase activity in the neuronal and glial cells of rabbit in vitro.''; Lipids, 1975 PubMed Europe PMC
  104. Ward KB, Pattabiraman N; ''Comparative anatomy of phospholipase A2 structures.''; Adv Exp Med Biol, 1990 PubMed Europe PMC
  105. Hjelmstad RH, Morash SC, McMaster CR, Bell RM; ''Chimeric enzymes. Structure-function analysis of segments of sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases.''; J Biol Chem, 1994 PubMed Europe PMC
  106. Chicco AJ, Sparagna GC; ''Role of cardiolipin alterations in mitochondrial dysfunction and disease.''; Am J Physiol Cell Physiol, 2007 PubMed Europe PMC
  107. Patil VA, Greenberg ML; ''Cardiolipin-mediated cellular signaling.''; Adv Exp Med Biol, 2013 PubMed Europe PMC
  108. Messner MC, Albert CJ, Hsu FF, Ford DA; ''Selective plasmenylcholine oxidation by hypochlorous acid: formation of lysophosphatidylcholine chlorohydrins.''; Chem Phys Lipids, 2006 PubMed Europe PMC
  109. Snyder F; ''Alkylglycerol phosphotransferase.''; Methods Enzymol, 1992 PubMed Europe PMC
  110. Kawasaki K, Kuge O, Yamakawa Y, Nishijima M; ''Purification of phosphatidylglycerophosphate synthase from Chinese hamster ovary cells.''; Biochem J, 2001 PubMed Europe PMC
  111. Hajra AK, Datta SC, Ghosh MK; ''Acyl/alkyldihydroxyacetone phosphate reductase from guinea pig liver peroxisomes.''; Methods Enzymol, 1992 PubMed Europe PMC
  112. Shenker BJ, Ali H, Boesze-Battaglia K; ''PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases.''; Curr Pharm Des, 2011 PubMed Europe PMC
  113. Macfarlane MG; ''Phosphatidylglycerols and lipoamino acids.''; Adv Lipid Res, 1964 PubMed Europe PMC
  114. Waugh MG; ''Phosphatidylinositol 4-kinases, phosphatidylinositol 4-phosphate and cancer.''; Cancer Lett, 2012 PubMed Europe PMC
  115. Coleman RA; ''Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine.''; Methods Enzymol, 1992 PubMed Europe PMC
  116. Liteplo RG, Sribney M; ''The stimulation of rat liver microsomal CTP: phosphatidate cytidylyltransferase activity by guanosine triphosphate.''; Biochim Biophys Acta, 1980 PubMed Europe PMC
  117. Yost CC, Weyrich AS, Zimmerman GA; ''The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.''; Biochimie, 2010 PubMed Europe PMC
  118. Lake BD; ''Histochemical demonstration of cytosolic alpha-glycerophosphate dehydrogenase (EC 1.1.1.8) and mitochondrial alpha-glycerophosphate dehydrogenase (EC 1.1.99.5).''; J Neurol Sci, 1987 PubMed Europe PMC
  119. Nagan N, Zoeller RA; ''Plasmalogens: biosynthesis and functions.''; Prog Lipid Res, 2001 PubMed Europe PMC
  120. Haagsman HP, de Haas CG, Geelen MJ, van Golde LM; ''Regulation of triacylglycerol synthesis in the liver: a decrease in diacylglycerol acyltransferase activity after treatment of isolated rat hepatocytes with glucagon.''; Biochim Biophys Acta, 1981 PubMed Europe PMC
  121. Zammit VA, Buckett LK, Turnbull AV, Wure H, Proven A; ''Diacylglycerol acyltransferases: Potential roles as pharmacological targets.''; Pharmacol Ther, 2008 PubMed Europe PMC
  122. Sorger D, Daum G; ''Triacylglycerol biosynthesis in yeast.''; Appl Microbiol Biotechnol, 2003 PubMed Europe PMC
  123. Takenawa T, Itoh T, Fukami K; ''Regulation of phosphatidylinositol 4,5-bisphosphate levels and its roles in cytoskeletal re-organization and malignant transformation.''; Chem Phys Lipids, 1999 PubMed Europe PMC
  124. Agranoff BW, Hajra AK; ''The acyl dihydroxyacetone phosphate pathway for glycerolipid biosynthesis in mouse liver and Ehrlich ascites tumor cells.''; Proc Natl Acad Sci U S A, 1971 PubMed Europe PMC
  125. Kumaran D, Bonanno JB, Burley SK, Swaminathan S; ''Crystal structure of phosphatidylglycerophosphatase (PGPase), a putative membrane-bound lipid phosphatase, reveals a novel binuclear metal binding site and two "proton wires".''; Proteins, 2006 PubMed Europe PMC
  126. Gibellini F, Smith TK; ''The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine.''; IUBMB Life, 2010 PubMed Europe PMC
  127. Murakami M, Lambeau G; ''Emerging roles of secreted phospholipase A(2) enzymes: an update.''; Biochimie, 2013 PubMed Europe PMC
  128. van den Bout I, Divecha N; ''PIP5K-driven PtdIns(4,5)P2 synthesis: regulation and cellular functions.''; J Cell Sci, 2009 PubMed Europe PMC
  129. Sukumaran S, Barnes RI, Garg A, Agarwal AK; ''Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10/glycerol-3-phosphate acyltransferase isoform 3.''; J Mol Endocrinol, 2009 PubMed Europe PMC
  130. Arenth PM, Russell KC, Ricker JH, Zafonte RD; ''CDP-choline as a biological supplement during neurorecovery: a focused review.''; PM R, 2011 PubMed Europe PMC
  131. Ansell GB, Metcalfe RF; ''Studies on the CDP-ethanolamine-1,2-diglyceride ethanolaminephosphotransferase of rat brain.''; J Neurochem, 1971 PubMed Europe PMC
  132. Whatley RE, Clay KL, Chilton FH, Triggiani M, Zimmerman GA, McIntyre TM, Prescott SM; ''Relative amounts of 1-O-alkyl- and 1-acyl-2-acetyl-sn-glycero-3-phosphocholine in stimulated endothelial cells.''; Prostaglandins, 1992 PubMed Europe PMC
  133. Paltauf F; ''Isolation of soluble proteins capable of stimulating aerobic plasmalogen biosynthesis.''; Eur J Biochem, 1978 PubMed Europe PMC
  134. Baker RR, Chang HY; ''Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex.''; Biochim Biophys Acta, 1996 PubMed Europe PMC
  135. Jones AR, Gillan L; ''Metabolism of glycerol 3-phosphate by mature boar spermatozoa.''; J Reprod Fertil, 1996 PubMed Europe PMC
  136. Hjelmstad RH, Bell RM; ''The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene.''; J Biol Chem, 1990 PubMed Europe PMC
  137. Mackenzie CG, Reiss OK, Moritz E, Mackenzie JB; ''Metabolism of glycerol monoethers in cultured liver cells and implications for monoglyceride pathways.''; J Lipid Res, 1976 PubMed Europe PMC
  138. McMaster CR, Bell RM; ''CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  139. de Vet EC, Hilkes YH, Fraaije MW, van den Bosch H; ''Alkyl-dihydroxyacetonephosphate synthase. Presence and role of flavin adenine dinucleotide.''; J Biol Chem, 2000 PubMed Europe PMC
  140. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed Europe PMC
  141. Arthur G, Page L; ''Synthesis of phosphatidylethanolamine and ethanolamine plasmalogen by the CDP-ethanolamine and decarboxylase pathways in rat heart, kidney and liver.''; Biochem J, 1991 PubMed Europe PMC
  142. Blank ML, Lee YJ, Cress EA, Snyder F; ''Stimulation of the de novo pathway for the biosynthesis of platelet-activating factor (PAF) via cytidylyltransferase activation in cells with minimal endogenous PAF production.''; J Biol Chem, 1988 PubMed Europe PMC
  143. Giudici ML, Hinchliffe KA, Irvine RF; ''Phosphatidylinositol phosphate kinases.''; J Endocrinol Invest, 2004 PubMed Europe PMC
  144. Gonzalvez F, Gottlieb E; ''Cardiolipin: setting the beat of apoptosis.''; Apoptosis, 2007 PubMed Europe PMC
  145. Rudkowska I, Roynette CE, Demonty I, Vanstone CA, Jew S, Jones PJ; ''Diacylglycerol: efficacy and mechanism of action of an anti-obesity agent.''; Obes Res, 2005 PubMed Europe PMC
  146. Tzagournis M; ''Triglycerides in clinical medicine. A review.''; Am J Clin Nutr, 1978 PubMed Europe PMC
  147. Wu G, Vance DE; ''Choline kinase and its function.''; Biochem Cell Biol, 2010 PubMed Europe PMC
  148. Hartz CS, Schalinske KL; ''Phosphatidylethanolamine N-methyltransferase and regulation of homocysteine.''; Nutr Rev, 2006 PubMed Europe PMC
  149. Yin H, Zhu M; ''Free radical oxidation of cardiolipin: chemical mechanisms, detection and implication in apoptosis, mitochondrial dysfunction and human diseases.''; Free Radic Res, 2012 PubMed Europe PMC
