Integrated Lung Cancer Pathway (Homo sapiens)

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P53AIP1JNK 1/2/3NF-KBNoxaRASTRADD/FADDAPAF1RAF1MEK4/7p70S6KTNFaDAGAktPAK1ABLARF1ARF6BAKMDM2PKCCASP7JUNCBLTNFRERBB2SH2D1ATNF-R1CRAFERK1 and ERK2 cascadeSTAT3PIP2MEK1/2GeneProductCRKERBB1SMAGPBIMRAC1JUNRIPK1BCL2PIP3GRB2BRAFSHCPDK1CASP8TRAF2EGFRBCLXLFASCASP9IKBsPIK3C2ARASGRF1TGFACASP3RASCASP6IKKA_HUMANP53TYKRAP1MYD88MAP3KsPIXMERTNFCAMPBADERC1STAT5SRCEGFMAP2KNIK/NF-kappaB cascadePKLRFAKSAMSN1MKKSPCL-yProcaspase8STAT1CASP9PIK3R/PIK3CPUMAFOSGaQ/11EPACMTORNCKSOSPOR


Description

No description

Quality Tags

Ontology Terms

 

Bibliography

  1. Huang TH, Wu F, Loeb GB, Hsu R, Heidersbach A, Brincat A, Horiuchi D, Lebbink RJ, Mo YY, Goga A, McManus MT; ''Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion.''; J Biol Chem, 2009 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
108111view10:19, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
108110view10:19, 29 November 2019FehrhartOntology Term : 'lung cancer' added !
98363view06:45, 24 August 2018EgonwUpdated the MIR21 identifier.
95231view18:59, 26 November 2017DeSlModified description
95137view02:27, 17 November 2017AlexanderPicoconnected interactions
88670view15:35, 12 August 2016JmeliusOntology Term : 'lung cancer pathway' added !
80240view05:04, 28 May 2015Khanspersdecreasing board size
80239view05:04, 28 May 2015Khansperschanging board size
80203view20:06, 22 May 2015KhanspersAdded mir21 targeting
71235view14:49, 16 October 2013MaintBotAutomated update of data sources
67932view05:52, 28 June 2013MehdishadmandPeriodical save, work in progress
67872view16:18, 27 June 2013MehdishadmandPeriodical save, work in progress
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External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABLGeneProductABL
APAF1GeneProductENSG00000120868 (Ensembl)
ARF1GeneProductENSG00000143761 (Ensembl)
ARF6GeneProductENSG00000165527 (Ensembl)
AktProteinAKT1 (EMBL)
BADGeneProductBAD
BAKProteinBAK (Uniprot/TrEMBL)
BCL2GeneProductBCL2
BCLXLGeneProductBCLXL
BIMGeneProductBIM
BRAFGeneProductENSG00000157764 (Ensembl)
CAMPGeneProductENSG00000164047 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP6GeneProductENSG00000138794 (Ensembl)
CASP7GeneProductCASP7
CASP8GeneProductCASP8
CASP9GeneProductCASP9
CASP9GeneProductENSG00000132906 (Ensembl)
CBLGeneProductENSG00000110395 (Ensembl)
CRAFGeneProductCRAF
CRKGeneProductENSG00000167193 (Ensembl)
DAGGeneProductDAG
EGFGeneProductEGF
EGFRGeneProductEGFR
EPACGeneProductEPAC
ERBB1GeneProductERBB1
ERBB2GeneProductENSG00000141736 (Ensembl)
ERC1GeneProductENSG00000082805 (Ensembl)
ERK1 and ERK2 cascadeGeneProductGO:0070371 (GeneOntology)
FAKGeneProductFAK
FASGeneProductENSG00000026103 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
GRB2GeneProductGRB2
GaQ/11GeneProductGaQ/11
GeneProductGeneProduct
IKBsGeneProductIKBs
IKKA_HUMANProteinO15111 (Uniprot/TrEMBL)
JNK 1/2/3GeneProductJNK 1/2/3
JUNGeneProductENSG00000177606 (Ensembl)
MAP2KGeneProductMAP2K
MAP3KsGeneProductMAP3Ks
MDM2GeneProductENSG00000135679 (Ensembl)
MEK1/2GeneProductMEK1/2
MEK4/7GeneProductMEK4/7
MERGeneProductMer5
MKKSGeneProductENSG00000125863 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MYD88GeneProductENSG00000172936 (Ensembl)
NCKGeneProductNCK
NF-KBGeneProductNF-KB
NIK/NF-kappaB cascadeGeneProductGO:0038061 (GeneOntology)
NoxaGeneProductNoxa
P53AIP1GeneProductP53AIP1
P53ProteinP53 (Uniprot/TrEMBL)
PAK1GeneProductENSG00000149269 (Ensembl)
PCL-yGeneProductPCL-y
PDK1GeneProductENSG00000152256 (Ensembl)
PIK3C2AGeneProductENSG00000011405 (Ensembl)
PIK3R/PIK3CGeneProductPIK3R/PIK3C
PIP2GeneProductPIP2
PIP3GeneProductPIP3
PIXGeneProductPIX
PKCGeneProductPKC
PKLRGeneProductENSG00000143627 (Ensembl)
PORGeneProductENSG00000127948 (Ensembl)
PUMAGeneProductPUMA
Procaspase8GeneProductProcaspase8
RAC1GeneProduct5879 (Entrez Gene)
RAF1GeneProductENSG00000132155 (Ensembl)
RAP1GeneProductENSG00000116473 (Ensembl)
RASGRF1GeneProductENSG00000058335 (Ensembl)
RASGeneProductRAS
RIPK1GeneProductENSG00000137275 (Ensembl)
SAMSN1GeneProductENSG00000155307 (Ensembl)
SH2D1AGeneProductENSG00000183918 (Ensembl)
SHCGeneProductSHC
SMAGPGeneProductENSG00000170545 (Ensembl)
SOSGeneProductSOS
SRCGeneProductENSG00000197122 (Ensembl)
STAT1GeneProductSTAT1
STAT3GeneProductSTAT3
STAT5GeneProductSTAT5
TGFAGeneProductENSG00000163235 (Ensembl)
TNF-R1GeneProductTNF-R1
TNFRGeneProductTNFR
TNFGeneProductTNF
TNFaGeneProductTNFa
TRADD/FADDGeneProductTRADD/FADD
TRAF2GeneProductENSG00000127191 (Ensembl)
TYKGeneProductTYK
p70S6KGeneProductp70S6K

Annotated Interactions

No annotated interactions

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