Nanoparticle triggered regulated necrosis (Homo sapiens)

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1DNA damageNECROSOMELipid peroxidationLysosomeMitochondriaROSGe NPFADDRIPK1JNKTRIFCalciumCalpainsATP ↓TNFR1CASP8PARP1cPLA₂lipoxygenaseTRADDpH ↓PAMPsCeramideSMasesGlutaminolysisNecroptosisTNFIronArachidonic acidNec-12RIPK3TLRsFerritinLabile iron poolGlycogenolysisGlycolysisIron


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Ontology Terms



  1. Andón FT, Fadeel B; ''Programmed Cell Death: Molecular Mechanisms and Implications for Safety Assessment of Nanomaterials.''; Acc Chem Res, 2012 PubMed Europe PMC Scholia
  2. Ma YH, Huang CP, Tsai JS, Shen MY, Li YK, Lin LY; ''Water-soluble germanium nanoparticles cause necrotic cell death and the damage can be attenuated by blocking the transduction of necrotic signaling pathway.''; Toxicol Lett, 2011 PubMed Europe PMC Scholia


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110691view13:47, 28 May 2020LaurentAdded missing DataNode types - added ID to Ge NP
106661view21:20, 12 September 2019KhanspersModified description
106207view12:10, 16 August 2019MaintBotHMDB identifier normalization
105662view05:17, 10 August 2019KhanspersModified description
102135view09:25, 2 December 2018EgonwFixed the Uniprot ID of TNF.
102134view09:24, 2 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
97539view14:33, 24 May 2018EgonwFixed a character encoding issue.
97519view13:52, 24 May 2018Timverbruggenincrease mappings
97510view13:39, 24 May 2018Timverbruggenincreased mapping
92316view08:50, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
86006view00:51, 24 June 2016Khansperschanged look of pathway nodes
86000view00:30, 24 June 2016KhanspersConnected interactions, updated xrefs, assigned node types
85999view00:22, 24 June 2016Khanspersconnected lines, changed gene nodes to pathway nodes where appropriate
85026view14:21, 6 April 2016Mkutmonremove special characters and add graphical annotations instead
81068view18:23, 19 July 2015EgonwTyped ceramide as metabolite.
81067view18:22, 19 July 2015EgonwUse a ChEBI identifier instead of a Wikipedia one.
77901view14:47, 28 October 2014Bart SmeetsModified description
77900view14:47, 28 October 2014Bart SmeetsModified description
77667view12:01, 5 October 2014EgonwReplaced 'Uniprot-SwissProt' by 'Uniprot-TrEMBL'.
74182view09:32, 3 April 2014Bart SmeetsAdded wiki entries
74143view10:31, 1 April 2014Bart SmeetsExpanded description of nanoparticles in pathway, added corresponding literature references.
73826view15:05, 25 February 2014Bart SmeetsFixed some wikipedia entries
73825view15:01, 25 February 2014Bart SmeetsAdded a few GeneIDs
71447view19:13, 17 October 2013MaintBotUpdated data sources
70991view20:50, 21 September 2013EgonwAdded a few identifiers.
68057view13:10, 29 June 2013EgonwCompleted the pathway as given in the figure.
68054view13:04, 29 June 2013EgonwPeriodical save, work in progress
66148view08:19, 15 June 2013EgonwAdded the literature ref again.
65706view12:26, 11 June 2013EgonwAdded the caspase 8 identifier, and widened the Necroptosis box.
65603view16:18, 10 June 2013EgonwMore content of the pathway.
65457view10:27, 8 June 2013EgonwOntology Term : 'necrosis pathway' added !
65447view08:02, 8 June 2013EgonwNew pathway

External references


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NameTypeDatabase referenceComment
ATP ↓Metabolite
Arachidonic acidMetaboliteHMDB01043 (HMDB)
CASP8GeneProductENSG00000064012 (Ensembl)
CalciumMetaboliteHMDB00464 (HMDB)
CeramideCeramide (Wikipedia)
FADDGeneProductENSG00000168040 (Ensembl)
FerritinProteinP02792 (Uniprot-SwissProt)
GlutaminolysisGlutaminolysis (Wikipedia)
GlycogenolysisGlycogenolysis (Wikipedia)
GlycolysisGlycolysis (Wikipedia)
IronMetaboliteHMDB00692 (HMDB)
JNKGeneProductENSG00000107643 (Ensembl)
Labile iron pool
Nec-1Metabolite2828334 (PubChem-compound)
PARP1GeneProductENSG00000143799 (Ensembl)
RIPK1GeneProductENSG00000137275 (Ensembl)
RIPK3GeneProductENSG00000129465 (Ensembl)
ROSMetaboliteCHEBI:26523 (ChEBI)
SMasesSphingomyelinase (Wikipedia)
TLRsProteinToll-like_receptor (Wikipedia)
TNFR1GeneProductENSG00000067182 (Ensembl)
TNFProteinTNF (Uniprot-TrEMBL)
TRADDGeneProductENSG00000102871 (Ensembl)
TRIFGeneProductENSG00000127666 (Ensembl)
pH ↓

Annotated Interactions

No annotated interactions

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