  150. Schlame M, Greenberg ML; ''Cardiolipin synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  151. Heacock AM, Agranoff BW; ''CDP-diacylglycerol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  152. Ridgway ND; ''The role of phosphatidylcholine and choline metabolites to cell proliferation and survival.''; Crit Rev Biochem Mol Biol, 2013 PubMed Europe PMC
  153. Xu FY, O K, Choy PC; ''Biosynthesis of plasmenylethanolamine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphoethanolamine) in the guinea pig heart.''; J Lipid Res, 1997 PubMed Europe PMC
  154. Vance DE, Walkey CJ, Cui Z; ''Phosphatidylethanolamine N-methyltransferase from liver.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  155. McGee TP, Skinner HB, Bankaitis VA; ''Functional redundancy of CDP-ethanolamine and CDP-choline pathway enzymes in phospholipid biosynthesis: ethanolamine-dependent effects on steady-state membrane phospholipid composition in Saccharomyces cerevisiae.''; J Bacteriol, 1994 PubMed Europe PMC
  156. Mavis RD, Vang MJ; ''Optimal assay and subcellular location of phosphatidylglycerol synthesis in lung.''; Biochim Biophys Acta, 1981 PubMed Europe PMC
  157. Secades JJ, Frontera G; ''CDP-choline: pharmacological and clinical review.''; Methods Find Exp Clin Pharmacol, 1995 PubMed Europe PMC
  158. Grimm MO, Kuchenbecker J, Rothhaar TL, Grösgen S, Hundsdörfer B, Burg VK, Friess P, Müller U, Grimm HS, Riemenschneider M, Hartmann T; ''Plasmalogen synthesis is regulated via alkyl-dihydroxyacetonephosphate-synthase by amyloid precursor protein processing and is affected in Alzheimer's disease.''; J Neurochem, 2011 PubMed Europe PMC
  159. Salamon RS, Backer JM; ''Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases.''; Bioessays, 2013 PubMed Europe PMC
  160. Tsuboi K, Ikematsu N, Uyama T, Deutsch DG, Tokumura A, Ueda N; ''Biosynthetic pathways of bioactive N-acylethanolamines in brain.''; CNS Neurol Disord Drug Targets, 2013 PubMed Europe PMC
  161. Baker RR; ''Enzymes of platelet activating factor synthesis in brain.''; Neurochem Res, 1995 PubMed Europe PMC
  162. Lykidis A, Wang J, Karim MA, Jackowski S; ''Overexpression of a mammalian ethanolamine-specific kinase accelerates the CDP-ethanolamine pathway.''; J Biol Chem, 2001 PubMed Europe PMC
  163. Kent C; ''Eukaryotic phospholipid biosynthesis.''; Annu Rev Biochem, 1995 PubMed Europe PMC
  164. Roberti R, Vecchini A, Freysz L, Masoom M, Binaglia L; ''An improved procedure for the purification of ethanolaminephosphotransferase. Reconstitution of the purified enzyme with lipids.''; Biochim Biophys Acta, 1989 PubMed Europe PMC
  165. Suh BC, Hille B; ''Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate.''; Curr Opin Neurobiol, 2005 PubMed Europe PMC
  166. Montero J, Mari M, Colell A, Morales A, Basañez G, Garcia-Ruiz C, Fernández-Checa JC; ''Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death.''; Biochim Biophys Acta, 2010 PubMed Europe PMC
  167. Pascual F, Carman GM; ''Phosphatidate phosphatase, a key regulator of lipid homeostasis.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  168. Gamper N, Shapiro MS; ''Target-specific PIP(2) signalling: how might it work?''; J Physiol, 2007 PubMed Europe PMC
  169. Gale SE, Frolov A, Han X, Bickel PE, Cao L, Bowcock A, Schaffer JE, Ory DS; ''A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.''; J Biol Chem, 2006 PubMed Europe PMC
  170. Favrelière S, Barrier L, Durand G, Chalon S, Tallineau C; ''Chronic dietary n-3 polyunsaturated fatty acids deficiency affects the fatty acid composition of plasmenylethanolamine and phosphatidylethanolamine differently in rat frontal cortex, striatum, and cerebellum.''; Lipids, 1998 PubMed Europe PMC
  171. Hammond LE, Neschen S, Romanelli AJ, Cline GW, Ilkayeva OR, Shulman GI, Muoio DM, Coleman RA; ''Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs.''; J Biol Chem, 2005 PubMed Europe PMC
  172. Maurice A, Malgat M; ''Phosphatidylethanolamine: ceramide-ethanolaminephosphotransferase activity in synaptic plasma membrane vesicles. Influence of some cations and phospholipid environment on transferase activity. Further proof of its location.''; Int J Biochem, 1993 PubMed Europe PMC
  173. Paradies G, Petrosillo G, Paradies V, Ruggiero FM; ''Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging.''; Free Radic Biol Med, 2010 PubMed Europe PMC
  174. Gupta CM, Radhakrishnan R, Khorana HG; ''Glycerophospholipid synthesis: improved general method and new analogs containing photoactivable groups.''; Proc Natl Acad Sci U S A, 1977 PubMed Europe PMC
  175. Nakanishi K, Yasugi E, Morita H, Dohi T, Oshima M; ''Plasmenylethanolamine in human intestinal mucosa detected by an improved method for analysis of phospholipid.''; Biochem Mol Biol Int, 1994 PubMed Europe PMC
  176. Snyder F, Lee TC; ''1-alkyl-2-acetyl-sn-glycero-3-phosphate phosphatase.''; Methods Enzymol, 1992 PubMed Europe PMC
  177. Snyder F; ''Metabolic processing of PAF.''; Clin Rev Allergy, 1994 PubMed Europe PMC
  178. Downes P, Michell RH; ''Phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: lipids in search of a function.''; Cell Calcium, 1982 PubMed Europe PMC
  179. Nieto ML, Velasco S, Sanchez Crespo M; ''Modulation of acetyl-CoA:1-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PAF) acetyltransferase in human polymorphonuclears. The role of cyclic AMP-dependent and phospholipid sensitive, calcium-dependent protein kinases.''; J Biol Chem, 1988 PubMed Europe PMC
  180. Vance JE; ''Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids.''; J Lipid Res, 2008 PubMed Europe PMC
  181. Tijburg LB, Geelen MJ, van Golde LM; ''Regulation of the biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine in the liver.''; Biochim Biophys Acta, 1989 PubMed Europe PMC
  182. Ishii S, Shimizu T; ''Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice.''; Prog Lipid Res, 2000 PubMed Europe PMC
  183. McMaster CR, Bell RM; ''CDP-choline:1,2-diacylglycerol cholinephosphotransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  184. André A, Tessier C, Brétillon L, Sébédio JL, Chardigny JM; ''In situ hybridization of dihydroxyacetone phosphate acyltransferase, the regulating enzyme involved in plasmalogen biosynthesis.''; Brain Res Mol Brain Res, 2005 PubMed Europe PMC
  185. Rosonina E, Manley JL; ''From transcription to mRNA: PAF provides a new path.''; Mol Cell, 2005 PubMed Europe PMC
  186. Vance DE; ''Physiological roles of phosphatidylethanolamine N-methyltransferase.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  187. Delage E, Puyaubert J, Zachowski A, Ruelland E; ''Signal transduction pathways involving phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate: convergences and divergences among eukaryotic kingdoms.''; Prog Lipid Res, 2013 PubMed Europe PMC
  188. Vance JE, Steenbergen R; ''Metabolism and functions of phosphatidylserine.''; Prog Lipid Res, 2005 PubMed Europe PMC
  189. Jambou R, El-Assaad F, Combes V, Grau GE; ''Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases.''; Int J Biochem Cell Biol, 2009 PubMed Europe PMC
  190. Mott GE, Brinkley AW; ''Plasmenylethanolamine: growth factor for cholesterol-reducing Eubacterium.''; J Bacteriol, 1979 PubMed Europe PMC
  191. Lee TC, Qian CG, Snyder F; ''Biosynthesis of choline plasmalogens in neonatal rat myocytes.''; Arch Biochem Biophys, 1991 PubMed Europe PMC
  192. Frentzen M; ''Phosphatidylglycerol and sulfoquinovosyldiacylglycerol: anionic membrane lipids and phosphate regulation.''; Curr Opin Plant Biol, 2004 PubMed Europe PMC
