Trans-sulfuration and one carbon metabolism (Homo sapiens)

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One-carbon (1C) metabolism is a universal metabolic process that serves to activate and transfer 1C units for biosynthetic processes including purine and thymidine synthesis and homocysteine remethylation. The transsulfuration pathway is a metabolic pathway involving the interconversion of cysteine and homocysteine, through the intermediate cystathionine. One carbon metabolism indirectly controls cysteine levels via its effect on the transsulfuration pathway that transfers sulfur from homocysteine to serine to make cysteine.

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Ontology Terms



  1. Ducker GS, Rabinowitz JD; ''One-Carbon Metabolism in Health and Disease.''; Cell Metab, 2017 PubMed Europe PMC Scholia


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106716view13:15, 17 September 2019MaintBotHMDB identifier normalization
105844view23:13, 15 August 2019KhanspersModified description
101747view05:25, 5 November 2018EgonwEquivalent CID (different protonation) but this CID is approved.
97822view15:27, 9 June 2018EgonwModified description
97786view14:10, 7 June 2018DeSlChanged arrows to catalysis MIM-type where applicable.
97785view14:05, 7 June 2018DeSlModified description
97782view14:00, 7 June 2018DeSlAdded info from One Carbon Donor PW (WP2190) in green.
97737view13:00, 7 June 2018Jessev1993Added literature reference.
97734view12:57, 7 June 2018Jessev1993Modified description
97730view12:51, 7 June 2018Jessev1993Modified description
87802view11:23, 25 July 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
80205view20:49, 22 May 2015KhanspersReverted to version '10:30, 7 January 2015' by Khanspers
80149view18:41, 14 May 2015KhanspersAdded mir29 family targeting and associated lit ref
78541view10:30, 7 January 2015MaintBotadded missing graphIds
72048view16:55, 24 October 2013Mkutmonupdated annotations
72039view13:49, 24 October 2013Mkutmonfixed unconnected lines
71253view20:51, 16 October 2013MaintBotAutomated update of data sources
69727view17:06, 10 July 2013Leonjohn2008Ver 1.3
69726view15:53, 10 July 2013Leonjohn2008Ver 1.2
69725view15:43, 10 July 2013Leonjohn2008Ver 1.2
69724view15:40, 10 July 2013Leonjohn2008Periodical save, work in progress
69723view15:30, 10 July 2013Leonjohn2008Periodical save, work in progress
69722view15:11, 10 July 2013Leonjohn2008Ver 1.1
69721view14:30, 10 July 2013Leonjohn2008Periodical save, work in progress
69720view14:19, 10 July 2013Leonjohn2008Periodical save, work in progress
69719view14:09, 10 July 2013Leonjohn2008Periodical save, work in progress
69718view13:45, 10 July 2013Leonjohn2008Periodical save, work in progress
69717view13:42, 10 July 2013Leonjohn2008Ver 1.1
69716view13:37, 10 July 2013Leonjohn2008V1.1
69715view13:31, 10 July 2013Leonjohn2008Ver1.1
69713view04:28, 10 July 2013Leonjohn2008Ver1.0
69712view03:57, 10 July 2013Leonjohn2008Periodical save, work in progress
69711view03:33, 10 July 2013Leonjohn2008New pathway

External references


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NameTypeDatabase referenceComment
10-Formyl-THFMetaboliteC00234 (KEGG Compound)
3P-GlycerateMetaboliteC00597 (KEGG Compound)
3P-HydroxypyruvateMetaboliteC03232 (KEGG Compound)
5,10-Methenyl-THFMetaboliteC00445 (KEGG Compound)
5,10-Methylene-THFMetaboliteC00143 (KEGG Compound)
5-Methyl-THFMetaboliteC00440 (KEGG Compound)
AHCYGeneProduct191 (Entrez Gene)
AHCYL1GeneProduct10768 (Entrez Gene)
AHCYL2GeneProduct23382 (Entrez Gene)
AMTGeneProduct275 (Entrez Gene)
BHMTGeneProduct635 (Entrez Gene)
CBSGeneProduct875 (Entrez Gene)
CTHGeneProduct1491 (Entrez Gene)
CystathionineMetaboliteC02291 (KEGG Compound)
CysteineMetaboliteC00097 (KEGG Compound)
DHFRGeneProduct1719 (Entrez Gene)
DHFRL1GeneProduct200895 (Entrez Gene)
DNMT1GeneProduct1786 (Entrez Gene)
DNMT3AGeneProduct1788 (Entrez Gene)
DNMT3BGeneProduct1789 (Entrez Gene)
DNMT3LGeneProduct29947 (Entrez Gene)
DihydrofolateMetaboliteC00415 (KEGG Compound)
GCLCGeneProduct2729 (Entrez Gene)
GCLMGeneProduct2730 (Entrez Gene)
GSSGeneProduct2937 (Entrez Gene)
GlutathioneMetaboliteC00051 (KEGG Compound)
GlycineMetaboliteC00037 (KEGG Compound)
HomocysteineMetaboliteHMDB00742 (HMDB)
MAT1AGeneProduct4143 (Entrez Gene)
MAT2AGeneProduct4144 (Entrez Gene)
MAT2BGeneProduct27430 (Entrez Gene)
MTHFD1GeneProduct4522 (Entrez Gene)
MTHFD1LGeneProduct1719 (Entrez Gene)
MTHFD1LGeneProduct25902 (Entrez Gene)
MTHFD2GeneProduct10797 (Entrez Gene)
MTHFD2LGeneProduct441024 (Entrez Gene)
MTHFRGeneProduct4524 (Entrez Gene)
MTRGeneProduct4548 (Entrez Gene)
MethionineMetaboliteC00073 (KEGG Compound)
PHGDHGeneProduct26227 (Entrez Gene)
PSAT1GeneProduct29968 (Entrez Gene)
PSPHGeneProduct5723 (Entrez Gene)
PhosphoserineMetaboliteC01005 (KEGG Compound)
SAHMetaboliteC00021 (KEGG Compound)
SAMeMetaboliteC00019 (KEGG Compound)
SHMT1GeneProduct6470 (Entrez Gene)
SHMT2GeneProduct6472 (Entrez Gene)
SerineMetaboliteC00065 (KEGG Compound)
THFMetaboliteC00101 (KEGG Compound)
TYMSGeneProduct7298 (Entrez Gene)
dTMPMetaboliteC00364 (KEGG Compound)
dUMPMetaboliteC00365 (KEGG Compound)

Annotated Interactions

No annotated interactions

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