  193. Kannan L, Knudsen J, Jolly CA; ''Aging and acyl-CoA binding protein alter mitochondrial glycerol-3-phosphate acyltransferase activity.''; Biochim Biophys Acta, 2003 PubMed Europe PMC
  194. van Heusden GP, van den Bosch H; ''The influence of exogenous and of membrane-bound phosphatidate concentration on the activity of CTP: phosphatidate cytidylyltransferase and phosphatidate phosphohydrolase.''; Eur J Biochem, 1978 PubMed Europe PMC
  195. Brown A, Snyder F; ''Alkyldihydroxyacetonephosphate synthase.''; Methods Enzymol, 1992 PubMed Europe PMC
  196. Das AK, Hajra AK; ''Estimation of acyldihydroxyacetone phosphate and lysophosphatidate in animal tissues.''; Biochim Biophys Acta, 1984 PubMed Europe PMC
  197. Baker RR; ''Lipid acetylation reactions and the metabolism of platelet-activating factor.''; Neurochem Res, 2000 PubMed Europe PMC
  198. Siegel A, Baker RR; ''Activities of enzymes in platelet activating factor biosynthetic pathways in the gerbil model of cerebral ischemia.''; Biochem Cell Biol, 1996 PubMed Europe PMC
  199. Tijburg LB, Geelen MJ, Van Golde LM; ''Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes.''; Biochem Biophys Res Commun, 1989 PubMed Europe PMC
  200. Webber KO, Hajra AK; ''Dihydroxyacetone phosphate acyltransferase.''; Methods Enzymol, 1992 PubMed Europe PMC
  201. Aoki J, Inoue A, Okudaira S; ''Two pathways for lysophosphatidic acid production.''; Biochim Biophys Acta, 2008 PubMed Europe PMC
  202. Nikawa J, Yamashita S; ''Phosphatidylinositol synthase from yeast.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  203. Lapetina EG, Crouch MF; ''The relationship between phospholipases A2 and C in signal transduction.''; Ann N Y Acad Sci, 1989 PubMed Europe PMC
  204. Blank ML, Spector AA, Kaduce TL, Lee TC, Snyder F; ''Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and 1-alkyl-2-acetyl-sn-glycerol by human endothelial cells.''; Biochim Biophys Acta, 1986 PubMed Europe PMC
  205. Kent C; ''CTP:phosphocholine cytidylyltransferase.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  206. Leventis PA, Grinstein S; ''The distribution and function of phosphatidylserine in cellular membranes.''; Annu Rev Biophys, 2010 PubMed Europe PMC
  207. Tijburg LB, Vermeulen PS, van Golde LM; ''Ethanolamine-phosphate cytidylyltransferase.''; Methods Enzymol, 1992 PubMed Europe PMC
  208. Berdichevets IN, Tyazhelova TV, Shimshilashvili KhR, Rogaev EI; ''Lysophosphatidic acid is a lipid mediator with wide range of biological activities. Biosynthetic pathways and mechanism of action.''; Biochemistry (Mosc), 2010 PubMed Europe PMC
  209. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''PAF. A review of its effects, antagonists and possible future clinical implications (Part II).''; Drugs, 1991 PubMed Europe PMC
  210. Yamashita S, Hosaka K, Miki Y, Numa S; ''Glycerolipid acyltransferases from rat liver: 1-acylglycerophosphate acyltransferase, 1-acylglycerophosphorylcholine acyltransferase, and diacylglycerol acyltransferase.''; Methods Enzymol, 1981 PubMed Europe PMC
  211. Axelrod J; ''Phospholipase A2 and G proteins.''; Trends Neurosci, 1995 PubMed Europe PMC
  212. Glaser KB, Mobilio D, Chang JY, Senko N; ''Phospholipase A2 enzymes: regulation and inhibition.''; Trends Pharmacol Sci, 1993 PubMed Europe PMC
  213. Vance DE, Li Z, Jacobs RL; ''Hepatic phosphatidylethanolamine N-methyltransferase, unexpected roles in animal biochemistry and physiology.''; J Biol Chem, 2007 PubMed Europe PMC
  214. Reue K, Brindley DN; ''Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.''; J Lipid Res, 2008 PubMed Europe PMC
  215. Koltai M, Hosford D, Guinot P, Esanu A, Braquet P; ''Platelet activating factor (PAF). A review of its effects, antagonists and possible future clinical implications (Part I).''; Drugs, 1991 PubMed Europe PMC
  216. Singh H, Beckman K, Poulos A; ''Exclusive localization in peroxisomes of dihydroxyacetone phosphate acyltransferase and alkyl-dihydroxyacetone phosphate synthase in rat liver.''; J Lipid Res, 1993 PubMed Europe PMC
  217. Han XL, Gross RW; ''Plasmenylcholine and phosphatidylcholine membrane bilayers possess distinct conformational motifs.''; Biochemistry, 1990 PubMed Europe PMC
  218. Snyder F; ''CDP-choline:alkylacetylglycerol cholinephosphotransferase catalyzes the final step in the de novo synthesis of platelet-activating factor.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  219. Snyder F, Blank M, Lee TC, Robinson M, Woodard D; ''Measurement of key enzyme activities involved in the metabolism of platelet activating factor.''; Methods Enzymol, 1987 PubMed Europe PMC
  220. Brown AJ, Glish GL, McBay EH, Snyder F; ''Alkyldihydroxyacetonephosphate synthase mechanism: 18O studies of fatty acid release from acyldihydroxyacetone phosphate.''; Biochemistry, 1985 PubMed Europe PMC
  221. Henneberry AL, Wistow G, McMaster CR; ''Cloning, genomic organization, and characterization of a human cholinephosphotransferase.''; J Biol Chem, 2000 PubMed Europe PMC
  222. Bobenchik AM, Augagneur Y, Hao B, Hoch JC, Ben Mamoun C; ''Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.''; FEMS Microbiol Rev, 2011 PubMed Europe PMC
  223. Gibbons GF, Islam K, Pease RJ; ''Mobilisation of triacylglycerol stores.''; Biochim Biophys Acta, 2000 PubMed Europe PMC
  224. Biermann J, Just WW, Wanders RJ, Van Den Bosch H; ''Alkyl-dihydroxyacetone phosphate synthase and dihydroxyacetone phosphate acyltransferase form a protein complex in peroxisomes.''; Eur J Biochem, 1999 PubMed Europe PMC
  225. Yang CY, Frohman MA; ''Mitochondria: signaling with phosphatidic acid.''; Int J Biochem Cell Biol, 2012 PubMed Europe PMC
  226. Holmsen H, Hindenes JO, Fukami M; ''Glycerophospholipid metabolism: back to the future.''; Thromb Res, 1992 PubMed Europe PMC
  227. Debeer LJ, Declercq PE, Mannaerts GP; ''Glycerol-3-phosphate content and triacylglycerol synthesis in isolated hepatocytes from fed and starved rats.''; FEBS Lett, 1981 PubMed Europe PMC
  228. Divecha N; ''Lipid kinases: charging PtdIns(4,5)P2 synthesis.''; Curr Biol, 2010 PubMed Europe PMC
  229. Wykle RL, Schremmer JM; ''Biosynthesis of plasmalogens by the microsomal fraction of fischer R-3259 sarcoma. Influence of specific 2-acyl chains on the desaturation of 1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine.''; Biochemistry, 1979 PubMed Europe PMC
  230. Schug ZT, Gottlieb E; ''Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  231. Santiago OM, Rosenberg LI, Monaco ME; ''Organization of the phosphoinositide cycle. Assessment of inositol transferase activity in purified plasma membranes.''; Biochem J, 1993 PubMed Europe PMC
  232. Vance JE, Tasseva G; ''Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  233. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed Europe PMC
  234. Vance DE; ''Phosphatidylethanolamine N-methyltransferase: unexpected findings from curiosity-driven research.''; Eur J Med Res, 1996 PubMed Europe PMC
  235. Horibata Y, Hirabayashi Y; ''Identification and characterization of human ethanolaminephosphotransferase1.''; J Lipid Res, 2007 PubMed Europe PMC
  236. El-Bassiouni EA, Piantadosi C, Snyder F; ''Metabolism of alkyldihydroxyacetone phosphate in rat brain.''; Biochim Biophys Acta, 1975 PubMed Europe PMC
  237. Shindou H, Hishikawa D, Nakanishi H, Harayama T, Ishii S, Taguchi R, Shimizu T; ''A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase.''; J Biol Chem, 2007 PubMed Europe PMC
  238. Carman GM, Kelley MJ; ''CDPdiacylglycerol synthase from yeast.''; Methods Enzymol, 1992 PubMed Europe PMC
  239. Rooney SA; ''Lung surfactant.''; Environ Health Perspect, 1984 PubMed Europe PMC
  240. Talmud PJ; ''Genetic determinants of plasma triglycerides: impact of rare and common mutations.''; Curr Atheroscler Rep, 2001 PubMed Europe PMC
  241. Wright MM, McMaster CR; ''PC and PE synthesis: mixed micellar analysis of the cholinephosphotransferase and ethanolaminephosphotransferase activities of human choline/ethanolamine phosphotransferase 1 (CEPT1).''; Lipids, 2002 PubMed Europe PMC
  242. Thomas JR, Dwek RA, Rademacher TW; ''Structure, biosynthesis, and function of glycosylphosphatidylinositols.''; Biochemistry, 1990 PubMed Europe PMC
  243. Xu YF, O K, Choy PC; ''Plasmenylcholine (1-O-alk-1'-enyl-2-acyl-sn-glycero-3-phosphocholine) biosynthesis in guinea-pig heart and liver: cholinephosphotransferase is a bifunctional enzyme for the synthesis of phosphatidylcholine and plasmenylcholine.''; Biochem J, 1994 PubMed Europe PMC
  244. Thompson DH, Shin J, Boomer J, Kim JM; ''Preparation of plasmenylcholine lipids and plasmenyl-type liposome dispersions.''; Methods Enzymol, 2004 PubMed Europe PMC
  245. Ishidate K, Matsuo R, Nakazawa Y; ''CDPcholine:1,2-diacylglycerol cholinephosphotransferase from rat liver microsomes. I. Solubilization and characterization of the partially purified enzyme and the possible existence of an endogenous inhibitor.''; Lipids, 1993 PubMed Europe PMC
  246. Scherer M, Schmitz G; ''Metabolism, function and mass spectrometric analysis of bis(monoacylglycero)phosphate and cardiolipin.''; Chem Phys Lipids, 2011 PubMed Europe PMC
  247. Kwiatkowska K; ''One lipid, multiple functions: how various pools of PI(4,5)P(2) are created in the plasma membrane.''; Cell Mol Life Sci, 2010 PubMed Europe PMC
  248. Cole LK, Vance JE, Vance DE; ''Phosphatidylcholine biosynthesis and lipoprotein metabolism.''; Biochim Biophys Acta, 2012 PubMed Europe PMC
  249. Ohtsuka J, Nagata K, Lee WC, Ono Y, Fukuda R, Ohta A, Tanokura M; ''Crystallization and preliminary X-ray analysis of CTP:phosphoethanolamine cytidylyltransferase (ECT) from Saccharomyces cerevisiae.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 PubMed Europe PMC
  250. Bewley GC, Cook JL; ''Molecular structure, developmental regulation, and evolution of the gene encoding glycerol-3-phosphate dehydrogenase isozymes in Drosophila melanogaster.''; Prog Clin Biol Res, 1990 PubMed Europe PMC
  251. Muzia TI, Kulikov VN; ''[1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine: acetylhydrolase is associated primarily with low density lipoproteins in human blood].''; Biokhimiia, 1991 PubMed Europe PMC
  252. Sinha RK, Subrahmanyam G; ''Type II phosphatidylinositol 4-kinase(s) in cell signaling cascades.''; Indian J Biochem Biophys, 2007 PubMed Europe PMC
  253. Henneberry AL, McMaster CR; ''Cloning and expression of a human choline/ethanolaminephosphotransferase: synthesis of phosphatidylcholine and phosphatidylethanolamine.''; Biochem J, 1999 PubMed Europe PMC
  254. Schümperli M, Pellaux R, Panke S; ''Chemical and enzymatic routes to dihydroxyacetone phosphate.''; Appl Microbiol Biotechnol, 2007 PubMed Europe PMC
  255. Fagone P, Jackowski S; ''Phosphatidylcholine and the CDP-choline cycle.''; Biochim Biophys Acta, 2013 PubMed Europe PMC
  256. Rabert U, Völkl A, Debuch H; ''Distribution of alkylglycerone-phosphate synthase in subcellular fractions of rat liver.''; Biol Chem Hoppe Seyler, 1986 PubMed Europe PMC
  257. Claypool SM; ''Cardiolipin, a critical determinant of mitochondrial carrier protein assembly and function.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  258. Cornell RB; ''Cholinephosphotransferase from mammalian sources.''; Methods Enzymol, 1992 PubMed Europe PMC
  259. Bleijerveld OB, Klein W, Vaandrager AB, Helms JB, Houweling M; ''Control of the CDPethanolamine pathway in mammalian cells: effect of CTP:phosphoethanolamine cytidylyltransferase overexpression and the amount of intracellular diacylglycerol.''; Biochem J, 2004 PubMed Europe PMC
  260. Vance JE; ''Molecular and cell biology of phosphatidylserine and phosphatidylethanolamine metabolism.''; Prog Nucleic Acid Res Mol Biol, 2003 PubMed Europe PMC
  261. Clement JM, Kent C; ''CTP:phosphocholine cytidylyltransferase: insights into regulatory mechanisms and novel functions.''; Biochem Biophys Res Commun, 1999 PubMed Europe PMC
  262. Alarcon DA, Nandi M, Carpena X, Fita I, Loewen PC; ''Structure of glycerol-3-phosphate dehydrogenase (GPD1) from Saccharomyces cerevisiae at 2.45 Å resolution.''; Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012 PubMed Europe PMC
  263. Vance DE, Walkey CJ, Agellon LB; ''Why has phosphatidylethanolamine N-methyltransferase survived in evolution?''; Biochem Soc Trans, 1998 PubMed Europe PMC
  264. Tie A, Bakovic M; ''Alternative splicing of CTP:phosphoethanolamine cytidylyltransferase produces two isoforms that differ in catalytic properties.''; J Lipid Res, 2007 PubMed Europe PMC
  265. Piantadosi C, Ishaq KS, Wykle RL, Snyder F; ''Synthesis and characterization of 1-O-alkyldihydroxyacetone phosphates and derivatives.''; Biochemistry, 1971 PubMed Europe PMC
  266. Mancini A, Roberti R, Binaglia L, el Missiri A, Freysz L; ''Factors affecting the stability of detergent-solubilized cholinephosphotransferase and ethanolaminephosphotransferase.''; Membr Biochem, 1993 PubMed Europe PMC
  267. Janardhan S, Srivani P, Sastry GN; ''Choline kinase: an important target for cancer.''; Curr Med Chem, 2006 PubMed Europe PMC
  268. Turkish A, Sturley SL; ''Regulation of triglyceride metabolism. I. Eukaryotic neutral lipid synthesis: "Many ways to skin ACAT or a DGAT".''; Am J Physiol Gastrointest Liver Physiol, 2007 PubMed Europe PMC
  269. Zimmerman GA, Elstad MR, Lorant DE, Mclntyre TM, Prescott SM, Topham MK, Weyrich AS, Whatley RE; ''Platelet-activating factor (PAF): signalling and adhesion in cell-cell interactions.''; Adv Exp Med Biol, 1996 PubMed Europe PMC
  270. Ellis JM, Paul DS, Depetrillo MA, Singh BP, Malarkey DE, Coleman RA; ''Mice deficient in glycerol-3-phosphate acyltransferase-1 have a reduced susceptibility to liver cancer.''; Toxicol Pathol, 2012 PubMed Europe PMC
  271. Idahl LA, Lembert N; ''Glycerol 3-phosphate-induced ATP production in intact mitochondria from pancreatic B-cells.''; Biochem J, 1995 PubMed Europe PMC
  272. Kooijman EE, Burger KN; ''Biophysics and function of phosphatidic acid: a molecular perspective.''; Biochim Biophys Acta, 2009 PubMed Europe PMC
  273. Hajra AK, Das AK; ''Lipid biosynthesis in peroxisomes.''; Ann N Y Acad Sci, 1996 PubMed Europe PMC
  274. Lacal JC; ''Choline kinase: a novel target for antitumor drugs.''; IDrugs, 2001 PubMed Europe PMC
  275. Ramanadham S, Bohrer A, Mueller M, Jett P, Gross RW, Turk J; ''Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species.''; Biochemistry, 1993 PubMed Europe PMC
  276. Lee TC, Malone B, Blank ML, Fitzgerald V, Snyder F; ''Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets.''; J Biol Chem, 1990 PubMed Europe PMC
  277. Downes CP, Carter AN; ''Inositol lipids and phosphates.''; Curr Opin Cell Biol, 1990 PubMed Europe PMC
  278. de Vet EC, Ijlst L, Oostheim W, Dekker C, Moser HW, van Den Bosch H, Wanders RJ; ''Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities.''; J Lipid Res, 1999 PubMed Europe PMC
  279. Nakagawa Y, Waku K; ''The metabolism of glycerophospholipid and its regulation in monocytes and macrophages.''; Prog Lipid Res, 1989 PubMed Europe PMC
  280. Tufano MA, Biancone L, Rossano F, Capasso C, Baroni A, De Martino A, Iorio EL, Silvestro L, Camussi G; ''Outer-membrane porins from gram-negative bacteria stimulate platelet-activating-factor biosynthesis by cultured human endothelial cells.''; Eur J Biochem, 1993 PubMed Europe PMC
  281. Sugimoto H, Banchio C, Vance DE; ''Transcriptional regulation of phosphatidylcholine biosynthesis.''; Prog Lipid Res, 2008 PubMed Europe PMC
  282. Lamers JM, Dekkers DH, Bezstarosti K, Meij JT, van Heugten HA; ''Occurrence and functions of the phosphatidylinositol cycle in the myocardium.''; Mol Cell Biochem, 1992 PubMed Europe PMC
  283. Rauchová H, Drahota Z; ''Inhibition of the glycerol 3-phosphate oxidation by free fatty acids.''; Int J Biochem, 1984 PubMed Europe PMC
  284. Secades JJ, Lorenzo JL; ''Citicoline: pharmacological and clinical review, 2006 update.''; Methods Find Exp Clin Pharmacol, 2006 PubMed Europe PMC
  285. Schlame M, Hostetler KY; ''Cardiolipin synthase from mammalian mitochondria.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  286. Kume K, Shimizu T; ''cDNA cloning and expression of murine 1-acyl-sn-glycerol-3-phosphate acyltransferase.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC
  287. Thompson RJ; ''The biosynthesis of cytidine diphosphate diacylglycerol in the mammalian cerebral cortex.''; Biochem Soc Trans, 1977 PubMed Europe PMC
  288. Large WA, Saleh SN, Albert AP; ''Role of phosphoinositol 4,5-bisphosphate and diacylglycerol in regulating native TRPC channel proteins in vascular smooth muscle.''; Cell Calcium, 2009 PubMed Europe PMC
  289. Edwards YH, Shaw MA; ''The isozymes of membrane-associated enzymes: acetylcholinesterase, succinate dehydrogenase, and glycerol-3-phosphate dehydrogenase.''; Isozymes Curr Top Biol Med Res, 1983 PubMed Europe PMC
  290. Coleman R, Bell RM; ''Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities.''; J Biol Chem, 1977 PubMed Europe PMC
  291. Insall RH, Weiner OD; ''PIP3, PIP2, and cell movement--similar messages, different meanings?''; Dev Cell, 2001 PubMed Europe PMC
  292. Ishidate K; ''Choline/ethanolamine kinase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  293. Leonardi R, Frank MW, Jackson PD, Rock CO, Jackowski S; ''Elimination of the CDP-ethanolamine pathway disrupts hepatic lipid homeostasis.''; J Biol Chem, 2009 PubMed Europe PMC
  294. Meyers RE, Cantley LC; ''Phosphatidylinositol 4-kinases. Assays and product analysis.''; Methods Mol Biol, 1998 PubMed Europe PMC
  295. Nakashima A, Hosaka K, Nikawa J; ''Cloning of a human cDNA for CTP-phosphoethanolamine cytidylyltransferase by complementation in vivo of a yeast mutant.''; J Biol Chem, 1997 PubMed Europe PMC
  296. Kashiwada M, Lu P, Rothman PB; ''PIP3 pathway in regulatory T cells and autoimmunity.''; Immunol Res, 2007 PubMed Europe PMC
  297. Willier S, Butt E, Grunewald TG; ''Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: A focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays.''; Biol Cell, 2013 PubMed Europe PMC
  298. Antonsson B; ''Phosphatidylinositol synthase from mammalian tissues.''; Biochim Biophys Acta, 1997 PubMed Europe PMC
  299. Verheij HM, Slotboom AJ, de Haas GH; ''Structure and function of phospholipase A2.''; Rev Physiol Biochem Pharmacol, 1981 PubMed Europe PMC
  300. Ford DA, Gross RW; ''Plasmenylethanolamine is the major storage depot for arachidonic acid in rabbit vascular smooth muscle and is rapidly hydrolyzed after angiotensin II stimulation.''; Proc Natl Acad Sci U S A, 1989 PubMed Europe PMC
  301. Gehrmann T, Heilmeyer LM Jr; ''Phosphatidylinositol 4-kinases.''; Eur J Biochem, 1998 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107760view16:15, 1 November 2019DeSlOntology Term : 'phosphatidylcholine metabolic pathway' added !
107759view16:14, 1 November 2019DeSlOntology Term : 'phosphoinositide metabolic pathway' added !
107758view16:12, 1 November 2019DeSlOntology Term : 'PW:0001156' removed !
107757view16:11, 1 November 2019DeSlUpdated all curved lines for side metabolites to MIMconversion pointing to/away from anchor.
107756view15:48, 1 November 2019DeSlUpdated IDs for EC 2.7.1.153 (bottom right corner).
107755view09:55, 1 November 2019DeSlUpdated top half of PW, so side metabolites are connected to anchors.
107754view09:49, 1 November 2019DeSlAdded separate IDs for proteins under EC 2.3.1.15 .
107753view09:31, 1 November 2019DeSlChanged 2- to "1-" in 1-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA) (reaction otherwise doesn't occure in humans.
107133view14:21, 17 September 2019MaintBotChEBI identifier normalization
106718view13:15, 17 September 2019MaintBotHMDB identifier normalization
106449view11:34, 29 August 2019DeSlUpdated LipidMaps ID for TAG.
105333view12:05, 31 July 2019EgonwThe class, not the reference lipid.
98235view12:32, 14 August 2018EgonwReplace a PubChem SID with a ChEBI ID.
98103view11:11, 20 July 2018DeSlOntology Term : 'glycerophospholipid metabolic pathway' added !
95594view14:18, 5 January 2018DeSlChanged part of the layout for readability of this pathway.
93096view15:17, 28 July 2017DeSlChanged all the PubChem Substance ID's (around 13) to more stereospecific IDs.
93077view08:52, 28 July 2017ElisaFixed unconnected lines and changed arrows in the legend from interactions to graphical elements
93029view16:02, 26 July 2017DeSlChanged hydrate ID from PubChem compounds to correct HMDB ID for D-glucose-6-P
92861view15:19, 10 July 2017EgonwFixed PubChem compound ID (was salt, now pure compound).
85647view17:10, 4 June 2016EgonwFixed the PubChem SID.
84117view10:00, 16 January 2016EgonwFixed a typo in the label.
83825view11:17, 14 December 2015EgonwRemoved data source info from identifiers.
76320view07:17, 2 July 2014Mkutmonadded chebi identifiers to metabolites annotated with GO terms
71989view11:13, 24 October 2013MkutmonChanged Unknown -> Metabolite for 3 (S-adenosyl-methionine) and 3 (S-adenosylhomocysteine)
71699view19:49, 17 October 2013MaintBotUpdated data sources
70448view22:31, 1 August 2013AmanzoPeriodical save, work in progress
70447view22:21, 1 August 2013AmanzoPeriodical save, work in progress
70404view16:13, 29 July 2013AmanzoWork in progress
70403view16:07, 29 July 2013AmanzoPeriodical save, work in progress
70390view16:04, 26 July 2013AmanzoPeriodical save, work in progress
70389view23:52, 25 July 2013AmanzoWork in progress
70388view23:42, 25 July 2013AmanzoPeriodical save, work in progress
70387view23:32, 25 July 2013AmanzoPeriodical save, work in progress
70384view17:34, 23 July 2013AmanzoWork in progress
70381view23:33, 21 July 2013AmanzoPeriodical save, work in progress
70380view23:22, 21 July 2013AmanzoPeriodical save, work in progress
70379view23:12, 21 July 2013AmanzoPeriodical save, work in progress
70378view23:02, 21 July 2013AmanzoPeriodical save, work in progress
70377view22:52, 21 July 2013AmanzoPeriodical save, work in progress
70376view22:42, 21 July 2013AmanzoPeriodical save, work in progress
70375view22:32, 21 July 2013AmanzoPeriodical save, work in progress
70374view22:21, 21 July 2013AmanzoPeriodical save, work in progress
70373view22:11, 21 July 2013AmanzoPeriodical save, work in progress
70372view22:01, 21 July 2013AmanzoPeriodical save, work in progress
70371view21:51, 21 July 2013AmanzoPeriodical save, work in progress
70370view21:41, 21 July 2013AmanzoPeriodical save, work in progress
70369view00:17, 21 July 2013AmanzoWork in progress
70368view00:14, 21 July 2013AmanzoPeriodical save, work in progress
70367view00:04, 21 July 2013AmanzoPeriodical save, work in progress
70366view23:53, 20 July 2013AmanzoPeriodical save, work in progress

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1,2-diacyl-sn-glycero-3-cytidine-5'-diphosphate (CDP-DAG, CMP-PA)MetaboliteLMGP13010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphate (Phosphatidic acid; PA)MetaboliteLMGP10010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol) (PI)MetaboliteLMGP06010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-phosphate) (PGP)
1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) (PG)MetaboliteLMGP04010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphocholine (PC, Lecithin)MetaboliteLMGP01010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoethanolamine (PE)MetaboliteLMGP02010000 (LIPID MAPS)
1,2-diacyl-sn-glycero-3-phosphoserine (PS)MetaboliteLMGP03010000 (LIPID MAPS)
1,2-diacyl-sn-glycerol (1,2-diacylglycerol; 1,2-DAG)MetaboliteLMGL02010000 (LIPID MAPS)
1-Acyl dihydroxyacetone phosphate (Acyl-DHAP)MetaboliteHMDB11750 (HMDB)
1-Alkenyl-2-acylglycerophosphocholine (Plasmenylcholine)MetaboliteSID 4209 (PubChem-substance)
1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (Platelet Activating Factor, PAF)MetaboliteCHEBI:36707 (ChEBI)
1-Alkyl-sn-glycerol 3-phosphateMetaboliteSID 92741300 (PubChem-substance)
1-Alkyldihydroxyacetone phosphate (Octanoyl DHAP)MetaboliteCID 53481029 (PubChem-compound)
1-alkenyl-2-acylglycerophosphoethanolamine (Plasmenylethanolamine)MetaboliteSID 7325 (PubChem-substance)
1-alkyl-2-acyl-sn-glycero-3-phosphate phosphatase

(Phosphatidate phosphatase)

EC 3.1.3.4
ProteinQ92539 (Uniprot/TrEMBL)
1-alkyl-2-acyl-sn-glycero-3-phosphocholine (Plasmanylcholine)MetaboliteCHEBI:36702 (ChEBI)
1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine (Plasmanylethanolamine)MetaboliteCHEBI:36712 (ChEBI)
1-alkyl-2-acyl-sn-glycerol 3-phosphateMetaboliteCHEBI:37296 (ChEBI)
1-alkyl-2-acyl-sn-glycerolMetaboliteCID 17756737 (PubChem-compound)
1-alkyl-2-acyl-sn-glycerophoethanolamine desaturase

(Plasmanylethanolamine desaturase)

EC 1.14.99.19
ProteinEC 1.14.99.19 (Enzyme Nomenclature)
1-phosphatidylinositol 4-kinase EC 2.7.1.67ProteinQ9BTU6 (Uniprot/TrEMBL)
1-phosphatidylinositol 4-phosphate 5-kinase EC 2.7.1.68ProteinQ99755 (Uniprot/TrEMBL)
1D-myo-Inositol-1-PMetaboliteCID 5288642 (PubChem-compound)
2-acyl-sn-glycero-3-phosphate (Lysophosphatidic acid; LPA)MetaboliteLMGP10050000 (LIPID MAPS)
2-acylglycerol-3-phosphate O-acyltransferase EC 2.3.1.52ProteinEC 2.3.1.52 (Enzyme Nomenclature)
2H2OMetabolite
3 (S-adenosyl-methionine)CID 34756 (PubChem-compound)
3 (S-adenosylhomocysteine)CID 439155 (PubChem-compound)
ADPMetaboliteCID 6022 (PubChem-compound)
ATPMetaboliteCID 5957 (PubChem-compound)
Acyl coenzyme A (Acyl-CoA)MetaboliteSID 3342 (PubChem-substance)
Acyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acyltransferase EC 2.3.1.-ProteinEC 2.3.1.- (Enzyme Nomenclature)
Acyl-CoAMetaboliteSID 3342 (PubChem-substance)
Acylglycerone-phosphate reductase

(1-alkyl-sn-glycerol-3-phosphate dehydrogenase)

EC 1.1.1.101
ProteinP40471 (Uniprot/TrEMBL)
Adenosine diphosphate (ADP)MetaboliteCID 6022 (PubChem-compound)
Adenosine triphosphate (ATP)MetaboliteCID 5957 (PubChem-compound)
Alkyldihydroxyacetonephosphate synthase

(Alkyl-DHAP synthase)

EC 2.5.1.26
ProteinO00116 (Uniprot/TrEMBL)
CDP-DAGMetaboliteLMGP13010000 (LIPID MAPS)
CDP-choline:1-alkyl-2-acyl-sn-glycerophosphocholine transferase

(Diacylglycerol cholinephosphotransferase)

EC 2.7.8.2
ProteinQ9Y6K0 (Uniprot/TrEMBL)
CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EC 2.7.8.5ProteinQ32NB8 (Uniprot/TrEMBL)
CDP-diacylglyreol-inositol 3-phosphatidyltransferase EC 2.7.8.11ProteinO14735 (Uniprot/TrEMBL)
CDP-ethanolamine:1-alkyl-2-acyl-sn-glycerophosphoethanolamine transferase

(Ethanolaminephosphotransferase)

EC 2.7.8.1
ProteinQ92539 (Uniprot/TrEMBL)
CMPMetaboliteCID 6131 (PubChem-compound)
CTPMetaboliteCID 6176 (PubChem-compound)
Cardiolipin (DPG, CL)MetaboliteLMPG12010000 (LIPID MAPS)
Cardiolipin synthase EC 2.7.8.-ProteinQ9UJA2 (Uniprot/TrEMBL)
Choline kinase EC 2.7.1.32ProteinQ9Y259 (Uniprot/TrEMBL)
Choline-phosphate cytidylyltransferase EC 2.7.7.15ProteinQ9Y259 (Uniprot/TrEMBL)
CholineMetaboliteCID 305 (PubChem-substance)
CoA-SHMetaboliteCID 6816 (PubChem-compound)
Coenzyme A (CoA-SH)MetaboliteCID 6816 (PubChem-compound)
Cytidine diphosphate choline (CDP-choline)MetaboliteCID 25202509 (PubChem-compound)
Cytidine diphosphate ethanolamine (CDP-ethanolamine)MetaboliteCID 123727 (PubChem-compound)
Cytidine monophosphate (CMP)MetaboliteCID 6131 (PubChem-compound)
Cytidine triphosphate (CTP)MetaboliteCID 6176 (PubChem-compound)
Cytochrome bMetaboliteCHEBI:38551 (ChEBI)
D-Glucose-6-PMetaboliteCID 44134741 (PubChem-compound)
Diacylglycerol O-acyltransferase EC 2.3.1.20ProteinQ86VF5 (Uniprot/TrEMBL)
Diacylglycerol cholinephosphotransferase EC 2.7.8.2ProteinQ8WUD6 (Uniprot/TrEMBL)
Dihydroxyacetone phosphateMetaboliteCID 668 (PubChem-compound)
Ethanolamine kinase EC 2.7.1.82ProteinQ9Y259 (Uniprot/TrEMBL)
Ethanolamine-phosphate cytidylyltransferase EC 2.7.7.14ProteinQ99447 (Uniprot/TrEMBL)
EthanolamineMetaboliteCID 700 (PubChem-compound)
Ethanolaminephosphotransferase EC 2.7.8.1ProteinQ9Y6K0 (Uniprot/TrEMBL)
Fatty acid MetabolismPathway00071 (KEGG Pathway)
Fatty acyl-CoAMetaboliteSID 24701368 (PubChem-substance)
Glycerol kinase EC 2.7.1.30ProteinP32189 (Uniprot/TrEMBL)
Glycerol-3-PMetaboliteCID 7048686 (PubChem-compound)
Glycerol-3-phosphate 2-O-acyltransferase EC 2.3.1.198ProteinO80437 (Uniprot/TrEMBL)
Glycerol-3-phosphate dehydrogenase (NAD+) EC 1.1.1.8ProteinP21695 (Uniprot/TrEMBL)
GlycerolMetaboliteCID 753 (PubChem-compound)
GlycolysisPathway00010 (KEGG Pathway)
H2O
InositolMetaboliteCID 892 (PubChem-compound)
L-serine-phosphatidylethanolamine phosphatidyltransferase EC 2.7.8.29ProteinP48651 (Uniprot/TrEMBL)
NAD+ (Coenzyme I)MetaboliteCID 5892 (PubChem-compound)
NADH + H+MetaboliteCID 439153 (PubChem-compound)
NADP (Coenzyme II)MetaboliteCID 5886 (PubChem-compound)
NADPH + H+MetaboliteCID 5884 (PubChem-compound)
O2 + NADH + H+Metabolite
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PIP3[3',4',5']MetaboliteLMGP09010001 (LIPID MAPS)
PPiMetabolite
Phosphatidate cytidylyltransferase EC 2.7.7.41ProteinO95674 (Uniprot/TrEMBL)
Phosphatidate phosphatase EC 3.1.3.4ProteinQ14693 (Uniprot/TrEMBL)
Phosphatidylethanolamine N-methyltransferase EC 2.1.1.17ProteinQ9UBM1 (Uniprot/TrEMBL)
Phosphatidylglycerophosphatase EC 3.1.3.27ProteinQ8WUK0 (Uniprot/TrEMBL)
Phosphatidylinositol-4,5-bisphosphate 3-kinase EC 2.7.1.153ProteinQ42338 (Uniprot/TrEMBL)
Phosphatidylinositol-4-phosphate (PIP)MetaboliteLMGP07010003 (LIPID MAPS)
Phosphocholine (Choline-P)MetaboliteCID 1014 (PubChem-compound)
PhosphorylethanolamineMetaboliteCID 1015 (PubChem-compound)
PiMetabolite
Pyrimidine MetabolismPathway00240 (KEGG Pathway)
SerineMetaboliteCID 5951 (PubChem-compound)
sn-glycerol-3-phosphate (glycerol-3-P)MetaboliteCID 7048686 (PubChem-compound)
triacyl-sn-glycerol (Triacylglycerol; TAG)MetaboliteLMGL03010000 (LIPID MAPS)

Annotated Interactions

No annotated interactions

Personal tools